RU2124519C1 - Производные гуанидиналкил-1,1-бис-фосфоновой кислоты, способ их получения, лекарственное средство и способ его получения - Google Patents

Производные гуанидиналкил-1,1-бис-фосфоновой кислоты, способ их получения, лекарственное средство и способ его получения Download PDF

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RU2124519C1
RU2124519C1 RU92004530A RU92004530A RU2124519C1 RU 2124519 C1 RU2124519 C1 RU 2124519C1 RU 92004530 A RU92004530 A RU 92004530A RU 92004530 A RU92004530 A RU 92004530A RU 2124519 C1 RU2124519 C1 RU 2124519C1
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Russia
Prior art keywords
hydrogen
amino
bisphosphonic acid
alkyl
branched
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RU92004530A
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English (en)
Russian (ru)
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RU92004530A (ru
Inventor
Ланг Ханс-Йохен
Нойманн Кристоф
Карньято Дени
Мура Анн-Мари
Сато Риоиши
Като Масаказу
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Хехст АГ
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025—Esters of poly(thio)phosphonic acids
    • C07F9/405—Esters of poly(thio)phosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
    • C07F9/65068—Five-membered rings having the nitrogen atoms in positions 1 and 3 condensed with carbocyclic rings or carbocyclic ring systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
RU92004530A 1991-12-12 1992-12-11 Производные гуанидиналкил-1,1-бис-фосфоновой кислоты, способ их получения, лекарственное средство и способ его получения RU2124519C1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE4140908 1991-12-12
DEP4140908.6 1991-12-12
DE4211976 1992-04-09
DEP4211976.6 1992-04-09

Publications (2)

Publication Number Publication Date
RU92004530A RU92004530A (ru) 1995-06-19
RU2124519C1 true RU2124519C1 (ru) 1999-01-10

Family

ID=25910001

Family Applications (1)

Application Number Title Priority Date Filing Date
RU92004530A RU2124519C1 (ru) 1991-12-12 1992-12-11 Производные гуанидиналкил-1,1-бис-фосфоновой кислоты, способ их получения, лекарственное средство и способ его получения

Country Status (16)

Country Link
US (1) US5294608A (enExample)
EP (1) EP0546548B1 (enExample)
JP (1) JP3377234B2 (enExample)
KR (1) KR100269544B1 (enExample)
AT (1) ATE152453T1 (enExample)
AU (1) AU657018B2 (enExample)
BR (1) BR9204984A (enExample)
CA (1) CA2085171C (enExample)
DE (1) DE59208426D1 (enExample)
DK (1) DK0546548T3 (enExample)
ES (1) ES2101012T3 (enExample)
FI (1) FI105550B (enExample)
MX (1) MX9207215A (enExample)
NZ (1) NZ245414A (enExample)
RU (1) RU2124519C1 (enExample)
TW (1) TW222637B (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8922026D0 (en) * 1989-09-29 1989-11-15 Pharma Mar Sa Novel anti-viral and cytotoxic agent
US20030148933A1 (en) * 1990-10-01 2003-08-07 Pharma Mar S.A. Derivatives of dehydrodidemnin B
DE4223940A1 (de) * 1992-07-21 1994-01-27 Boehringer Mannheim Gmbh Neue acyclische Amidingruppen-haltige Diphosphonsäurederivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
ES2129485T3 (es) * 1992-12-02 1999-06-16 Hoechst Ag Derivados de acidos guanidinoalquil-1,1-bisfosfonicos, procedimiento para su preparacion y su utilizacion.
JPH06298779A (ja) * 1993-04-15 1994-10-25 Hoechst Japan Ltd ヘテロ環イミノビスメチレンビスホスホン酸誘導体
US5854227A (en) * 1994-03-04 1998-12-29 Hartmann; John F. Therapeutic derivatives of diphosphonates
DE19546736A1 (de) * 1995-12-14 1997-06-19 Hoechst Ag Substituierte Chromanylsulfonyl(thio)harnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung pharmazeutischer Präparate
DE69819311T2 (de) * 1997-03-07 2004-07-29 Metabasis Therapeutics Inc., San Diego Neue benzimidazol inhibitoren der fructose-1,6-bisphosphatase
WO1998039344A1 (en) * 1997-03-07 1998-09-11 Metabasis Therapeutics, Inc. Novel purine inhibitors of fructose-1,6-bisphosphatase
IT1303672B1 (it) 1998-07-28 2001-02-23 Nicox Sa Sali nitrati di farmaci attivi nei disordini ossei
JP2003519183A (ja) * 2000-01-04 2003-06-17 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 心臓および動脈の石灰化を抑制する低用量ビスホスホネートの使用
WO2008128056A1 (en) * 2004-10-08 2008-10-23 The Board Of Trustees Of The University Of Illinois Bisphosphonate compounds and methods with enhanced potency for multiple targets including fpps, ggpps, and dpps
WO2006039721A2 (en) * 2004-10-08 2006-04-13 The Board Of Trustees Of The University Of Illinois Bisphosphonate compounds and methods for bone resorption diseases, cancer, bone pain, immune disorders, and infectious diseases
EP2001486A4 (en) * 2006-03-17 2010-12-29 Univ Illinois BIPHOSPHONATE COMPOUNDS AND CORRESPONDING METHODS
US7457149B2 (en) 2006-05-05 2008-11-25 Macronix International Co., Ltd. Methods and apparatus for thermally assisted programming of a magnetic memory device
JP2010523709A (ja) * 2007-04-12 2010-07-15 ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティー オブ イリノイ Ｆｐｐｓ、ｇｇｐｐｓ及びｄｐｐｓを含む複数の標的に対して高い効能を有するビスホスホネート化合物及び方法
KR102956231B1 (ko) * 2023-10-12 2026-04-23 재단법인대구경북과학기술원 포스폰산 디페닐아민 화합물 및 이를 포함하는 페로브스카이트 태양전지

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4812311A (en) * 1984-12-21 1989-03-14 The Procter & Gamble Company Kit for use in the treatment of osteoporosis

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3225469A1 (de) * 1982-07-05 1984-01-05 Schering AG, 1000 Berlin und 4709 Bergkamen Diphosphonsaeure-derivate und diese enthaltende pharmazeutische praeparate
IL77243A (en) * 1984-12-21 1996-11-14 Procter & Gamble Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds
EP0243173B1 (en) * 1986-04-24 1991-06-26 Fujisawa Pharmaceutical Co., Ltd. New diphosphonic acid compounds, processes for the preparation thereof and pharmaceutical composition comprising the same
EP0282309A3 (en) * 1987-03-11 1990-03-14 Yamanouchi Pharmaceutical Co. Ltd. Azole-aminomethylene bisphosphonic acid derivatives
IL86951A (en) * 1987-07-06 1996-07-23 Procter & Gamble Pharma Methylene phosphonoalkylphosphinates and pharmaceutical preparations containing them
US4990503A (en) * 1988-08-12 1991-02-05 Yamanouchi Pharmaceutical Co., Ltd. Heterocyclic bisphosphonic acid derivatives

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4812311A (en) * 1984-12-21 1989-03-14 The Procter & Gamble Company Kit for use in the treatment of osteoporosis

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
L. Maier, phosphorus and Sulfur. 11, 1981, 311-322. Машковский М.Д. Лекарственные средства. -М.: Медицина, 1987, ч.1, с.604-605. *

Also Published As

Publication number Publication date
FI925617A0 (fi) 1992-12-10
EP0546548A1 (de) 1993-06-16
DK0546548T3 (da) 1997-10-13
JPH05271260A (ja) 1993-10-19
DE59208426D1 (de) 1997-06-05
AU3017392A (en) 1993-06-17
CA2085171C (en) 2003-12-02
BR9204984A (pt) 1993-06-15
EP0546548B1 (de) 1997-05-02
NZ245414A (en) 1995-04-27
MX9207215A (es) 1993-06-01
FI105550B (fi) 2000-09-15
US5294608A (en) 1994-03-15
ATE152453T1 (de) 1997-05-15
CA2085171A1 (en) 1993-06-13
FI925617A7 (fi) 1993-06-13
TW222637B (enExample) 1994-04-21
KR100269544B1 (ko) 2000-10-16
ES2101012T3 (es) 1997-07-01
AU657018B2 (en) 1995-02-23
JP3377234B2 (ja) 2003-02-17

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Effective date: 20061212