RU2124519C1 - Производные гуанидиналкил-1,1-бис-фосфоновой кислоты, способ их получения, лекарственное средство и способ его получения - Google Patents

Производные гуанидиналкил-1,1-бис-фосфоновой кислоты, способ их получения, лекарственное средство и способ его получения Download PDF

Info

Publication number
RU2124519C1
RU2124519C1 RU92004530A RU92004530A RU2124519C1 RU 2124519 C1 RU2124519 C1 RU 2124519C1 RU 92004530 A RU92004530 A RU 92004530A RU 92004530 A RU92004530 A RU 92004530A RU 2124519 C1 RU2124519 C1 RU 2124519C1
Authority
RU
Russia
Prior art keywords
hydrogen
amino
bisphosphonic acid
alkyl
branched
Prior art date
Application number
RU92004530A
Other languages
English (en)
Russian (ru)
Other versions
RU92004530A (ru
Inventor
Ланг Ханс-Йохен
Нойманн Кристоф
Карньято Дени
Мура Анн-Мари
Сато Риоиши
Като Масаказу
Original Assignee
Хехст АГ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Хехст АГ filed Critical Хехст АГ
Publication of RU92004530A publication Critical patent/RU92004530A/ru
Application granted granted Critical
Publication of RU2124519C1 publication Critical patent/RU2124519C1/ru

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025—Esters of poly(thio)phosphonic acids
    • C07F9/405—Esters of poly(thio)phosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
    • C07F9/65068—Five-membered rings having the nitrogen atoms in positions 1 and 3 condensed with carbocyclic rings or carbocyclic ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
RU92004530A 1991-12-12 1992-12-11 Производные гуанидиналкил-1,1-бис-фосфоновой кислоты, способ их получения, лекарственное средство и способ его получения RU2124519C1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE4140908 1991-12-12
DEP4140908.6 1991-12-12
DE4211976 1992-04-09
DEP4211976.6 1992-04-09

Publications (2)

Publication Number Publication Date
RU92004530A RU92004530A (ru) 1995-06-19
RU2124519C1 true RU2124519C1 (ru) 1999-01-10

Family

ID=25910001

Family Applications (1)

Application Number Title Priority Date Filing Date
RU92004530A RU2124519C1 (ru) 1991-12-12 1992-12-11 Производные гуанидиналкил-1,1-бис-фосфоновой кислоты, способ их получения, лекарственное средство и способ его получения

Country Status (16)

Country Link
US (1) US5294608A (enExample)
EP (1) EP0546548B1 (enExample)
JP (1) JP3377234B2 (enExample)
KR (1) KR100269544B1 (enExample)
AT (1) ATE152453T1 (enExample)
AU (1) AU657018B2 (enExample)
BR (1) BR9204984A (enExample)
CA (1) CA2085171C (enExample)
DE (1) DE59208426D1 (enExample)
DK (1) DK0546548T3 (enExample)
ES (1) ES2101012T3 (enExample)
FI (1) FI105550B (enExample)
MX (1) MX9207215A (enExample)
NZ (1) NZ245414A (enExample)
RU (1) RU2124519C1 (enExample)
TW (1) TW222637B (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8922026D0 (en) * 1989-09-29 1989-11-15 Pharma Mar Sa Novel anti-viral and cytotoxic agent
US20030148933A1 (en) * 1990-10-01 2003-08-07 Pharma Mar S.A. Derivatives of dehydrodidemnin B
DE4223940A1 (de) * 1992-07-21 1994-01-27 Boehringer Mannheim Gmbh Neue acyclische Amidingruppen-haltige Diphosphonsäurederivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
DE59309360D1 (de) * 1992-12-02 1999-03-18 Hoechst Ag Guanidinalkyl-1, 1-bisphosphonsäurederivate, Verfahren zu ihrer Herstellung und ihre Verwendung
JPH06298779A (ja) * 1993-04-15 1994-10-25 Hoechst Japan Ltd ヘテロ環イミノビスメチレンビスホスホン酸誘導体
US5854227A (en) * 1994-03-04 1998-12-29 Hartmann; John F. Therapeutic derivatives of diphosphonates
DE19546736A1 (de) * 1995-12-14 1997-06-19 Hoechst Ag Substituierte Chromanylsulfonyl(thio)harnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung pharmazeutischer Präparate
ATE253073T1 (de) 1997-03-07 2003-11-15 Metabasis Therapeutics Inc Neue benzimidazol inhibitoren der fructose-1,6- bisphosphatase
AU6452098A (en) 1997-03-07 1998-09-22 Metabasis Therapeutics, Inc. Novel purine inhibitors of fructose-1,6-bisphosphatase
IT1303672B1 (it) 1998-07-28 2001-02-23 Nicox Sa Sali nitrati di farmaci attivi nei disordini ossei
WO2001049295A1 (en) * 2000-01-04 2001-07-12 The Regents Of The University Of California Use of low dosage bisphosphonates to inhibit cardiac and arterial calcification
WO2006039721A2 (en) * 2004-10-08 2006-04-13 The Board Of Trustees Of The University Of Illinois Bisphosphonate compounds and methods for bone resorption diseases, cancer, bone pain, immune disorders, and infectious diseases
US8012949B2 (en) * 2004-10-08 2011-09-06 The Board Of Trustees Of The University Of Illinois Bisphosphonate compounds and methods with enhanced potency for multiple targets including FPPS, GGPPS, and DPPS
US7687482B2 (en) * 2006-03-17 2010-03-30 The Board Of Trustees Of The University Of Illinois Bisphosphonate compounds and methods
US7457149B2 (en) 2006-05-05 2008-11-25 Macronix International Co., Ltd. Methods and apparatus for thermally assisted programming of a magnetic memory device
AU2008240266A1 (en) * 2007-04-12 2008-10-23 The Board Of Trustees Of The University Of Illinois Bisphosphonate compounds and methods with enhanced potency for multiple targets including FPPS, GGPPS, and DPPS

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4812311A (en) * 1984-12-21 1989-03-14 The Procter & Gamble Company Kit for use in the treatment of osteoporosis

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3225469A1 (de) * 1982-07-05 1984-01-05 Schering AG, 1000 Berlin und 4709 Bergkamen Diphosphonsaeure-derivate und diese enthaltende pharmazeutische praeparate
IL77243A (en) * 1984-12-21 1996-11-14 Procter & Gamble Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds
DE3770982D1 (de) * 1986-04-24 1991-08-01 Fujisawa Pharmaceutical Co Diphosphonsaeure-verbindungen, verfahren zu deren herstellung und sie enthaltende arzneimittel.
KR880011136A (ko) * 1987-03-11 1988-10-26 모리오까 시게오 아졸- 아미노메틸렌 비스포스폰산 유도체
IL86951A (en) * 1987-07-06 1996-07-23 Procter & Gamble Pharma Methylene phosphonoalkylphosphinates and pharmaceutical preparations containing them
US4990503A (en) * 1988-08-12 1991-02-05 Yamanouchi Pharmaceutical Co., Ltd. Heterocyclic bisphosphonic acid derivatives

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4812311A (en) * 1984-12-21 1989-03-14 The Procter & Gamble Company Kit for use in the treatment of osteoporosis

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
L. Maier, phosphorus and Sulfur. 11, 1981, 311-322. Машковский М.Д. Лекарственные средства. -М.: Медицина, 1987, ч.1, с.604-605. *

Also Published As

Publication number Publication date
TW222637B (enExample) 1994-04-21
FI925617A7 (fi) 1993-06-13
CA2085171C (en) 2003-12-02
EP0546548A1 (de) 1993-06-16
FI925617A0 (fi) 1992-12-10
MX9207215A (es) 1993-06-01
DE59208426D1 (de) 1997-06-05
AU3017392A (en) 1993-06-17
US5294608A (en) 1994-03-15
FI105550B (fi) 2000-09-15
KR100269544B1 (ko) 2000-10-16
ATE152453T1 (de) 1997-05-15
CA2085171A1 (en) 1993-06-13
JPH05271260A (ja) 1993-10-19
DK0546548T3 (da) 1997-10-13
AU657018B2 (en) 1995-02-23
JP3377234B2 (ja) 2003-02-17
EP0546548B1 (de) 1997-05-02
BR9204984A (pt) 1993-06-15
NZ245414A (en) 1995-04-27
ES2101012T3 (es) 1997-07-01

Similar Documents

Publication Publication Date Title
RU2124519C1 (ru) Производные гуанидиналкил-1,1-бис-фосфоновой кислоты, способ их получения, лекарственное средство и способ его получения
US5661174A (en) Guanidinealkyl-1,1-bisphosphonic acid derivatives, process for their preparation and their use
US4621077A (en) Pharmacologically active biphosphonates, process for the preparation thereof and pharmaceutical compositions therefrom
US4732998A (en) Bisphosphonic acids and esters
EP0830863A1 (de) Die gastrointestinale Durchblutung fördernde Arzneimittel
JP2701952B2 (ja) Ｎ‐複素環プロピリデン‐１，１‐ビスホスホン酸、その製法および薬剤組成物
HUT74562A (en) Optically active benzothiepin derivatives, their preparation and use
EP0166302A2 (en) "1-[Bis-(4-fluorophyl)methyl]-4-(3-phenyl-2-propenyl)-hexahydro-1H-1,4-diazepine, preparation thereof and compositions containing it
US6172050B1 (en) Phospholipid derivatives
CZ182993A3 (en) N-/(4,5-dihydroxy- and 4,5,8-trihydroxy-9,10-dihydro - 9,10-dioxo-2-anthracenyl)carbonyl/ amino acids, process of their preparation and pharmaceutical preparations in which they are comprised
TW318852B (enExample)
IE65571B1 (en) Unsaturated aminodicarboxylic acid derivatives
CS266599B2 (en) Method of (s)-1-/6-amino-2-//hydroxy-(4-phenylbutyl) phosphinile /oxy/-1-oxohehexil/ -l-proline production
HU215918B (hu) Eljárás acil-amino-alkilidén-hidroxi-bifoszfonsav-származékok, valamint e vegyületeket tartalmazó gyógyászati készítmények előállítására
TW295587B (enExample)
DK200200115U3 (da) Hidtil ukendte salte af 4-amino-1-hydroxybutyliden-1, 1-bisphosphonsyre, deres fremstilling og anvendelse
WO2001030788A1 (en) Novel salts of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid, their preparation and use
RU1838298C (ru) Цис-1-(3 @ -ацетилтиоприпионил)-6-метил-пипеколинова кислота, обладающа антинипертензивной активностью, и способ ее получени
US3341409A (en) Acylsulfamoylphenyl phosphate warmblooded animal systemic insecticides
JPH0551317A (ja) 脳機能改善薬

Legal Events

Date Code Title Description
MM4A The patent is invalid due to non-payment of fees

Effective date: 20061212