ATE152453T1 - Guanidinalkyl-1,1-bisphosphonsäurederivate, verfahren zu ihrer herstellung und ihre verwendung - Google Patents
Guanidinalkyl-1,1-bisphosphonsäurederivate, verfahren zu ihrer herstellung und ihre verwendungInfo
- Publication number
- ATE152453T1 ATE152453T1 AT92121077T AT92121077T ATE152453T1 AT E152453 T1 ATE152453 T1 AT E152453T1 AT 92121077 T AT92121077 T AT 92121077T AT 92121077 T AT92121077 T AT 92121077T AT E152453 T1 ATE152453 T1 AT E152453T1
- Authority
- AT
- Austria
- Prior art keywords
- hydrogen atom
- chemical structure
- guanidinalkyl
- production
- acid derivatives
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 239000000126 substance Substances 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000006701 (C1-C7) alkyl group Chemical group 0.000 abstract 1
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910052736 halogen Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-N phosphoric acid Substances OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 abstract 1
- 150000003016 phosphoric acids Chemical class 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4025—Esters of poly(thio)phosphonic acids
- C07F9/405—Esters of poly(thio)phosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
- C07F9/65068—Five-membered rings having the nitrogen atoms in positions 1 and 3 condensed with carbocyclic rings or carbocyclic ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Physical Education & Sports Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Rheumatology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4140908 | 1991-12-12 | ||
| DE4211976 | 1992-04-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE152453T1 true ATE152453T1 (de) | 1997-05-15 |
Family
ID=25910001
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92121077T ATE152453T1 (de) | 1991-12-12 | 1992-12-10 | Guanidinalkyl-1,1-bisphosphonsäurederivate, verfahren zu ihrer herstellung und ihre verwendung |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5294608A (enExample) |
| EP (1) | EP0546548B1 (enExample) |
| JP (1) | JP3377234B2 (enExample) |
| KR (1) | KR100269544B1 (enExample) |
| AT (1) | ATE152453T1 (enExample) |
| AU (1) | AU657018B2 (enExample) |
| BR (1) | BR9204984A (enExample) |
| CA (1) | CA2085171C (enExample) |
| DE (1) | DE59208426D1 (enExample) |
| DK (1) | DK0546548T3 (enExample) |
| ES (1) | ES2101012T3 (enExample) |
| FI (1) | FI105550B (enExample) |
| MX (1) | MX9207215A (enExample) |
| NZ (1) | NZ245414A (enExample) |
| RU (1) | RU2124519C1 (enExample) |
| TW (1) | TW222637B (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030148933A1 (en) * | 1990-10-01 | 2003-08-07 | Pharma Mar S.A. | Derivatives of dehydrodidemnin B |
| GB8922026D0 (en) * | 1989-09-29 | 1989-11-15 | Pharma Mar Sa | Novel anti-viral and cytotoxic agent |
| DE4223940A1 (de) * | 1992-07-21 | 1994-01-27 | Boehringer Mannheim Gmbh | Neue acyclische Amidingruppen-haltige Diphosphonsäurederivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
| DE59309360D1 (de) * | 1992-12-02 | 1999-03-18 | Hoechst Ag | Guanidinalkyl-1, 1-bisphosphonsäurederivate, Verfahren zu ihrer Herstellung und ihre Verwendung |
| JPH06298779A (ja) * | 1993-04-15 | 1994-10-25 | Hoechst Japan Ltd | ヘテロ環イミノビスメチレンビスホスホン酸誘導体 |
| US5854227A (en) * | 1994-03-04 | 1998-12-29 | Hartmann; John F. | Therapeutic derivatives of diphosphonates |
| DE19546736A1 (de) * | 1995-12-14 | 1997-06-19 | Hoechst Ag | Substituierte Chromanylsulfonyl(thio)harnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung pharmazeutischer Präparate |
| JP2001515482A (ja) | 1997-03-07 | 2001-09-18 | メタバシス・セラピューティクス・インコーポレイテッド | フルクトース−１，６−ビスホスファターゼの新規なベンズイミダゾールインヒビター |
| AU6452098A (en) * | 1997-03-07 | 1998-09-22 | Metabasis Therapeutics, Inc. | Novel purine inhibitors of fructose-1,6-bisphosphatase |
| IT1303672B1 (it) | 1998-07-28 | 2001-02-23 | Nicox Sa | Sali nitrati di farmaci attivi nei disordini ossei |
| WO2001049295A1 (en) * | 2000-01-04 | 2001-07-12 | The Regents Of The University Of California | Use of low dosage bisphosphonates to inhibit cardiac and arterial calcification |
| US8012949B2 (en) * | 2004-10-08 | 2011-09-06 | The Board Of Trustees Of The University Of Illinois | Bisphosphonate compounds and methods with enhanced potency for multiple targets including FPPS, GGPPS, and DPPS |
| US7358361B2 (en) * | 2004-10-08 | 2008-04-15 | The Board Of Trustees Of The University Of Illinois | Biophosphonate compounds and methods for bone resorption diseases, cancer, bone pain, immune disorders, and infectious diseases |
| JP2009530414A (ja) * | 2006-03-17 | 2009-08-27 | ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティー オブ イリノイ | ビスホスホネート化合物及び方法 |
| US7457149B2 (en) | 2006-05-05 | 2008-11-25 | Macronix International Co., Ltd. | Methods and apparatus for thermally assisted programming of a magnetic memory device |
| EP2203460A4 (en) * | 2007-04-12 | 2012-03-14 | Univ Illinois | BIPHOSPHONATE COMPOUNDS AND METHODS WITH INCREASED POTENTIAL FOR MULTIPLE OBJECTIVES, INCLUDING FPPS, GGPPS AND DPPS |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3225469A1 (de) * | 1982-07-05 | 1984-01-05 | Schering AG, 1000 Berlin und 4709 Bergkamen | Diphosphonsaeure-derivate und diese enthaltende pharmazeutische praeparate |
| IL77243A (en) * | 1984-12-21 | 1996-11-14 | Procter & Gamble | Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds |
| US4812311A (en) * | 1984-12-21 | 1989-03-14 | The Procter & Gamble Company | Kit for use in the treatment of osteoporosis |
| ES2039237T3 (es) * | 1986-04-24 | 1993-09-16 | Fujisawa Pharmaceutical Co., Ltd. | Procedimiento para preparar nuevos compuestos de acido difosfonico. |
| KR880011136A (ko) * | 1987-03-11 | 1988-10-26 | 모리오까 시게오 | 아졸- 아미노메틸렌 비스포스폰산 유도체 |
| IL86951A (en) * | 1987-07-06 | 1996-07-23 | Procter & Gamble Pharma | Methylene phosphonoalkylphosphinates and pharmaceutical preparations containing them |
| US4990503A (en) * | 1988-08-12 | 1991-02-05 | Yamanouchi Pharmaceutical Co., Ltd. | Heterocyclic bisphosphonic acid derivatives |
-
1992
- 1992-12-05 TW TW081109748A patent/TW222637B/zh active
- 1992-12-09 NZ NZ245414A patent/NZ245414A/en unknown
- 1992-12-10 FI FI925617A patent/FI105550B/fi not_active IP Right Cessation
- 1992-12-10 ES ES92121077T patent/ES2101012T3/es not_active Expired - Lifetime
- 1992-12-10 US US07/988,890 patent/US5294608A/en not_active Expired - Lifetime
- 1992-12-10 AT AT92121077T patent/ATE152453T1/de not_active IP Right Cessation
- 1992-12-10 DE DE59208426T patent/DE59208426D1/de not_active Expired - Fee Related
- 1992-12-10 DK DK92121077.9T patent/DK0546548T3/da active
- 1992-12-10 EP EP92121077A patent/EP0546548B1/de not_active Expired - Lifetime
- 1992-12-11 KR KR1019920023961A patent/KR100269544B1/ko not_active Expired - Fee Related
- 1992-12-11 AU AU30173/92A patent/AU657018B2/en not_active Ceased
- 1992-12-11 BR BR9204984A patent/BR9204984A/pt not_active Application Discontinuation
- 1992-12-11 RU RU92004530A patent/RU2124519C1/ru not_active IP Right Cessation
- 1992-12-11 CA CA002085171A patent/CA2085171C/en not_active Expired - Fee Related
- 1992-12-11 MX MX9207215A patent/MX9207215A/es not_active IP Right Cessation
- 1992-12-11 JP JP33133392A patent/JP3377234B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| RU2124519C1 (ru) | 1999-01-10 |
| DK0546548T3 (da) | 1997-10-13 |
| ES2101012T3 (es) | 1997-07-01 |
| AU3017392A (en) | 1993-06-17 |
| NZ245414A (en) | 1995-04-27 |
| KR100269544B1 (ko) | 2000-10-16 |
| EP0546548B1 (de) | 1997-05-02 |
| DE59208426D1 (de) | 1997-06-05 |
| FI925617A7 (fi) | 1993-06-13 |
| CA2085171A1 (en) | 1993-06-13 |
| US5294608A (en) | 1994-03-15 |
| JPH05271260A (ja) | 1993-10-19 |
| JP3377234B2 (ja) | 2003-02-17 |
| FI105550B (fi) | 2000-09-15 |
| TW222637B (enExample) | 1994-04-21 |
| AU657018B2 (en) | 1995-02-23 |
| FI925617A0 (fi) | 1992-12-10 |
| EP0546548A1 (de) | 1993-06-16 |
| BR9204984A (pt) | 1993-06-15 |
| CA2085171C (en) | 2003-12-02 |
| MX9207215A (es) | 1993-06-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE152453T1 (de) | Guanidinalkyl-1,1-bisphosphonsäurederivate, verfahren zu ihrer herstellung und ihre verwendung | |
| ATE186727T1 (de) | Substituierte 3-arylidinene-7-azaoxindol verbindungen und verfahren zu ihrer herstellung | |
| ATE143941T1 (de) | Salpetersäureester von 2-(2,6- dihalophenylamino)phenylessigsäurederivaten und verfahren zu ihrer herstellung | |
| MXPA02008600A (es) | 1,5-benzotiazepinas y su uso como hipolipidemicos. | |
| HU912485D0 (en) | Process for producing diazines | |
| HU9402302D0 (en) | New benzocycloheptienes, and benzoxepines, pharmaceutical compositions containing them and process for producing them | |
| CA2289409A1 (en) | Sulfoxide compounds and acetone complexes, and a process for producing the same | |
| UA41869C2 (uk) | Похідні етаноламіну, спосіб їх одержання, фармацевтична композиція, спосіб лікування | |
| ATE25677T1 (de) | Disubstituierte prolinderivate, verfahren zu ihrer herstellung und ihre verwendung. | |
| NO812355L (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive 3,1-benzoksazin-2-on-derivater | |
| HUT62563A (en) | Process for producing 4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydroproin derivatives and pharmaceutical compositions comprising same | |
| DE3769563D1 (de) | Neue derivate von 4,5-dihydro-oxazolen, verfahren zu ihrer herstellung und ihre verwendung. | |
| ATE42295T1 (de) | Penem-derivate, verfahren zu deren herstellung, ihre verwendung und pharmazeutische zusammensetzungen. | |
| ES2016017A6 (es) | Procedimiento para preparar derivados de acido 1,1-dioxocefem-4-carbotiolico. | |
| PT83786A (de) | Neue basisch substituierte pyridinverbindungen verfahren zu ihrer herstellung die sie enthaltenden arzneimittel und ihre verwendung | |
| DE69818051D1 (de) | N-benzenesulfonyl-l-prolin-derivate, verfahren zu ihrer herstellung und ihre therapeutische verwendung | |
| ES464013A1 (es) | Procedimiento para preparar derivados sustituidos de orto- fenilendiamina. | |
| ATE22284T1 (de) | 2-aminomethyl-6-sulfamoylphenolderivate, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen. | |
| DK104388D0 (da) | Hidtil ukendte 2-(2,3-dihydro-2-oxo-3-benzofuranyl)-eddikesyrederivater, fremgangsmaade til deres fremstilling og farmaceutiske midler indeholdende dem | |
| ATE168982T1 (de) | Neues verfahren zur herstellung von beta- alkoxyacrylsäure | |
| ATE18223T1 (de) | Ergolinderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen. | |
| ATE312091T1 (de) | Neue piperidinylalkylaminopyridazinonderivate, ein verfahren zu deren herstellung und pharmazeutische zusammensetzungen, die diese verbindungen enthalten | |
| DK0635021T3 (da) | Fremgangsmåde til fremstilling af derivater af bis(aminomethyl)phosphinsyre | |
| PT82416A (de) | Mehrfach substituierte pyridin-1-oxide verfahren zu ihrer herstellung die sie enthaltenden arzneimittel und ihre verwendung | |
| TH2024A (th) | พิเพอราซิโนนส์ |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| REN | Ceased due to non-payment of the annual fee |