RU2099333C1 - Производное 3-дезоксиманнозамина, способ его получения и фармацевтическая композиция, обладающая ингибирующей активностью к развитию сосудов и метастазов - Google Patents

Производное 3-дезоксиманнозамина, способ его получения и фармацевтическая композиция, обладающая ингибирующей активностью к развитию сосудов и метастазов Download PDF

Info

Publication number
RU2099333C1
RU2099333C1 SU925052492A SU5052492A RU2099333C1 RU 2099333 C1 RU2099333 C1 RU 2099333C1 SU 925052492 A SU925052492 A SU 925052492A SU 5052492 A SU5052492 A SU 5052492A RU 2099333 C1 RU2099333 C1 RU 2099333C1
Authority
RU
Russia
Prior art keywords
mannopyranose
dideoxy
formula
compound
acetamido
Prior art date
Application number
SU925052492A
Other languages
English (en)
Russian (ru)
Inventor
Монгелли Никола
Барджиотти Альберто
Онето Нуччиа
Джерони Кристина
Original Assignee
Фармиталиа Карло Эрба С.Р.Л.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Фармиталиа Карло Эрба С.Р.Л. filed Critical Фармиталиа Карло Эрба С.Р.Л.
Application granted granted Critical
Publication of RU2099333C1 publication Critical patent/RU2099333C1/ru

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/02—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
    • C07H5/06—Aminosugars
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/02—Acyclic radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
SU925052492A 1991-08-06 1992-08-05 Производное 3-дезоксиманнозамина, способ его получения и фармацевтическая композиция, обладающая ингибирующей активностью к развитию сосудов и метастазов RU2099333C1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9116896.3 1991-08-06
GB919116896A GB9116896D0 (en) 1991-08-06 1991-08-06 3-deoxymannosamine derivatives and process for their preparation

Publications (1)

Publication Number Publication Date
RU2099333C1 true RU2099333C1 (ru) 1997-12-20

Family

ID=10699545

Family Applications (1)

Application Number Title Priority Date Filing Date
SU925052492A RU2099333C1 (ru) 1991-08-06 1992-08-05 Производное 3-дезоксиманнозамина, способ его получения и фармацевтическая композиция, обладающая ингибирующей активностью к развитию сосудов и метастазов

Country Status (16)

Country Link
US (1) US5332756A (enExample)
EP (1) EP0527042A2 (enExample)
JP (1) JPH05208988A (enExample)
KR (1) KR930004325A (enExample)
AU (1) AU646173B2 (enExample)
CA (1) CA2075336A1 (enExample)
FI (1) FI923498L (enExample)
GB (1) GB9116896D0 (enExample)
HU (1) HU213208B (enExample)
IL (1) IL102500A (enExample)
MX (1) MX9204395A (enExample)
MY (1) MY108749A (enExample)
NZ (1) NZ243627A (enExample)
RU (1) RU2099333C1 (enExample)
TW (1) TW248564B (enExample)
ZA (1) ZA925871B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2266734C2 (ru) * 1999-05-13 2005-12-27 Фарма Мар, С.А. Композиции и применение ет743 для лечения злокачественных опухолей

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9216962D0 (en) * 1992-08-11 1992-09-23 Erba Carlo Spa Therapeutically active naphthalenesulfonic-pyrrolecarboxamido derivatives
GB9304589D0 (en) * 1993-03-05 1993-04-21 Erba Carlo Spa Biologically active ureido derivatives useful as antimetastic agents
FR2723947B1 (fr) * 1994-08-31 1996-09-27 Adir Nouveaux composes tetrahydropyraniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
JP4943839B2 (ja) * 2004-05-26 2012-05-30 株式会社希少糖生産技術研究所 血管新生抑制剤
US8148335B2 (en) 2004-06-23 2012-04-03 Children's Hospital & Research Center Oakland De-N-acetyl sialic acid antigens, antibodies thereto, and methods of use in cancer therapy
WO2006002402A2 (en) * 2004-06-23 2006-01-05 Children's Hospital & Research Center At Oakland Polysaccharide derivatives and uses in induction of an immune response
US20090214439A1 (en) * 2006-03-15 2009-08-27 Trustees Of Tufts College Fluorinated Carbohydrates and Their Use in Tumor Visualization, Tissue Engineering, and Cancer Chemotherapy
KR100780868B1 (ko) 2006-07-10 2007-11-30 부경대학교 산학협력단 항암효과를 나타내는 4급 아미노 글루코사민 화합물
US8999954B2 (en) * 2007-07-03 2015-04-07 Childern's Hospital & Research Center at Oakland Inhibitors of polysialic acid de-N-acetylase and methods for using the same
JP5523313B2 (ja) 2007-07-03 2014-06-18 チルドレンズ ホスピタル アンド リサーチ センター アット オークランド ポリシアル酸誘導体、製造方法、ならびにがん抗原産生の増強およびターゲティングにおける使用
JP5702600B2 (ja) * 2007-07-03 2015-04-15 チルドレンズ ホスピタル アンド リサーチ センター アット オークランド オリゴシアル酸誘導体、製造方法および免疫学的使用
FR2930943B1 (fr) * 2008-05-07 2011-03-18 Centre Nat Rech Scient Nouvelles utilisations de derives de d-mannopyranose inhibiteurs de l'angiogenese

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4216208A (en) * 1978-07-31 1980-08-05 Proter S.P.A. N-Acyl derivatives of glucosamines having antitumor chemotherapeutic activity
US4647453A (en) * 1984-10-18 1987-03-03 Peritain, Ltd. Treatment for tissue degenerative inflammatory disease
DE3906174A1 (de) * 1989-02-28 1990-08-30 Forschungszentrum Juelich Gmbh Verfahren zur herstellung von d-mannosaminderivaten

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
1. Journal Org. Chem., 1961, т. 26, с. 2455 - 2458. 2. Arg. Biol. Chem., 1969, т. 33, в. 5, с. 748 - 754. 3. Carbohydrates Research, 1974, т. 38, с. 205 - 216. 4. Tetrahedron Letters, 1968, т. 18, с. 2271. *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2266734C2 (ru) * 1999-05-13 2005-12-27 Фарма Мар, С.А. Композиции и применение ет743 для лечения злокачественных опухолей

Also Published As

Publication number Publication date
IL102500A (en) 1996-01-19
ZA925871B (en) 1993-04-28
HU9202329D0 (en) 1992-10-28
EP0527042A3 (enExample) 1994-01-05
MX9204395A (es) 1993-02-01
KR930004325A (ko) 1993-03-22
FI923498A7 (fi) 1993-02-07
FI923498L (fi) 1993-02-07
HUT62593A (en) 1993-05-28
NZ243627A (en) 1994-04-27
EP0527042A2 (en) 1993-02-10
FI923498A0 (fi) 1992-08-03
CA2075336A1 (en) 1993-02-07
AU2037492A (en) 1993-02-11
GB9116896D0 (en) 1991-09-18
IL102500A0 (en) 1993-01-14
TW248564B (enExample) 1995-06-01
JPH05208988A (ja) 1993-08-20
MY108749A (en) 1996-11-30
AU646173B2 (en) 1994-02-10
US5332756A (en) 1994-07-26
HU213208B (en) 1997-03-28

Similar Documents

Publication Publication Date Title
RU2099333C1 (ru) Производное 3-дезоксиманнозамина, способ его получения и фармацевтическая композиция, обладающая ингибирующей активностью к развитию сосудов и метастазов
JP3356324B2 (ja) 抗痙攣剤性フルクトピラノース環式亜硫酸エステル類および硫酸エステル類
US4511582A (en) Phenanthrene derivatives
EP0598359A1 (en) Hypoglycemic dihydrochalcone derivatives
DE69710573T2 (de) Morpholinyl-anthracyclinderivate
Suhara et al. Total synthesis of kasugamycin
CA1234107A (en) Retinoid acylates of sugars and amino sugars
WO1998024795A1 (en) Novel triterpene glycoside compound, process for preparation thereof and anti-cancer composition containing the same
JPS62209018A (ja) 血液粘度低下剤
MATSUURA et al. Studies on the constituents of useful plants. VI. Constituents of the calyx of Diospyros kaki (2), and carbon-13 nuclear magnetic resonance spectra of flavonol glycosides
KR920007273B1 (ko) 프로토카테큐알데히드류의 당유도체
DE68907857T2 (de) Beta-D-phenylthioxyloside, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel.
EP0374759A2 (de) Rhodomycine mit einer modifizierten Kohlenhydrat-Einheit
JPS632279B2 (enExample)
US3761464A (en) Cardio active pyranosides of 3beta-hydroxy-4-chloro carda-4,20(22)-dienolides
Watanabe et al. Nucleosides. LXXIV. Synthetic studies on nucleoside antibiotics. 8. Syntheses of 1-[4-deoxy-4-(sarcosyl-D-seryl) amino-. beta.-D-glucopyranosyl] cytosine and related analogs of gougerotin
Welch et al. The synthesis of 3-acetamido-2, 3, 5, 6-tetradeoxy-5-fluoro-d, l-ribo-hexofuranose by the direct fluorination of methyl 3-acetamido-2, 3, 6-trideoxy-d, l-arabino-hexopyranoside (methyl N-acetyl-d, l-acosaminide)
JPS61271217A (ja) 消化器潰瘍治療予防剤
US20030100515A1 (en) Benzophenone glycopyranosides, preparation and therapeutic use
CN107903231B (zh) 含有金刚烷结构的作为sglt-2抑制剂的化合物
KR0177806B1 (ko) 신규 안트라사이클린 글리코사이드 유도체 및 그 제조방법
US20030139349A1 (en) Benzophenone alpha-d-glycopyranosides, preparation and therapeutic use
ES2202212T3 (es) Benzofenona-a-d.glicopiranosidos, preparacion y uso terapeutico.
JPH05202088A (ja) グリコシド及びこれを含有する抗肝炎剤
CN117224529A (zh) 一种佛司可林四环类似物在制备抗炎药物中的应用