RU2020128111A - ВЕДЕНИЕ БЕЛКОВ СЛИЯНИЯ IL-22 Fc ДЛЯ ЛЕЧЕНИЯ - Google Patents
ВЕДЕНИЕ БЕЛКОВ СЛИЯНИЯ IL-22 Fc ДЛЯ ЛЕЧЕНИЯ Download PDFInfo
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- RU2020128111A RU2020128111A RU2020128111A RU2020128111A RU2020128111A RU 2020128111 A RU2020128111 A RU 2020128111A RU 2020128111 A RU2020128111 A RU 2020128111A RU 2020128111 A RU2020128111 A RU 2020128111A RU 2020128111 A RU2020128111 A RU 2020128111A
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- Prior art keywords
- subject
- fusion protein
- paragraphs
- dose
- dosing cycle
- Prior art date
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- 108010074109 interleukin-22 Proteins 0.000 title claims 57
- 108091006020 Fc-tagged proteins Proteins 0.000 title claims 52
- 238000000034 method Methods 0.000 claims 110
- 208000009329 Graft vs Host Disease Diseases 0.000 claims 33
- 208000024908 graft versus host disease Diseases 0.000 claims 33
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 19
- 230000001154 acute effect Effects 0.000 claims 12
- 208000024891 symptom Diseases 0.000 claims 7
- 206010009900 Colitis ulcerative Diseases 0.000 claims 6
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 6
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 239000005557 antagonist Substances 0.000 claims 6
- 230000004044 response Effects 0.000 claims 6
- 206010038063 Rectal haemorrhage Diseases 0.000 claims 5
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 claims 4
- 230000008859 change Effects 0.000 claims 4
- 239000003018 immunosuppressive agent Substances 0.000 claims 4
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 claims 4
- 238000002560 therapeutic procedure Methods 0.000 claims 4
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 230000035876 healing Effects 0.000 claims 3
- 229960003444 immunosuppressant agent Drugs 0.000 claims 3
- 230000001861 immunosuppressant effect Effects 0.000 claims 3
- 210000000056 organ Anatomy 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 230000004083 survival effect Effects 0.000 claims 3
- 102000003390 tumor necrosis factor Human genes 0.000 claims 3
- 208000011231 Crohn disease Diseases 0.000 claims 2
- 101001010626 Homo sapiens Interleukin-22 Proteins 0.000 claims 2
- 125000000539 amino acid group Chemical group 0.000 claims 2
- 230000001684 chronic effect Effects 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 2
- 230000006872 improvement Effects 0.000 claims 2
- 108010027445 interleukin-22 receptor Proteins 0.000 claims 2
- 210000000936 intestine Anatomy 0.000 claims 2
- 210000004185 liver Anatomy 0.000 claims 2
- 210000003491 skin Anatomy 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- WUBBRNOQWQTFEX-UHFFFAOYSA-N 4-aminosalicylic acid Chemical compound NC1=CC=C(C(O)=O)C(O)=C1 WUBBRNOQWQTFEX-UHFFFAOYSA-N 0.000 claims 1
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical group CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 1
- 108010036949 Cyclosporine Proteins 0.000 claims 1
- QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 claims 1
- 230000003187 abdominal effect Effects 0.000 claims 1
- 230000000735 allogeneic effect Effects 0.000 claims 1
- 229940113720 aminosalicylate Drugs 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 230000003510 anti-fibrotic effect Effects 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 229960001265 ciclosporin Drugs 0.000 claims 1
- 238000002648 combination therapy Methods 0.000 claims 1
- 239000003246 corticosteroid Substances 0.000 claims 1
- 229930182912 cyclosporin Natural products 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 238000011134 hematopoietic stem cell transplantation Methods 0.000 claims 1
- XXSMGPRMXLTPCZ-UHFFFAOYSA-N hydroxychloroquine Chemical compound ClC1=CC=C2C(NC(C)CCCN(CCO)CC)=CC=NC2=C1 XXSMGPRMXLTPCZ-UHFFFAOYSA-N 0.000 claims 1
- 229960004171 hydroxychloroquine Drugs 0.000 claims 1
- 230000002519 immonomodulatory effect Effects 0.000 claims 1
- 229940125721 immunosuppressive agent Drugs 0.000 claims 1
- 238000001802 infusion Methods 0.000 claims 1
- 230000000968 intestinal effect Effects 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 210000003097 mucus Anatomy 0.000 claims 1
- 238000001126 phototherapy Methods 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 230000009467 reduction Effects 0.000 claims 1
- 238000009097 single-agent therapy Methods 0.000 claims 1
- 150000003431 steroids Chemical class 0.000 claims 1
- 238000010254 subcutaneous injection Methods 0.000 claims 1
- 239000007929 subcutaneous injection Substances 0.000 claims 1
- 229960001967 tacrolimus Drugs 0.000 claims 1
- QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Transplantation (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862633534P | 2018-02-21 | 2018-02-21 | |
| US62/633,534 | 2018-02-21 | ||
| PCT/US2019/019042 WO2019165140A1 (en) | 2018-02-21 | 2019-02-21 | DOSING FOR TREATMENT WITH IL-22 Fc FUSION PROTEINS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2020128111A true RU2020128111A (ru) | 2022-03-21 |
Family
ID=65724526
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2020128111A RU2020128111A (ru) | 2018-02-21 | 2019-02-21 | ВЕДЕНИЕ БЕЛКОВ СЛИЯНИЯ IL-22 Fc ДЛЯ ЛЕЧЕНИЯ |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20210139552A1 (https=) |
| EP (1) | EP3755364A1 (https=) |
| JP (1) | JP2021514354A (https=) |
| KR (1) | KR20200123118A (https=) |
| CN (1) | CN111757751A (https=) |
| AU (1) | AU2019226085A1 (https=) |
| CA (1) | CA3091139A1 (https=) |
| IL (1) | IL276616A (https=) |
| MA (1) | MA51907A (https=) |
| MX (1) | MX2020008502A (https=) |
| RU (1) | RU2020128111A (https=) |
| SG (1) | SG11202007694UA (https=) |
| TW (1) | TW201946647A (https=) |
| WO (1) | WO2019165140A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104623637A (zh) | 2013-11-07 | 2015-05-20 | 健能隆医药技术（上海）有限公司 | Il-22二聚体在制备静脉注射药物中的应用 |
| WO2017181143A1 (en) | 2016-04-15 | 2017-10-19 | Generon (Shanghai) Corporation, Ltd. | Use of il-22 in treating necrotizing enterocolitis |
| TW202118793A (zh) * | 2019-07-26 | 2021-05-16 | 美商建南德克公司 | 以 IL-22 Fc 融合蛋白預防或治療移植物抗宿主疾病 (GVHD) 之投藥 |
| EP4103219A4 (en) * | 2020-02-14 | 2024-03-27 | Evive Biotechnology (Shanghai) Ltd | METHODS OF PREVENTING OR TREATING VIRUS-INDUCED ORGAN INJURY OR INSUFFICIENCY WITH IL-22 DIMER |
| EP4106794A4 (en) | 2020-02-19 | 2024-03-20 | Evive Biotechnology (Shanghai) Ltd | METHOD FOR TREATING TRANSPLANT AND HOST DISEASE |
| WO2021207662A1 (en) * | 2020-04-10 | 2021-10-14 | Genentech, Inc. | Use of il-22fc for the treatment or prevention of pneumonia, acute respiratory distress syndrome, or cytokine release syndrome |
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| WO2005053742A1 (ja) | 2003-12-04 | 2005-06-16 | Kyowa Hakko Kogyo Co., Ltd. | 抗体組成物を含有する医薬 |
| KR100891620B1 (ko) | 2004-04-13 | 2009-04-02 | 에프. 호프만-라 로슈 아게 | 항-ｐ-셀렉틴 항체 |
| TWI309240B (en) | 2004-09-17 | 2009-05-01 | Hoffmann La Roche | Anti-ox40l antibodies |
| KR101270829B1 (ko) | 2004-09-23 | 2013-06-07 | 제넨테크, 인크. | 시스테인 유전자조작 항체 및 접합체 |
| JO3000B1 (ar) | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
| BRPI0613284A2 (pt) | 2005-06-17 | 2010-12-28 | Genentech Inc | métodos de aceleração de cicatrização de ferida |
| US20080226635A1 (en) | 2006-12-22 | 2008-09-18 | Hans Koll | Antibodies against insulin-like growth factor I receptor and uses thereof |
| CN102946906B (zh) | 2010-04-23 | 2015-07-15 | 弗·哈夫曼-拉罗切有限公司 | 生产异源多聚体蛋白质 |
| CR20150477A (es) * | 2013-03-15 | 2015-10-26 | Genentech Inc | Polipéptidos de il-22 y proteínas de fusión de il-22 fc y métodos de uso |
| EP3385277A1 (en) * | 2013-03-15 | 2018-10-10 | F. Hoffmann-La Roche AG | Il-22 polypeptides and il-22 fc fusion proteins and methods of use |
| WO2015070077A1 (en) * | 2013-11-07 | 2015-05-14 | Memorial Sloan-Kettering Cancer Center | Methods of use for il-22 in the treatment of gastrointestinal graft vs. host disease |
| CN106146668A (zh) * | 2015-04-01 | 2016-11-23 | 中国人民解放军第二军医大学 | 长效白细胞介素22的制备方法及其用途 |
| RU2018105687A (ru) * | 2015-07-16 | 2019-08-16 | Филоджен С.П.А. | Иммуноконъюгаты на основе il22 |
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2019
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- 2019-02-21 MX MX2020008502A patent/MX2020008502A/es unknown
- 2019-02-21 AU AU2019226085A patent/AU2019226085A1/en not_active Abandoned
- 2019-02-21 CN CN201980014830.0A patent/CN111757751A/zh active Pending
- 2019-02-21 RU RU2020128111A patent/RU2020128111A/ru unknown
- 2019-02-21 CA CA3091139A patent/CA3091139A1/en active Pending
- 2019-02-21 TW TW108105889A patent/TW201946647A/zh unknown
- 2019-02-21 EP EP19710206.4A patent/EP3755364A1/en not_active Withdrawn
- 2019-02-21 KR KR1020207023400A patent/KR20200123118A/ko not_active Ceased
- 2019-02-21 MA MA051907A patent/MA51907A/fr unknown
- 2019-02-21 SG SG11202007694UA patent/SG11202007694UA/en unknown
- 2019-02-21 WO PCT/US2019/019042 patent/WO2019165140A1/en not_active Ceased
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2020
- 2020-08-10 IL IL276616A patent/IL276616A/en unknown
- 2020-08-20 US US16/998,597 patent/US20210139552A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2021514354A (ja) | 2021-06-10 |
| CN111757751A (zh) | 2020-10-09 |
| TW201946647A (zh) | 2019-12-16 |
| SG11202007694UA (en) | 2020-09-29 |
| US20210139552A1 (en) | 2021-05-13 |
| AU2019226085A1 (en) | 2020-09-17 |
| MA51907A (fr) | 2021-05-26 |
| IL276616A (en) | 2020-09-30 |
| CA3091139A1 (en) | 2019-08-29 |
| KR20200123118A (ko) | 2020-10-28 |
| EP3755364A1 (en) | 2020-12-30 |
| WO2019165140A1 (en) | 2019-08-29 |
| MX2020008502A (es) | 2020-09-25 |
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