RU2019123406A - Технология приготовления таблеток для cgrp-активных соединений - Google Patents

Технология приготовления таблеток для cgrp-активных соединений Download PDF

Info

Publication number
RU2019123406A
RU2019123406A RU2019123406A RU2019123406A RU2019123406A RU 2019123406 A RU2019123406 A RU 2019123406A RU 2019123406 A RU2019123406 A RU 2019123406A RU 2019123406 A RU2019123406 A RU 2019123406A RU 2019123406 A RU2019123406 A RU 2019123406A
Authority
RU
Russia
Prior art keywords
tablet
formula
aforementioned
compound
extrudate
Prior art date
Application number
RU2019123406A
Other languages
English (en)
Russian (ru)
Inventor
Мэри Энн ДЖОНСОН
Леонардо Рисенд АЛЛЕЙН
У Марк ЭЙКХОФФ
Крейг Б. ИКЕДА
Чад Д. БРАУН
Фрэнсис Дж. Мл. ФЛЭНЭГАН
Ребекка НОФСИНГЕР
Мелани МАРОТА
Лиза ЛАПТОН
Пареш Б. ПАТЕЛ
Ханьми СИ
Вей Сюй
Original Assignee
Мерк Шарп И Доум Корп.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53778348&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RU2019123406(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Мерк Шарп И Доум Корп. filed Critical Мерк Шарп И Доум Корп.
Publication of RU2019123406A publication Critical patent/RU2019123406A/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Inorganic Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
RU2019123406A 2014-02-05 2015-01-30 Технология приготовления таблеток для cgrp-активных соединений RU2019123406A (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201461936019P 2014-02-05 2014-02-05
US61/936,019 2014-02-05
US201462087366P 2014-12-04 2014-12-04
US62/087,366 2014-12-04

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
RU2016135536A Division RU2696578C1 (ru) 2014-02-05 2015-01-30 Технология приготовления таблеток для cgrp-активных соединений

Publications (1)

Publication Number Publication Date
RU2019123406A true RU2019123406A (ru) 2019-10-03

Family

ID=53778348

Family Applications (2)

Application Number Title Priority Date Filing Date
RU2019123406A RU2019123406A (ru) 2014-02-05 2015-01-30 Технология приготовления таблеток для cgrp-активных соединений
RU2016135536A RU2696578C1 (ru) 2014-02-05 2015-01-30 Технология приготовления таблеток для cgrp-активных соединений

Family Applications After (1)

Application Number Title Priority Date Filing Date
RU2016135536A RU2696578C1 (ru) 2014-02-05 2015-01-30 Технология приготовления таблеток для cgrp-активных соединений

Country Status (13)

Country Link
US (4) US10117836B2 (fr)
EP (1) EP3102564A4 (fr)
JP (2) JP6491669B2 (fr)
KR (3) KR102448369B1 (fr)
CN (2) CN112022818A (fr)
AU (4) AU2015214502B2 (fr)
CA (1) CA2937315A1 (fr)
HK (1) HK1232218A1 (fr)
IL (1) IL246828B (fr)
MX (2) MX2016010169A (fr)
RU (2) RU2019123406A (fr)
SA (1) SA516371613B1 (fr)
WO (1) WO2015119848A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI487706B (zh) * 2010-11-12 2015-06-11 Merck Sharp & Dohme 六氫吡啶酮甲醯胺氮雜茚滿ｃｇｒｐ受體拮抗劑
KR102448369B1 (ko) 2014-02-05 2022-09-28 머크 샤프 앤드 돔 엘엘씨 Cgrp-활성 화합물에 대한 정제 제제
CN105126111A (zh) * 2015-09-30 2015-12-09 清华大学 提高索拉非尼生物利用度的制剂
FI3601277T3 (fi) * 2017-03-30 2024-01-09 Merck Patent Gmbh Farmaseuttinen formulaatio
AU2019242604A1 (en) * 2018-03-25 2020-10-22 Pfizer Ireland Pharmaceuticals Rimegepant for CGRP related disorders
RU2755571C1 (ru) * 2020-06-09 2021-09-17 Сергей Геннадьевич Каплунов Способ изготовления гравюры на металле
EP4188375A4 (fr) 2020-07-29 2024-07-24 Allergan Pharmaceuticals Int Ltd Traitement de migraine
CA3206184A1 (fr) 2020-12-22 2022-06-30 Allergan Pharmaceuticals International Limited Traitement de la migraine

Family Cites Families (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4166452A (en) 1976-05-03 1979-09-04 Generales Constantine D J Jr Apparatus for testing human responses to stimuli
US4256108A (en) 1977-04-07 1981-03-17 Alza Corporation Microporous-semipermeable laminated osmotic system
US4265874A (en) 1980-04-25 1981-05-05 Alza Corporation Method of delivering drug with aid of effervescent activity generated in environment of use
DE3612212A1 (de) 1986-04-11 1987-10-15 Basf Ag Verfahren zur herstellung von festen pharmazeutischen formen
TW486370B (en) 1996-12-25 2002-05-11 Yamanouchi Pharma Co Ltd Rapidly disintegrable pharmaceutical composition
US6103260A (en) * 1997-07-17 2000-08-15 Mcneil-Ppc, Inc. Simethicone/anhydrous calcium phosphate compositions
US20040076668A1 (en) * 2002-07-03 2004-04-22 Pfizer Inc. Controlled-release pharmaceutical formulations
CA2518830A1 (fr) 2003-03-14 2004-09-30 Merck & Co., Inc. Antagonistes des recepteurs du cgrp a base de carboxamide spirohydantoine
CA2519515A1 (fr) 2003-03-14 2004-10-14 Merck & Co., Inc. Antagonistes benodiazepine spirohydantoin des recepteurs de cgrp
JO2355B1 (en) 2003-04-15 2006-12-12 ميرك شارب اند دوم كوربوريشن Hereditary calcitonin polypeptide receptor antagonists
AU2005285109B2 (en) 2004-09-13 2011-03-03 Merck Sharp & Dohme Corp. Bicyclic anilide spirolactam CGRP receptor antagonists
US7390798B2 (en) 2004-09-13 2008-06-24 Merck & Co., Inc. Carboxamide spirolactam CGRP receptor antagonists
DE102004063755A1 (de) * 2004-12-29 2006-07-20 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verwendung von CGRP-Antagonisten zur Behandlung und Vorbeugung von Hitzewallungen bei Patienten mit Prostatakrebs
US7994325B2 (en) 2005-03-14 2011-08-09 Merck Sharp & Dohme Corp. CGRP receptor antagonists
RU2457841C2 (ru) * 2006-02-09 2012-08-10 Мерк Шарп Энд Домэ Корп. Полимерные композиции ингибиторов сетр
CA2650932C (fr) 2006-05-09 2013-01-22 Merck & Co., Inc. Antagonistes spirocycliques substitues des recepteurs cgrp
WO2008153849A1 (fr) 2007-06-05 2008-12-18 Merck & Co., Inc. Antagonistes des récepteurs cgrp à base de carboxamide hétérocyclique
AU2008313733A1 (en) 2007-10-18 2009-04-23 Boehringer Ingelheim International Gmbh CGRP antagonists
WO2009065922A2 (fr) 2007-11-22 2009-05-28 Boehringer Ingelheim International Gmbh Nouveaux composés
CA2722536A1 (fr) * 2008-02-05 2009-08-13 Merck & Co., Inc. Promedicaments d'antagoniste des recepteurs du cgrp
US8044043B2 (en) 2008-04-11 2011-10-25 Bristol-Myers Squibb Company CGRP receptor antagonists
BRPI0910627A2 (pt) 2008-04-15 2015-09-22 Schering Corp composições de alta densidade contendo posaconazol e formulações compreendendo as mesmas
JP2012522058A (ja) * 2009-03-31 2012-09-20 リガンド・ファーマシューティカルズ・インコーポレイテッド 血圧上昇および糖尿病性腎症を処置するための、ジフェニルスルホンアミドエンドセリンおよびアンジオテンシンｉｉ受容体アゴニストの経口製剤
EP2438067B1 (fr) 2009-06-05 2015-08-26 Boehringer Ingelheim International GmbH Spirolactames comme antagonistes du cgrp
NZ605440A (en) * 2010-06-10 2014-05-30 Abbvie Bahamas Ltd Solid compositions comprising an hcv inhibitor
UA113500C2 (xx) * 2010-10-29 2017-02-10 Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб
AU2011326455A1 (en) 2010-11-12 2013-05-23 Merck Sharp & Dohme Corp. Piperidinone carboxamide indane CGRP receptor antagonists
TWI487706B (zh) 2010-11-12 2015-06-11 Merck Sharp & Dohme 六氫吡啶酮甲醯胺氮雜茚滿ｃｇｒｐ受體拮抗劑
WO2012087777A1 (fr) 2010-12-22 2012-06-28 Merck Sharp & Dohme Corp. Antagonistes des récepteurs du cgrp indanecarboxamides hétérocycliques condensés
EP2654423B1 (fr) 2010-12-22 2016-12-07 Merck Sharp & Dohme Corp. Antagonistes azaindane carboxamides hétérocycliques fusionnés de récepteurs du cgrp
EP2654726A4 (fr) * 2011-03-08 2013-10-30 Zalicus Pharmaceuticals Ltd Formulations de dispersions solides et leurs procédés d'utilisation
WO2012129013A1 (fr) 2011-03-18 2012-09-27 Merck Sharp & Dohme Corp. Pipéridinone carboxamide spirohydantoïne, antagonistes du récepteur cgrp
US9109209B2 (en) 2011-09-08 2015-08-18 Codexis, Inc. Biocatalysts and methods for the synthesis of substituted lactams
JP5944514B2 (ja) 2011-10-14 2016-07-05 アレイ バイオファーマ、インコーポレイテッド 固体分散体
US9487523B2 (en) 2012-03-14 2016-11-08 Merck Sharp & Dohme Corp. Process for making CGRP receptor antagonists
KR102061180B1 (ko) 2012-03-14 2019-12-31 머크 샤프 앤드 돔 코포레이션 비대칭 상 이동 촉매로서의 비스-4급 신코나 알칼로이드 염
US9833488B2 (en) 2012-04-25 2017-12-05 Centric Research Institute Sensitization composition and method of use
WO2013169563A1 (fr) 2012-05-09 2013-11-14 Merck Sharp & Dohme Corp. Antagonistes de récepteur de cgrp à base de pyridine
EP2846799B1 (fr) 2012-05-09 2017-11-15 Merck Sharp & Dohme Corp. Antagonistes de récepteur de cgrp à base de spirolactame
US9227972B2 (en) 2012-05-09 2016-01-05 Merck Sharp & Dohme Corp. Aliphatic spirolactam CGRP receptor antagonists
US9174989B2 (en) 2012-05-09 2015-11-03 Merck Sharp & Dohme Corp. Process for making CGRP receptor antagonists
HRP20240648T1 (hr) 2013-03-15 2024-08-02 Tonix Pharma Holdings Limited Eutektičke formulacije ciklobenzaprin hidroklorida i manitola
CN105531275B (zh) 2013-09-16 2020-12-18 默沙东公司 用于cgrp受体拮抗剂的制剂
KR102448369B1 (ko) 2014-02-05 2022-09-28 머크 샤프 앤드 돔 엘엘씨 Cgrp-활성 화합물에 대한 정제 제제
EP3102188A4 (fr) 2014-02-05 2017-07-12 Merck Sharp & Dohme Corp. Nouveaux systèmes de désintégration de formes dosifiées pharmaceutiques
US20170189443A1 (en) 2014-02-24 2017-07-06 C. Lowell Parsons Compositions and methods for treatment of diseases and conditions employing oral administration of sodium pentosan polysulfate and other pentosan polysulfate salts
BR112017000865A2 (pt) 2014-08-22 2017-12-05 Clovis Oncology Inc comprimidos de rucaparibe de concentração de dosagem alta
DK3247352T3 (da) 2015-01-23 2020-09-07 Gruenenthal Gmbh Cebranopadol til behandling af smerter hos individer med forringet lever- og/eller forringet nyrefunktion
EP3353202B1 (fr) 2015-09-24 2020-11-04 Teva Pharmaceuticals International GmbH Prévention, traitement, et diminution (persistance) d'une céphalée post-traumatique
US20180092899A1 (en) 2016-09-30 2018-04-05 Merck Sharp & Dohme Corp. Method of treating acute migraine with cgrp-active compound
JP7195262B2 (ja) 2017-03-02 2022-12-23 ベス イスラエル デアコネス メディカル センター インコーポレイティッド カルシトニン遺伝子関連ペプチドを指向する抗体に応答性の頭痛患者の選択方法
TWI754772B (zh) 2017-09-06 2022-02-11 美商美國禮來大藥廠 用於治療偏頭痛之拉米迪坦(lasmiditan)與cgrp拮抗劑之組合療法
US20190135927A1 (en) 2017-09-29 2019-05-09 Bhl Patent Holdings, Llc Migraine, headache, chronic pain treatment, and prophylaxis options
US20190374518A1 (en) 2018-06-08 2019-12-12 Allergan Pharmaceuticals International Limited Treatment of migraine
US20190374520A1 (en) 2018-06-08 2019-12-12 Allergan Pharmaceuticals International Limited Treatment of migraine
TWI826514B (zh) 2018-09-04 2023-12-21 美商美國禮來大藥廠 用於預防偏頭痛之拉米迪坦(lasmiditan)長期夜間投藥
US20200383983A1 (en) 2019-04-18 2020-12-10 Allergan Sales, Llc Cgrp antagonists for the treatment of medication overuse headache, post-traumatic headache, post-concussion syndrome and vertigo
AU2020355233A1 (en) 2019-09-25 2022-05-19 Allergan Pharmaceuticals International Limited Combination therapy with CGRP antagonists
EP4188375A4 (fr) 2020-07-29 2024-07-24 Allergan Pharmaceuticals Int Ltd Traitement de migraine
CA3206184A1 (fr) 2020-12-22 2022-06-30 Allergan Pharmaceuticals International Limited Traitement de la migraine
EP4408418A1 (fr) 2021-09-27 2024-08-07 Allergan Pharmaceuticals International Limited Combinaison comprenant de l'atogépant pour le traitement de la migraine

Also Published As

Publication number Publication date
AU2023258317A1 (en) 2023-11-16
EP3102564A1 (fr) 2016-12-14
US11925709B2 (en) 2024-03-12
KR102448369B1 (ko) 2022-09-28
US10117836B2 (en) 2018-11-06
SA516371613B1 (ar) 2021-06-19
US20160346214A1 (en) 2016-12-01
CN105960397B (zh) 2020-09-04
RU2696578C1 (ru) 2019-08-05
JP6491669B2 (ja) 2019-03-27
BR112016017999A2 (fr) 2017-08-08
KR20220136460A (ko) 2022-10-07
CA2937315A1 (fr) 2015-08-13
CN105960397A (zh) 2016-09-21
AU2015214502A1 (en) 2016-07-21
HK1232218A1 (zh) 2018-01-05
KR20230107902A (ko) 2023-07-18
MX2021006790A (es) 2021-07-15
IL246828B (en) 2019-05-30
US20190209478A1 (en) 2019-07-11
AU2015214502B2 (en) 2019-06-06
WO2015119848A1 (fr) 2015-08-13
EP3102564A4 (fr) 2017-10-18
BR112016017999A8 (pt) 2023-04-11
MX2016010169A (es) 2016-10-07
AU2019226239A1 (en) 2019-09-26
KR20160113296A (ko) 2016-09-28
JP2019108366A (ja) 2019-07-04
JP2017505306A (ja) 2017-02-16
AU2021245229A1 (en) 2021-11-04
JP6666490B2 (ja) 2020-03-13
AU2019226239B2 (en) 2021-07-08
US20230248655A1 (en) 2023-08-10
CN112022818A (zh) 2020-12-04
US20210085612A1 (en) 2021-03-25
IL246828A0 (en) 2016-08-31

Similar Documents

Publication Publication Date Title
RU2019123406A (ru) Технология приготовления таблеток для cgrp-активных соединений
US10632074B2 (en) Composite granulated product including sugar or sugar alcohol, swelling binder, disintegrating agent and highly absorbent excipient, and method for manufacturing composite granulated product
FI2346495T4 (fi) Farmaseuttinen formulaatio 514
JP2019108366A5 (fr)
RU2014127142A (ru) Фармацевтическая композиция с улучшенной биодоступностью для высокоплавкого гидрофобного соединения
CN101167700A (zh) 硝苯地平控释片及其制备方法
CN105287361B (zh) 含有非甾体抗炎药微乳的皮肤外用制剂
WO2014154029A1 (fr) Matériau structurel composite et composition pharmaceutique le comprenant
RU2013105481A (ru) Комбинированная система доставки с немедленным/замедленным высвобождением для лекарственных средств с коротким периодом полувыведения, в том числе для ремоглифлозина
WO2011160541A1 (fr) Dispersion solide de tolvaptan et son procédé de préparation
CN105521492A (zh) 一种多孔性白及胶及其制备方法和用途
WO2007004425A1 (fr) Comprime contenant une substance active faiblement soluble
CN103127025A (zh) 消旋2-(α-羟基戊基)苯甲酸盐片及其制备方法
JP2020518611A (ja) 水溶解度及びバイオアベイラビリティが改善された組成物
CN103263402A (zh) 一种无需饮水的口服药物组合物及其制备方法
KR20110048317A (ko) 위체류 약물 전달시스템을 이용한 서방성 경구용 제제
CN102406622A (zh) 一种托伐普坦的固体制剂
CN104490835A (zh) 一种阿齐沙坦酯片剂及其制备方法
CN101773474A (zh) 一种妥曲珠利可溶性粉的制备方法
CN106138006A (zh) 一种含吲哚美辛固体分散体的胶囊及其制备方法
CN103599140B (zh) 银杏内酯控释片及制备方法
RU2006145311A (ru) Твердая фармацевтическая композиция
CN103860511A (zh) 一种含有厄贝沙坦和苯磺酸氨氯地平的药用组合物及其制备方法
CN106074420B (zh) 一种高生物利用度的水飞蓟宾葡甲胺片的制备方法
CN105357966A (zh) 提高药物和膳食补充剂的生物利用度的方法和产品