SA516371613B1 - Cgrp صيغة قرص لمركبات نشطة تجاه - Google Patents

Cgrp صيغة قرص لمركبات نشطة تجاه

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Publication number
SA516371613B1
SA516371613B1 SA516371613A SA516371613A SA516371613B1 SA 516371613 B1 SA516371613 B1 SA 516371613B1 SA 516371613 A SA516371613 A SA 516371613A SA 516371613 A SA516371613 A SA 516371613A SA 516371613 B1 SA516371613 B1 SA 516371613B1
Authority
SA
Saudi Arabia
Prior art keywords
cgrp
active compounds
tablet formulation
api
formula
Prior art date
Application number
SA516371613A
Other languages
English (en)
Inventor
بي. باتيل باريش
دي. براون تشاد
مارك ايكشوف دبليو.
نوفسينجير ريبيكا
جيه. فلاناجان الابن فرانسيس
بي. ايكيدا كاريج
لوبتون ليزا
ريسيندي الاين ليناردو
آن حونسون ماري
ماروتا ميلاني
زي هامي
زو ويي
Original Assignee
ميرك شارب آند دوهم كورب
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53778348&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SA516371613(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by ميرك شارب آند دوهم كورب filed Critical ميرك شارب آند دوهم كورب
Publication of SA516371613B1 publication Critical patent/SA516371613B1/ar

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2072Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/2027Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2009Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2013Organic compounds, e.g. phospholipids, fats
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/2031Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

يتم توجيه هذا الاختراع لتركيبات تتألف من مادة ناتج بثق extrudate أو محلول صلب من مركب، أو ملح منه، له الصيغة 1 ( مكون صيدلاني فعال active pharmaceutical ingredients " API " ) : الصيغة 1، حيث "Ra" هى بشكل مستقل -H أو - F، في قالب البوليمر polymer matrix القابل للذوبان في الماء والذي يتضمن كذلك نظام تفتيت يسمح للقرص المصنوع منه بالتفتت disintegration بسرعة في البيئة التي سيتم إطلاق مكون صيدلاني فعال active pharmaceutical ingredients ( API ) فيها. شكل 3.
SA516371613A 2014-02-05 2016-08-04 Cgrp صيغة قرص لمركبات نشطة تجاه SA516371613B1 (ar)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461936019P 2014-02-05 2014-02-05
US201462087366P 2014-12-04 2014-12-04
PCT/US2015/013672 WO2015119848A1 (en) 2014-02-05 2015-01-30 Tablet formulation for cgrp-active compounds

Publications (1)

Publication Number Publication Date
SA516371613B1 true SA516371613B1 (ar) 2021-06-19

Family

ID=53778348

Family Applications (1)

Application Number Title Priority Date Filing Date
SA516371613A SA516371613B1 (ar) 2014-02-05 2016-08-04 Cgrp صيغة قرص لمركبات نشطة تجاه

Country Status (13)

Country Link
US (4) US10117836B2 (ar)
EP (1) EP3102564A4 (ar)
JP (2) JP6491669B2 (ar)
KR (3) KR102448369B1 (ar)
CN (2) CN112022818A (ar)
AU (4) AU2015214502B2 (ar)
CA (1) CA2937315A1 (ar)
HK (1) HK1232218A1 (ar)
IL (1) IL246828B (ar)
MX (2) MX2016010169A (ar)
RU (2) RU2696578C1 (ar)
SA (1) SA516371613B1 (ar)
WO (1) WO2015119848A1 (ar)

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Also Published As

Publication number Publication date
AU2021245229A1 (en) 2021-11-04
JP2019108366A (ja) 2019-07-04
AU2019226239A1 (en) 2019-09-26
IL246828A0 (en) 2016-08-31
IL246828B (en) 2019-05-30
JP6666490B2 (ja) 2020-03-13
KR102448369B1 (ko) 2022-09-28
KR20230107902A (ko) 2023-07-18
MX2021006790A (es) 2021-07-15
AU2023258317A1 (en) 2023-11-16
HK1232218A1 (zh) 2018-01-05
RU2696578C1 (ru) 2019-08-05
MX2016010169A (es) 2016-10-07
US11925709B2 (en) 2024-03-12
US10117836B2 (en) 2018-11-06
CN105960397A (zh) 2016-09-21
BR112016017999A2 (ar) 2017-08-08
KR20160113296A (ko) 2016-09-28
CN105960397B (zh) 2020-09-04
US20210085612A1 (en) 2021-03-25
AU2019226239B2 (en) 2021-07-08
US20190209478A1 (en) 2019-07-11
WO2015119848A1 (en) 2015-08-13
AU2015214502B2 (en) 2019-06-06
BR112016017999A8 (pt) 2023-04-11
EP3102564A4 (en) 2017-10-18
JP2017505306A (ja) 2017-02-16
AU2015214502A1 (en) 2016-07-21
CN112022818A (zh) 2020-12-04
JP6491669B2 (ja) 2019-03-27
EP3102564A1 (en) 2016-12-14
US20230248655A1 (en) 2023-08-10
US20160346214A1 (en) 2016-12-01
CA2937315A1 (en) 2015-08-13
RU2019123406A (ru) 2019-10-03
KR20220136460A (ko) 2022-10-07

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