RU2019107600A - Бета-казеины и кишечная микробиота - Google Patents
Бета-казеины и кишечная микробиота Download PDFInfo
- Publication number
- RU2019107600A RU2019107600A RU2019107600A RU2019107600A RU2019107600A RU 2019107600 A RU2019107600 A RU 2019107600A RU 2019107600 A RU2019107600 A RU 2019107600A RU 2019107600 A RU2019107600 A RU 2019107600A RU 2019107600 A RU2019107600 A RU 2019107600A
- Authority
- RU
- Russia
- Prior art keywords
- beta
- casein
- milk
- animal
- variant
- Prior art date
Links
- 102000011632 Caseins Human genes 0.000 title claims 23
- 108010076119 Caseins Proteins 0.000 title claims 23
- 244000005709 gut microbiome Species 0.000 title claims 3
- 235000021247 β-casein Nutrition 0.000 claims 22
- 241001465754 Metazoa Species 0.000 claims 6
- 235000013336 milk Nutrition 0.000 claims 5
- 239000008267 milk Substances 0.000 claims 5
- 210000004080 milk Anatomy 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- 241000894006 Bacteria Species 0.000 claims 2
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 claims 2
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 235000013351 cheese Nutrition 0.000 claims 2
- 235000013365 dairy product Nutrition 0.000 claims 2
- 210000000936 intestine Anatomy 0.000 claims 2
- 239000000843 powder Substances 0.000 claims 2
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 2
- 235000021391 short chain fatty acids Nutrition 0.000 claims 2
- 150000004666 short chain fatty acids Chemical class 0.000 claims 2
- 230000004936 stimulating effect Effects 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000012902 Nervous system disease Diseases 0.000 claims 1
- 208000025966 Neurological disease Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 230000009286 beneficial effect Effects 0.000 claims 1
- 235000014121 butter Nutrition 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 235000020186 condensed milk Nutrition 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 230000002550 fecal effect Effects 0.000 claims 1
- 235000013350 formula milk Nutrition 0.000 claims 1
- 235000020603 homogenised milk Nutrition 0.000 claims 1
- 235000015243 ice cream Nutrition 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 208000019423 liver disease Diseases 0.000 claims 1
- DUWWHGPELOTTOE-UHFFFAOYSA-N n-(5-chloro-2,4-dimethoxyphenyl)-3-oxobutanamide Chemical compound COC1=CC(OC)=C(NC(=O)CC(C)=O)C=C1Cl DUWWHGPELOTTOE-UHFFFAOYSA-N 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 235000020200 pasteurised milk Nutrition 0.000 claims 1
- 235000019260 propionic acid Nutrition 0.000 claims 1
- 235000020185 raw untreated milk Nutrition 0.000 claims 1
- 235000020122 reconstituted milk Nutrition 0.000 claims 1
- 235000020183 skimmed milk Nutrition 0.000 claims 1
- 230000009885 systemic effect Effects 0.000 claims 1
- 235000013618 yogurt Nutrition 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J1/00—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
- A23J1/20—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from milk, e.g. casein; from whey
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C13/00—Cream; Cream preparations; Making thereof
- A23C13/12—Cream preparations
- A23C13/14—Cream preparations containing milk products or non-fat milk components
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C15/00—Butter; Butter preparations; Making thereof
- A23C15/12—Butter preparations
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C19/00—Cheese; Cheese preparations; Making thereof
- A23C19/06—Treating cheese curd after whey separation; Products obtained thereby
- A23C19/09—Other cheese preparations; Mixtures of cheese with other foodstuffs
- A23C19/0917—Addition, to cheese or curd, of whey, whey components, substances recovered from separated whey, isolated or concentrated proteins from milk
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
- A23C9/13—Fermented milk preparations; Treatment using microorganisms or enzymes using additives
- A23C9/1307—Milk products or derivatives; Fruit or vegetable juices; Sugars, sugar alcohols, sweeteners; Oligosaccharides; Organic acids or salts thereof or acidifying agents; Flavours, dyes or pigments; Inert or aerosol gases; Carbonation methods
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/15—Reconstituted or recombined milk products containing neither non-milk fat nor non-milk proteins
- A23C9/1512—Reconstituted or recombined milk products containing neither non-milk fat nor non-milk proteins containing isolated milk or whey proteins, caseinates or cheese; Enrichment of milk products with milk proteins in isolated or concentrated form, e.g. ultrafiltration retentate
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/19—Dairy proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/20—Milk; Whey; Colostrum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/01—Hydrolysed proteins; Derivatives thereof
- A61K38/012—Hydrolysed proteins; Derivatives thereof from animals
- A61K38/018—Hydrolysed proteins; Derivatives thereof from animals from milk
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J1/00—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
- A23J1/20—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from milk, e.g. casein; from whey
- A23J1/202—Casein or caseinates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/32—Foods, ingredients or supplements having a functional effect on health having an effect on the health of the digestive tract
- A23V2200/3202—Prebiotics, ingredients fermented in the gastrointestinal tract by beneficial microflora
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/54—Proteins
- A23V2250/542—Animal Protein
- A23V2250/5424—Dairy protein
- A23V2250/54246—Casein
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Developmental Biology & Embryology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Marine Sciences & Fisheries (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Dairy Products (AREA)
- Confectionery (AREA)
Claims (13)
1. Способ улучшения уровней полезной кишечной микробиоты у животного путем приема внутрь композиции, содержащей бета-казеин, или путем введения животному композиции, содержащей бета-казеин, где по меньшей мере 75% по массе бета-казеина представляет собой вариант бета-казеина, который содержит пролин в положении 67 аминокислотной последовательности бета-казеина.
2. Способ по п. 1, отличающийся тем, что вариант бета-казеина представляет собой бета-казеин А2, бета-казеин A3, бета-казеин D, бета-казеин Е или бета-казеин I.
3. Способ по п. 1 или 2, отличающийся тем, что вариант бета-казеина представляет собой бета-казеин А2.
4. Способ по любому из пп. 1-3, отличающийся тем, что бета-казеин содержит по меньшей мере 90% по массе бета-казеина А2.
5. Способ по любому из пп. 1-4, отличающийся тем, что бета-казеин содержит 100% бета-казеина А2.
6. Способ по любому из пп. 1-5, отличающийся тем, что улучшение микробиоты кишечника оценивают путем измерения уровней одной или более короткоцепочечных жирных кислот в образце фекалий.
7. Способ по п. 6, отличающийся тем, что одну или более короткоцепочечных жирных кислот выбирают из группы, включающей уксусную кислоту, пропановую кислоту и бутановую кислоту или сложный эфир указанной кислоты.
8. Способ по любому из пп. 1-7, отличающийся тем, что указанная композиция представляет собой молоко или молочный продукт.
9. Способ по п. 8, отличающийся тем, что указанное молоко представляет собой свежее молоко, сухое молоко, жидкое молоко, восстановленное из порошка, обезжиренное молоко, детскую смесь, гомогенизированное молоко, концентрированное молоко, сгущенное молоко, пастеризованное молоко или непастеризованное молоко.
10. Способ по п. 8, отличающийся тем, что молочный продукт представляет собой сливки, йогурт, творог, сыр, масло или мороженое.
11. Способ по любому из пп. 1-10, отличающийся тем, что животное представляет собой человека.
12. Способ стимуляции роста бактерий в кишечнике животного, включающий прием внутрь указанным животным композиции, содержащей бета-казеин, или введение указанному животному композиции, содержащей бета-казеин, где по меньшей мере 75% по массе бета-казеина представляет собой вариант бета-казеина, который содержит пролин в положении 67 аминокислотной последовательности бета-казеина.
13. Способ по п. 12, отличающийся тем, что стимуляция роста бактерий в кишечнике позволяет избежать или снизить риск возникновения одного или более из группы, включающей рак, заболевание печени, системные инфекции, воспалительные и аутоиммунные заболевания, ожирение и метаболический синдром, а также неврологические заболевания.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/NZ2016/050161 WO2018063008A1 (en) | 2016-09-30 | 2016-09-30 | Beta-caseins and gut microbiota |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2019107600A true RU2019107600A (ru) | 2020-10-30 |
| RU2019107600A3 RU2019107600A3 (ru) | 2020-10-30 |
| RU2769989C2 RU2769989C2 (ru) | 2022-04-12 |
Family
ID=61759958
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2019107600A RU2769989C2 (ru) | 2016-09-30 | 2016-09-30 | Бета-казеины и кишечная микробиота |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US11925197B2 (ru) |
| JP (1) | JP6873234B2 (ru) |
| KR (2) | KR20220040497A (ru) |
| AU (1) | AU2016424981B2 (ru) |
| BR (1) | BR112019006336B1 (ru) |
| CA (1) | CA3036494C (ru) |
| MX (1) | MX2019003636A (ru) |
| MY (1) | MY186302A (ru) |
| PH (1) | PH12019550035A1 (ru) |
| RU (1) | RU2769989C2 (ru) |
| WO (1) | WO2018063008A1 (ru) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023099750A1 (en) * | 2021-12-03 | 2023-06-08 | N.V. Nutricia | Nutritional composition for improving infant microbiota |
| WO2024056784A1 (en) | 2022-09-14 | 2024-03-21 | N.V. Nutricia | Nutritional composition |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE442585T1 (de) | 1994-11-04 | 2009-09-15 | A2 Corp Ltd | Selektionsverfahren für nicht-diabetogene milch oder milchprodukte sowie hierdurch erfasste milch oder milchprodukte |
| WO1996036239A1 (en) | 1995-05-16 | 1996-11-21 | Corran Norman Stuart Mclachlan | Food product and process |
| EP1196047A4 (en) * | 1999-06-29 | 2004-12-22 | New Zealand Milk Inst Ltd | MILK-BASED PROPHYLACTIC FOOD SUPPLEMENTS |
| WO2002019832A1 (en) | 2000-09-08 | 2002-03-14 | New Zealand Dairy Board | MILK CONTAINING β-CASEIN WITH PROLINE AT POSITION 67 DOES NOT AGGRAVATE NEUROLOGICAL DISORDERS |
| US20060280802A1 (en) * | 2002-10-04 | 2006-12-14 | Campbell Julie H | Therapeutic uses of beta-casein a2 and dietary supplement containing beta-casein a2 |
| AR072142A1 (es) * | 2008-06-13 | 2010-08-11 | Nutricia Nv | Nutricion para prevenir infecciones.proceso. composicion. uso. |
| WO2013080911A1 (ja) * | 2011-11-30 | 2013-06-06 | 株式会社明治 | 腸内菌叢改善用栄養組成物 |
| AU2014271423B2 (en) * | 2013-05-31 | 2018-12-20 | The A2 Milk Company Limited | Beta-casein A2 and prevention of inflammation of the bowel |
| SG10201710237PA (en) * | 2013-07-12 | 2018-01-30 | A2 Milk Co Ltd | Beta-Casein A2 And Reducing Or Preventing Symptoms Of Lactose Intolerance |
| RU2698794C2 (ru) * | 2013-08-23 | 2019-08-30 | Зэ А2 Милк Компани Лимитед | Бета-казеин а2 и уровень глюкозы в крови |
| CN103918792A (zh) | 2014-04-10 | 2014-07-16 | 陕西科技大学 | 一种木糖醇益生菌羊奶片及其制备方法 |
| RU2751945C9 (ru) * | 2015-05-22 | 2021-12-21 | Зе А2 Милк Компани Лимитед | Бета-казеин а2 и антиоксидантная способность |
-
2016
- 2016-09-30 BR BR112019006336-6A patent/BR112019006336B1/pt active IP Right Grant
- 2016-09-30 MY MYPI2019001532A patent/MY186302A/en unknown
- 2016-09-30 JP JP2019517409A patent/JP6873234B2/ja active Active
- 2016-09-30 RU RU2019107600A patent/RU2769989C2/ru active
- 2016-09-30 AU AU2016424981A patent/AU2016424981B2/en active Active
- 2016-09-30 KR KR1020227008438A patent/KR20220040497A/ko not_active Application Discontinuation
- 2016-09-30 WO PCT/NZ2016/050161 patent/WO2018063008A1/en active Application Filing
- 2016-09-30 US US16/333,939 patent/US11925197B2/en active Active
- 2016-09-30 KR KR1020197009048A patent/KR102431753B1/ko active IP Right Grant
- 2016-09-30 CA CA3036494A patent/CA3036494C/en active Active
- 2016-09-30 MX MX2019003636A patent/MX2019003636A/es unknown
-
2019
- 2019-03-08 PH PH12019550035A patent/PH12019550035A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US11925197B2 (en) | 2024-03-12 |
| JP2019532645A (ja) | 2019-11-14 |
| PH12019550035A1 (en) | 2019-07-24 |
| JP6873234B2 (ja) | 2021-05-19 |
| BR112019006336A2 (pt) | 2019-06-25 |
| AU2016424981A1 (en) | 2019-04-11 |
| RU2769989C2 (ru) | 2022-04-12 |
| MX2019003636A (es) | 2019-06-17 |
| KR20190063463A (ko) | 2019-06-07 |
| KR102431753B1 (ko) | 2022-08-11 |
| KR20220040497A (ko) | 2022-03-30 |
| US20200008458A1 (en) | 2020-01-09 |
| AU2016424981B2 (en) | 2021-11-04 |
| RU2019107600A3 (ru) | 2020-10-30 |
| CA3036494C (en) | 2022-10-18 |
| MY186302A (en) | 2021-07-07 |
| CA3036494A1 (en) | 2018-04-05 |
| WO2018063008A1 (en) | 2018-04-05 |
| BR112019006336B1 (pt) | 2021-09-21 |
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