RU2018133818A - Способы лечения заболеваний, характеризующихся вазоконстрикцией - Google Patents
Способы лечения заболеваний, характеризующихся вазоконстрикцией Download PDFInfo
- Publication number
- RU2018133818A RU2018133818A RU2018133818A RU2018133818A RU2018133818A RU 2018133818 A RU2018133818 A RU 2018133818A RU 2018133818 A RU2018133818 A RU 2018133818A RU 2018133818 A RU2018133818 A RU 2018133818A RU 2018133818 A RU2018133818 A RU 2018133818A
- Authority
- RU
- Russia
- Prior art keywords
- compound
- use according
- disease
- disorder
- vasoconstriction
- Prior art date
Links
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims 19
- 201000010099 disease Diseases 0.000 title claims 10
- 150000001875 compounds Chemical class 0.000 claims 15
- 208000035475 disorder Diseases 0.000 claims 9
- 206010047139 Vasoconstriction Diseases 0.000 claims 7
- 238000011282 treatment Methods 0.000 claims 7
- 230000025033 vasoconstriction Effects 0.000 claims 7
- 206010061218 Inflammation Diseases 0.000 claims 3
- 101710096361 Prostaglandin E synthase Proteins 0.000 claims 3
- 206010064911 Pulmonary arterial hypertension Diseases 0.000 claims 3
- 206010039710 Scleroderma Diseases 0.000 claims 3
- 230000004054 inflammatory process Effects 0.000 claims 3
- 239000003112 inhibitor Substances 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 230000002265 prevention Effects 0.000 claims 3
- 238000011321 prophylaxis Methods 0.000 claims 3
- 206010056340 Diabetic ulcer Diseases 0.000 claims 2
- 208000003782 Raynaud disease Diseases 0.000 claims 2
- 208000012322 Raynaud phenomenon Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000000651 prodrug Substances 0.000 claims 2
- 229940002612 prodrug Drugs 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 208000032131 Diabetic Neuropathies Diseases 0.000 claims 1
- 206010012689 Diabetic retinopathy Diseases 0.000 claims 1
- 206010040943 Skin Ulcer Diseases 0.000 claims 1
- 229940111134 coxibs Drugs 0.000 claims 1
- 239000003255 cyclooxygenase 2 inhibitor Substances 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1603311.0 | 2016-02-25 | ||
| GBGB1603311.0A GB201603311D0 (en) | 2016-02-25 | 2016-02-25 | New uses and methods |
| PCT/GB2017/050498 WO2017144909A1 (en) | 2016-02-25 | 2017-02-24 | Methods of treating diseases characterised by vasoconstriction |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2018133818A true RU2018133818A (ru) | 2020-03-25 |
| RU2018133818A3 RU2018133818A3 (enExample) | 2020-05-27 |
Family
ID=55806947
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2018133818A RU2018133818A (ru) | 2016-02-25 | 2017-02-24 | Способы лечения заболеваний, характеризующихся вазоконстрикцией |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20190038603A1 (enExample) |
| EP (1) | EP3419620A1 (enExample) |
| JP (1) | JP2019510079A (enExample) |
| CN (1) | CN109069487A (enExample) |
| AU (1) | AU2017222406B2 (enExample) |
| CA (1) | CA3014728A1 (enExample) |
| GB (1) | GB201603311D0 (enExample) |
| RU (1) | RU2018133818A (enExample) |
| WO (1) | WO2017144909A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE070649T2 (hu) | 2017-10-19 | 2025-06-28 | Teijin Pharma Ltd | Benzimidazol-származékok és felhasználásuk |
| WO2020097400A1 (en) | 2018-11-07 | 2020-05-14 | Dana-Farber Cancer Institute, Inc. | Imidazopyridine derivatives and aza-imidazopyridine derivatives as janus kinase 2 inhibitors and uses thereof |
| EP3876939A4 (en) | 2018-11-07 | 2022-08-10 | Dana-Farber Cancer Institute, Inc. | Benzothiazole derivatives and 7-aza-benzothiazole derivatives as janus kinase 2 inhibitors and uses thereof |
| EP3876930A4 (en) | 2018-11-07 | 2022-07-20 | Dana-Farber Cancer Institute, Inc. | BENZIMIDAZOLE DERIVATIVES AND AZA-BENZIMIDAZOLE DERIVATIVES AS JANUS KINASE 2 INHIBITORS AND USES THEREOF |
| KR20210059663A (ko) * | 2019-11-15 | 2021-05-25 | 가천대학교 산학협력단 | 신규한 벤즈이미다졸 유도체 및 이의 용도 |
| BR112022022409A2 (pt) | 2020-05-06 | 2023-02-07 | Ajax Therapeutics Inc | 6-heteroarilóxi benzimidazóis e azabenzimidazóis como inibidores de jak2 |
| WO2022140527A1 (en) | 2020-12-23 | 2022-06-30 | Ajax Therapeutics, Inc. | 6-heteroaryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors |
| CA3234638A1 (en) | 2021-11-09 | 2023-05-19 | Ajax Therapeutics, Inc. | 6-heteroaryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors |
| WO2023086320A1 (en) | 2021-11-09 | 2023-05-19 | Ajax Therapeutics, Inc. | Forms and compositions of inhibitors of jak2 |
| TW202345806A (zh) | 2022-03-31 | 2023-12-01 | 美商艾伯維有限公司 | 噻唑并〔５，４－ｂ〕吡啶ｍａｌｔ－１抑制劑 |
| US20250340557A1 (en) * | 2022-07-06 | 2025-11-06 | Aska Pharmaceutical Co., Ltd. | Pyrimidine derivative |
| GB202212749D0 (en) | 2022-09-01 | 2022-10-19 | Gesynta Pharma Ab | New uses |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2207547A4 (en) * | 2007-10-05 | 2010-11-17 | Amira Pharmaceuticals Inc | PROTEIN INHIBITORS THAT ACTIVATE 5-LIPOXYGENASE |
| UY32470A (es) * | 2009-03-05 | 2010-10-29 | Boehringer Ingelheim Int | Derivados de 2-{2-cloro-5-[(sustituido) metil]fenilamino} -1-metil]fenilamino}-1-metilbencimidazol-5-carboxamidas-n-(sustituidas) y sus sales fisiológicamente aceptables, composiciones conteniéndolos y aplicaciones |
| WO2011023812A1 (en) * | 2009-08-27 | 2011-03-03 | Novasaid Ab | Microsomal prostaglandin e synthase-1 (mpges1) inhibitors |
| US8759537B2 (en) * | 2010-08-20 | 2014-06-24 | Boehringer Ingelheim International Gmbh | 3H-imidazo [4, 5-C] pyridine-6-carboxamides as anti-inflammatory agents |
| EP2495244A1 (en) * | 2011-03-02 | 2012-09-05 | NovaSaid AB | Piperidinyl benzoimidazole derivatives as mPGEs-1 inhibitors |
| SI2746265T1 (sl) * | 2011-08-18 | 2016-03-31 | Nippon Shinyaku Co., Ltd. | Heterociklični derivat kot zaviralec mikrosomske prostaglandin-e sintaze (mpges) |
| TWI651310B (zh) * | 2014-02-20 | 2019-02-21 | 日商日本煙草產業股份有限公司 | 三化合物及其醫藥用途 |
| MX368504B (es) * | 2014-04-14 | 2019-10-04 | Shanghai hengrui pharmaceutical co ltd | Derivados de amidas y sales farmaceuticamente aceptables de los mismos, método de preparación de los mismos y aplicación médica de los mismos. |
-
2016
- 2016-02-25 GB GBGB1603311.0A patent/GB201603311D0/en not_active Ceased
-
2017
- 2017-02-24 WO PCT/GB2017/050498 patent/WO2017144909A1/en not_active Ceased
- 2017-02-24 CA CA3014728A patent/CA3014728A1/en active Pending
- 2017-02-24 US US16/079,203 patent/US20190038603A1/en not_active Abandoned
- 2017-02-24 JP JP2018563946A patent/JP2019510079A/ja active Pending
- 2017-02-24 AU AU2017222406A patent/AU2017222406B2/en not_active Ceased
- 2017-02-24 CN CN201780012516.XA patent/CN109069487A/zh active Pending
- 2017-02-24 EP EP17713372.5A patent/EP3419620A1/en not_active Withdrawn
- 2017-02-24 RU RU2018133818A patent/RU2018133818A/ru unknown
-
2022
- 2022-01-05 US US17/569,049 patent/US20220218670A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20190038603A1 (en) | 2019-02-07 |
| RU2018133818A3 (enExample) | 2020-05-27 |
| CN109069487A (zh) | 2018-12-21 |
| GB201603311D0 (en) | 2016-04-13 |
| CA3014728A1 (en) | 2017-08-31 |
| US20220218670A1 (en) | 2022-07-14 |
| AU2017222406A1 (en) | 2018-08-30 |
| AU2017222406B2 (en) | 2022-06-02 |
| WO2017144909A1 (en) | 2017-08-31 |
| EP3419620A1 (en) | 2019-01-02 |
| JP2019510079A (ja) | 2019-04-11 |
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