JP2019510079A5 - - Google Patents
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- Publication number
- JP2019510079A5 JP2019510079A5 JP2018563946A JP2018563946A JP2019510079A5 JP 2019510079 A5 JP2019510079 A5 JP 2019510079A5 JP 2018563946 A JP2018563946 A JP 2018563946A JP 2018563946 A JP2018563946 A JP 2018563946A JP 2019510079 A5 JP2019510079 A5 JP 2019510079A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- use according
- disease
- disorder
- vasoconstriction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 18
- 150000001875 compounds Chemical class 0.000 claims 15
- 201000010099 disease Diseases 0.000 claims 9
- 208000035475 disorder Diseases 0.000 claims 9
- 206010047139 Vasoconstriction Diseases 0.000 claims 7
- 230000025033 vasoconstriction Effects 0.000 claims 7
- 230000002265 prevention Effects 0.000 claims 5
- 239000003112 inhibitor Substances 0.000 claims 4
- 206010061218 Inflammation Diseases 0.000 claims 3
- 101710096361 Prostaglandin E synthase Proteins 0.000 claims 3
- 206010064911 Pulmonary arterial hypertension Diseases 0.000 claims 3
- 230000004054 inflammatory process Effects 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 206010056340 Diabetic ulcer Diseases 0.000 claims 2
- 208000012322 Raynaud phenomenon Diseases 0.000 claims 2
- 206010039710 Scleroderma Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000009472 formulation Methods 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000000651 prodrug Substances 0.000 claims 2
- 229940002612 prodrug Drugs 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 208000032131 Diabetic Neuropathies Diseases 0.000 claims 1
- 206010012689 Diabetic retinopathy Diseases 0.000 claims 1
- 206010040943 Skin Ulcer Diseases 0.000 claims 1
- 229940111134 coxibs Drugs 0.000 claims 1
- 239000003255 cyclooxygenase 2 inhibitor Substances 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1603311.0A GB201603311D0 (en) | 2016-02-25 | 2016-02-25 | New uses and methods |
| GB1603311.0 | 2016-02-25 | ||
| PCT/GB2017/050498 WO2017144909A1 (en) | 2016-02-25 | 2017-02-24 | Methods of treating diseases characterised by vasoconstriction |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019510079A JP2019510079A (ja) | 2019-04-11 |
| JP2019510079A5 true JP2019510079A5 (enExample) | 2020-04-02 |
Family
ID=55806947
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018563946A Pending JP2019510079A (ja) | 2016-02-25 | 2017-02-24 | 血管収縮を特徴とする疾患を治療する方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20190038603A1 (enExample) |
| EP (1) | EP3419620A1 (enExample) |
| JP (1) | JP2019510079A (enExample) |
| CN (1) | CN109069487A (enExample) |
| AU (1) | AU2017222406B2 (enExample) |
| CA (1) | CA3014728A1 (enExample) |
| GB (1) | GB201603311D0 (enExample) |
| RU (1) | RU2018133818A (enExample) |
| WO (1) | WO2017144909A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102697255B1 (ko) | 2017-10-19 | 2024-08-23 | 데이진 화-마 가부시키가이샤 | 벤즈이미다졸 유도체 및 이의 용도 |
| EP3877371A4 (en) | 2018-11-07 | 2022-07-27 | Dana-Farber Cancer Institute, Inc. | IMIDAZOPYRIDINE DERIVATIVES AND AZA-IMIDAZOPYRIDINE DERIVATIVES USED AS JANUS KINASE 2 INHIBITORS AND ASSOCIATED USES |
| US12415816B2 (en) | 2018-11-07 | 2025-09-16 | Dana-Farber Cancer Institute, Inc. | Benzothiazole derivatives and 7-aza-benzothiazole derivatives as janus kinase 2 inhibitors and uses thereof |
| EP3876930A4 (en) | 2018-11-07 | 2022-07-20 | Dana-Farber Cancer Institute, Inc. | BENZIMIDAZOLE DERIVATIVES AND AZA-BENZIMIDAZOLE DERIVATIVES AS JANUS KINASE 2 INHIBITORS AND THEIR USES |
| KR20210059663A (ko) * | 2019-11-15 | 2021-05-25 | 가천대학교 산학협력단 | 신규한 벤즈이미다졸 유도체 및 이의 용도 |
| WO2021226261A1 (en) | 2020-05-06 | 2021-11-11 | Ajax Therapeutics, Inc. | 6-heteroaryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors |
| EP4267574B1 (en) | 2020-12-23 | 2025-04-23 | Ajax Therapeutics, Inc. | 6-heteroaryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors |
| JP7782035B2 (ja) | 2021-11-09 | 2025-12-08 | エイジャックス セラピューティクス， インコーポレイテッド | Ｊａｋ２阻害剤としての６－ヘテロアリールオキシベンゾイミダゾール及びアザベンゾイミダゾール |
| WO2023086320A1 (en) | 2021-11-09 | 2023-05-19 | Ajax Therapeutics, Inc. | Forms and compositions of inhibitors of jak2 |
| TW202345806A (zh) | 2022-03-31 | 2023-12-01 | 美商艾伯維有限公司 | 噻唑并〔５，４－ｂ〕吡啶ｍａｌｔ－１抑制劑 |
| US20250340557A1 (en) * | 2022-07-06 | 2025-11-06 | Aska Pharmaceutical Co., Ltd. | Pyrimidine derivative |
| GB202212749D0 (en) | 2022-09-01 | 2022-10-19 | Gesynta Pharma Ab | New uses |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100298343A1 (en) * | 2007-10-05 | 2010-11-25 | John Howard Hutchinson | 5-lipoxygenase-activating protein (flap) inhibitors |
| UY32470A (es) * | 2009-03-05 | 2010-10-29 | Boehringer Ingelheim Int | Derivados de 2-{2-cloro-5-[(sustituido) metil]fenilamino} -1-metil]fenilamino}-1-metilbencimidazol-5-carboxamidas-n-(sustituidas) y sus sales fisiológicamente aceptables, composiciones conteniéndolos y aplicaciones |
| WO2011023812A1 (en) * | 2009-08-27 | 2011-03-03 | Novasaid Ab | Microsomal prostaglandin e synthase-1 (mpges1) inhibitors |
| US8759537B2 (en) * | 2010-08-20 | 2014-06-24 | Boehringer Ingelheim International Gmbh | 3H-imidazo [4, 5-C] pyridine-6-carboxamides as anti-inflammatory agents |
| EP2495244A1 (en) * | 2011-03-02 | 2012-09-05 | NovaSaid AB | Piperidinyl benzoimidazole derivatives as mPGEs-1 inhibitors |
| PL2746265T3 (pl) * | 2011-08-18 | 2016-04-29 | Nippon Shinyaku Co Ltd | POCHODNA HETEROCYKLICZNA JAKO INHIBITOR MIKROSOMALNEJ SYNTAZY PROSTAGLANDYNY E (mPGEs) |
| TWI651310B (zh) * | 2014-02-20 | 2019-02-21 | 日商日本煙草產業股份有限公司 | 三化合物及其醫藥用途 |
| ES2838625T3 (es) * | 2014-04-14 | 2021-07-02 | Shanghai hengrui pharmaceutical co ltd | Derivados de amida y sales farmacéuticamente aceptables de los mismos, su método de preparación y aplicación médica de los mismos |
-
2016
- 2016-02-25 GB GBGB1603311.0A patent/GB201603311D0/en not_active Ceased
-
2017
- 2017-02-24 JP JP2018563946A patent/JP2019510079A/ja active Pending
- 2017-02-24 AU AU2017222406A patent/AU2017222406B2/en not_active Ceased
- 2017-02-24 US US16/079,203 patent/US20190038603A1/en not_active Abandoned
- 2017-02-24 RU RU2018133818A patent/RU2018133818A/ru unknown
- 2017-02-24 EP EP17713372.5A patent/EP3419620A1/en not_active Withdrawn
- 2017-02-24 WO PCT/GB2017/050498 patent/WO2017144909A1/en not_active Ceased
- 2017-02-24 CA CA3014728A patent/CA3014728A1/en active Pending
- 2017-02-24 CN CN201780012516.XA patent/CN109069487A/zh active Pending
-
2022
- 2022-01-05 US US17/569,049 patent/US20220218670A1/en not_active Abandoned
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