JP2020500907A5 - - Google Patents
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- Publication number
- JP2020500907A5 JP2020500907A5 JP2019530714A JP2019530714A JP2020500907A5 JP 2020500907 A5 JP2020500907 A5 JP 2020500907A5 JP 2019530714 A JP2019530714 A JP 2019530714A JP 2019530714 A JP2019530714 A JP 2019530714A JP 2020500907 A5 JP2020500907 A5 JP 2020500907A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- substituted
- compound
- methyl
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 14
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 7
- 229910052801 chlorine Inorganic materials 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 2
- -1 2-thiazolyl Chemical group 0.000 claims 2
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims 2
- 229910052794 bromium Inorganic materials 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 208000016097 disease of metabolism Diseases 0.000 claims 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 208000030159 metabolic disease Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16203086.0 | 2016-12-09 | ||
| EP16203086 | 2016-12-09 | ||
| PCT/EP2017/081359 WO2018104220A1 (en) | 2016-12-09 | 2017-12-04 | Sulfonamides as inhibitors of the uptake of extracellular citrate |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020500907A JP2020500907A (ja) | 2020-01-16 |
| JP2020500907A5 true JP2020500907A5 (enExample) | 2021-01-21 |
| JP7007381B2 JP7007381B2 (ja) | 2022-01-24 |
Family
ID=57539116
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019530714A Active JP7007381B2 (ja) | 2016-12-09 | 2017-12-04 | 細胞外クエン酸の取込みの阻害剤としてのスルホンアミド |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US10793522B2 (enExample) |
| EP (1) | EP3551618B1 (enExample) |
| JP (1) | JP7007381B2 (enExample) |
| CN (1) | CN110325527B (enExample) |
| WO (1) | WO2018104220A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018104220A1 (en) | 2016-12-09 | 2018-06-14 | Boehringer Ingelheim International Gmbh | Sulfonamides as inhibitors of the uptake of extracellular citrate |
| GB2560713A (en) * | 2017-03-20 | 2018-09-26 | Eternygen Gmbh | Inhibitor of citrate transporter |
| GB201918410D0 (en) * | 2019-12-13 | 2020-01-29 | Z Factor Ltd | Compounds and their use for the treatment of alpha1-antitrypsin deficiency |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5219150B2 (ja) * | 2005-12-12 | 2013-06-26 | ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ | キナーゼ阻害薬として活性な置換ピラゾロ［４，３−ｃ］ピリジン誘導体 |
| CN101821238A (zh) | 2007-07-26 | 2010-09-01 | 科门蒂斯公司 | 抑制β-分泌酶(BETA-SECRETASE)活性的间苯二酰胺衍生物 |
| WO2010080183A1 (en) | 2009-01-08 | 2010-07-15 | The Trustees Of Columbia University In The City Of New York | Potent non-urea inhibitors of soluble epoxide hydrolase |
| US8258158B2 (en) * | 2009-09-11 | 2012-09-04 | Hoffmann-La Roche Inc. | HSL inhibitors useful in the treatment of diabetes |
| EP2763990B1 (en) | 2011-09-01 | 2017-02-22 | F. Hoffmann-La Roche AG | Pyrrolopyrazine kinase inhibitors |
| TWI641595B (zh) | 2013-07-17 | 2018-11-21 | 日商大塚製藥股份有限公司 | 氰基三唑化合物類 |
| WO2018104220A1 (en) | 2016-12-09 | 2018-06-14 | Boehringer Ingelheim International Gmbh | Sulfonamides as inhibitors of the uptake of extracellular citrate |
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2017
- 2017-12-04 WO PCT/EP2017/081359 patent/WO2018104220A1/en not_active Ceased
- 2017-12-04 JP JP2019530714A patent/JP7007381B2/ja active Active
- 2017-12-04 EP EP17811906.1A patent/EP3551618B1/en active Active
- 2017-12-04 CN CN201780074706.4A patent/CN110325527B/zh active Active
- 2017-12-04 US US16/467,499 patent/US10793522B2/en active Active