RU2017133854A - Вектор - Google Patents

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RU2017133854A
RU2017133854A RU2017133854A RU2017133854A RU2017133854A RU 2017133854 A RU2017133854 A RU 2017133854A RU 2017133854 A RU2017133854 A RU 2017133854A RU 2017133854 A RU2017133854 A RU 2017133854A RU 2017133854 A RU2017133854 A RU 2017133854A
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cell
viral vector
mitogenic
transmembrane protein
retroviral
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RU2017133854A
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English (en)
Russian (ru)
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RU2017133854A3 (enExample
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Мартен ПЮЛЕ
Лейла МЕККАУИ
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ЮСиЭл БИЗНЕС ПиЭлСи
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52876362&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RU2017133854(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by ЮСиЭл БИЗНЕС ПиЭлСи filed Critical ЮСиЭл БИЗНЕС ПиЭлСи
Publication of RU2017133854A publication Critical patent/RU2017133854A/ru
Publication of RU2017133854A3 publication Critical patent/RU2017133854A3/ru

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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86Viral vectors
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    • C12N2740/10011Retroviridae
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RU2017133854A 2015-03-02 2016-03-01 Вектор RU2017133854A (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1503500.9 2015-03-02
GB201503500A GB201503500D0 (en) 2015-03-02 2015-03-02 Cell
PCT/GB2016/050537 WO2016139463A1 (en) 2015-03-02 2016-03-01 Retroviral and lentiviral vectors

Publications (2)

Publication Number Publication Date
RU2017133854A true RU2017133854A (ru) 2019-04-02
RU2017133854A3 RU2017133854A3 (enExample) 2019-07-30

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RU2017133854A RU2017133854A (ru) 2015-03-02 2016-03-01 Вектор

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US (2) US10954530B2 (enExample)
EP (2) EP3265570B2 (enExample)
JP (3) JP6695347B2 (enExample)
KR (1) KR20180002602A (enExample)
CN (1) CN107406860A (enExample)
AU (1) AU2016227474A1 (enExample)
BR (1) BR112017018251A2 (enExample)
CA (1) CA2977472A1 (enExample)
CL (1) CL2017002199A1 (enExample)
ES (1) ES2877398T5 (enExample)
GB (1) GB201503500D0 (enExample)
IL (1) IL253820B (enExample)
MX (1) MX2017010553A (enExample)
RU (1) RU2017133854A (enExample)
SG (1) SG11201706721PA (enExample)
WO (1) WO2016139463A1 (enExample)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR201802728T4 (tr) 2013-10-25 2018-03-21 Psioxus Therapeutics Ltd Heterolog genlerle donatılmış onkolitik adenovirüsler.
GB201415344D0 (en) 2014-08-29 2014-10-15 Ucl Business Plc Protein
KR101697473B1 (ko) 2014-11-26 2017-01-18 주식회사 녹십자랩셀 T 세포를 이용한 자연살해세포의 배양방법
PE20180241A1 (es) 2015-04-30 2018-01-31 Psioxus Therapeutics Ltd Adenovirus oncolitico que codifica una proteina b7
US10046317B2 (en) * 2015-08-11 2018-08-14 Chevron U.S.A. Inc. Middle distillate hydrocracking catalyst containing zeolite beta with low OD acidity and large domain size
RU2761555C2 (ru) 2015-10-22 2021-12-09 Джуно Терапьютикс Гмбх Способы, наборы, средства и устройства для трансдукции
KR102857666B1 (ko) 2015-12-17 2025-09-10 아카미스 바이오 리미티드 항-tcr-복합체 항체 또는 단편을 암호화하는 군 b 아데노바이러스
US11111505B2 (en) 2016-03-19 2021-09-07 Exuma Biotech, Corp. Methods and compositions for transducing lymphocytes and regulating the activity thereof
SG10202104509PA (en) * 2016-03-19 2021-06-29 Exuma Biotech Corp Methods and compositions for transducing lymphocytes and regulated expansion thereof
US11325948B2 (en) 2016-03-19 2022-05-10 Exuma Biotech Corp. Methods and compositions for genetically modifying lymphocytes to express polypeptides comprising the intracellular domain of MPL
GB201614093D0 (en) * 2016-08-17 2016-09-28 Autolus Ltd Vector
GB201713765D0 (en) 2017-08-28 2017-10-11 Psioxus Therapeutics Ltd Modified adenovirus
AU2017320776B2 (en) 2016-08-29 2024-10-10 Akamis Bio Limited Adenovirus armed with bispecific T cell activator
US20190350978A1 (en) * 2016-12-05 2019-11-21 Juno Therapeutics, Inc. Production of engineered cells for adoptive cell therapy
EP3575319A4 (en) * 2016-12-30 2021-03-10 Shanghai Sinobio Biotech Co., Ltd. BIFUNCTIONAL MOLECULE AND USE OF IT
EP3564265A4 (en) * 2016-12-30 2021-02-17 Cytocares (Shanghai) Inc. Trifunctional molecule and application thereof
BR112019018288A2 (pt) * 2017-03-03 2020-03-31 F1 Oncology, Inc. Métodos e composições para transduzir e expandir linfócitos e regular a atividade dos mesmos
JP7039623B2 (ja) * 2017-05-26 2022-03-22 グリーン・クロス・ラブ・セル・コーポレイション 形質転換されたt細胞を用いてナチュラルキラー細胞を培養する方法
CN118895313A (zh) * 2017-09-18 2024-11-05 埃克苏马生物技术公司 用于以基因方式修饰且扩增淋巴细胞以及调节其活性的方法及组合物
JP7262465B2 (ja) * 2017-12-20 2023-04-21 ミルテニイ ビオテック ベー.ファー. ウント コー.カーゲー Nk細胞形質導入のための方法
SG11202009975TA (en) 2018-04-12 2020-11-27 Umoja Biopharma Inc Viral vectors and packaging cell lines
US20210301260A1 (en) * 2018-08-10 2021-09-30 Kyoto University Method for producing cd3-positive cell
JP7672187B2 (ja) * 2018-09-02 2025-05-07 エクスマ バイオテック コーポレイション 血液中または濃縮pbmc中のリンパ球を遺伝子改変するための方法および組成物
SG11202104662UA (en) 2018-11-14 2021-06-29 Green Cross Lab Cell Corp Method for culturing cord blood-derived natural killer cells using transformed t-cells
EP3884058A1 (en) 2018-11-21 2021-09-29 Umoja Biopharma, Inc. Multicistronic vector for surface engineering lentiviral particles
CN109722420A (zh) * 2019-03-15 2019-05-07 江苏艾洛特医药研究院有限公司 一种改良嵌合抗原受体t细胞的制备及其应用
KR102503349B1 (ko) 2019-05-14 2023-02-23 프로벤션 바이오, 인코포레이티드 제1형 당뇨병을 예방하기 위한 방법 및 조성물
JP2022553200A (ja) * 2019-10-16 2022-12-22 ウモジャ バイオファーマ, インコーポレイテッド ユニバーサル受容体療法のためのレトロウイルスベクター
CN115697388A (zh) 2020-01-30 2023-02-03 优莫佳生物制药股份有限公司 双特异性转导增强子
IL298999A (en) 2020-06-11 2023-02-01 Provention Bio Inc Methods and compositions for the prevention of type 1 diabetes
CN116745427A (zh) 2020-11-20 2023-09-12 优莫佳生物制药股份有限公司 用于递送多种多核苷酸的载体系统及其用途
JP2024505887A (ja) 2021-01-27 2024-02-08 ウモジャ バイオファーマ, インコーポレイテッド 抗cd19キメラ抗原受容体を発現する細胞を生成するためのレンチウイルス
CN112941039A (zh) * 2021-02-01 2021-06-11 南京大学 一种新型类囊泡溶瘤病毒及其在制备抗肿瘤药物上的应用
AU2023212736A1 (en) * 2022-01-25 2024-08-01 Sunshine Lake Pharma Co., Ltd. Viral vector and application thereof
WO2023198828A1 (en) 2022-04-13 2023-10-19 Universitat Autònoma De Barcelona Treatment of neuromuscular diseases via gene therapy that expresses klotho protein
IL316839A (en) 2022-05-17 2025-01-01 Umoja Biopharma Inc Production of viral particles
AU2023371650A1 (en) 2022-11-04 2025-05-29 Umoja Biopharma, Inc. Polynucleotide construct and related viral vectors and methods
WO2024098028A2 (en) 2022-11-04 2024-05-10 Umoja Biopharma, Inc. Lentiviral particles displaying fusion molecules and uses thereof
WO2024097992A2 (en) 2022-11-04 2024-05-10 Umoja Biopharma, Inc. Particles displaying adhesion-molecule fusions
WO2024102954A1 (en) 2022-11-10 2024-05-16 Massachusetts Institute Of Technology Activation induced clipping system (aics)
WO2024179465A1 (zh) * 2023-02-27 2024-09-06 上海君赛生物科技有限公司 表达膜结合细胞因子的肿瘤浸润淋巴细胞
WO2024223847A1 (en) * 2023-04-27 2024-10-31 Miltenyi Biotec B.V. & Co. KG Pseudotyped retroviral vector particle with anti-cd3 display
WO2024238153A1 (en) 2023-05-15 2024-11-21 Umoja Biopharma, Inc. Lentiviral delivery of anti-cd20 chimeric antigen receptors
CN116496417B (zh) * 2023-06-27 2023-10-10 北京市肿瘤防治研究所 含有膜型il7的融合蛋白及t细胞
WO2025059162A1 (en) 2023-09-11 2025-03-20 Dana-Farber Cancer Institute, Inc. Car-engager containing il-2 variants to enhance the functionality of car t cells
US12269882B1 (en) 2023-09-25 2025-04-08 Kelonia Therapeutics, Inc. Antigen binding polypeptides
US12403194B2 (en) 2023-09-25 2025-09-02 Kelonia Therapeutics, Inc. Compositions for treating cancer
WO2025072257A1 (en) * 2023-09-25 2025-04-03 Kelonia Therapeutics, Inc. Compositions for treating cancer
WO2025090978A1 (en) 2023-10-26 2025-05-01 Cargo Therapeutics, Inc. Modified immune effector cells
WO2025149068A1 (zh) * 2024-01-10 2025-07-17 深圳市济因生物科技有限公司 一种病毒颗粒及其制备方法与应用
WO2025231174A1 (en) 2024-04-30 2025-11-06 Umoja Biopharma, Inc. Manufacturing viral particles
WO2025235604A1 (en) 2024-05-08 2025-11-13 Umoja Biopharma, Inc. Fusion protein for use as immune cell engager
WO2025235862A1 (en) 2024-05-10 2025-11-13 Inndura Therapeutics Inc. A modified immune cell receptor comprising a target-binding domain and the extracellular domain of cd16a

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994027643A1 (en) * 1993-06-01 1994-12-08 Targeted Genetics Corporation Envelope fusion vectors for use in gene delivery
AU727531B2 (en) * 1995-07-25 2000-12-14 Crucell Holland B.V. Methods and means for targeted gene delivery
WO2004080404A2 (en) 2003-03-07 2004-09-23 University Of Utah Research Foundation Il-2 transmembrane constructs
CA2572467A1 (en) * 2004-07-01 2006-01-19 Virxsys Corporation Vector packaging cell line
WO2007095201A2 (en) * 2006-02-15 2007-08-23 The Regents Of The University Of California Pseudotyped retroviral vectors and methods of use thereof
US8293685B2 (en) * 2007-07-26 2012-10-23 The Regents Of The University Of California Methods for enhancing bacterial cell display of proteins and peptides
GB0920775D0 (en) * 2009-11-26 2010-01-13 King S College Cells
GB201206559D0 (en) 2012-04-13 2012-05-30 Ucl Business Plc Polypeptide
GB201415344D0 (en) 2014-08-29 2014-10-15 Ucl Business Plc Protein
GB201614093D0 (en) 2016-08-17 2016-09-28 Autolus Ltd Vector
GB201910651D0 (en) 2019-07-25 2019-09-11 Autolus Ltd Virus-like particle

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