RU2017123184A - Лечение глазных патологий с применением клеток-предшественников - Google Patents
Лечение глазных патологий с применением клеток-предшественников Download PDFInfo
- Publication number
- RU2017123184A RU2017123184A RU2017123184A RU2017123184A RU2017123184A RU 2017123184 A RU2017123184 A RU 2017123184A RU 2017123184 A RU2017123184 A RU 2017123184A RU 2017123184 A RU2017123184 A RU 2017123184A RU 2017123184 A RU2017123184 A RU 2017123184A
- Authority
- RU
- Russia
- Prior art keywords
- population
- cells
- tsp
- cord tissue
- umbilical cord
- Prior art date
Links
- 210000004027 cell Anatomy 0.000 claims 18
- 210000001519 tissue Anatomy 0.000 claims 12
- 238000000034 method Methods 0.000 claims 10
- 210000003954 umbilical cord Anatomy 0.000 claims 10
- 230000003107 synaptogenic effect Effects 0.000 claims 8
- 101100208237 Bos taurus THBS2 gene Proteins 0.000 claims 4
- 101100202932 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) tsp-4 gene Proteins 0.000 claims 4
- 101100208249 Rattus norvegicus Thbs4 gene Proteins 0.000 claims 4
- 108010046722 Thrombospondin 1 Proteins 0.000 claims 4
- 239000008280 blood Substances 0.000 claims 4
- 210000004369 blood Anatomy 0.000 claims 4
- 201000007737 Retinal degeneration Diseases 0.000 claims 3
- 230000004258 retinal degeneration Effects 0.000 claims 3
- 210000001116 retinal neuron Anatomy 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 102100022464 5'-nucleotidase Human genes 0.000 claims 1
- 102100022749 Aminopeptidase N Human genes 0.000 claims 1
- 102100032912 CD44 antigen Human genes 0.000 claims 1
- 102000011786 HLA-A Antigens Human genes 0.000 claims 1
- 108010075704 HLA-A Antigens Proteins 0.000 claims 1
- 102000006354 HLA-DR Antigens Human genes 0.000 claims 1
- 108010058597 HLA-DR Antigens Proteins 0.000 claims 1
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 1
- 101000678236 Homo sapiens 5'-nucleotidase Proteins 0.000 claims 1
- 101000757160 Homo sapiens Aminopeptidase N Proteins 0.000 claims 1
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 claims 1
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 1
- 101001008874 Homo sapiens Mast/stem cell growth factor receptor Kit Proteins 0.000 claims 1
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 claims 1
- 101000763314 Homo sapiens Thrombomodulin Proteins 0.000 claims 1
- 101000800116 Homo sapiens Thy-1 membrane glycoprotein Proteins 0.000 claims 1
- 102000004890 Interleukin-8 Human genes 0.000 claims 1
- 108090001007 Interleukin-8 Proteins 0.000 claims 1
- 102100027754 Mast/stem cell growth factor receptor Kit Human genes 0.000 claims 1
- 102000003729 Neprilysin Human genes 0.000 claims 1
- 108090000028 Neprilysin Proteins 0.000 claims 1
- 102100024616 Platelet endothelial cell adhesion molecule Human genes 0.000 claims 1
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 claims 1
- 101710122684 Reticulon-1 Proteins 0.000 claims 1
- 102100022647 Reticulon-1 Human genes 0.000 claims 1
- 102100026966 Thrombomodulin Human genes 0.000 claims 1
- 102100033523 Thy-1 membrane glycoprotein Human genes 0.000 claims 1
- 210000000411 amacrine cell Anatomy 0.000 claims 1
- 210000002798 bone marrow cell Anatomy 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000002950 fibroblast Anatomy 0.000 claims 1
- 210000002287 horizontal cell Anatomy 0.000 claims 1
- 210000005260 human cell Anatomy 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- XKTZWUACRZHVAN-VADRZIEHSA-N interleukin-8 Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](NC(C)=O)CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N1[C@H](CCC1)C(=O)N1[C@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC(O)=CC=1)C(=O)N[C@H](CO)C(=O)N1[C@H](CCC1)C(N)=O)C1=CC=CC=C1 XKTZWUACRZHVAN-VADRZIEHSA-N 0.000 claims 1
- 229940096397 interleukin-8 Drugs 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims 1
- 230000001537 neural effect Effects 0.000 claims 1
- 210000002241 neurite Anatomy 0.000 claims 1
- 108091008695 photoreceptors Proteins 0.000 claims 1
- 230000001902 propagating effect Effects 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 210000001525 retina Anatomy 0.000 claims 1
- 210000003994 retinal ganglion cell Anatomy 0.000 claims 1
- 210000000225 synapse Anatomy 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/51—Umbilical cord; Umbilical cord blood; Umbilical stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A61K9/0051—Ocular inserts, ocular implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0605—Cells from extra-embryonic tissues, e.g. placenta, amnion, yolk sac, Wharton's jelly
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/062—Sensory transducers, e.g. photoreceptors; Sensory neurons, e.g. for hearing, taste, smell, pH, touch, temperature, pain
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/02—Coculture with; Conditioned medium produced by embryonic cells
- C12N2502/025—Coculture with; Conditioned medium produced by embryonic cells extra-embryonic cells, e.g. amniotic epithelium, placental cells, Wharton's jelly
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Reproductive Health (AREA)
- Biochemistry (AREA)
- Gynecology & Obstetrics (AREA)
- Neurology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Pregnancy & Childbirth (AREA)
- Physics & Mathematics (AREA)
- Acoustics & Sound (AREA)
- Analytical Chemistry (AREA)
- Dermatology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462088429P | 2014-12-05 | 2014-12-05 | |
| US62/088,429 | 2014-12-05 | ||
| US201562126370P | 2015-02-27 | 2015-02-27 | |
| US62/126,370 | 2015-02-27 | ||
| US201562220873P | 2015-09-18 | 2015-09-18 | |
| US62/220,873 | 2015-09-18 | ||
| PCT/US2015/063923 WO2016090215A2 (en) | 2014-12-05 | 2015-12-04 | Treatment of ocular conditions using progenitor cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2017123184A true RU2017123184A (ru) | 2019-01-10 |
| RU2017123184A3 RU2017123184A3 (enExample) | 2019-07-17 |
Family
ID=56092673
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2017123184A RU2017123184A (ru) | 2014-12-05 | 2015-12-04 | Лечение глазных патологий с применением клеток-предшественников |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20160158293A1 (enExample) |
| EP (1) | EP3258946A4 (enExample) |
| JP (1) | JP2017537702A (enExample) |
| KR (1) | KR20170093178A (enExample) |
| CN (1) | CN107206028A (enExample) |
| AU (1) | AU2015358330A1 (enExample) |
| BR (1) | BR112017011513A2 (enExample) |
| CA (1) | CA2969690A1 (enExample) |
| HK (1) | HK1250329A1 (enExample) |
| MX (1) | MX2017007207A (enExample) |
| PH (1) | PH12017500998A1 (enExample) |
| RU (1) | RU2017123184A (enExample) |
| SG (1) | SG11201704268TA (enExample) |
| TW (1) | TW201636032A (enExample) |
| WO (1) | WO2016090215A2 (enExample) |
| ZA (1) | ZA201704521B (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8790637B2 (en) | 2003-06-27 | 2014-07-29 | DePuy Synthes Products, LLC | Repair and regeneration of ocular tissue using postpartum-derived cells |
| WO2018102174A1 (en) * | 2016-12-01 | 2018-06-07 | Janssen Biotech, Inc. | Treatment of retinal degeneration using progenitor cells |
| GB201703058D0 (en) | 2017-02-24 | 2017-04-12 | Ucl Business Plc | Biomarkers |
| JP7348892B2 (ja) * | 2019-12-30 | 2023-09-21 | 佛教慈濟醫療財團法人 | 眼疾患を予防または治療する組成物及び方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8790637B2 (en) * | 2003-06-27 | 2014-07-29 | DePuy Synthes Products, LLC | Repair and regeneration of ocular tissue using postpartum-derived cells |
| CA2530421C (en) * | 2003-06-27 | 2015-04-21 | Ethicon, Incorporated | Repair and regeneration of ocular tissue using postpartum-derived cells |
| EP2752483B1 (en) * | 2009-05-13 | 2018-01-17 | Medipost, Co., Ltd. | TSP-1, TSP-2, IL-17BR and HB-EGF associated with stem cell activities and applications thereof |
| WO2013009100A2 (ko) * | 2011-07-11 | 2013-01-17 | (주)차바이오메드 | 탯줄 추출물의 제조방법 및 그의 용도 |
| US20130251670A1 (en) * | 2011-09-13 | 2013-09-26 | Aidan Products, Inc | Treatment of Macular Edema Utilizing Stem Cell and Conditioned Media Thereof |
-
2015
- 2015-12-04 RU RU2017123184A patent/RU2017123184A/ru not_active Application Discontinuation
- 2015-12-04 MX MX2017007207A patent/MX2017007207A/es unknown
- 2015-12-04 JP JP2017529751A patent/JP2017537702A/ja active Pending
- 2015-12-04 HK HK18108224.1A patent/HK1250329A1/zh unknown
- 2015-12-04 TW TW104140661A patent/TW201636032A/zh unknown
- 2015-12-04 EP EP15865014.3A patent/EP3258946A4/en not_active Withdrawn
- 2015-12-04 KR KR1020177018057A patent/KR20170093178A/ko not_active Withdrawn
- 2015-12-04 US US14/960,055 patent/US20160158293A1/en not_active Abandoned
- 2015-12-04 BR BR112017011513A patent/BR112017011513A2/pt not_active Application Discontinuation
- 2015-12-04 CN CN201580075547.0A patent/CN107206028A/zh active Pending
- 2015-12-04 SG SG11201704268TA patent/SG11201704268TA/en unknown
- 2015-12-04 WO PCT/US2015/063923 patent/WO2016090215A2/en not_active Ceased
- 2015-12-04 CA CA2969690A patent/CA2969690A1/en not_active Abandoned
- 2015-12-04 AU AU2015358330A patent/AU2015358330A1/en not_active Abandoned
-
2017
- 2017-05-30 PH PH12017500998A patent/PH12017500998A1/en unknown
- 2017-07-04 ZA ZA2017/04521A patent/ZA201704521B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2017537702A (ja) | 2017-12-21 |
| US20160158293A1 (en) | 2016-06-09 |
| WO2016090215A2 (en) | 2016-06-09 |
| SG11201704268TA (en) | 2017-06-29 |
| ZA201704521B (en) | 2019-01-30 |
| CA2969690A1 (en) | 2016-06-09 |
| EP3258946A4 (en) | 2018-08-01 |
| PH12017500998A1 (en) | 2017-12-18 |
| KR20170093178A (ko) | 2017-08-14 |
| MX2017007207A (es) | 2018-01-30 |
| AU2015358330A1 (en) | 2017-06-08 |
| HK1250329A1 (zh) | 2018-12-14 |
| TW201636032A (zh) | 2016-10-16 |
| BR112017011513A2 (pt) | 2018-07-10 |
| EP3258946A2 (en) | 2017-12-27 |
| CN107206028A (zh) | 2017-09-26 |
| RU2017123184A3 (enExample) | 2019-07-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20191021 |