RU2015144385A - Ациклические цианоэтилпиразолопиридоны в качестве ингибиторов янус-киназы - Google Patents
Ациклические цианоэтилпиразолопиридоны в качестве ингибиторов янус-киназы Download PDFInfo
- Publication number
- RU2015144385A RU2015144385A RU2015144385A RU2015144385A RU2015144385A RU 2015144385 A RU2015144385 A RU 2015144385A RU 2015144385 A RU2015144385 A RU 2015144385A RU 2015144385 A RU2015144385 A RU 2015144385A RU 2015144385 A RU2015144385 A RU 2015144385A
- Authority
- RU
- Russia
- Prior art keywords
- dihydro
- oxo
- pyridin
- pyrazolo
- amino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Transplantation (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Epidemiology (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361803241P | 2013-03-19 | 2013-03-19 | |
| US61/803,241 | 2013-03-19 | ||
| PCT/CN2014/000299 WO2014146493A1 (en) | 2013-03-19 | 2014-03-19 | Acyclic cyanoethylpyrazolo pyridones as janus kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2015144385A true RU2015144385A (ru) | 2017-04-26 |
Family
ID=51579322
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015144385A RU2015144385A (ru) | 2013-03-19 | 2014-03-19 | Ациклические цианоэтилпиразолопиридоны в качестве ингибиторов янус-киназы |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US10059705B2 (enExample) |
| EP (1) | EP2976341B1 (enExample) |
| JP (1) | JP6305510B2 (enExample) |
| KR (1) | KR20150132170A (enExample) |
| CN (1) | CN105121444B (enExample) |
| AU (1) | AU2014234909B2 (enExample) |
| BR (1) | BR112015024050A2 (enExample) |
| CA (1) | CA2901770A1 (enExample) |
| MX (1) | MX2015013419A (enExample) |
| RU (1) | RU2015144385A (enExample) |
| WO (1) | WO2014146493A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014146246A1 (en) * | 2013-03-19 | 2014-09-25 | Merck Sharp & Dohme Corp. | Cycloalkyl nitrile pyrazolo pyridones as janus kinase inhibitors |
| WO2016061751A1 (en) * | 2014-10-22 | 2016-04-28 | Merck Sharp & Dohme Corp. | Ethyl n-boc piperidinyl pyrazolo pyridones as janus kinase inhibitors |
| CN105327207A (zh) * | 2015-12-07 | 2016-02-17 | 雷文金 | 一种治疗风湿热痹的中药组合物 |
| CN105435170A (zh) * | 2015-12-11 | 2016-03-30 | 张量才 | 一种食药同源的中药保健食品 |
| SG11201912770SA (en) | 2017-06-23 | 2020-01-30 | Kyowa Kirin Co Ltd | a, ß-UNSATURATED AMIDE COMPOUND |
| US11098216B2 (en) | 2017-09-28 | 2021-08-24 | Ricoh Company, Ltd. | Image forming method, image forming apparatus, and method for manufacturing printed matter |
| EP3650447A1 (en) * | 2018-11-08 | 2020-05-13 | Universite de Nantes | New selective modulators of insect nicotinic acetylcholine receptors |
| CN111499592B (zh) * | 2020-03-14 | 2023-06-23 | 江苏省农用激素工程技术研究中心有限公司 | 5-氨甲基糖精的合成方法 |
| WO2021241875A1 (ko) * | 2020-05-29 | 2021-12-02 | 재단법인 대구경북첨단의료산업진흥재단 | 설폰아미드 유도체 및 이를 유효성분으로 함유하는 정신질환의 예방 또는 치료용 약학적 조성물 |
| CN112694497A (zh) * | 2020-12-25 | 2021-04-23 | 蚌埠中实化学技术有限公司 | 一种4-异丙基磺酰基苯硼酸的制备方法 |
| EP4540230A4 (en) * | 2022-06-16 | 2026-06-24 | Ensem Therapeutics Inc | ANILINO-PYRAZOLE DERIVATIVES, COMPOSITIONS AND ASSOCIATED PROCESSES |
| CN118373771A (zh) * | 2023-01-20 | 2024-07-23 | 江苏柯菲平医药股份有限公司 | 一种喹啉衍生化合物或其可药用的盐及其制备方法和应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100105661A1 (en) | 2007-01-12 | 2010-04-29 | Astellas Pharma Inc. | Condensed pyridine compound |
| JP5690823B2 (ja) * | 2009-07-08 | 2015-03-25 | レオ ファーマ アクティーゼルスカブ | Ｊａｋ受容体およびタンパク質チロシンキナーゼ阻害薬としての複素環化合物 |
| MX2012002641A (es) * | 2009-09-10 | 2012-03-14 | Hoffmann La Roche | Inhibidores de cinasa janus (jak). |
| CA2792508C (en) | 2010-03-10 | 2018-01-16 | Incyte Corporation | Piperidin-4-yl azetidine derivatives as jak1 inhibitors |
| AU2012232658B2 (en) * | 2011-03-22 | 2016-06-09 | Advinus Therapeutics Limited | Substituted fused tricyclic compounds, compositions and medicinal applications thereof |
| WO2013017479A1 (en) * | 2011-07-29 | 2013-02-07 | Cellzome Limited | Pyrazolo[4,3-c]pyridine derivatives as jak inhibitors |
| WO2013017480A1 (en) * | 2011-07-29 | 2013-02-07 | Cellzome Limited | Pyrazolo[4,3-c]pyridine derivatives as jak inhibitors |
| CA2874987A1 (en) * | 2012-06-01 | 2013-12-05 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
-
2014
- 2014-03-19 MX MX2015013419A patent/MX2015013419A/es unknown
- 2014-03-19 EP EP14770056.1A patent/EP2976341B1/en active Active
- 2014-03-19 KR KR1020157025520A patent/KR20150132170A/ko not_active Withdrawn
- 2014-03-19 BR BR112015024050A patent/BR112015024050A2/pt not_active Application Discontinuation
- 2014-03-19 WO PCT/CN2014/000299 patent/WO2014146493A1/en not_active Ceased
- 2014-03-19 CN CN201480016814.2A patent/CN105121444B/zh not_active Expired - Fee Related
- 2014-03-19 RU RU2015144385A patent/RU2015144385A/ru not_active Application Discontinuation
- 2014-03-19 US US14/778,055 patent/US10059705B2/en active Active
- 2014-03-19 CA CA2901770A patent/CA2901770A1/en not_active Abandoned
- 2014-03-19 AU AU2014234909A patent/AU2014234909B2/en not_active Ceased
- 2014-03-19 JP JP2016503523A patent/JP6305510B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP2976341A4 (en) | 2016-10-12 |
| US10059705B2 (en) | 2018-08-28 |
| AU2014234909B2 (en) | 2017-10-05 |
| CN105121444A (zh) | 2015-12-02 |
| BR112015024050A2 (pt) | 2017-07-18 |
| KR20150132170A (ko) | 2015-11-25 |
| CA2901770A1 (en) | 2014-09-25 |
| EP2976341A1 (en) | 2016-01-27 |
| MX2015013419A (es) | 2016-07-19 |
| JP6305510B2 (ja) | 2018-04-04 |
| AU2014234909A1 (en) | 2015-08-13 |
| WO2014146493A1 (en) | 2014-09-25 |
| US20160272634A1 (en) | 2016-09-22 |
| JP2016514711A (ja) | 2016-05-23 |
| EP2976341B1 (en) | 2018-02-28 |
| CN105121444B (zh) | 2018-02-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2016514711A5 (enExample) | ||
| TWI579284B (zh) | 咪唑并吡咯啶酮化合物 | |
| JP6542212B2 (ja) | ブロモドメイン阻害剤としての新規キナゾリノン | |
| RU2454405C2 (ru) | Производные 3-пиридинкарбоксамида и 2-пиразинкарбоксамида в качестве агентов, повышающих уровень лвп-холестерина | |
| HRP20191821T1 (hr) | Antiproliferativni spojevi i načini njihove uporabe | |
| JP2017525757A5 (enExample) | ||
| RU2015144386A (ru) | Циклоалкилнитрилпиразолопиридоны в качестве ингибиторов янус-киназы | |
| JP2022542396A5 (enExample) | ||
| HRP20212000T1 (hr) | Aminotriazolopiridini kao inhibitori kinaze | |
| RU2017121044A (ru) | Производные амидотиадиазола в качестве ингибиторов надфн-оксидазы | |
| JP2021503458A5 (enExample) | ||
| JP2013544893A5 (enExample) | ||
| JP2011504497A5 (enExample) | ||
| ME00427B (me) | N-supstituisani hidroksipiramidinon karboksamidni inhibitori hiv integraze | |
| JP2016507496A (ja) | ブロモドメイン阻害剤としての新規複素環式化合物 | |
| JP2005536475A5 (enExample) | ||
| RU2016115868A (ru) | Замещенные гетероциклические сульфонамидные соединения, полезные в качестве модуляторов trpa 1 | |
| RU2009148673A (ru) | Производные пиразинона и их применение для лечения легочных заболеваний | |
| JP2018530571A5 (enExample) | ||
| RU2008145225A (ru) | Соединения индазола и способы ингибирования cd7 | |
| RU2010110640A (ru) | Соединения и композиции 5-(4-(галогеналкокси)фенил)пиримидин-2-амина в качестве ингибиторов киназ | |
| RU2013154117A (ru) | Производные 1-фенил-2-пиридинилалкильных спиртов в качестве ингибиторов фосфодиэстеразы | |
| JP2010510319A5 (enExample) | ||
| RU2014119254A (ru) | Средства, вызывающие апоптоз, для лечения злокачественных новообразований и иммунных и аутоиммунных заболеваний | |
| JP2016523976A5 (enExample) |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA94 | Acknowledgement of application withdrawn (non-payment of fees) |
Effective date: 20191001 |