CN105121444B - 作为janus激酶抑制剂的非环形的氰基乙基吡唑并吡啶酮 - Google Patents

作为janus激酶抑制剂的非环形的氰基乙基吡唑并吡啶酮 Download PDF

Info

Publication number
CN105121444B
CN105121444B CN201480016814.2A CN201480016814A CN105121444B CN 105121444 B CN105121444 B CN 105121444B CN 201480016814 A CN201480016814 A CN 201480016814A CN 105121444 B CN105121444 B CN 105121444B
Authority
CN
China
Prior art keywords
oxo
dihydro
amino
pyrazolo
pyridin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201480016814.2A
Other languages
English (en)
Chinese (zh)
Other versions
CN105121444A (zh
Inventor
C.丁斯摩尔
P.富勒
D.盖林
J.D.卡茨
C.F.汤普森
D.法尔孔
W.邓
L.托雷斯
H.曾
Y.白
J.付
N.孔
Y.刘
Z.郑
M.E.斯科特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of CN105121444A publication Critical patent/CN105121444A/zh
Application granted granted Critical
Publication of CN105121444B publication Critical patent/CN105121444B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epidemiology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN201480016814.2A 2013-03-19 2014-03-19 作为janus激酶抑制剂的非环形的氰基乙基吡唑并吡啶酮 Expired - Fee Related CN105121444B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361803241P 2013-03-19 2013-03-19
US61/803241 2013-03-19
PCT/CN2014/000299 WO2014146493A1 (en) 2013-03-19 2014-03-19 Acyclic cyanoethylpyrazolo pyridones as janus kinase inhibitors

Publications (2)

Publication Number Publication Date
CN105121444A CN105121444A (zh) 2015-12-02
CN105121444B true CN105121444B (zh) 2018-02-16

Family

ID=51579322

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201480016814.2A Expired - Fee Related CN105121444B (zh) 2013-03-19 2014-03-19 作为janus激酶抑制剂的非环形的氰基乙基吡唑并吡啶酮

Country Status (11)

Country Link
US (1) US10059705B2 (enExample)
EP (1) EP2976341B1 (enExample)
JP (1) JP6305510B2 (enExample)
KR (1) KR20150132170A (enExample)
CN (1) CN105121444B (enExample)
AU (1) AU2014234909B2 (enExample)
BR (1) BR112015024050A2 (enExample)
CA (1) CA2901770A1 (enExample)
MX (1) MX2015013419A (enExample)
RU (1) RU2015144385A (enExample)
WO (1) WO2014146493A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014146246A1 (en) * 2013-03-19 2014-09-25 Merck Sharp & Dohme Corp. Cycloalkyl nitrile pyrazolo pyridones as janus kinase inhibitors
WO2016061751A1 (en) * 2014-10-22 2016-04-28 Merck Sharp & Dohme Corp. Ethyl n-boc piperidinyl pyrazolo pyridones as janus kinase inhibitors
CN105327207A (zh) * 2015-12-07 2016-02-17 雷文金 一种治疗风湿热痹的中药组合物
CN105435170A (zh) * 2015-12-11 2016-03-30 张量才 一种食药同源的中药保健食品
SG11201912770SA (en) 2017-06-23 2020-01-30 Kyowa Kirin Co Ltd a, ß-UNSATURATED AMIDE COMPOUND
US11098216B2 (en) 2017-09-28 2021-08-24 Ricoh Company, Ltd. Image forming method, image forming apparatus, and method for manufacturing printed matter
EP3650447A1 (en) * 2018-11-08 2020-05-13 Universite de Nantes New selective modulators of insect nicotinic acetylcholine receptors
CN111499592B (zh) * 2020-03-14 2023-06-23 江苏省农用激素工程技术研究中心有限公司 5-氨甲基糖精的合成方法
US20230212121A1 (en) * 2020-05-29 2023-07-06 Daegu-Gyeongbuk Medical Innovation Foundation Sulfonamide derivative and pharmaceutical composition comprising same as active ingredient for preventing or treating mental illness
CN112694497A (zh) * 2020-12-25 2021-04-23 蚌埠中实化学技术有限公司 一种4-异丙基磺酰基苯硼酸的制备方法
CN119384413A (zh) * 2022-06-16 2025-01-28 昂胜医药有限公司 苯胺基-吡唑衍生物、其组合物和方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102574857A (zh) * 2009-07-08 2012-07-11 利奥制药有限公司 作为jak受体和蛋白酪氨酸激酶抑制剂的杂环化合物
WO2012127506A1 (en) * 2011-03-22 2012-09-27 Advinus Therapeutics Limited Substituted fused tricyclic compounds, compositions and medicinal applications thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2123651A4 (en) 2007-01-12 2011-05-04 Astellas Pharma Inc CONDENSED PYRIDINE COMPOUND
RU2538204C2 (ru) * 2009-09-10 2015-01-10 Ф.Хоффманн-Ля Рош Аг Ингибиторы jak
SMT201800137T1 (it) 2010-03-10 2018-07-17 Incyte Holdings Corp Derivati di piperidin-4-il azetidina come inibitori di jak1
WO2013017480A1 (en) 2011-07-29 2013-02-07 Cellzome Limited Pyrazolo[4,3-c]pyridine derivatives as jak inhibitors
WO2013017479A1 (en) * 2011-07-29 2013-02-07 Cellzome Limited Pyrazolo[4,3-c]pyridine derivatives as jak inhibitors
BR112014029705A2 (pt) 2012-06-01 2017-06-27 Takeda Pharmaceuticals Co composto ou sal, medicamento, métodos para inibir quinase de janus em um mamífero, e para a profilaxia ou tratamento de doenças autoimunes, e, uso de um composto ou sal

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102574857A (zh) * 2009-07-08 2012-07-11 利奥制药有限公司 作为jak受体和蛋白酪氨酸激酶抑制剂的杂环化合物
WO2012127506A1 (en) * 2011-03-22 2012-09-27 Advinus Therapeutics Limited Substituted fused tricyclic compounds, compositions and medicinal applications thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Synthesis and reactivity of 3-amino-1H-pyrazole[4,3-c]pyridine-4(5H)-ones:development of a novel kinase-focussed library;Lynette A. Smyth，等;《Tetrahedron》;20120213;第15卷(第66期);全文 *

Also Published As

Publication number Publication date
KR20150132170A (ko) 2015-11-25
MX2015013419A (es) 2016-07-19
AU2014234909B2 (en) 2017-10-05
JP6305510B2 (ja) 2018-04-04
US20160272634A1 (en) 2016-09-22
US10059705B2 (en) 2018-08-28
AU2014234909A1 (en) 2015-08-13
EP2976341A4 (en) 2016-10-12
BR112015024050A2 (pt) 2017-07-18
EP2976341A1 (en) 2016-01-27
EP2976341B1 (en) 2018-02-28
JP2016514711A (ja) 2016-05-23
WO2014146493A1 (en) 2014-09-25
RU2015144385A (ru) 2017-04-26
CN105121444A (zh) 2015-12-02
CA2901770A1 (en) 2014-09-25

Similar Documents

Publication Publication Date Title
CN105121444B (zh) 作为janus激酶抑制剂的非环形的氰基乙基吡唑并吡啶酮
US11168079B2 (en) Alkene compounds as farnesoid x receptor modulators
US11078198B2 (en) Spirocyclic compounds as farnesoid X receptor modulators
JP2014530203A (ja) ヤヌスキナーゼ阻害剤としてのシアノメチルピラゾールカルボキサミド
US11286252B2 (en) Alkene spirocyclic compounds as farnesoid X receptor modulators
RU2669922C2 (ru) N-(2-цианогетероциклил)пиразолопиридоны в качестве ингибиторов янус-киназы
US20210380578A1 (en) Multicyclic compounds as farnesoid x receptor modulators
JP2016514709A (ja) ヤヌスキナーゼ阻害剤としてのジェミナル置換シアノエチルピラゾロピリドン
CN105189508A (zh) 作为janus激酶抑制剂的环烷基腈吡唑并吡啶酮

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20180216

Termination date: 20190319