RU2015144360A - Модификация и новые композиции на основе секретоглобинов человека - Google Patents
Модификация и новые композиции на основе секретоглобинов человека Download PDFInfo
- Publication number
- RU2015144360A RU2015144360A RU2015144360A RU2015144360A RU2015144360A RU 2015144360 A RU2015144360 A RU 2015144360A RU 2015144360 A RU2015144360 A RU 2015144360A RU 2015144360 A RU2015144360 A RU 2015144360A RU 2015144360 A RU2015144360 A RU 2015144360A
- Authority
- RU
- Russia
- Prior art keywords
- chemically
- composition
- enzymatically oxidized
- oxidized synthetic
- lys
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims 10
- 230000004048 modification Effects 0.000 title claims 2
- 238000012986 modification Methods 0.000 title claims 2
- 102000018146 globin Human genes 0.000 title 1
- 108060003196 globin Proteins 0.000 title 1
- 102100031083 Uteroglobin Human genes 0.000 claims 9
- 108090000203 Uteroglobin Proteins 0.000 claims 9
- 235000001014 amino acid Nutrition 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 3
- OYIFNHCXNCRBQI-UHFFFAOYSA-N 2-aminoadipic acid Chemical compound OC(=O)C(N)CCCC(O)=O OYIFNHCXNCRBQI-UHFFFAOYSA-N 0.000 claims 2
- QDHHCQZDFGDHMP-UHFFFAOYSA-N Chloramine Chemical class ClN QDHHCQZDFGDHMP-UHFFFAOYSA-N 0.000 claims 2
- 235000018417 cysteine Nutrition 0.000 claims 2
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 2
- HKDIYFPRGVYHOI-QMMMGPOBSA-N (2s)-2-(chloroamino)-3-(4-hydroxyphenyl)propanoic acid Chemical class OC(=O)[C@@H](NCl)CC1=CC=C(O)C=C1 HKDIYFPRGVYHOI-QMMMGPOBSA-N 0.000 claims 1
- GIANIJCPTPUNBA-QMMMGPOBSA-N (2s)-3-(4-hydroxyphenyl)-2-nitramidopropanoic acid Chemical class [O-][N+](=O)N[C@H](C(=O)O)CC1=CC=C(O)C=C1 GIANIJCPTPUNBA-QMMMGPOBSA-N 0.000 claims 1
- SAUCHDKDCUROAO-UHFFFAOYSA-N 2-amino-3-oxobutanoic acid Chemical class CC(=O)C(N)C(O)=O SAUCHDKDCUROAO-UHFFFAOYSA-N 0.000 claims 1
- -1 HNE cysteines Chemical class 0.000 claims 1
- PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 claims 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 1
- OQVOZFPJUCUPLW-LURJTMIESA-N N-(1-Carboxymethyl)-L-lysine Chemical class NCCCC[C@@H](C(O)=O)NCC(O)=O OQVOZFPJUCUPLW-LURJTMIESA-N 0.000 claims 1
- VTPJSQTVPKSYCB-QMMMGPOBSA-N N-hydroxy-L-phenylalanine Chemical class ON[C@H](C(O)=O)CC1=CC=CC=C1 VTPJSQTVPKSYCB-QMMMGPOBSA-N 0.000 claims 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 claims 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 1
- 229960002591 hydroxyproline Drugs 0.000 claims 1
- 239000000543 intermediate Substances 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
- 150000002913 oxalic acids Chemical class 0.000 claims 1
- 238000005502 peroxidation Methods 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 claims 1
- 150000004717 pyruvic acids Chemical class 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 150000003462 sulfoxides Chemical class 0.000 claims 1
- FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 claims 1
- 239000004474 valine Substances 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Marine Sciences & Fisheries (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/843,773 US9394349B2 (en) | 2013-03-15 | 2013-03-15 | Modification and compositions of human secretoglobin proteins |
| US13/843,773 | 2013-03-15 | ||
| PCT/US2014/030117 WO2014145368A2 (en) | 2013-03-15 | 2014-03-17 | Modification and novel compositions of human secretoglobin proteins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2015144360A true RU2015144360A (ru) | 2017-04-24 |
Family
ID=51530119
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015144360A RU2015144360A (ru) | 2013-03-15 | 2014-03-17 | Модификация и новые композиции на основе секретоглобинов человека |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US9394349B2 (enExample) |
| EP (2) | EP2968449A4 (enExample) |
| JP (2) | JP6670987B2 (enExample) |
| KR (1) | KR20160030076A (enExample) |
| CN (1) | CN105744946A (enExample) |
| AU (1) | AU2014233127A1 (enExample) |
| BR (1) | BR112015021266A2 (enExample) |
| CA (1) | CA2907439A1 (enExample) |
| IL (1) | IL241417A0 (enExample) |
| MX (1) | MX2015013092A (enExample) |
| RU (1) | RU2015144360A (enExample) |
| SG (1) | SG11201507277YA (enExample) |
| WO (1) | WO2014145368A2 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9394349B2 (en) * | 2013-03-15 | 2016-07-19 | Therabron Therapeutics, Inc. | Modification and compositions of human secretoglobin proteins |
| US12162914B2 (en) | 2013-03-15 | 2024-12-10 | Apc Research Assets Llc | Modification and compositions of human secretoglobin proteins |
| US20180112200A1 (en) * | 2014-12-22 | 2018-04-26 | The Regents Of The University Of California | Compositions and methods for generating antigens, antibodies, and immunotherapeutic compositions and methods |
| JP6827113B2 (ja) | 2017-01-21 | 2021-02-10 | 広州白雲山漢方現代薬業有限公司Ｇｕａｎｇｚｈｏｕ Ｈａｎｆａｎｇ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｃｏ．，Ｌｔｄ． | シェーグレン症候群の治療におけるペオニフロリン−６’−ｏ−ベンゼンスルホン酸の使用 |
| JP2022509856A (ja) * | 2018-11-30 | 2022-01-24 | エーピーシー リサーチ アセッツ，エルエルシー | ヘパラン硫酸プロテオグリカンタンパク質との相互作用を介してグリコカリックスを保護するためのセクレトグロビンの組成物及び使用方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE1006919A3 (nl) * | 1993-03-15 | 1995-01-24 | Ley Marc Jozef Philemon De | Farmaceutisch preparaat op basis van clara celeiwit cc10, en het gebruik daarvan als geneesmiddel en diagnosticum. |
| US20060281681A1 (en) | 1997-05-28 | 2006-12-14 | Pilon Aprile L | Methods and compositions for the reduction of neutrophil influx and for the treatment of bronchpulmonary dysplasia, respiratory distress syndrome, chronic lung disease, pulmonary fibrosis, asthma and chronic obstructive pulmonary disease |
| US20030008816A1 (en) | 1997-05-28 | 2003-01-09 | Pilon Aprile L. | Methods and compositions for the treatment of fibrotic conditions & impaired lung function & to enhance lymphocyte production |
| US20040047857A1 (en) * | 1997-05-28 | 2004-03-11 | Pilon Aprile L. | Methods and compositions for the treatment of fibrotic conditions & impaired lung function & to enhance lymphocyte production |
| AU5551299A (en) | 1998-08-13 | 2000-03-06 | Trustees Of The University Of Pennsylvania, The | Method of identifying proteins |
| US6953666B1 (en) | 1998-11-06 | 2005-10-11 | Emory University | Biomarkers for oxidative stress |
| WO2004101824A1 (ja) | 2003-05-14 | 2004-11-25 | Shionogi & Co., Ltd. | 慢性閉塞性肺疾患の検出方法 |
| AU2004254600A1 (en) | 2003-06-26 | 2005-01-13 | Lifesensors, Inc. | Methods and compositions for enhanced protein expression and purification |
| CN1580261A (zh) * | 2003-08-06 | 2005-02-16 | 上海富纯中南生物技术有限公司 | Cc10蛋白的制备及应用 |
| US7318936B2 (en) | 2003-11-14 | 2008-01-15 | Alza Corporation | Minimization of drug oxidation in drug irradiated excipients formulations |
| US20060275794A1 (en) | 2005-03-07 | 2006-12-07 | Invitrogen Corporation | Collections of matched biological reagents and methods for identifying matched reagents |
| WO2008039941A2 (en) | 2006-09-27 | 2008-04-03 | The Government Of The Usa As Represented By The Secretary Of The Dpt. Of Health And Human Services | Scgb3a2 as a growth factor and anti-apoptotic agent |
| US20090004684A1 (en) | 2007-05-23 | 2009-01-01 | Claudia Susanne Maier | Compositions and Methods for Detection and Quantification of Protein Oxidation |
| EP2488205B1 (en) * | 2009-10-15 | 2016-09-21 | Clarassance, Inc. | Recombinant human cc10 protein for treatment of influenza |
| US9394349B2 (en) * | 2013-03-15 | 2016-07-19 | Therabron Therapeutics, Inc. | Modification and compositions of human secretoglobin proteins |
-
2013
- 2013-03-15 US US13/843,773 patent/US9394349B2/en active Active
-
2014
- 2014-03-17 RU RU2015144360A patent/RU2015144360A/ru unknown
- 2014-03-17 MX MX2015013092A patent/MX2015013092A/es unknown
- 2014-03-17 EP EP14765106.1A patent/EP2968449A4/en not_active Withdrawn
- 2014-03-17 CN CN201480015618.3A patent/CN105744946A/zh active Pending
- 2014-03-17 BR BR112015021266A patent/BR112015021266A2/pt not_active IP Right Cessation
- 2014-03-17 CA CA2907439A patent/CA2907439A1/en not_active Abandoned
- 2014-03-17 EP EP18167516.6A patent/EP3403666A1/en active Pending
- 2014-03-17 AU AU2014233127A patent/AU2014233127A1/en not_active Abandoned
- 2014-03-17 WO PCT/US2014/030117 patent/WO2014145368A2/en not_active Ceased
- 2014-03-17 KR KR1020157029582A patent/KR20160030076A/ko not_active Ceased
- 2014-03-17 SG SG11201507277YA patent/SG11201507277YA/en unknown
- 2014-03-17 JP JP2016503333A patent/JP6670987B2/ja active Active
-
2015
- 2015-09-09 IL IL241417A patent/IL241417A0/en unknown
-
2016
- 2016-07-17 US US15/212,277 patent/US10294285B2/en active Active
-
2019
- 2019-05-20 US US16/416,268 patent/US10676513B2/en active Active
- 2019-12-02 JP JP2019218277A patent/JP2020055833A/ja active Pending
-
2020
- 2020-06-09 US US16/896,213 patent/US20200325190A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| IL241417A0 (en) | 2015-11-30 |
| US20160362462A1 (en) | 2016-12-15 |
| EP2968449A4 (en) | 2017-03-22 |
| CA2907439A1 (en) | 2014-09-18 |
| US20200325190A1 (en) | 2020-10-15 |
| KR20160030076A (ko) | 2016-03-16 |
| EP3403666A1 (en) | 2018-11-21 |
| BR112015021266A2 (pt) | 2017-10-10 |
| US9394349B2 (en) | 2016-07-19 |
| US10676513B2 (en) | 2020-06-09 |
| JP2020055833A (ja) | 2020-04-09 |
| US20190337999A1 (en) | 2019-11-07 |
| US20140275477A1 (en) | 2014-09-18 |
| WO2014145368A3 (en) | 2014-11-27 |
| CN105744946A (zh) | 2016-07-06 |
| JP2016515532A (ja) | 2016-05-30 |
| WO2014145368A2 (en) | 2014-09-18 |
| SG11201507277YA (en) | 2015-10-29 |
| EP2968449A2 (en) | 2016-01-20 |
| MX2015013092A (es) | 2016-06-02 |
| US10294285B2 (en) | 2019-05-21 |
| JP6670987B2 (ja) | 2020-03-25 |
| AU2014233127A1 (en) | 2015-09-24 |
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| HE9A | Changing address for correspondence with an applicant |