RU2015102067A - Активированная лейкоцитарная композиция - Google Patents
Активированная лейкоцитарная композиция Download PDFInfo
- Publication number
- RU2015102067A RU2015102067A RU2015102067/15A RU2015102067A RU2015102067A RU 2015102067 A RU2015102067 A RU 2015102067A RU 2015102067/15 A RU2015102067/15 A RU 2015102067/15A RU 2015102067 A RU2015102067 A RU 2015102067A RU 2015102067 A RU2015102067 A RU 2015102067A
- Authority
- RU
- Russia
- Prior art keywords
- cells
- wound
- composition according
- composition
- paragraphs
- Prior art date
Links
- 210000000265 leukocyte Anatomy 0.000 title claims abstract 13
- 208000027418 Wounds and injury Diseases 0.000 claims abstract 19
- 206010052428 Wound Diseases 0.000 claims abstract 18
- 210000003714 granulocyte Anatomy 0.000 claims abstract 8
- 208000025865 Ulcer Diseases 0.000 claims abstract 6
- 231100000397 ulcer Toxicity 0.000 claims abstract 6
- 101000581981 Homo sapiens Neural cell adhesion molecule 1 Proteins 0.000 claims abstract 4
- 102100027347 Neural cell adhesion molecule 1 Human genes 0.000 claims abstract 4
- 210000004027 cell Anatomy 0.000 claims abstract 4
- 239000003814 drug Substances 0.000 claims abstract 4
- 210000004698 lymphocyte Anatomy 0.000 claims abstract 4
- 230000002980 postoperative effect Effects 0.000 claims abstract 4
- 210000003752 saphenous vein Anatomy 0.000 claims abstract 4
- 206010002153 Anal fissure Diseases 0.000 claims abstract 2
- 208000016583 Anus disease Diseases 0.000 claims abstract 2
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims abstract 2
- 206010011985 Decubitus ulcer Diseases 0.000 claims abstract 2
- 208000009531 Fissure in Ano Diseases 0.000 claims abstract 2
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims abstract 2
- 101001046686 Homo sapiens Integrin alpha-M Proteins 0.000 claims abstract 2
- 102100022338 Integrin alpha-M Human genes 0.000 claims abstract 2
- 208000004210 Pressure Ulcer Diseases 0.000 claims abstract 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims abstract 2
- 208000000558 Varicose Ulcer Diseases 0.000 claims abstract 2
- 210000003719 b-lymphocyte Anatomy 0.000 claims abstract 2
- 210000003651 basophil Anatomy 0.000 claims abstract 2
- 239000003795 chemical substances by application Substances 0.000 claims abstract 2
- 206010012601 diabetes mellitus Diseases 0.000 claims abstract 2
- 210000003979 eosinophil Anatomy 0.000 claims abstract 2
- 210000002443 helper t lymphocyte Anatomy 0.000 claims abstract 2
- 208000014674 injury Diseases 0.000 claims abstract 2
- 210000003141 lower extremity Anatomy 0.000 claims abstract 2
- 238000004519 manufacturing process Methods 0.000 claims abstract 2
- 239000011159 matrix material Substances 0.000 claims abstract 2
- 210000001616 monocyte Anatomy 0.000 claims abstract 2
- 210000000822 natural killer cell Anatomy 0.000 claims abstract 2
- 210000000440 neutrophil Anatomy 0.000 claims abstract 2
- 210000001562 sternum Anatomy 0.000 claims abstract 2
- 230000029663 wound healing Effects 0.000 claims abstract 2
- 230000008733 trauma Effects 0.000 claims 1
- 230000006378 damage Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/19—Platelets; Megacaryocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/15—Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/16—Blood plasma; Blood serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/18—Erythrocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0057—Ingredients of undetermined constitution or reaction products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0642—Granulocytes, e.g. basopils, eosinophils, neutrophils, mast cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Developmental Biology & Embryology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Materials Engineering (AREA)
- Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Biochemistry (AREA)
- Dermatology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20929809P | 2009-03-05 | 2009-03-05 | |
| US61/209,298 | 2009-03-05 | ||
| US21158709P | 2009-04-01 | 2009-04-01 | |
| US61/211,587 | 2009-04-01 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2011139016/15A Division RU2548741C2 (ru) | 2009-03-05 | 2010-03-05 | Активированная лейкоцитарная композиция |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2015102067A true RU2015102067A (ru) | 2015-06-20 |
Family
ID=42710060
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015102067/15A RU2015102067A (ru) | 2009-03-05 | 2010-03-05 | Активированная лейкоцитарная композиция |
| RU2011139016/15A RU2548741C2 (ru) | 2009-03-05 | 2010-03-05 | Активированная лейкоцитарная композиция |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2011139016/15A RU2548741C2 (ru) | 2009-03-05 | 2010-03-05 | Активированная лейкоцитарная композиция |
Country Status (15)
| Country | Link |
|---|---|
| EP (2) | EP2403509B1 (https=) |
| JP (2) | JP5713924B2 (https=) |
| KR (1) | KR101548783B1 (https=) |
| CN (1) | CN102438635B (https=) |
| AU (1) | AU2010220132B2 (https=) |
| BR (1) | BRPI1006759A2 (https=) |
| CA (2) | CA2867976A1 (https=) |
| DK (1) | DK2403509T3 (https=) |
| ES (1) | ES2428102T3 (https=) |
| IL (1) | IL214953A0 (https=) |
| MX (1) | MX2011009277A (https=) |
| PL (1) | PL2403509T3 (https=) |
| RU (2) | RU2015102067A (https=) |
| WO (1) | WO2010100570A2 (https=) |
| ZA (1) | ZA201107269B (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8574902B2 (en) | 2009-03-05 | 2013-11-05 | Macrocure Ltd. | Activated leukocyte composition and uses for wound healing |
| JP2013537889A (ja) | 2010-09-09 | 2013-10-07 | マクロキュア，リミテッド | 活性化白血球馴化上清および創傷治癒のための使用 |
| EP2825182A1 (en) | 2012-03-15 | 2015-01-21 | Macrocure, Ltd. | Activated immunostimulatory cell composition for therapy of infection |
| US20150030635A1 (en) | 2012-03-15 | 2015-01-29 | Macrocure, Ltd. | Activated Immunostimulatory Cell Composition and Uses Thereof |
| EP2781224A1 (en) | 2013-03-18 | 2014-09-24 | Khorionyx | Implantable preparations comrpsing globin insoluble at physiological pH and serum for regeneration of tissues and treatment of wounds. |
| EP3258945B1 (en) | 2015-02-16 | 2020-10-07 | Nayacure Therapeutics Ltd. | Modified blood clots |
| GB201618106D0 (en) | 2016-10-26 | 2016-12-07 | Lift Biosciences Ltd | Cancer-killing cells |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60120821A (ja) * | 1983-12-05 | 1985-06-28 | Asahi Chem Ind Co Ltd | 悪性腫瘍治療用白血球刺激材および刺激方法 |
| US4751001A (en) * | 1984-09-24 | 1988-06-14 | Becton Dickinson And Company | Blood partitioning apparatus |
| JPH02167071A (ja) * | 1988-12-19 | 1990-06-27 | Terumo Corp | 非ヒト動物由来白血球系細胞の分離材、分離器および分離方法 |
| JPH07102151B2 (ja) * | 1994-06-03 | 1995-11-08 | 中外製薬株式会社 | 新規なポリペプチドの製造法 |
| US6146890A (en) | 1994-07-03 | 2000-11-14 | Danon; David | Method and system for cultivating macrophages |
| IL110195A (en) * | 1994-07-03 | 2003-10-31 | David Danon | Method and system for cultivating macrophages |
| JP3201610B2 (ja) * | 1995-03-17 | 2001-08-27 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 腫瘍を処置する方法 |
| JPH10259134A (ja) * | 1997-01-16 | 1998-09-29 | Sekisui Chem Co Ltd | 創傷治癒促進剤 |
| RU2143685C1 (ru) * | 1998-05-19 | 1999-12-27 | Коган Александр Харитонович | Способ дифференциального подсчета гранулоцитов, моноцитов и лимфоцитов |
| CN1335757A (zh) * | 1998-11-12 | 2002-02-13 | 聚合体生物科学公司 | 可用于快速凝血和止血的止血聚合物 |
| MXPA04004813A (es) * | 2001-11-21 | 2004-08-11 | Yeda Res & Dev | Procedimientos para la produccion de leucocitos fagociticos mononucleares humanos. |
| JP4108393B2 (ja) * | 2002-07-15 | 2008-06-25 | テルモ株式会社 | 細胞増殖剤の製造方法 |
| JP4245324B2 (ja) * | 2002-10-09 | 2009-03-25 | 旭化成クラレメディカル株式会社 | 単球の分離回収方法 |
| EP2198873A1 (en) * | 2008-12-18 | 2010-06-23 | Aposcience AG | Pharmaceutical preparation comprising supernatant of blood mononuclear cell culture |
| EP2201954A1 (en) * | 2008-12-18 | 2010-06-30 | Aposcience AG | Pharmaceutical preparation |
-
2010
- 2010-03-05 RU RU2015102067/15A patent/RU2015102067A/ru not_active Application Discontinuation
- 2010-03-05 PL PL10723285T patent/PL2403509T3/pl unknown
- 2010-03-05 AU AU2010220132A patent/AU2010220132B2/en not_active Ceased
- 2010-03-05 EP EP10723285.2A patent/EP2403509B1/en not_active Not-in-force
- 2010-03-05 BR BRPI1006759A patent/BRPI1006759A2/pt not_active IP Right Cessation
- 2010-03-05 CA CA2867976A patent/CA2867976A1/en not_active Abandoned
- 2010-03-05 CN CN201080020134.XA patent/CN102438635B/zh not_active Expired - Fee Related
- 2010-03-05 WO PCT/IB2010/000882 patent/WO2010100570A2/en not_active Ceased
- 2010-03-05 ES ES10723285T patent/ES2428102T3/es active Active
- 2010-03-05 CA CA2754190A patent/CA2754190A1/en not_active Abandoned
- 2010-03-05 JP JP2011552537A patent/JP5713924B2/ja not_active Expired - Fee Related
- 2010-03-05 MX MX2011009277A patent/MX2011009277A/es active IP Right Grant
- 2010-03-05 KR KR1020117023251A patent/KR101548783B1/ko not_active Expired - Fee Related
- 2010-03-05 RU RU2011139016/15A patent/RU2548741C2/ru not_active IP Right Cessation
- 2010-03-05 DK DK10723285.2T patent/DK2403509T3/da active
- 2010-03-05 EP EP13176068.8A patent/EP2650001B1/en not_active Not-in-force
-
2011
- 2011-09-04 IL IL214953A patent/IL214953A0/en unknown
- 2011-10-05 ZA ZA2011/07269A patent/ZA201107269B/en unknown
-
2015
- 2015-03-10 JP JP2015046833A patent/JP2015129180A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP2650001B1 (en) | 2016-09-07 |
| KR101548783B1 (ko) | 2015-08-31 |
| RU2548741C2 (ru) | 2015-04-20 |
| EP2403509B1 (en) | 2013-08-21 |
| ZA201107269B (en) | 2014-03-26 |
| DK2403509T3 (da) | 2013-09-16 |
| WO2010100570A3 (en) | 2010-12-16 |
| JP5713924B2 (ja) | 2015-05-07 |
| EP2403509A2 (en) | 2012-01-11 |
| ES2428102T3 (es) | 2013-11-05 |
| CA2867976A1 (en) | 2010-09-10 |
| CN102438635A (zh) | 2012-05-02 |
| CA2754190A1 (en) | 2010-09-10 |
| AU2010220132A1 (en) | 2011-10-13 |
| RU2011139016A (ru) | 2013-04-10 |
| CN102438635B (zh) | 2014-09-17 |
| JP2015129180A (ja) | 2015-07-16 |
| MX2011009277A (es) | 2011-12-16 |
| BRPI1006759A2 (pt) | 2016-03-15 |
| KR20120002530A (ko) | 2012-01-05 |
| WO2010100570A2 (en) | 2010-09-10 |
| PL2403509T3 (pl) | 2013-11-29 |
| AU2010220132B2 (en) | 2013-10-10 |
| IL214953A0 (en) | 2011-11-30 |
| JP2012519681A (ja) | 2012-08-30 |
| EP2650001A1 (en) | 2013-10-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA93 | Acknowledgement of application withdrawn (no request for examination) |
Effective date: 20180129 |