RU2014143008A - Способ лечения остановки родов - Google Patents
Способ лечения остановки родов Download PDFInfo
- Publication number
- RU2014143008A RU2014143008A RU2014143008A RU2014143008A RU2014143008A RU 2014143008 A RU2014143008 A RU 2014143008A RU 2014143008 A RU2014143008 A RU 2014143008A RU 2014143008 A RU2014143008 A RU 2014143008A RU 2014143008 A RU2014143008 A RU 2014143008A
- Authority
- RU
- Russia
- Prior art keywords
- heparan sulfate
- chemically modified
- modified heparin
- use according
- heparin
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 4
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical class OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims abstract 42
- 229920002971 Heparan sulfate Polymers 0.000 claims abstract 38
- 230000000694 effects Effects 0.000 claims abstract 16
- 208000037805 labour Diseases 0.000 claims abstract 14
- 150000004676 glycans Polymers 0.000 claims abstract 10
- 150000004804 polysaccharides Polymers 0.000 claims abstract 9
- 239000003795 chemical substances by application Substances 0.000 claims abstract 8
- 210000000754 myometrium Anatomy 0.000 claims abstract 7
- 230000003213 activating effect Effects 0.000 claims abstract 5
- 230000008602 contraction Effects 0.000 claims abstract 5
- 108010029144 Factor IIa Proteins 0.000 claims abstract 4
- 108010074860 Factor Xa Proteins 0.000 claims abstract 4
- 230000001858 anti-Xa Effects 0.000 claims abstract 4
- 230000002429 anti-coagulating effect Effects 0.000 claims abstract 4
- 150000001720 carbohydrates Chemical group 0.000 claims abstract 4
- 229920000669 heparin Polymers 0.000 claims abstract 4
- 229960002897 heparin Drugs 0.000 claims abstract 4
- 210000004197 pelvis Anatomy 0.000 claims abstract 2
- 150000002302 glucosamines Chemical class 0.000 claims 5
- XNOPRXBHLZRZKH-UHFFFAOYSA-N Oxytocin Natural products N1C(=O)C(N)CSSCC(C(=O)N2C(CCC2)C(=O)NC(CC(C)C)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C(C(C)CC)NC(=O)C1CC1=CC=C(O)C=C1 XNOPRXBHLZRZKH-UHFFFAOYSA-N 0.000 claims 4
- 101800000989 Oxytocin Proteins 0.000 claims 4
- 102100031951 Oxytocin-neurophysin 1 Human genes 0.000 claims 4
- 150000002016 disaccharides Chemical class 0.000 claims 4
- XNOPRXBHLZRZKH-DSZYJQQASA-N oxytocin Chemical group C([C@H]1C(=O)N[C@H](C(N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@H](N)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 XNOPRXBHLZRZKH-DSZYJQQASA-N 0.000 claims 4
- 229960001723 oxytocin Drugs 0.000 claims 4
- 238000000425 proton nuclear magnetic resonance spectrum Methods 0.000 claims 4
- 239000000825 pharmaceutical preparation Substances 0.000 claims 2
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 150000007513 acids Chemical class 0.000 claims 1
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 claims 1
- 238000009826 distribution Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229960002442 glucosamine Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
- 230000013948 uterine smooth muscle contraction Effects 0.000 claims 1
- 238000005160 1H NMR spectroscopy Methods 0.000 abstract 1
- 238000001228 spectrum Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/727—Heparin; Heparan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/095—Oxytocins; Vasopressins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Reproductive Health (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261615400P | 2012-03-26 | 2012-03-26 | |
| US61/615,400 | 2012-03-26 | ||
| PCT/SE2013/050333 WO2013147690A1 (en) | 2012-03-26 | 2013-03-25 | Method for treatment of labor arrest |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2014143008A true RU2014143008A (ru) | 2016-05-20 |
Family
ID=49260784
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014143008A RU2014143008A (ru) | 2012-03-26 | 2013-03-25 | Способ лечения остановки родов |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20150057226A1 (enExample) |
| EP (1) | EP2830634A4 (enExample) |
| JP (1) | JP2015514705A (enExample) |
| CN (1) | CN104244957B (enExample) |
| AU (1) | AU2013240598A1 (enExample) |
| CA (1) | CA2868479A1 (enExample) |
| HK (1) | HK1203370A1 (enExample) |
| MX (1) | MX2014011451A (enExample) |
| MY (1) | MY185108A (enExample) |
| NZ (1) | NZ631279A (enExample) |
| RU (1) | RU2014143008A (enExample) |
| SG (1) | SG11201406118QA (enExample) |
| UA (1) | UA117907C2 (enExample) |
| WO (1) | WO2013147690A1 (enExample) |
| ZA (1) | ZA201406567B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2794665T3 (da) | 2011-12-19 | 2018-01-29 | Dilafor Ab | Ikke-antikoagulative glycosaminoglycaner omfattende disaccharid-gentagelsesenhed og medicinsk anvendelse deraf |
| WO2013095215A1 (en) | 2011-12-19 | 2013-06-27 | Dilaforette Ab | Low anticoagulant heparins |
| MY169816A (en) | 2012-03-26 | 2019-05-16 | Santen Pharmaceutical Co Ltd | Ophthalmic solution comprising diquafosol |
| US20150099703A1 (en) * | 2012-05-08 | 2015-04-09 | Dilafor Ab | Treatment of postpartum haemorrhage with chemically modified heparin or heparan sulphate and a uterotonic agent |
| US12502403B2 (en) | 2020-02-17 | 2025-12-23 | Dilafor Ab | Tafoxiparin for the treatment of preeclampsia |
| CA3255831A1 (en) | 2022-05-03 | 2023-11-09 | Dilafor Ab | NEW MEDICAL USE OF TAFOXIPARIN |
| EP4272749A1 (en) | 2022-05-03 | 2023-11-08 | Dilafor AB | New medical use of tafoxiparin |
| CN120603543A (zh) * | 2023-02-01 | 2025-09-05 | 马特纳医疗公司 | 用于防止分娩期间阴道撕裂伤的方法和设备 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000065837A (ja) * | 1998-08-24 | 2000-03-03 | Seikagaku Kogyo Co Ltd | グリコサミノグリカン又はグリコサミノグリカン結合性分子の測定方法及びその測定用キット |
| JP2000309544A (ja) * | 1999-02-25 | 2000-11-07 | Seikagaku Kogyo Co Ltd | 早産または流産防止剤および子宮頚管熟化抑制剤ならびにヒアルロニダーゼの阻害剤 |
| SE521676C2 (sv) * | 2002-01-02 | 2003-11-25 | Dilafor Ab | Användning av glykosaminoglykaner för prevention och behandling av värksvaghet vid fullgången graviditet |
| US8445436B2 (en) * | 2007-12-03 | 2013-05-21 | Florida State University Research Foundation, Inc. | Oxytocin and melatonin compositions and associated methods for inducing labor |
| DK2794665T3 (da) * | 2011-12-19 | 2018-01-29 | Dilafor Ab | Ikke-antikoagulative glycosaminoglycaner omfattende disaccharid-gentagelsesenhed og medicinsk anvendelse deraf |
-
2013
- 2013-03-25 NZ NZ631279A patent/NZ631279A/en unknown
- 2013-03-25 CN CN201380016529.6A patent/CN104244957B/zh active Active
- 2013-03-25 UA UAA201411545A patent/UA117907C2/uk unknown
- 2013-03-25 CA CA2868479A patent/CA2868479A1/en not_active Abandoned
- 2013-03-25 WO PCT/SE2013/050333 patent/WO2013147690A1/en not_active Ceased
- 2013-03-25 US US14/387,929 patent/US20150057226A1/en not_active Abandoned
- 2013-03-25 MX MX2014011451A patent/MX2014011451A/es unknown
- 2013-03-25 SG SG11201406118QA patent/SG11201406118QA/en unknown
- 2013-03-25 RU RU2014143008A patent/RU2014143008A/ru not_active Application Discontinuation
- 2013-03-25 MY MYPI2014002744A patent/MY185108A/en unknown
- 2013-03-25 JP JP2015503159A patent/JP2015514705A/ja active Pending
- 2013-03-25 AU AU2013240598A patent/AU2013240598A1/en not_active Abandoned
- 2013-03-25 EP EP13768034.4A patent/EP2830634A4/en not_active Withdrawn
- 2013-03-25 HK HK15103909.7A patent/HK1203370A1/xx unknown
-
2014
- 2014-09-08 ZA ZA2014/06567A patent/ZA201406567B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN104244957A (zh) | 2014-12-24 |
| UA117907C2 (uk) | 2018-10-25 |
| JP2015514705A (ja) | 2015-05-21 |
| CN104244957B (zh) | 2017-11-17 |
| AU2013240598A1 (en) | 2014-10-02 |
| SG11201406118QA (en) | 2014-11-27 |
| EP2830634A1 (en) | 2015-02-04 |
| US20150057226A1 (en) | 2015-02-26 |
| EP2830634A4 (en) | 2016-01-20 |
| CA2868479A1 (en) | 2013-10-03 |
| HK1203370A1 (en) | 2015-10-30 |
| WO2013147690A1 (en) | 2013-10-03 |
| MY185108A (en) | 2021-04-30 |
| ZA201406567B (en) | 2017-06-28 |
| MX2014011451A (es) | 2014-11-10 |
| NZ631279A (en) | 2016-06-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20170721 |