RU2014127714A - ВАКЦИНА НА ОСНОВЕ ТОКСИНОВ Clostridium difficile - Google Patents
ВАКЦИНА НА ОСНОВЕ ТОКСИНОВ Clostridium difficile Download PDFInfo
- Publication number
- RU2014127714A RU2014127714A RU2014127714A RU2014127714A RU2014127714A RU 2014127714 A RU2014127714 A RU 2014127714A RU 2014127714 A RU2014127714 A RU 2014127714A RU 2014127714 A RU2014127714 A RU 2014127714A RU 2014127714 A RU2014127714 A RU 2014127714A
- Authority
- RU
- Russia
- Prior art keywords
- antigen
- seq
- toxa
- toxb
- immunogenic composition
- Prior art date
Links
- 241000193163 Clostridioides difficile Species 0.000 title claims abstract 7
- 229960005486 vaccine Drugs 0.000 title claims 8
- 239000003053 toxin Substances 0.000 title 1
- 231100000765 toxin Toxicity 0.000 title 1
- 239000000427 antigen Substances 0.000 claims abstract 98
- 102000036639 antigens Human genes 0.000 claims abstract 98
- 108091007433 antigens Proteins 0.000 claims abstract 98
- 239000000203 mixture Substances 0.000 claims abstract 30
- 230000002163 immunogen Effects 0.000 claims abstract 21
- 229920001184 polypeptide Polymers 0.000 claims abstract 16
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract 16
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract 16
- 125000003275 alpha amino acid group Chemical group 0.000 claims abstract 7
- 150000001413 amino acids Chemical class 0.000 claims abstract 7
- 239000012634 fragment Substances 0.000 claims abstract 7
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 6
- 241000124008 Mammalia Species 0.000 claims 4
- 239000013256 coordination polymer Substances 0.000 claims 4
- 230000028993 immune response Effects 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- 101710084578 Short neurotoxin 1 Proteins 0.000 claims 1
- 101710182223 Toxin B Proteins 0.000 claims 1
- 101710182532 Toxin a Proteins 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 230000003472 neutralizing effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/08—Clostridium, e.g. Clostridium tetani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1121149.7 | 2011-12-08 | ||
| GB201121149A GB201121149D0 (en) | 2011-12-08 | 2011-12-08 | Clostridium difficile toxin-based vaccine |
| GBGB1217321.7A GB201217321D0 (en) | 2012-09-27 | 2012-09-27 | Vaccine |
| GB1217321.7 | 2012-09-27 | ||
| PCT/IB2012/002955 WO2013084071A2 (en) | 2011-12-08 | 2012-12-07 | Clostridium difficile toxin-based vaccine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2014127714A true RU2014127714A (ru) | 2016-01-27 |
Family
ID=47747684
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014127714A RU2014127714A (ru) | 2011-12-08 | 2012-12-07 | ВАКЦИНА НА ОСНОВЕ ТОКСИНОВ Clostridium difficile |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US9694063B2 (https=) |
| EP (1) | EP2788022B1 (https=) |
| JP (1) | JP6084631B2 (https=) |
| KR (1) | KR20140101835A (https=) |
| CN (1) | CN103974718A (https=) |
| AU (1) | AU2012349753A1 (https=) |
| BR (1) | BR112014013876A2 (https=) |
| CA (1) | CA2858519A1 (https=) |
| ES (1) | ES2704069T3 (https=) |
| IL (1) | IL232957A0 (https=) |
| IN (1) | IN2014CN04071A (https=) |
| MX (1) | MX2014006630A (https=) |
| RU (1) | RU2014127714A (https=) |
| SG (1) | SG11201402375VA (https=) |
| WO (1) | WO2013084071A2 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2781057C2 (ru) * | 2017-03-15 | 2022-10-04 | Новавакс, Инк. | Способы и композиции для индукции иммунного ответа против clostridium difficile |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR086199A1 (es) | 2011-04-22 | 2013-11-27 | Wyeth Llc | Composiciones relacionadas con una toxina de clostridium difficile mutante y sus metodos |
| SG11201500980WA (en) * | 2012-09-19 | 2015-04-29 | Novartis Ag | Clostridium difficile polypeptides as vaccine |
| BR122016023101B1 (pt) | 2012-10-21 | 2022-03-22 | Pfizer Inc | Polipeptídeo, composição imunogênica que o compreende, bem como célula recombinante derivada de clostridium difficile |
| WO2014197651A1 (en) * | 2013-06-05 | 2014-12-11 | Tufts University | Atoxic recombinant holotoxins of clostridium difficile as immunogens |
| KR20220062143A (ko) * | 2014-01-06 | 2022-05-13 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | Pd1 및 pdl1 항체 및 백신 조합 및 면역요법을 위한 이들의 사용 |
| ES2749701T3 (es) * | 2014-06-25 | 2020-03-23 | Glaxosmithkline Biologicals Sa | Composición inmunógena de Clostridium difficile |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US10668140B2 (en) | 2017-02-24 | 2020-06-02 | University Of South Floirida | Non-toxigenic Clostridium difficile spores for use in oral vaccination |
| US10555992B2 (en) | 2017-05-31 | 2020-02-11 | University Of South Florida | Immunogenic proteins against clostridium difficile |
| US10933126B2 (en) | 2018-05-03 | 2021-03-02 | The Board Of Regents Of The University Of Oklahoma | Clostridium difficile immunogenic compositions and methods of use |
| EP3972638A4 (en) * | 2019-05-21 | 2023-09-13 | The Regents Of The University Of California | VACCINE COMPOSITION FOR CLOSTRIDIUM DIFFICILE |
| EP4168032A2 (en) | 2020-06-19 | 2023-04-26 | Pfizer Inc. | Immunogenic compositions against clostridioides (clostridium) difficile and methods thereof |
| AU2022249381A1 (en) * | 2021-04-02 | 2023-11-09 | Matrivax, Inc. | METHODS AND COMPOSITIONS FOR TREATING <i>CLOSTRIDIODES DIFFICILE</i> INFECTIONS |
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-
2012
- 2012-12-07 AU AU2012349753A patent/AU2012349753A1/en not_active Abandoned
- 2012-12-07 CA CA2858519A patent/CA2858519A1/en not_active Abandoned
- 2012-12-07 RU RU2014127714A patent/RU2014127714A/ru not_active Application Discontinuation
- 2012-12-07 US US14/363,387 patent/US9694063B2/en active Active
- 2012-12-07 IN IN4071CHN2014 patent/IN2014CN04071A/en unknown
- 2012-12-07 SG SG11201402375VA patent/SG11201402375VA/en unknown
- 2012-12-07 ES ES12826538T patent/ES2704069T3/es active Active
- 2012-12-07 WO PCT/IB2012/002955 patent/WO2013084071A2/en not_active Ceased
- 2012-12-07 JP JP2014545387A patent/JP6084631B2/ja active Active
- 2012-12-07 MX MX2014006630A patent/MX2014006630A/es unknown
- 2012-12-07 KR KR1020147018480A patent/KR20140101835A/ko not_active Withdrawn
- 2012-12-07 BR BR112014013876A patent/BR112014013876A2/pt not_active IP Right Cessation
- 2012-12-07 EP EP12826538.6A patent/EP2788022B1/en active Active
- 2012-12-07 CN CN201280060487.1A patent/CN103974718A/zh active Pending
-
2014
- 2014-06-05 IL IL232957A patent/IL232957A0/en unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2781057C2 (ru) * | 2017-03-15 | 2022-10-04 | Новавакс, Инк. | Способы и композиции для индукции иммунного ответа против clostridium difficile |
| RU2781057C9 (ru) * | 2017-03-15 | 2022-11-10 | Новавакс, Инк. | Способы и композиции для индукции иммунного ответа против clostridium difficile |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2858519A1 (en) | 2013-06-13 |
| WO2013084071A2 (en) | 2013-06-13 |
| IL232957A0 (en) | 2014-07-31 |
| CN103974718A (zh) | 2014-08-06 |
| EP2788022B1 (en) | 2018-10-31 |
| MX2014006630A (es) | 2014-07-09 |
| BR112014013876A2 (pt) | 2019-09-24 |
| WO2013084071A3 (en) | 2013-11-07 |
| IN2014CN04071A (https=) | 2015-10-23 |
| EP2788022A2 (en) | 2014-10-15 |
| ES2704069T3 (es) | 2019-03-14 |
| US9694063B2 (en) | 2017-07-04 |
| JP2015500827A (ja) | 2015-01-08 |
| US20150132333A1 (en) | 2015-05-14 |
| SG11201402375VA (en) | 2014-10-30 |
| AU2012349753A1 (en) | 2014-06-19 |
| KR20140101835A (ko) | 2014-08-20 |
| JP6084631B2 (ja) | 2017-02-22 |
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