RU2014117558A - Лечение ожирения и нарушений, связанных с ожирением, путем нацеливания фармакологических агентов на калиевые каналы - Google Patents
Лечение ожирения и нарушений, связанных с ожирением, путем нацеливания фармакологических агентов на калиевые каналы Download PDFInfo
- Publication number
- RU2014117558A RU2014117558A RU2014117558/15A RU2014117558A RU2014117558A RU 2014117558 A RU2014117558 A RU 2014117558A RU 2014117558/15 A RU2014117558/15 A RU 2014117558/15A RU 2014117558 A RU2014117558 A RU 2014117558A RU 2014117558 A RU2014117558 A RU 2014117558A
- Authority
- RU
- Russia
- Prior art keywords
- aeeac
- chemical compound
- shk toxin
- pmp
- compound attached
- Prior art date
Links
- 208000008589 Obesity Diseases 0.000 title claims abstract 8
- 235000020824 obesity Nutrition 0.000 title claims abstract 8
- 102000004257 Potassium Channel Human genes 0.000 title claims abstract 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims abstract 4
- 108020001213 potassium channel Proteins 0.000 title claims abstract 4
- 239000002831 pharmacologic agent Substances 0.000 title 1
- 230000008685 targeting Effects 0.000 title 1
- 239000003053 toxin Substances 0.000 claims abstract 48
- 231100000765 toxin Toxicity 0.000 claims abstract 48
- 150000001875 compounds Chemical class 0.000 claims abstract 40
- 239000003795 chemical substances by application Substances 0.000 claims abstract 17
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims abstract 3
- 241001465754 Metazoa Species 0.000 claims abstract 3
- 125000000729 N-terminal amino-acid group Chemical group 0.000 claims abstract 3
- 230000003213 activating effect Effects 0.000 claims abstract 3
- 210000003486 adipose tissue brown Anatomy 0.000 claims abstract 3
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1767—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43595—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from coelenteratae, e.g. medusae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Tropical Medicine & Parasitology (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Child & Adolescent Psychology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161542751P | 2011-10-03 | 2011-10-03 | |
| US61/542,751 | 2011-10-03 | ||
| PCT/US2012/058495 WO2013052507A1 (en) | 2011-10-03 | 2012-10-02 | TREATMENT OF OBESITY AND OBESITY-RELATED DISORDERS BY PHARMACOLOGICAL TARGETING OF Kv1.3 POTASSIUM CHANNELS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2014117558A true RU2014117558A (ru) | 2015-11-10 |
Family
ID=48044112
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014117558/15A RU2014117558A (ru) | 2011-10-03 | 2012-10-02 | Лечение ожирения и нарушений, связанных с ожирением, путем нацеливания фармакологических агентов на калиевые каналы |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US20150072940A1 (enExample) |
| EP (1) | EP2763702A4 (enExample) |
| JP (1) | JP2014531469A (enExample) |
| KR (1) | KR20140108518A (enExample) |
| CN (1) | CN103987408A (enExample) |
| AU (1) | AU2012318736A1 (enExample) |
| BR (1) | BR112014008065A2 (enExample) |
| CA (1) | CA2850357A1 (enExample) |
| HK (1) | HK1201048A1 (enExample) |
| IL (1) | IL231873A0 (enExample) |
| IN (1) | IN2014CN03333A (enExample) |
| MX (1) | MX2014004029A (enExample) |
| RU (1) | RU2014117558A (enExample) |
| SG (1) | SG11201401193XA (enExample) |
| TW (1) | TW201321403A (enExample) |
| WO (1) | WO2013052507A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2474316B1 (en) * | 2004-10-07 | 2016-04-06 | The Regents of The University of California | Analogs of shk toxin and their uses in selective inhibition of kv1.3 potassium channels |
| TW201542231A (zh) * | 2011-06-06 | 2015-11-16 | Kineta One Llc | 以ｓｈｋ為主之醫藥組合物及其製備方法及用途 |
| IN2014CN03333A (enExample) | 2011-10-03 | 2015-07-03 | Univ California | |
| JP7211704B2 (ja) * | 2015-01-29 | 2023-01-24 | ノヴォ ノルディスク アー／エス | Ｇｌｐ－１アゴニスト及び腸溶コーティングを含む錠剤 |
| TWI701249B (zh) | 2015-03-13 | 2020-08-11 | 德商４Ｓｃ製藥公司 | Ｋv１.３抑制劑及其醫學應用 |
| TWI698438B (zh) | 2015-03-13 | 2020-07-11 | 德商４Ｓｃ製藥公司 | Ｋv１.３抑制劑及其醫學應用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5453270A (en) | 1992-03-30 | 1995-09-26 | Hypermetabolic Therapies, Inc. | Pharmaceutical composition and method for hypermetabolic weight loss |
| US6077680A (en) * | 1996-11-27 | 2000-06-20 | The University Of Florida | ShK toxin compositions and methods of use |
| WO1999013895A1 (en) * | 1997-09-17 | 1999-03-25 | University Of Florida | Polypeptide compositions that inhibit potassium channel activity and uses therefor |
| JP3207823B2 (ja) | 1999-04-28 | 2001-09-10 | リノール油脂株式会社 | 共役リノール酸を有効成分とする褐色脂肪増加剤 |
| US6616944B2 (en) | 2000-03-08 | 2003-09-09 | Medinnova Gesellschaft Fur Medizinsche Innovationen Aus Adkademischer Forschung Mbh | Self-assembling colloidal carriers for protein delivery |
| US6861405B2 (en) * | 2001-06-12 | 2005-03-01 | Yale University | Compositions and methods relating to glucose metabolism, weight control, and food intake |
| EP2474316B1 (en) | 2004-10-07 | 2016-04-06 | The Regents of The University of California | Analogs of shk toxin and their uses in selective inhibition of kv1.3 potassium channels |
| US7833979B2 (en) * | 2005-04-22 | 2010-11-16 | Amgen Inc. | Toxin peptide therapeutic agents |
| RU2008109911A (ru) * | 2005-08-17 | 2009-09-27 | Зольвай Фармасьютикалз Гмбх (De) | Способ применения соединений, ингибирующих калиевые каналы |
| TW201026708A (en) * | 2008-12-12 | 2010-07-16 | Solvay Pharm Bv | Spiro azepane-oxazolidinones as Kv1.3 potassium channel blockers |
| IN2014CN03333A (enExample) | 2011-10-03 | 2015-07-03 | Univ California |
-
2012
- 2012-10-02 IN IN3333CHN2014 patent/IN2014CN03333A/en unknown
- 2012-10-02 WO PCT/US2012/058495 patent/WO2013052507A1/en not_active Ceased
- 2012-10-02 RU RU2014117558/15A patent/RU2014117558A/ru not_active Application Discontinuation
- 2012-10-02 US US14/347,602 patent/US20150072940A1/en not_active Abandoned
- 2012-10-02 CA CA2850357A patent/CA2850357A1/en not_active Abandoned
- 2012-10-02 JP JP2014534641A patent/JP2014531469A/ja active Pending
- 2012-10-02 SG SG11201401193XA patent/SG11201401193XA/en unknown
- 2012-10-02 HK HK15101586.1A patent/HK1201048A1/xx unknown
- 2012-10-02 MX MX2014004029A patent/MX2014004029A/es unknown
- 2012-10-02 EP EP12838795.8A patent/EP2763702A4/en not_active Withdrawn
- 2012-10-02 BR BR112014008065A patent/BR112014008065A2/pt not_active IP Right Cessation
- 2012-10-02 KR KR1020147012093A patent/KR20140108518A/ko not_active Withdrawn
- 2012-10-02 AU AU2012318736A patent/AU2012318736A1/en not_active Abandoned
- 2012-10-02 CN CN201280049696.6A patent/CN103987408A/zh active Pending
- 2012-10-03 TW TW101136560A patent/TW201321403A/zh unknown
-
2014
- 2014-04-02 IL IL231873A patent/IL231873A0/en unknown
-
2016
- 2016-02-22 US US15/049,353 patent/US9878006B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2763702A1 (en) | 2014-08-13 |
| BR112014008065A2 (pt) | 2019-09-24 |
| KR20140108518A (ko) | 2014-09-11 |
| HK1201048A1 (en) | 2015-08-21 |
| EP2763702A4 (en) | 2015-04-15 |
| SG11201401193XA (en) | 2014-05-29 |
| AU2012318736A1 (en) | 2014-05-22 |
| US20170095530A1 (en) | 2017-04-06 |
| US20150072940A1 (en) | 2015-03-12 |
| MX2014004029A (es) | 2014-08-01 |
| IL231873A0 (en) | 2014-05-28 |
| CA2850357A1 (en) | 2013-04-11 |
| JP2014531469A (ja) | 2014-11-27 |
| TW201321403A (zh) | 2013-06-01 |
| IN2014CN03333A (enExample) | 2015-07-03 |
| US9878006B2 (en) | 2018-01-30 |
| CN103987408A (zh) | 2014-08-13 |
| WO2013052507A1 (en) | 2013-04-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA93 | Acknowledgement of application withdrawn (no request for examination) |
Effective date: 20151005 |