RU2013125755A - Твердые формы 3-(4-аминометил)-1-(5-метил-7н-пирроло[2,3-d]пиримидин-4-ил)пиперидин-4-карбоксамидо)фенил диметилкарбамата - Google Patents
Твердые формы 3-(4-аминометил)-1-(5-метил-7н-пирроло[2,3-d]пиримидин-4-ил)пиперидин-4-карбоксамидо)фенил диметилкарбамата Download PDFInfo
- Publication number
- RU2013125755A RU2013125755A RU2013125755/04A RU2013125755A RU2013125755A RU 2013125755 A RU2013125755 A RU 2013125755A RU 2013125755/04 A RU2013125755/04 A RU 2013125755/04A RU 2013125755 A RU2013125755 A RU 2013125755A RU 2013125755 A RU2013125755 A RU 2013125755A
- Authority
- RU
- Russia
- Prior art keywords
- pyrrolo
- pyrimidin
- carboxamido
- aminomethyl
- methyl
- Prior art date
Links
- -1 PIPERIDIN-4-CARBOXAMIDO Chemical class 0.000 title claims abstract 13
- MYOHNZJKOAODMX-UHFFFAOYSA-N phenyl n,n-dimethylcarbamate Chemical compound CN(C)C(=O)OC1=CC=CC=C1 MYOHNZJKOAODMX-UHFFFAOYSA-N 0.000 title claims 2
- 239000007787 solid Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 24
- 150000003839 salts Chemical class 0.000 claims abstract 7
- 238000001938 differential scanning calorimetry curve Methods 0.000 claims abstract 6
- 238000002844 melting Methods 0.000 claims abstract 6
- 230000008018 melting Effects 0.000 claims abstract 6
- 238000000634 powder X-ray diffraction Methods 0.000 claims abstract 5
- 229910019142 PO4 Inorganic materials 0.000 claims abstract 2
- PWPNYABQEOGNNC-UHFFFAOYSA-N [3-[[4-(aminomethyl)-1-(5-methyl-7h-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carbonyl]amino]phenyl] n,n-dimethylcarbamate Chemical group CN(C)C(=O)OC1=CC=CC(NC(=O)C2(CN)CCN(CC2)C=2C=3C(C)=CNC=3N=CN=2)=C1 PWPNYABQEOGNNC-UHFFFAOYSA-N 0.000 claims abstract 2
- 239000012458 free base Substances 0.000 claims abstract 2
- 239000010452 phosphate Substances 0.000 claims abstract 2
- 238000000034 method Methods 0.000 claims 5
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical group CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
- 239000012296 anti-solvent Substances 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 238000010438 heat treatment Methods 0.000 claims 2
- 208000010412 Glaucoma Diseases 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 238000001816 cooling Methods 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 230000004438 eyesight Effects 0.000 claims 1
- 230000004410 intraocular pressure Effects 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 238000001757 thermogravimetry curve Methods 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- DWLVWMUCHSLGSU-UHFFFAOYSA-M n,n-dimethylcarbamate Chemical compound CN(C)C([O-])=O DWLVWMUCHSLGSU-UHFFFAOYSA-M 0.000 abstract 3
- NNSBERWEQGBTOO-UHFFFAOYSA-N 4-(aminomethyl)-n-(3-chlorophenyl)-1-(5-methyl-7h-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide Chemical compound C=12C(C)=CNC2=NC=NC=1N(CC1)CCC1(CN)C(=O)NC1=CC=CC(Cl)=C1 NNSBERWEQGBTOO-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41060210P | 2010-11-05 | 2010-11-05 | |
| US61/410,602 | 2010-11-05 | ||
| PCT/US2011/059086 WO2012061565A1 (en) | 2010-11-05 | 2011-11-03 | Solid forms of 3-(4-(aminomethyl)-1-(5-methyl-7h-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamido)phenyl dimethylcarbamate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2013125755A true RU2013125755A (ru) | 2014-12-10 |
Family
ID=45002136
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2013125755/04A RU2013125755A (ru) | 2010-11-05 | 2011-11-03 | Твердые формы 3-(4-аминометил)-1-(5-метил-7н-пирроло[2,3-d]пиримидин-4-ил)пиперидин-4-карбоксамидо)фенил диметилкарбамата |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8735408B2 (https=) |
| EP (1) | EP2635584A1 (https=) |
| JP (1) | JP2013541588A (https=) |
| KR (1) | KR20140003433A (https=) |
| CN (1) | CN103298815A (https=) |
| AR (1) | AR083756A1 (https=) |
| AU (1) | AU2011323371A1 (https=) |
| BR (1) | BR112013011094A2 (https=) |
| CA (1) | CA2817112A1 (https=) |
| IL (1) | IL225884A0 (https=) |
| MX (1) | MX2013004923A (https=) |
| RU (1) | RU2013125755A (https=) |
| SG (1) | SG190098A1 (https=) |
| TW (1) | TW201302754A (https=) |
| WO (1) | WO2012061565A1 (https=) |
| ZA (1) | ZA201302996B (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015150337A1 (en) | 2014-04-01 | 2015-10-08 | Amakem Nv | Lim kinase inhibitors |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI439457B (zh) * | 2007-09-28 | 2014-06-01 | Lexicon Pharmaceuticals Inc | （ｓ）－２－胺基－３－（４－（２－胺基－６－（（ｒ）－１－（４－氯－２－（３－甲基－１ｈ－吡唑－１－基）苯基）－２，２，２－三氟乙氧）－嘧啶－４－基）苯基）丙酸乙酯之固體形式與其使用方法 |
| US8193202B2 (en) | 2008-04-21 | 2012-06-05 | Lexicon Pharmaceuticals, Inc. | LIMK2 inhibitors, compositions comprising them, and methods of their use |
-
2011
- 2011-11-01 TW TW100139812A patent/TW201302754A/zh unknown
- 2011-11-03 BR BR112013011094A patent/BR112013011094A2/pt not_active IP Right Cessation
- 2011-11-03 WO PCT/US2011/059086 patent/WO2012061565A1/en not_active Ceased
- 2011-11-03 AU AU2011323371A patent/AU2011323371A1/en not_active Abandoned
- 2011-11-03 US US13/288,321 patent/US8735408B2/en active Active
- 2011-11-03 CA CA2817112A patent/CA2817112A1/en not_active Abandoned
- 2011-11-03 KR KR1020137014386A patent/KR20140003433A/ko not_active Withdrawn
- 2011-11-03 MX MX2013004923A patent/MX2013004923A/es not_active Application Discontinuation
- 2011-11-03 EP EP11785536.1A patent/EP2635584A1/en not_active Withdrawn
- 2011-11-03 RU RU2013125755/04A patent/RU2013125755A/ru not_active Application Discontinuation
- 2011-11-03 SG SG2013033618A patent/SG190098A1/en unknown
- 2011-11-03 CN CN2011800533551A patent/CN103298815A/zh active Pending
- 2011-11-03 JP JP2013537811A patent/JP2013541588A/ja active Pending
- 2011-11-04 AR ARP110104111A patent/AR083756A1/es unknown
-
2013
- 2013-04-22 IL IL225884A patent/IL225884A0/en unknown
- 2013-04-24 ZA ZA2013/02996A patent/ZA201302996B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN103298815A (zh) | 2013-09-11 |
| JP2013541588A (ja) | 2013-11-14 |
| ZA201302996B (en) | 2014-06-25 |
| WO2012061565A1 (en) | 2012-05-10 |
| US20120122898A1 (en) | 2012-05-17 |
| US8735408B2 (en) | 2014-05-27 |
| AU2011323371A1 (en) | 2013-05-23 |
| TW201302754A (zh) | 2013-01-16 |
| EP2635584A1 (en) | 2013-09-11 |
| IL225884A0 (en) | 2013-07-31 |
| AR083756A1 (es) | 2013-03-20 |
| MX2013004923A (es) | 2013-06-28 |
| KR20140003433A (ko) | 2014-01-09 |
| BR112013011094A2 (pt) | 2016-08-23 |
| CA2817112A1 (en) | 2011-11-05 |
| SG190098A1 (en) | 2013-06-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20160314 |