JP2013541588A - ３−（４−（アミノメチル）−１−（５−メチル−７Ｈ−ピロロ［２，３−ｄ］ピリミジン−４−イル）ピペリジン−４−カルボキサミド）フェニルジメチルカルバメートの固体形態 - Google Patents

３−（４−（アミノメチル）−１−（５−メチル−７Ｈ−ピロロ［２，３−ｄ］ピリミジン−４−イル）ピペリジン−４−カルボキサミド）フェニルジメチルカルバメートの固体形態 Download PDF

Info

Publication number
JP2013541588A
JP2013541588A JP2013537811A JP2013537811A JP2013541588A JP 2013541588 A JP2013541588 A JP 2013541588A JP 2013537811 A JP2013537811 A JP 2013537811A JP 2013537811 A JP2013537811 A JP 2013537811A JP 2013541588 A JP2013541588 A JP 2013541588A
Authority
JP
Japan
Prior art keywords
degrees
methyl
pyrrolo
piperidine
pyrimidin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2013537811A
Other languages
English (en)
Japanese (ja)
Other versions
JP2013541588A5 (https=
Inventor
ポール マーガレット スーザン デュ
チュン リー
ハイミン チャン
Original Assignee
レクシコン ファーマシューティカルズ インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by レクシコン ファーマシューティカルズ インコーポレイテッド filed Critical レクシコン ファーマシューティカルズ インコーポレイテッド
Publication of JP2013541588A publication Critical patent/JP2013541588A/ja
Publication of JP2013541588A5 publication Critical patent/JP2013541588A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2013537811A 2010-11-05 2011-11-03 ３−（４−（アミノメチル）−１−（５−メチル−７Ｈ−ピロロ［２，３−ｄ］ピリミジン−４−イル）ピペリジン−４−カルボキサミド）フェニルジメチルカルバメートの固体形態 Pending JP2013541588A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41060210P 2010-11-05 2010-11-05
US61/410,602 2010-11-05
PCT/US2011/059086 WO2012061565A1 (en) 2010-11-05 2011-11-03 Solid forms of 3-(4-(aminomethyl)-1-(5-methyl-7h-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamido)phenyl dimethylcarbamate

Publications (2)

Publication Number Publication Date
JP2013541588A true JP2013541588A (ja) 2013-11-14
JP2013541588A5 JP2013541588A5 (https=) 2014-12-04

Family

ID=45002136

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013537811A Pending JP2013541588A (ja) 2010-11-05 2011-11-03 ３−（４−（アミノメチル）−１−（５−メチル−７Ｈ−ピロロ［２，３−ｄ］ピリミジン−４−イル）ピペリジン−４−カルボキサミド）フェニルジメチルカルバメートの固体形態

Country Status (16)

Country Link
US (1) US8735408B2 (https=)
EP (1) EP2635584A1 (https=)
JP (1) JP2013541588A (https=)
KR (1) KR20140003433A (https=)
CN (1) CN103298815A (https=)
AR (1) AR083756A1 (https=)
AU (1) AU2011323371A1 (https=)
BR (1) BR112013011094A2 (https=)
CA (1) CA2817112A1 (https=)
IL (1) IL225884A0 (https=)
MX (1) MX2013004923A (https=)
RU (1) RU2013125755A (https=)
SG (1) SG190098A1 (https=)
TW (1) TW201302754A (https=)
WO (1) WO2012061565A1 (https=)
ZA (1) ZA201302996B (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015150337A1 (en) 2014-04-01 2015-10-08 Amakem Nv Lim kinase inhibitors

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009042733A1 (en) * 2007-09-28 2009-04-02 Lexicon Pharmaceuticals, Inc. Solids forms of ( s) -ethyl 2-amin0-3- (4- (2 -amino- 6- ( (r) -1- (4-chl0r0-2- o-methyl-ih-pyrazol- 1-yl) phenyl) -2, 2, 2-trifluorethoxy) -pyrimidin-4-yl) phenyl) propanoate
US20090264450A1 (en) * 2008-04-21 2009-10-22 Hugh Alfred Burgoon Limk2 inhibitors, compositions comprising them, and methods of their use

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009042733A1 (en) * 2007-09-28 2009-04-02 Lexicon Pharmaceuticals, Inc. Solids forms of ( s) -ethyl 2-amin0-3- (4- (2 -amino- 6- ( (r) -1- (4-chl0r0-2- o-methyl-ih-pyrazol- 1-yl) phenyl) -2, 2, 2-trifluorethoxy) -pyrimidin-4-yl) phenyl) propanoate
US20090264450A1 (en) * 2008-04-21 2009-10-22 Hugh Alfred Burgoon Limk2 inhibitors, compositions comprising them, and methods of their use

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JPN6015024145; 化学便覧　応用化学編　第６版 , 2003, ｐ．１７８, 丸善株式会社 *

Also Published As

Publication number Publication date
CN103298815A (zh) 2013-09-11
ZA201302996B (en) 2014-06-25
WO2012061565A1 (en) 2012-05-10
RU2013125755A (ru) 2014-12-10
US20120122898A1 (en) 2012-05-17
US8735408B2 (en) 2014-05-27
AU2011323371A1 (en) 2013-05-23
TW201302754A (zh) 2013-01-16
EP2635584A1 (en) 2013-09-11
IL225884A0 (en) 2013-07-31
AR083756A1 (es) 2013-03-20
MX2013004923A (es) 2013-06-28
KR20140003433A (ko) 2014-01-09
BR112013011094A2 (pt) 2016-08-23
CA2817112A1 (en) 2011-11-05
SG190098A1 (en) 2013-06-28

Similar Documents

Publication Publication Date Title
US10723730B2 (en) Solid forms of a selective CDK4/6 inhibitor
JP6559719B2 (ja) （ｓ）−６−（（１−アセチルピペリジン−４−イル）アミノ）−ｎ−（３−（３、４−ジヒドロイソキノリン−２（１ｈ）−イル）−２−ヒドロキシプロピル）ピリミジン−４−カルボキサミドの結晶塩
CN108785265B (zh) 杂环化合物和其用途
CA3214095A1 (en) Lactams as cbl-b inhibitors
CN111527076A (zh) 共晶体、其药物组合物以及涉及其的治疗方法
CN108290824A (zh) 索拉贝隆两性离子及其应用
EP1364959A1 (en) Crystal of pyrimidine nucleoside derivative
EP2740458B1 (en) Packaging comprising forms of sodium salt of 4-tert-butyl-N-[4-chloro-2-(1-oxy-pyridine-4-carbonyl)-phenyl]-benzenesulfonamide
RU2451016C2 (ru) Тозилатная соль транс-n-изобутил-3-фтор-3-[3-фтор-4-(пирролидин-1-илметил)фенил]циклобутанкарбоксамида
JP2013541588A (ja) ３−（４−（アミノメチル）−１−（５−メチル−７Ｈ−ピロロ［２，３−ｄ］ピリミジン−４−イル）ピペリジン−４−カルボキサミド）フェニルジメチルカルバメートの固体形態
CN116723833A (zh) 具有特定粒径分布的jak抑制剂
WO2021218930A1 (zh) 塞来昔布与普瑞巴林共无定型物及其制备方法
KR20250149691A (ko) 항섬유화 화합물의 고체 형태, 염 및 다형체
CN103562183B (zh) 奥米沙班的苯甲酸盐
WO2011149010A1 (ja) 新規インダゾール誘導体またはその塩およびその製造中間体、ならびに、それを用いた網脈絡膜変性疾患の予防または治療剤、網脈絡膜変性疾患の治療方法、インダゾール誘導体またはその塩の使用
WO2015107545A1 (en) Water soluble salts of dasatinib hydrate
HK1183667A (en) Solid forms of 3-(4-(aminomethyl)-1-(5-methyl-7h-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamido)phenyl dimethylcarbamate
CN110612290A (zh) 新的苯并咪唑酮化合物和其医药用途
HK1234032A1 (en) Crystalline form of 6-[(4r)-4-methyl-1,2-dioxido-1,2,6-thiadiazinan-2-yl]isoquinoline-1-carbonitrile
JP2016029037A (ja) 後眼部疾患の予防または治療剤
TW201605451A (zh) 老年性黃斑部病變之預防或治療劑

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20141020

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20141020

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20150702

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20150707

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20150812

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20160517