RU2013114980A - Вакцинная композиция - Google Patents
Вакцинная композиция Download PDFInfo
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- RU2013114980A RU2013114980A RU2013114980/15A RU2013114980A RU2013114980A RU 2013114980 A RU2013114980 A RU 2013114980A RU 2013114980/15 A RU2013114980/15 A RU 2013114980/15A RU 2013114980 A RU2013114980 A RU 2013114980A RU 2013114980 A RU2013114980 A RU 2013114980A
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- vaccine composition
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- 229960005486 vaccine Drugs 0.000 title claims abstract 25
- 150000003839 salts Chemical class 0.000 claims abstract 17
- 239000000427 antigen Substances 0.000 claims abstract 13
- 102000036639 antigens Human genes 0.000 claims abstract 13
- 108091007433 antigens Proteins 0.000 claims abstract 13
- 108010060804 Toll-Like Receptor 4 Proteins 0.000 claims abstract 6
- 102100039360 Toll-like receptor 4 Human genes 0.000 claims abstract 6
- 150000002632 lipids Chemical class 0.000 claims abstract 6
- 241000712461 unidentified influenza virus Species 0.000 claims abstract 6
- 229940123384 Toll-like receptor (TLR) agonist Drugs 0.000 claims abstract 5
- 239000002158 endotoxin Substances 0.000 claims abstract 5
- 229920006008 lipopolysaccharide Polymers 0.000 claims abstract 5
- 239000003970 toll like receptor agonist Substances 0.000 claims abstract 5
- 208000035473 Communicable disease Diseases 0.000 claims abstract 4
- 101000831567 Homo sapiens Toll-like receptor 2 Proteins 0.000 claims abstract 4
- 108010028921 Lipopeptides Proteins 0.000 claims abstract 4
- 241000607142 Salmonella Species 0.000 claims abstract 4
- 102100024333 Toll-like receptor 2 Human genes 0.000 claims abstract 4
- 239000003795 chemical substances by application Substances 0.000 claims abstract 4
- 208000015181 infectious disease Diseases 0.000 claims abstract 4
- 241000520272 Pantoea Species 0.000 claims abstract 3
- 125000004122 cyclic group Chemical group 0.000 claims abstract 3
- DMWMUMWKGKGSNW-OPMCLZTFSA-N (2S)-6-amino-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-4-amino-2-[[2-[[(2R)-2-amino-3-[(2R)-2,3-di(hexadecanoyloxy)propyl]sulfanylpropanoyl]amino]acetyl]amino]-4-oxobutanoyl]amino]-4-oxobutanoyl]amino]-3-carboxypropanoyl]amino]-4-carboxybutanoyl]amino]-3-hydroxypropanoyl]amino]-4-oxobutanoyl]amino]-3-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]hexanoyl]amino]-4-carboxybutanoyl]amino]hexanoic acid Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](CSC[C@H](N)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(O)=O)OC(=O)CCCCCCCCCCCCCCC DMWMUMWKGKGSNW-OPMCLZTFSA-N 0.000 claims abstract 2
- 241001468161 Acetobacterium Species 0.000 claims abstract 2
- 241000588914 Enterobacter Species 0.000 claims abstract 2
- 241000588724 Escherichia coli Species 0.000 claims abstract 2
- 101710154606 Hemagglutinin Proteins 0.000 claims abstract 2
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims abstract 2
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims abstract 2
- 101710176177 Protein A56 Proteins 0.000 claims abstract 2
- 241000700605 Viruses Species 0.000 claims abstract 2
- 241000589634 Xanthomonas Species 0.000 claims abstract 2
- 241000588901 Zymomonas Species 0.000 claims abstract 2
- 239000000556 agonist Substances 0.000 claims abstract 2
- PKFDLKSEZWEFGL-MHARETSRSA-N c-di-GMP Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]3[C@@H](O)[C@H](N4C5=C(C(NC(N)=N5)=O)N=C4)O[C@@H]3COP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=C(NC2=O)N)=C2N=C1 PKFDLKSEZWEFGL-MHARETSRSA-N 0.000 claims abstract 2
- PDXMFTWFFKBFIN-XPWFQUROSA-N cyclic di-AMP Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]3[C@@H](O)[C@H](N4C5=NC=NC(N)=C5N=C4)O[C@@H]3COP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=CN=C2N)=C2N=C1 PDXMFTWFFKBFIN-XPWFQUROSA-N 0.000 claims abstract 2
- -1 glucopyranosyl lipid Chemical class 0.000 claims abstract 2
- 108010051618 macrophage stimulatory lipopeptide 2 Proteins 0.000 claims abstract 2
- 210000000214 mouth Anatomy 0.000 claims abstract 2
- 230000028993 immune response Effects 0.000 claims 4
- 210000004877 mucosa Anatomy 0.000 claims 2
- 230000009885 systemic effect Effects 0.000 claims 2
- 230000024932 T cell mediated immunity Effects 0.000 claims 1
- 229940123560 Toll-like receptor 4 agonist Drugs 0.000 claims 1
- 125000002015 acyclic group Chemical group 0.000 abstract 1
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Abstract
1. Вакцинная композиция для введения в ротовую полость человека или животного, причем вакцинная композиция включает:по меньшей мере один антиген, выделенный из объекта с инфекционным заболеванием, ипо меньшей мере один агент, выбранный из группы, состоящей из:агониста toll-подобного рецептора 4 (TLR4),агониста toll-подобного рецептора 2/6 (TLR2/6) ициклического динуклеотида или их производного или соли.2. Вакцинная композиция по п.1, где антиген, выделенный из объекта с инфекционным заболеванием, представляет собой антиген, выделенный из вируса гриппа.3. Вакцинная композиция по п.2, где антиген, выделенный из вируса гриппа, представляет собой белок гемагглютинин.4. Вакцинная композиция по п.2, где антиген, выделенный из вируса гриппа, представляет собой инактивированный цельный вирус.5. Вакцинная композиция по п.1, где агонист toll-подобного рецептора 4 (TLR4) включает по меньшей мере один агент, выбранный из группы, состоящей из:липополисахарида или его соли имонофосфориллипида или его соли.6. Вакцинная композиция по п.5, где липополисахарид или его соль выделены из Escherichia coli, Salmonella, Pantoea, Acetobacterium, Zymomonas, Xanthomonas или Enterobacter; имонофосфориллипид или его соль представляет собой монофосфориллипид, выделенный из Salmonella, или синтетический глюкопиранозиллипид.7. Вакцинная композиция по п.1, где агонист toll-подобного рецептора 2/6 (TLR2/6) включает диацилированный липопептид или его производное или соль.8. Вакцинная композиция по п.7, где диацилированный липопептид включает PamCSK, MALP-2, FSL-1 или их производные или соли.9. Вакцинная композиция по п.1, где циклический динуклеотид включает c-di-GMP, c-di-AMP или их производные или соли.10. Вакцинная композиция по п.6, где ли
Claims (11)
1. Вакцинная композиция для введения в ротовую полость человека или животного, причем вакцинная композиция включает:
по меньшей мере один антиген, выделенный из объекта с инфекционным заболеванием, и
по меньшей мере один агент, выбранный из группы, состоящей из:
агониста toll-подобного рецептора 4 (TLR4),
агониста toll-подобного рецептора 2/6 (TLR2/6) и
циклического динуклеотида или их производного или соли.
2. Вакцинная композиция по п.1, где антиген, выделенный из объекта с инфекционным заболеванием, представляет собой антиген, выделенный из вируса гриппа.
3. Вакцинная композиция по п.2, где антиген, выделенный из вируса гриппа, представляет собой белок гемагглютинин.
4. Вакцинная композиция по п.2, где антиген, выделенный из вируса гриппа, представляет собой инактивированный цельный вирус.
5. Вакцинная композиция по п.1, где агонист toll-подобного рецептора 4 (TLR4) включает по меньшей мере один агент, выбранный из группы, состоящей из:
липополисахарида или его соли и
монофосфориллипида или его соли.
6. Вакцинная композиция по п.5, где липополисахарид или его соль выделены из Escherichia coli, Salmonella, Pantoea, Acetobacterium, Zymomonas, Xanthomonas или Enterobacter; и
монофосфориллипид или его соль представляет собой монофосфориллипид, выделенный из Salmonella, или синтетический глюкопиранозиллипид.
7. Вакцинная композиция по п.1, где агонист toll-подобного рецептора 2/6 (TLR2/6) включает диацилированный липопептид или его производное или соль.
8. Вакцинная композиция по п.7, где диацилированный липопептид включает Pam2CSK4, MALP-2, FSL-1 или их производные или соли.
9. Вакцинная композиция по п.1, где циклический динуклеотид включает c-di-GMP, c-di-AMP или их производные или соли.
10. Вакцинная композиция по п.6, где липополисахарид или его соль выделены из Pantoea.
11. Вакцинная композиция по п.1, где вакцинная композиция индуцирует иммунный ответ слизистой и системный иммунный ответ, причем иммунный ответ слизистой представляет собой выработку антиген-специфичного антитела IgA, а системный иммунный ответ представляет собой выработку антиген-специфичного антитела IgG, а также развитие антиген-специфичного клеточно-опосредованного иммунитета.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012-085839 | 2012-04-04 | ||
| JP2012085839 | 2012-04-04 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2013114980A true RU2013114980A (ru) | 2014-10-10 |
| RU2655627C2 RU2655627C2 (ru) | 2018-05-29 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2013114980A RU2655627C2 (ru) | 2012-04-04 | 2013-04-03 | Вакцинная композиция |
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| Country | Link |
|---|---|
| US (3) | US9498527B2 (ru) |
| EP (3) | EP3485904A1 (ru) |
| JP (3) | JP5650780B2 (ru) |
| KR (1) | KR102103606B1 (ru) |
| CN (2) | CN103357010A (ru) |
| CA (1) | CA2811762C (ru) |
| ES (1) | ES2568018T3 (ru) |
| PL (1) | PL2647387T3 (ru) |
| RU (1) | RU2655627C2 (ru) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5650780B2 (ja) * | 2012-04-04 | 2015-01-07 | 日東電工株式会社 | ワクチン組成物 |
| ES2678194T3 (es) | 2012-12-19 | 2018-08-09 | Board Of Regents, The University Of Texas System | Determinación farmacéutica de una vía de señalización de dinucleótido cíclico de mamífero |
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| US9504743B2 (en) | 2013-09-25 | 2016-11-29 | Sequoia Sciences, Inc | Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections |
| US9149522B2 (en) | 2013-09-25 | 2015-10-06 | Sequoia Sciences, Inc. | Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections |
| US9149521B2 (en) | 2013-09-25 | 2015-10-06 | Sequoia Sciences, Inc. | Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections |
| RU2016109368A (ru) * | 2013-10-03 | 2017-11-10 | Нитто Денко Корпорейшн | Мукозальная вакцинная композиция |
| CN105530954A (zh) * | 2013-10-03 | 2016-04-27 | 日东电工株式会社 | 鼻粘膜疫苗组合物 |
| CN105555308A (zh) * | 2013-10-03 | 2016-05-04 | 日东电工株式会社 | 粘膜疫苗组合物 |
| EP3071229A4 (en) | 2013-11-22 | 2017-05-10 | Brock University | Use of fluorinated cyclic dinucleotides as oral vaccine adjuvants |
| US10450341B2 (en) | 2014-06-04 | 2019-10-22 | Glaxosmithkline Intellectual Property Development Limited | Cyclic di-nucleotides as modulators of STING |
| WO2016052698A1 (ja) | 2014-10-02 | 2016-04-07 | 日東電工株式会社 | 経皮投与用ワクチン医薬組成物 |
| GB201501462D0 (en) | 2015-01-29 | 2015-03-18 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| WO2016130616A1 (en) | 2015-02-11 | 2016-08-18 | The Johns Hopkins University | Bacteria over-expressing c-di-amp and therapeutic methods |
| JP2016210771A (ja) * | 2015-05-01 | 2016-12-15 | 日東電工株式会社 | アレルギーワクチン組成物 |
| EP3322713B1 (en) | 2015-12-03 | 2021-01-20 | GlaxoSmithKline Intellectual Property Development Limited | Cyclic purine dinucleotides as modulators of sting |
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| BR112022018160A2 (pt) * | 2020-03-24 | 2022-10-25 | Byung Chul Ahn | Método de produção de composição de soro para prevenir ou tratar doenças infecciosas relacionadas à mucosa em mamíferos jovens, composição de soro produzida por ele, e uso da mesma |
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| EP0688205A1 (en) | 1993-03-11 | 1995-12-27 | Secretech, Inc. | Polymeric mucoadhesives in the delivery of immunogens at mucosal surfaces |
| JP4043533B2 (ja) * | 1995-01-27 | 2008-02-06 | 水野 傳一 | 低分子量リポポリサッカライド |
| JPH08245702A (ja) * | 1995-03-13 | 1996-09-24 | Denichi Mizuno | 高分子量リポポリサッカライド |
| GB0000891D0 (en) | 2000-01-14 | 2000-03-08 | Allergy Therapeutics Ltd | Formulation |
| EP1987841A1 (de) | 2002-04-04 | 2008-11-05 | Helmholtz-Zentrum für Infektionsforschung GmbH | Verwendung eines Lipopeptids oder Lipoproteins als Adjuvans bei therapeutischer oder prophylaktischer Vakzinierung |
| WO2005087238A2 (en) | 2004-03-15 | 2005-09-22 | Karaolis David K R | Method for stimulating the immune, inflammatory or neuroprotective response |
| EP1782826A1 (en) | 2005-11-08 | 2007-05-09 | GBF Gesellschaft für Biotechnologische Forschung mbH | PQS and c-diGMP and its conjugates as adjuvants and their uses in pharmaceutical compositions |
| EP1961823B1 (en) * | 2005-11-28 | 2024-06-12 | Biomedical Research Group Inc. | Method for producing lipopolysaccharide and lipopolysaccharide |
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| US20100150952A1 (en) * | 2008-11-07 | 2010-06-17 | University Of Washington | pH-RESPONSIVE POLYMER CARRIER COMPOSITIONS FOR CYTOSOLIC PROTEIN DELIVERY |
| DK2437753T3 (en) * | 2009-06-05 | 2016-12-19 | Infectious Disease Res Inst | Synthetic glucopyranosyl lipid adjuvants and vaccine compositions containing them |
| AU2010270722B2 (en) | 2009-07-06 | 2015-06-04 | Variation Biotechnologies, Inc. | Methods for preparing vesicles and formulations produced therefrom |
| GB201009273D0 (en) | 2010-06-03 | 2010-07-21 | Glaxosmithkline Biolog Sa | Novel vaccine |
| US20120064110A1 (en) * | 2010-08-20 | 2012-03-15 | Selecta Biosciences, Inc. | Synthetic nanocarrier vaccines comprising peptides obtained or derived from human influenza a virus hemagglutinin |
| JP5650780B2 (ja) * | 2012-04-04 | 2015-01-07 | 日東電工株式会社 | ワクチン組成物 |
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| EP3485904A1 (en) | 2019-05-22 |
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| CA2811762A1 (en) | 2013-10-04 |
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| PL2647387T3 (pl) | 2016-09-30 |
| US20170028054A1 (en) | 2017-02-02 |
| KR20130112790A (ko) | 2013-10-14 |
| JP5650780B2 (ja) | 2015-01-07 |
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