RU2012157279A - Применение бактериальной бета-лактамазы для диагностики in vitro и визуализации, диагностики и лечения in vivo - Google Patents
Применение бактериальной бета-лактамазы для диагностики in vitro и визуализации, диагностики и лечения in vivo Download PDFInfo
- Publication number
- RU2012157279A RU2012157279A RU2012157279/10A RU2012157279A RU2012157279A RU 2012157279 A RU2012157279 A RU 2012157279A RU 2012157279/10 A RU2012157279/10 A RU 2012157279/10A RU 2012157279 A RU2012157279 A RU 2012157279A RU 2012157279 A RU2012157279 A RU 2012157279A
- Authority
- RU
- Russia
- Prior art keywords
- substrate
- cdc
- subject
- xhx3
- biological sample
- Prior art date
Links
- 102000006635 beta-lactamase Human genes 0.000 title claims abstract 17
- 108090000204 Dipeptidase 1 Proteins 0.000 title claims abstract 16
- 238000012800 visualization Methods 0.000 title claims abstract 6
- 230000001580 bacterial effect Effects 0.000 title claims 11
- 238000003745 diagnosis Methods 0.000 title claims 3
- 238000000338 in vitro Methods 0.000 title 1
- 238000000034 method Methods 0.000 claims abstract 61
- 239000000758 substrate Substances 0.000 claims abstract 37
- 244000052616 bacterial pathogen Species 0.000 claims abstract 21
- 239000012472 biological sample Substances 0.000 claims abstract 19
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims abstract 16
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract 10
- 229960002685 biotin Drugs 0.000 claims abstract 8
- 235000020958 biotin Nutrition 0.000 claims abstract 8
- 239000011616 biotin Substances 0.000 claims abstract 8
- 230000004069 differentiation Effects 0.000 claims abstract 8
- 239000000975 dye Substances 0.000 claims abstract 7
- 239000004005 microsphere Substances 0.000 claims abstract 7
- 239000002245 particle Substances 0.000 claims abstract 7
- 239000007850 fluorescent dye Substances 0.000 claims abstract 6
- UPSFMJHZUCSEHU-JYGUBCOQSA-N n-[(2s,3r,4r,5s,6r)-2-[(2r,3s,4r,5r,6s)-5-acetamido-4-hydroxy-2-(hydroxymethyl)-6-(4-methyl-2-oxochromen-7-yl)oxyoxan-3-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide Chemical compound CC(=O)N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@H]1[C@H](O)[C@@H](NC(C)=O)[C@H](OC=2C=C3OC(=O)C=C(C)C3=CC=2)O[C@@H]1CO UPSFMJHZUCSEHU-JYGUBCOQSA-N 0.000 claims abstract 6
- 239000000523 sample Substances 0.000 claims abstract 6
- 208000002151 Pleural effusion Diseases 0.000 claims abstract 4
- 206010036790 Productive cough Diseases 0.000 claims abstract 4
- 239000008280 blood Substances 0.000 claims abstract 4
- 210000004369 blood Anatomy 0.000 claims abstract 4
- 238000004624 confocal microscopy Methods 0.000 claims abstract 4
- 238000001514 detection method Methods 0.000 claims abstract 4
- 238000000684 flow cytometry Methods 0.000 claims abstract 4
- 238000001506 fluorescence spectroscopy Methods 0.000 claims abstract 4
- 238000011002 quantification Methods 0.000 claims abstract 4
- 210000003296 saliva Anatomy 0.000 claims abstract 4
- 210000003802 sputum Anatomy 0.000 claims abstract 4
- 208000024794 sputum Diseases 0.000 claims abstract 4
- 210000002700 urine Anatomy 0.000 claims abstract 4
- 230000004807 localization Effects 0.000 claims abstract 3
- 230000001225 therapeutic effect Effects 0.000 claims 11
- 150000001875 compounds Chemical class 0.000 claims 9
- 230000000694 effects Effects 0.000 claims 6
- 238000003384 imaging method Methods 0.000 claims 6
- 230000005855 radiation Effects 0.000 claims 6
- 230000004963 pathophysiological condition Effects 0.000 claims 5
- 206010062207 Mycobacterial infection Diseases 0.000 claims 4
- 241001502334 Mycobacterium avium complex bacterium Species 0.000 claims 4
- 241001302239 Mycobacterium tuberculosis complex Species 0.000 claims 4
- 208000027531 mycobacterial infectious disease Diseases 0.000 claims 4
- 241000606125 Bacteroides Species 0.000 claims 3
- 241000193403 Clostridium Species 0.000 claims 3
- 241000588722 Escherichia Species 0.000 claims 3
- 241000606790 Haemophilus Species 0.000 claims 3
- 241000589248 Legionella Species 0.000 claims 3
- 208000007764 Legionnaires' Disease Diseases 0.000 claims 3
- 241000186781 Listeria Species 0.000 claims 3
- 241000186359 Mycobacterium Species 0.000 claims 3
- 241000589516 Pseudomonas Species 0.000 claims 3
- 241000607142 Salmonella Species 0.000 claims 3
- 241000607768 Shigella Species 0.000 claims 3
- 241000191940 Staphylococcus Species 0.000 claims 3
- 238000002405 diagnostic procedure Methods 0.000 claims 2
- 239000012530 fluid Substances 0.000 claims 2
- 230000001991 pathophysiological effect Effects 0.000 claims 2
- 241000894007 species Species 0.000 claims 2
- 238000011269 treatment regimen Methods 0.000 claims 2
- 201000008827 tuberculosis Diseases 0.000 claims 2
- 108090001008 Avidin Proteins 0.000 claims 1
- 241000186367 Mycobacterium avium Species 0.000 claims 1
- 241000187479 Mycobacterium tuberculosis Species 0.000 claims 1
- 238000004891 communication Methods 0.000 claims 1
- 238000005259 measurement Methods 0.000 claims 1
- 244000000010 microbial pathogen Species 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 238000012806 monitoring device Methods 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 230000000007 visual effect Effects 0.000 claims 1
- 108020004256 Beta-lactamase Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0028—Oxazine dyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0032—Methine dyes, e.g. cyanine dyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0041—Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0052—Small organic molecules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/978—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
- G01N2333/986—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in cyclic amides (3.5.2), e.g. beta-lactamase (penicillinase, 3.5.2.6), creatinine amidohydrolase (creatininase, EC 3.5.2.10), N-methylhydantoinase (3.5.2.6)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Toxicology (AREA)
- Urology & Nephrology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Pharmacology & Pharmacy (AREA)
- Food Science & Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/802,340 US20110020240A1 (en) | 2008-08-06 | 2010-06-04 | Use of bacterial beta-lactamase for in vitro diagnostics and in vivo imaging, diagnostics and therapeutics |
| US12/802,340 | 2010-06-04 | ||
| PCT/US2011/001018 WO2011152883A2 (en) | 2010-06-04 | 2011-06-03 | Use of bacterial beta-lactamase for in vitro diagnostics and in vivo imaging, diagnostics and therapeutics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2012157279A true RU2012157279A (ru) | 2014-07-20 |
Family
ID=45067221
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2012157279/10A RU2012157279A (ru) | 2010-06-04 | 2011-06-03 | Применение бактериальной бета-лактамазы для диагностики in vitro и визуализации, диагностики и лечения in vivo |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20110020240A1 (enExample) |
| EP (1) | EP2585611A4 (enExample) |
| JP (1) | JP2013528386A (enExample) |
| KR (1) | KR20130132722A (enExample) |
| CN (1) | CN103038359A (enExample) |
| AU (1) | AU2011262374A1 (enExample) |
| CA (1) | CA2801299A1 (enExample) |
| RU (1) | RU2012157279A (enExample) |
| WO (1) | WO2011152883A2 (enExample) |
| ZA (1) | ZA201300050B (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1711504A2 (en) * | 2004-01-21 | 2006-10-18 | Molecular Probes Inc. | Derivatives of cephalosporin and clavulanic acid for detecting beta-lactamase in a sample |
| US9526803B2 (en) * | 2012-03-08 | 2016-12-27 | Julius-Maximilians-Universitaet Wuerzburg | Diagnostic chewing gum for pathogens |
| CN102633742A (zh) * | 2012-03-22 | 2012-08-15 | 盛世泰科生物医药技术(苏州)有限公司 | 一种2-(6-羟基苯并[d]噻唑-2-基)噻唑-4-羧酸钠的合成方法 |
| CN103360385A (zh) * | 2012-04-06 | 2013-10-23 | 上海交通大学医学院附属第三人民医院 | 一种治疗mrsa感染的化合物和药物 |
| US9677112B2 (en) * | 2012-05-15 | 2017-06-13 | The Texas A&M University System | β-lactamase substrates and methods of their use for the diagnosis of tuberculosis |
| US11268958B2 (en) | 2012-09-14 | 2022-03-08 | The Johns Hopkins University | Bacteria-specific labeled substrtates as imaging biomarkers to diagnose, locate, and monitor infections |
| CN104714006B (zh) * | 2015-02-04 | 2017-10-20 | 国家纳米科学中心 | 一种检测奶制品中β‑内酰胺酶的方法 |
| CN104697970A (zh) * | 2015-03-17 | 2015-06-10 | 华中科技大学同济医学院附属协和医院 | 一种三维重建观察细胞在载体内增殖分布的方法 |
| CN107703130A (zh) * | 2017-09-19 | 2018-02-16 | 淮海工学院 | 适用于检测牛奶中残留的β‑内酰胺酶的色差检测方法 |
| CN110551497B (zh) * | 2019-09-15 | 2022-06-10 | 四川农业大学 | 一种分子印迹量子点磷光探针的制备方法及其应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5407957A (en) * | 1990-02-13 | 1995-04-18 | Martek Corporation | Production of docosahexaenoic acid by dinoflagellates |
| US5338843A (en) * | 1992-01-30 | 1994-08-16 | Becton, Dickinson And Company | Fluorogenic and chromogenic β-lactamase substrates |
| US7427680B2 (en) * | 2001-01-12 | 2008-09-23 | The Regents Of The University Of California | Fluorogenic substrates for BETA-lactamase gene expression |
| US6166231A (en) * | 1998-12-15 | 2000-12-26 | Martek Biosciences Corporation | Two phase extraction of oil from biomass |
| SE0302840D0 (sv) * | 2003-10-29 | 2003-10-29 | Affibody Ab | Detection method |
| US20070048848A1 (en) * | 2005-08-25 | 2007-03-01 | Sunsource Industries | Method, apparatus and system for biodiesel production from algae |
| KR20110081147A (ko) * | 2008-08-06 | 2011-07-13 | 더 텍사스 에이 앤드 엠 유니버시티 시스템 | 시험관 내 진단 및 생체 내 이미지화, 진단 및 치료를 위한 박테리아 베타-락타마제의 용도 |
-
2010
- 2010-06-04 US US12/802,340 patent/US20110020240A1/en not_active Abandoned
-
2011
- 2011-06-03 AU AU2011262374A patent/AU2011262374A1/en not_active Abandoned
- 2011-06-03 EP EP20110790116 patent/EP2585611A4/en not_active Withdrawn
- 2011-06-03 WO PCT/US2011/001018 patent/WO2011152883A2/en not_active Ceased
- 2011-06-03 KR KR1020137000204A patent/KR20130132722A/ko not_active Withdrawn
- 2011-06-03 CN CN2011800335438A patent/CN103038359A/zh active Pending
- 2011-06-03 RU RU2012157279/10A patent/RU2012157279A/ru unknown
- 2011-06-03 CA CA2801299A patent/CA2801299A1/en not_active Abandoned
- 2011-06-03 JP JP2013513156A patent/JP2013528386A/ja active Pending
-
2013
- 2013-01-03 ZA ZA2013/00050A patent/ZA201300050B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN103038359A (zh) | 2013-04-10 |
| CA2801299A1 (en) | 2011-12-08 |
| WO2011152883A2 (en) | 2011-12-08 |
| ZA201300050B (en) | 2013-09-25 |
| WO2011152883A3 (en) | 2012-03-29 |
| EP2585611A2 (en) | 2013-05-01 |
| JP2013528386A (ja) | 2013-07-11 |
| KR20130132722A (ko) | 2013-12-05 |
| AU2011262374A1 (en) | 2013-01-24 |
| US20110020240A1 (en) | 2011-01-27 |
| EP2585611A4 (en) | 2013-12-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6186414B2 (ja) | 固体又は半固体培地上の微生物のキャラクタリゼーション方法 | |
| US10280446B2 (en) | Methods and articles for detecting deoxyribonuclease activity | |
| Kennedy et al. | Application of flow cytometry to the detection of pathogenic bacteria | |
| AlTamimi et al. | Comparison of phenotypic and PCR methods for detection of carbapenemases production by Enterobacteriaceae | |
| Thapa et al. | Direct detection of Mycobacterium tuberculosis in clinical samples by a dry methyl green loop-mediated isothermal amplification (LAMP) method | |
| EP2821499B1 (en) | Method for the rapid determination of susceptibility or resistance of bacteria to antibiotics | |
| Tannert et al. | Phenotypic antibiotic susceptibility testing of pathogenic bacteria using photonic readout methods: recent achievements and impact | |
| March-Rosselló | Rapid methods for detection of bacterial resistance to antibiotics | |
| JP2013528386A5 (enExample) | ||
| EP1432786A4 (en) | RAPID DETECTION OF REPLICATION CELLS | |
| WO2011152883A3 (en) | Use of bacterial beta-lactamase for in vitro diagnostics and in vivo imaging, diagnostics and therapeutics | |
| Zhuang et al. | Progress in methods for the detection of viable Escherichia coli | |
| Huang et al. | Probing minority population of antibiotic-resistant bacteria | |
| Suaifan et al. | Engineered colorimetric detection of Staphylococcus aureus extracellular proteases | |
| KR20210045879A (ko) | 표지물질이 접합된 콜리스틴 컨쥬게이트를 포함하는 그람 음성균 검출용 조성물 및 이를 이용한 그람 음성균의 검출 방법 | |
| Wang et al. | A broad-range method to detect genomic DNA of multiple pathogenic bacteria based on the aggregation strategy of gold nanorods | |
| US10031080B2 (en) | Method for recognizing resistant germs and device for performing same | |
| Li et al. | High-throughput fluorescence sensing array based on tetraphenylethylene derivatives for detecting and distinguishing pathogenic microbes | |
| CA2946721C (en) | Rapid determination of bacterial susceptibility to an antibiotic at the point of care | |
| Chen et al. | Ultrasensitive monoclonal antibody-based Salmonella detection through fluorescence single bacterial cell imaging selectively enhanced by tyramide signal amplification | |
| JP2024509708A (ja) | 自動式ファーゴグラム | |
| Iyer et al. | Modified PAP method to detect heteroresistance to vancomycin among methicillin resistant Staphylococcus aureus isolates at a tertiary care hospital | |
| FR2924127A1 (fr) | Milieu reactionnel pour la detection et/ou l'identification de staphyloccocus aureus | |
| JP2016536592A (ja) | 細菌診断 | |
| Feng et al. | An esterase activity-based biosensor for rapid and sensitive detection of viable Escherichia coli O157: H7 in milk |