CN103038359A - 细菌β-内酰胺酶在体外诊断及体内成像、诊断和治疗中的用途 - Google Patents

细菌β-内酰胺酶在体外诊断及体内成像、诊断和治疗中的用途 Download PDF

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Publication number
CN103038359A
CN103038359A CN2011800335438A CN201180033543A CN103038359A CN 103038359 A CN103038359 A CN 103038359A CN 2011800335438 A CN2011800335438 A CN 2011800335438A CN 201180033543 A CN201180033543 A CN 201180033543A CN 103038359 A CN103038359 A CN 103038359A
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substrate
cdc
signal
lactamase
imaging
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Pending
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CN2011800335438A
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Chinese (zh)
Inventor
J·D·奇里洛
J·C·萨凯帝尼
饶江洪
谢贺新
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Leland Stanford Junior University
Texas A&M University
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Leland Stanford Junior University
Texas A&M University
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Publication of CN103038359A publication Critical patent/CN103038359A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0028—Oxazine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0041—Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0052—Small organic molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/978—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • G01N2333/986—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in cyclic amides (3.5.2), e.g. beta-lactamase (penicillinase, 3.5.2.6), creatinine amidohydrolase (creatininase, EC 3.5.2.10), N-methylhydantoinase (3.5.2.6)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
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  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Pathology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN2011800335438A 2010-06-04 2011-06-03 细菌β-内酰胺酶在体外诊断及体内成像、诊断和治疗中的用途 Pending CN103038359A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12/802,340 US20110020240A1 (en) 2008-08-06 2010-06-04 Use of bacterial beta-lactamase for in vitro diagnostics and in vivo imaging, diagnostics and therapeutics
US12/802,340 2010-06-04
PCT/US2011/001018 WO2011152883A2 (en) 2010-06-04 2011-06-03 Use of bacterial beta-lactamase for in vitro diagnostics and in vivo imaging, diagnostics and therapeutics

Publications (1)

Publication Number Publication Date
CN103038359A true CN103038359A (zh) 2013-04-10

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CN2011800335438A Pending CN103038359A (zh) 2010-06-04 2011-06-03 细菌β-内酰胺酶在体外诊断及体内成像、诊断和治疗中的用途

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US (1) US20110020240A1 (enExample)
EP (1) EP2585611A4 (enExample)
JP (1) JP2013528386A (enExample)
KR (1) KR20130132722A (enExample)
CN (1) CN103038359A (enExample)
AU (1) AU2011262374A1 (enExample)
CA (1) CA2801299A1 (enExample)
RU (1) RU2012157279A (enExample)
WO (1) WO2011152883A2 (enExample)
ZA (1) ZA201300050B (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104714006A (zh) * 2015-02-04 2015-06-17 国家纳米科学中心 一种检测奶制品中β-内酰胺酶的方法
CN107703130A (zh) * 2017-09-19 2018-02-16 淮海工学院 适用于检测牛奶中残留的β‑内酰胺酶的色差检测方法
CN110551497A (zh) * 2019-09-15 2019-12-10 四川农业大学 一种分子印迹量子点磷光探针的制备方法及其应用

Families Citing this family (7)

* Cited by examiner, † Cited by third party
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WO2005071096A2 (en) 2004-01-21 2005-08-04 Molecular Probes, Inc. Derivatives of cephalosporin and clavulanic acid for detecting beta-lacamase in a sample
EP2823050B1 (en) * 2012-03-08 2017-03-01 Julius-Maximilians-Universität Würzburg Diagnostic chewing gum for pathogens
CN102633742A (zh) * 2012-03-22 2012-08-15 盛世泰科生物医药技术(苏州)有限公司 一种2-(6-羟基苯并[d]噻唑-2-基)噻唑-4-羧酸钠的合成方法
CN103360385A (zh) * 2012-04-06 2013-10-23 上海交通大学医学院附属第三人民医院 一种治疗mrsa感染的化合物和药物
WO2013173519A1 (en) * 2012-05-15 2013-11-21 The Texas A&M University System Beta-lactamase substrates and methods of their use for the diagnosis of tuberculosis
WO2014043606A1 (en) 2012-09-14 2014-03-20 The Johns Hopkins University Bacteria-specific labeled substrtates as imaging biomarkers to diagnose, locate, and monitor infections
CN104697970A (zh) * 2015-03-17 2015-06-10 华中科技大学同济医学院附属协和医院 一种三维重建观察细胞在载体内增殖分布的方法

Citations (1)

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US20100047172A1 (en) * 2008-08-06 2010-02-25 Cirillo Jeffrey D Use of bacterial beta-lactamase for in vitro diagnostics and in vivo imaging, diagnostics and therapeutics

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US5407957A (en) * 1990-02-13 1995-04-18 Martek Corporation Production of docosahexaenoic acid by dinoflagellates
US5338843A (en) * 1992-01-30 1994-08-16 Becton, Dickinson And Company Fluorogenic and chromogenic β-lactamase substrates
US7427680B2 (en) * 2001-01-12 2008-09-23 The Regents Of The University Of California Fluorogenic substrates for BETA-lactamase gene expression
US6166231A (en) * 1998-12-15 2000-12-26 Martek Biosciences Corporation Two phase extraction of oil from biomass
SE0302840D0 (sv) * 2003-10-29 2003-10-29 Affibody Ab Detection method
WO2007025145A2 (en) * 2005-08-25 2007-03-01 Solix Biofuels, Inc. Method, apparatus and system for biodiesel production from algae

Patent Citations (1)

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US20100047172A1 (en) * 2008-08-06 2010-02-25 Cirillo Jeffrey D Use of bacterial beta-lactamase for in vitro diagnostics and in vivo imaging, diagnostics and therapeutics

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
WENZHONG GAO, BENGANG XING, ROGER Y. TSIEN, AND JIANGHONG RAO: "Novel fluorogenic substrates for imaging beta-lactamase gene expression", 《J AM CHEM SOC》, vol. 125, no. 37, 19 August 2003 (2003-08-19), pages 11146 - 11147, XP002390470, DOI: doi:10.1021/ja036126o *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104714006A (zh) * 2015-02-04 2015-06-17 国家纳米科学中心 一种检测奶制品中β-内酰胺酶的方法
CN107703130A (zh) * 2017-09-19 2018-02-16 淮海工学院 适用于检测牛奶中残留的β‑内酰胺酶的色差检测方法
CN110551497A (zh) * 2019-09-15 2019-12-10 四川农业大学 一种分子印迹量子点磷光探针的制备方法及其应用
CN110551497B (zh) * 2019-09-15 2022-06-10 四川农业大学 一种分子印迹量子点磷光探针的制备方法及其应用

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Publication number Publication date
KR20130132722A (ko) 2013-12-05
WO2011152883A3 (en) 2012-03-29
US20110020240A1 (en) 2011-01-27
EP2585611A2 (en) 2013-05-01
AU2011262374A1 (en) 2013-01-24
WO2011152883A2 (en) 2011-12-08
ZA201300050B (en) 2013-09-25
RU2012157279A (ru) 2014-07-20
JP2013528386A (ja) 2013-07-11
EP2585611A4 (en) 2013-12-04
CA2801299A1 (en) 2011-12-08

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Application publication date: 20130410