RU2012114832A - Питательные композиции для модулирования воспаления, содержащие экзогенный витамин к2 - Google Patents
Питательные композиции для модулирования воспаления, содержащие экзогенный витамин к2 Download PDFInfo
- Publication number
- RU2012114832A RU2012114832A RU2012114832/13A RU2012114832A RU2012114832A RU 2012114832 A RU2012114832 A RU 2012114832A RU 2012114832/13 A RU2012114832/13 A RU 2012114832/13A RU 2012114832 A RU2012114832 A RU 2012114832A RU 2012114832 A RU2012114832 A RU 2012114832A
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- Russia
- Prior art keywords
- inflammation
- effects
- exogenous vitamin
- modulation
- effective amount
- Prior art date
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- 206010061218 Inflammation Diseases 0.000 title claims abstract 19
- 230000004054 inflammatory process Effects 0.000 title claims abstract 19
- 239000000203 mixture Substances 0.000 title claims abstract 12
- 235000016709 nutrition Nutrition 0.000 title claims abstract 12
- 239000011782 vitamin Substances 0.000 title abstract 2
- 235000013343 vitamin Nutrition 0.000 title abstract 2
- 229940088594 vitamin Drugs 0.000 title abstract 2
- 229930003231 vitamin Natural products 0.000 title abstract 2
- 150000003722 vitamin derivatives Chemical class 0.000 title abstract 2
- 238000000034 method Methods 0.000 claims abstract 31
- PFRQBZFETXBLTP-UHFFFAOYSA-N Vitamin K2 Natural products C1=CC=C2C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C(=O)C2=C1 PFRQBZFETXBLTP-UHFFFAOYSA-N 0.000 claims abstract 17
- DKHGMERMDICWDU-GHDNBGIDSA-N menaquinone-4 Chemical compound C1=CC=C2C(=O)C(C/C=C(C)/CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)=C(C)C(=O)C2=C1 DKHGMERMDICWDU-GHDNBGIDSA-N 0.000 claims abstract 16
- 235000019143 vitamin K2 Nutrition 0.000 claims abstract 14
- 239000011728 vitamin K2 Substances 0.000 claims abstract 14
- 230000000694 effects Effects 0.000 claims abstract 13
- 150000001413 amino acids Chemical class 0.000 claims abstract 4
- 238000009472 formulation Methods 0.000 claims abstract 4
- 239000011700 menaquinone-7 Substances 0.000 claims abstract 3
- LCWXJXMHJVIJFK-UHFFFAOYSA-N Hydroxylysine Natural products NCC(O)CC(N)CC(O)=O LCWXJXMHJVIJFK-UHFFFAOYSA-N 0.000 claims abstract 2
- PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 claims abstract 2
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims abstract 2
- CNIUEVQJABPUIJ-QMMMGPOBSA-N N-hydroxytyrosine Chemical compound ON[C@H](C(O)=O)CC1=CC=C(O)C=C1 CNIUEVQJABPUIJ-QMMMGPOBSA-N 0.000 claims abstract 2
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims abstract 2
- 239000003963 antioxidant agent Substances 0.000 claims abstract 2
- 230000003078 antioxidant effect Effects 0.000 claims abstract 2
- YSMODUONRAFBET-UHFFFAOYSA-N delta-DL-hydroxylysine Natural products NCC(O)CCC(N)C(O)=O YSMODUONRAFBET-UHFFFAOYSA-N 0.000 claims abstract 2
- 235000005911 diet Nutrition 0.000 claims abstract 2
- 230000000378 dietary effect Effects 0.000 claims abstract 2
- 235000015872 dietary supplement Nutrition 0.000 claims abstract 2
- PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 claims abstract 2
- YSMODUONRAFBET-UHNVWZDZSA-N erythro-5-hydroxy-L-lysine Chemical compound NC[C@H](O)CC[C@H](N)C(O)=O YSMODUONRAFBET-UHNVWZDZSA-N 0.000 claims abstract 2
- 235000019197 fats Nutrition 0.000 claims abstract 2
- 235000021323 fish oil Nutrition 0.000 claims abstract 2
- QJHBJHUKURJDLG-UHFFFAOYSA-N hydroxy-L-lysine Natural products NCCCCC(NO)C(O)=O QJHBJHUKURJDLG-UHFFFAOYSA-N 0.000 claims abstract 2
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- 239000002773 nucleotide Substances 0.000 claims abstract 2
- 125000003729 nucleotide group Chemical group 0.000 claims abstract 2
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- 239000008194 pharmaceutical composition Substances 0.000 claims abstract 2
- 235000013406 prebiotics Nutrition 0.000 claims abstract 2
- 239000006041 probiotic Substances 0.000 claims abstract 2
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- 102000004169 proteins and genes Human genes 0.000 claims abstract 2
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- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 1
- 206010002261 Androgen deficiency Diseases 0.000 claims 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims 1
- 201000003883 Cystic fibrosis Diseases 0.000 claims 1
- 206010012559 Developmental delay Diseases 0.000 claims 1
- 102100022466 Eukaryotic translation initiation factor 4E-binding protein 1 Human genes 0.000 claims 1
- 108050000946 Eukaryotic translation initiation factor 4E-binding protein 1 Proteins 0.000 claims 1
- 208000004262 Food Hypersensitivity Diseases 0.000 claims 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims 1
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- 102000008934 Muscle Proteins Human genes 0.000 claims 1
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- 108010081689 Osteopontin Proteins 0.000 claims 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims 1
- 208000001647 Renal Insufficiency Diseases 0.000 claims 1
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- 206010049416 Short-bowel syndrome Diseases 0.000 claims 1
- 102000005747 Transcription Factor RelA Human genes 0.000 claims 1
- 108010031154 Transcription Factor RelA Proteins 0.000 claims 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
- 102100040247 Tumor necrosis factor Human genes 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 229930003316 Vitamin D Natural products 0.000 claims 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
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- 229910052802 copper Inorganic materials 0.000 claims 1
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- 230000004064 dysfunction Effects 0.000 claims 1
- 235000020932 food allergy Nutrition 0.000 claims 1
- 230000006698 induction Effects 0.000 claims 1
- 230000000968 intestinal effect Effects 0.000 claims 1
- 229910052742 iron Inorganic materials 0.000 claims 1
- 201000006370 kidney failure Diseases 0.000 claims 1
- 239000011777 magnesium Substances 0.000 claims 1
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- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 claims 1
- 230000002232 neuromuscular Effects 0.000 claims 1
- 239000011574 phosphorus Substances 0.000 claims 1
- 229910052698 phosphorus Inorganic materials 0.000 claims 1
- 235000018102 proteins Nutrition 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
- 235000019166 vitamin D Nutrition 0.000 claims 1
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- 150000003710 vitamin D derivatives Chemical class 0.000 claims 1
- 229940046008 vitamin d Drugs 0.000 claims 1
- 230000004584 weight gain Effects 0.000 claims 1
- 235000019786 weight gain Nutrition 0.000 claims 1
- 239000011701 zinc Substances 0.000 claims 1
- 229910052725 zinc Inorganic materials 0.000 claims 1
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- Biochemistry (AREA)
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- General Engineering & Computer Science (AREA)
- Pathology (AREA)
- Molecular Biology (AREA)
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| US37184610P | 2010-08-09 | 2010-08-09 | |
| US61/371,846 | 2010-08-09 | ||
| PCT/US2010/047468 WO2011031602A1 (en) | 2009-09-14 | 2010-09-01 | Nutritional compositions for modulating inflammation including exogenous vitamin k2 |
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| RU2012114786/15A RU2012114786A (ru) | 2009-09-14 | 2010-09-01 | Питательные композиции, содержащие экзогенный витамин к2 |
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| TR (1) | TR201808128T4 (https=) |
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| US20130028864A1 (en) * | 1998-04-08 | 2013-01-31 | Theta Biomedical Consulting & Development Co., Inc. | Anti-inflammatory compositions for treating brain inflammation |
| ES2669004T3 (es) * | 2009-09-14 | 2018-05-23 | Nestec S.A. | Composiciones nutricionales para modular la inflamación, que incluyen vitamina K2 exógena |
| CN103491804A (zh) * | 2011-04-18 | 2014-01-01 | 雀巢产品技术援助有限公司 | 具有α-HICA 和二十碳五烯酸的营养组合物 |
| US8183227B1 (en) | 2011-07-07 | 2012-05-22 | Chemo S. A. France | Compositions, kits and methods for nutrition supplementation |
| US8168611B1 (en) | 2011-09-29 | 2012-05-01 | Chemo S.A. France | Compositions, kits and methods for nutrition supplementation |
| CN102772401A (zh) * | 2011-10-02 | 2012-11-14 | 南京大学 | 鼠尾草酚的抗骨质疏松新用途 |
| WO2013144267A2 (en) * | 2012-03-29 | 2013-10-03 | Nestec S.A. | Improvement of musculoskeletal health by nutrition and exercise |
| WO2013144268A1 (en) * | 2012-03-29 | 2013-10-03 | Nestec S.A. | Nutrition and exercise against drug-associated malnutrition in children |
| JP6368306B2 (ja) * | 2012-07-31 | 2018-08-01 | ネステク ソシエテ アノニム | 炎症性腸疾患（ｉｂｄ）患者の筋骨格の健康を促進させるための栄養組成物 |
| CN104717968A (zh) | 2012-09-11 | 2015-06-17 | 达科他星都有限公司 | 含铁的营养补充剂 |
| CN103142640A (zh) * | 2013-04-01 | 2013-06-12 | 李拖平 | 含有维生素k2的具有预防与治疗骨质疏松症的保健品 |
| WO2017114686A1 (en) * | 2015-12-30 | 2017-07-06 | Nestec S.A. | Method for determining fat free body mass |
| CN105815791B (zh) * | 2016-03-24 | 2018-12-18 | 刘超 | 一种具有增肌功能并消除不良反应的组合物 |
| JP2019517482A (ja) * | 2016-06-02 | 2019-06-24 | アナ ファーマシューティカルズ， インコーポレイテッドＡｎａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | 高カルシウム尿症及び腎結石症の治療方法及び治療用組成物 |
| US20220175851A1 (en) * | 2019-03-13 | 2022-06-09 | The Regents Of The University California | Compositions, methods for regulating uterine, placental growth |
| CN110122866A (zh) * | 2019-05-31 | 2019-08-16 | 广东双骏生物科技有限公司 | 一种慢性肾脏病血管钙化的特殊医学用途食品及制备方法 |
| TR202002698A2 (tr) * | 2020-02-21 | 2021-09-21 | Montero Gida Sanayi Ve Ticaret Anonim Sirketi | Kemoterapi̇ ve/veya radyoterapi̇ alan ve/veya cerrahi̇ öncesi̇ ve |
| WO2023275183A1 (en) | 2021-06-29 | 2023-01-05 | Kappa Bioscience As | Composition comprising vitamin k, vitamin d, xanthophyll and epa and/or dha |
| CN115989871A (zh) * | 2021-10-20 | 2023-04-21 | 安琪纽特股份有限公司 | 一种促进生长发育的组合物及其制备方法和应用 |
| CN115590198B (zh) * | 2022-09-26 | 2024-06-18 | 黑龙江飞鹤乳业有限公司 | 核苷酸的用途、营养组合物、食品及其用途 |
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| US5132113A (en) * | 1990-10-26 | 1992-07-21 | Maurizio Luca | Nutritional composition containing essential amino acids |
| EP0689835A3 (en) * | 1994-06-30 | 1996-04-17 | Ajinomoto Kk | Composition containing an amino acid mixture and at least one N-3 fatty acid |
| AU2804297A (en) * | 1996-04-22 | 1997-11-12 | Advanced Polymer Systems Inc. | Method of and composition for treating disorders of the skin using vitamin k |
| JP3459932B2 (ja) * | 1996-07-23 | 2003-10-27 | 株式会社ホーネンコーポレーション | 抗骨粗鬆症組成物 |
| EP1054066B1 (en) * | 1999-05-18 | 2007-10-17 | Nipro Corporation | Method for anticipating sensitivity to medicine for osteoporosis and a reagent therefor |
| ATE361001T1 (de) * | 2000-05-12 | 2007-05-15 | Vitak Bv | Nahrungsmittel enthaltend vitamin k2 |
| NZ507335A (en) * | 2000-10-05 | 2004-10-29 | New Zealand Dairy Board | Bone health compositions derived from milk comprising an acidic protein fraction but that does not contain CGMP |
| GB2370503A (en) * | 2000-12-27 | 2002-07-03 | Novartis Nutrition Ag | Compositions comprising vitamin K |
| JP4131443B2 (ja) * | 2001-08-27 | 2008-08-13 | 株式会社Ｊ−オイルミルズ | 抗骨粗鬆症組成物 |
| JP2004155658A (ja) * | 2002-11-01 | 2004-06-03 | Kyowa Hakko Kogyo Co Ltd | ＴＮＦ−α産生抑制剤 |
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| JPWO2005107731A1 (ja) * | 2004-05-12 | 2008-03-21 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ビタミンｋ２を有効成分として含む治療剤 |
| AU2005249147B2 (en) * | 2004-06-04 | 2011-03-24 | Poly Gain Pte Ltd | Natural sweetener |
| US20060223730A1 (en) * | 2005-04-04 | 2006-10-05 | Hl Distribution Company | Calcium supplements |
| JP2006325487A (ja) * | 2005-05-26 | 2006-12-07 | Pola Chem Ind Inc | 栄養補給用固形食品 |
| WO2006126541A1 (ja) * | 2005-05-27 | 2006-11-30 | Shionogi & Co., Ltd. | ビタミンｋ類含有医薬組成物 |
| BE1016895A6 (fr) * | 2005-12-16 | 2007-09-04 | Psaltopoulos Emmanuel | MOLECULE INCORPORANT LE CALCIUM (CA), LA VITAMINE "D" ET LA VITAMINE "K" POUR LA PREVENTION ET LE TRAITEMENT DE l'OSTEOPOROSE AINSI QUE POUR LA PREVENTION DE LA CALCIFICATION VASCULAIRE ET POUR LA PREVENTION DE LA CALCIFICATION DU CARTILAGE DES ARTICULATIONS. |
| EP1986655A4 (en) * | 2006-02-06 | 2009-12-23 | Tethys Bioscience Inc | MARKERS ASSOCIATED WITH OSTEOPOROSIS AND METHODS OF USE |
| US9011930B2 (en) * | 2006-05-01 | 2015-04-21 | Zycal Bioceuticals Healthcare Company, Inc. | Nutritional supplement and use thereof |
| NZ574882A (en) * | 2006-07-14 | 2012-08-31 | Nattopharma Asa | Pharmaceutical and nutraceutical products comprising vitamin k2 |
| FR2906816B1 (fr) * | 2006-10-04 | 2012-04-06 | Gervais Danone Sa | Variants de bacteries lactiques utiles pour produire la vitamine k2 et leurs applications a la preparation de produits alimentaires |
| US20080220094A1 (en) * | 2006-11-01 | 2008-09-11 | Wyeth | Compositions and methods for the treatment and/or prevention of osteoporosis |
| RU2454997C2 (ru) * | 2007-07-24 | 2012-07-10 | Виридис Байофарма Пвт Лтд. | Лечение болезненных состояний и заболеваний человека с использованием аналогов и производных витамина к |
| NL1034964C2 (nl) * | 2008-01-28 | 2009-07-30 | Friesland Brands Bv | Werkwijze en composities voor de behandeling van botaandoeningen. |
| WO2009105234A2 (en) * | 2008-02-19 | 2009-08-27 | Combinatorx, Incorporated | Methods and compositions for the treatment of disorders associated with defects of the cystic fibrosis transmembrane conductance regulator gene or protein |
| US8815953B2 (en) * | 2008-03-13 | 2014-08-26 | Spectrum Pharmaceuticals, Inc. | Formulations of vitamin K analogs for topical use |
| ES2669004T3 (es) * | 2009-09-14 | 2018-05-23 | Nestec S.A. | Composiciones nutricionales para modular la inflamación, que incluyen vitamina K2 exógena |
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2010
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- 2010-09-01 AU AU2010292439A patent/AU2010292439A1/en not_active Abandoned
- 2010-09-01 RU RU2012114832/13A patent/RU2012114832A/ru not_active Application Discontinuation
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- 2010-09-01 BR BR112012005783A patent/BR112012005783A2/pt not_active IP Right Cessation
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2012
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2013
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2015
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2016
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| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20140905 |