ZA201202711B - Nutritional compositions for modulating inflammation including exogenous vitamin k2 - Google Patents
Nutritional compositions for modulating inflammation including exogenous vitamin k2Info
- Publication number
- ZA201202711B ZA201202711B ZA2012/02711A ZA201202711A ZA201202711B ZA 201202711 B ZA201202711 B ZA 201202711B ZA 2012/02711 A ZA2012/02711 A ZA 2012/02711A ZA 201202711 A ZA201202711 A ZA 201202711A ZA 201202711 B ZA201202711 B ZA 201202711B
- Authority
- ZA
- South Africa
- Prior art keywords
- nutritional compositions
- inflammation including
- modulating inflammation
- including exogenous
- exogenous vitamin
- Prior art date
Links
- 206010061218 Inflammation Diseases 0.000 title 1
- 230000004054 inflammatory process Effects 0.000 title 1
- DKHGMERMDICWDU-GHDNBGIDSA-N menaquinone-4 Chemical compound C1=CC=C2C(=O)C(C/C=C(C)/CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)=C(C)C(=O)C2=C1 DKHGMERMDICWDU-GHDNBGIDSA-N 0.000 title 1
- 229960005481 menatetrenone Drugs 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 235000016709 nutrition Nutrition 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
- A23L2/52—Adding ingredients
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/175—Amino acids
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
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- A—HUMAN NECESSITIES
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- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
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- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K33/32—Manganese; Compounds thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P3/02—Nutrients, e.g. vitamins, minerals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/26—Androgens
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Organic Chemistry (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Zoology (AREA)
- Analytical Chemistry (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Pediatric Medicine (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- Pathology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24208709P | 2009-09-14 | 2009-09-14 | |
| US25084709P | 2009-10-12 | 2009-10-12 | |
| US34794510P | 2010-05-25 | 2010-05-25 | |
| US37184610P | 2010-08-09 | 2010-08-09 | |
| PCT/US2010/047468 WO2011031602A1 (en) | 2009-09-14 | 2010-09-01 | Nutritional compositions for modulating inflammation including exogenous vitamin k2 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA201202711B true ZA201202711B (en) | 2014-10-29 |
Family
ID=43098924
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA2012/02711A ZA201202711B (en) | 2009-09-14 | 2012-04-13 | Nutritional compositions for modulating inflammation including exogenous vitamin k2 |
| ZA2012/02712A ZA201202712B (en) | 2009-09-14 | 2012-04-13 | Nutritional compositions including exogenous vitamin k2 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA2012/02712A ZA201202712B (en) | 2009-09-14 | 2012-04-13 | Nutritional compositions including exogenous vitamin k2 |
Country Status (17)
| Country | Link |
|---|---|
| US (5) | US20130052274A1 (https=) |
| EP (2) | EP2477510B1 (https=) |
| JP (3) | JP2013504571A (https=) |
| CN (2) | CN102596190A (https=) |
| AU (2) | AU2010292439A1 (https=) |
| BR (1) | BR112012005783A2 (https=) |
| CA (2) | CA2773940A1 (https=) |
| DK (1) | DK2477510T3 (https=) |
| ES (1) | ES2669004T3 (https=) |
| IN (2) | IN2012DN02245A (https=) |
| MX (2) | MX2012003080A (https=) |
| PH (2) | PH12012500488A1 (https=) |
| RU (2) | RU2012114832A (https=) |
| SG (2) | SG179065A1 (https=) |
| TR (1) | TR201808128T4 (https=) |
| WO (2) | WO2011031602A1 (https=) |
| ZA (2) | ZA201202711B (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130028864A1 (en) * | 1998-04-08 | 2013-01-31 | Theta Biomedical Consulting & Development Co., Inc. | Anti-inflammatory compositions for treating brain inflammation |
| ES2669004T3 (es) * | 2009-09-14 | 2018-05-23 | Nestec S.A. | Composiciones nutricionales para modular la inflamación, que incluyen vitamina K2 exógena |
| CN103491804A (zh) * | 2011-04-18 | 2014-01-01 | 雀巢产品技术援助有限公司 | 具有α-HICA 和二十碳五烯酸的营养组合物 |
| US8183227B1 (en) | 2011-07-07 | 2012-05-22 | Chemo S. A. France | Compositions, kits and methods for nutrition supplementation |
| US8168611B1 (en) | 2011-09-29 | 2012-05-01 | Chemo S.A. France | Compositions, kits and methods for nutrition supplementation |
| CN102772401A (zh) * | 2011-10-02 | 2012-11-14 | 南京大学 | 鼠尾草酚的抗骨质疏松新用途 |
| WO2013144267A2 (en) * | 2012-03-29 | 2013-10-03 | Nestec S.A. | Improvement of musculoskeletal health by nutrition and exercise |
| WO2013144268A1 (en) * | 2012-03-29 | 2013-10-03 | Nestec S.A. | Nutrition and exercise against drug-associated malnutrition in children |
| JP6368306B2 (ja) * | 2012-07-31 | 2018-08-01 | ネステク ソシエテ アノニム | 炎症性腸疾患(ibd)患者の筋骨格の健康を促進させるための栄養組成物 |
| CN104717968A (zh) | 2012-09-11 | 2015-06-17 | 达科他星都有限公司 | 含铁的营养补充剂 |
| CN103142640A (zh) * | 2013-04-01 | 2013-06-12 | 李拖平 | 含有维生素k2的具有预防与治疗骨质疏松症的保健品 |
| WO2017114686A1 (en) * | 2015-12-30 | 2017-07-06 | Nestec S.A. | Method for determining fat free body mass |
| CN105815791B (zh) * | 2016-03-24 | 2018-12-18 | 刘超 | 一种具有增肌功能并消除不良反应的组合物 |
| JP2019517482A (ja) * | 2016-06-02 | 2019-06-24 | アナ ファーマシューティカルズ, インコーポレイテッドAna Pharmaceuticals, Inc. | 高カルシウム尿症及び腎結石症の治療方法及び治療用組成物 |
| US20220175851A1 (en) * | 2019-03-13 | 2022-06-09 | The Regents Of The University California | Compositions, methods for regulating uterine, placental growth |
| CN110122866A (zh) * | 2019-05-31 | 2019-08-16 | 广东双骏生物科技有限公司 | 一种慢性肾脏病血管钙化的特殊医学用途食品及制备方法 |
| TR202002698A2 (tr) * | 2020-02-21 | 2021-09-21 | Montero Gida Sanayi Ve Ticaret Anonim Sirketi | Kemoterapi̇ ve/veya radyoterapi̇ alan ve/veya cerrahi̇ öncesi̇ ve |
| WO2023275183A1 (en) | 2021-06-29 | 2023-01-05 | Kappa Bioscience As | Composition comprising vitamin k, vitamin d, xanthophyll and epa and/or dha |
| CN115989871A (zh) * | 2021-10-20 | 2023-04-21 | 安琪纽特股份有限公司 | 一种促进生长发育的组合物及其制备方法和应用 |
| CN115590198B (zh) * | 2022-09-26 | 2024-06-18 | 黑龙江飞鹤乳业有限公司 | 核苷酸的用途、营养组合物、食品及其用途 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US347945A (en) | 1886-08-24 | vavtu | ||
| US250847A (en) | 1881-12-13 | Vehicle-top | ||
| US242087A (en) | 1881-05-24 | Machine for making laps on belting | ||
| US371846A (en) | 1887-10-18 | Tennis-racket | ||
| JPH07119191B2 (ja) * | 1990-08-16 | 1995-12-20 | 株式会社日本触媒 | メナジオン亜硫酸水素塩の安定化方法及びメナジオン亜硫酸水素塩組成物 |
| US5132113A (en) * | 1990-10-26 | 1992-07-21 | Maurizio Luca | Nutritional composition containing essential amino acids |
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| AU2804297A (en) * | 1996-04-22 | 1997-11-12 | Advanced Polymer Systems Inc. | Method of and composition for treating disorders of the skin using vitamin k |
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| EP1054066B1 (en) * | 1999-05-18 | 2007-10-17 | Nipro Corporation | Method for anticipating sensitivity to medicine for osteoporosis and a reagent therefor |
| ATE361001T1 (de) * | 2000-05-12 | 2007-05-15 | Vitak Bv | Nahrungsmittel enthaltend vitamin k2 |
| NZ507335A (en) * | 2000-10-05 | 2004-10-29 | New Zealand Dairy Board | Bone health compositions derived from milk comprising an acidic protein fraction but that does not contain CGMP |
| GB2370503A (en) * | 2000-12-27 | 2002-07-03 | Novartis Nutrition Ag | Compositions comprising vitamin K |
| JP4131443B2 (ja) * | 2001-08-27 | 2008-08-13 | 株式会社J−オイルミルズ | 抗骨粗鬆症組成物 |
| JP2004155658A (ja) * | 2002-11-01 | 2004-06-03 | Kyowa Hakko Kogyo Co Ltd | TNF−α産生抑制剤 |
| WO2005030190A1 (en) * | 2003-09-26 | 2005-04-07 | Natural Asa | Natural menaquinone 7 compositions |
| JPWO2005107731A1 (ja) * | 2004-05-12 | 2008-03-21 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ビタミンk2を有効成分として含む治療剤 |
| AU2005249147B2 (en) * | 2004-06-04 | 2011-03-24 | Poly Gain Pte Ltd | Natural sweetener |
| US20060223730A1 (en) * | 2005-04-04 | 2006-10-05 | Hl Distribution Company | Calcium supplements |
| JP2006325487A (ja) * | 2005-05-26 | 2006-12-07 | Pola Chem Ind Inc | 栄養補給用固形食品 |
| WO2006126541A1 (ja) * | 2005-05-27 | 2006-11-30 | Shionogi & Co., Ltd. | ビタミンk類含有医薬組成物 |
| BE1016895A6 (fr) * | 2005-12-16 | 2007-09-04 | Psaltopoulos Emmanuel | MOLECULE INCORPORANT LE CALCIUM (CA), LA VITAMINE "D" ET LA VITAMINE "K" POUR LA PREVENTION ET LE TRAITEMENT DE l'OSTEOPOROSE AINSI QUE POUR LA PREVENTION DE LA CALCIFICATION VASCULAIRE ET POUR LA PREVENTION DE LA CALCIFICATION DU CARTILAGE DES ARTICULATIONS. |
| EP1986655A4 (en) * | 2006-02-06 | 2009-12-23 | Tethys Bioscience Inc | MARKERS ASSOCIATED WITH OSTEOPOROSIS AND METHODS OF USE |
| US9011930B2 (en) * | 2006-05-01 | 2015-04-21 | Zycal Bioceuticals Healthcare Company, Inc. | Nutritional supplement and use thereof |
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| FR2906816B1 (fr) * | 2006-10-04 | 2012-04-06 | Gervais Danone Sa | Variants de bacteries lactiques utiles pour produire la vitamine k2 et leurs applications a la preparation de produits alimentaires |
| US20080220094A1 (en) * | 2006-11-01 | 2008-09-11 | Wyeth | Compositions and methods for the treatment and/or prevention of osteoporosis |
| RU2454997C2 (ru) * | 2007-07-24 | 2012-07-10 | Виридис Байофарма Пвт Лтд. | Лечение болезненных состояний и заболеваний человека с использованием аналогов и производных витамина к |
| NL1034964C2 (nl) * | 2008-01-28 | 2009-07-30 | Friesland Brands Bv | Werkwijze en composities voor de behandeling van botaandoeningen. |
| WO2009105234A2 (en) * | 2008-02-19 | 2009-08-27 | Combinatorx, Incorporated | Methods and compositions for the treatment of disorders associated with defects of the cystic fibrosis transmembrane conductance regulator gene or protein |
| US8815953B2 (en) * | 2008-03-13 | 2014-08-26 | Spectrum Pharmaceuticals, Inc. | Formulations of vitamin K analogs for topical use |
| ES2669004T3 (es) * | 2009-09-14 | 2018-05-23 | Nestec S.A. | Composiciones nutricionales para modular la inflamación, que incluyen vitamina K2 exógena |
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2010
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- 2010-09-01 TR TR2018/08128T patent/TR201808128T4/tr unknown
- 2010-09-01 US US13/395,054 patent/US20130052274A1/en not_active Abandoned
- 2010-09-01 BR BR112012005783A patent/BR112012005783A2/pt not_active IP Right Cessation
- 2010-09-01 RU RU2012114786/15A patent/RU2012114786A/ru not_active Application Discontinuation
- 2010-09-01 US US13/395,060 patent/US20120208893A1/en not_active Abandoned
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