RU2010136988A - Антигенсвязывающие полипептиды против дегенерации хряща - Google Patents
Антигенсвязывающие полипептиды против дегенерации хряща Download PDFInfo
- Publication number
- RU2010136988A RU2010136988A RU2010136988/10A RU2010136988A RU2010136988A RU 2010136988 A RU2010136988 A RU 2010136988A RU 2010136988/10 A RU2010136988/10 A RU 2010136988/10A RU 2010136988 A RU2010136988 A RU 2010136988A RU 2010136988 A RU2010136988 A RU 2010136988A
- Authority
- RU
- Russia
- Prior art keywords
- binding polypeptide
- antigen binding
- polypeptide according
- antigen
- polypeptide
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title claims abstract 43
- 102000004196 processed proteins & peptides Human genes 0.000 title claims abstract 43
- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract 43
- 210000000845 cartilage Anatomy 0.000 title claims abstract 13
- 230000007850 degeneration Effects 0.000 title claims abstract 9
- 239000000427 antigen Substances 0.000 claims abstract 28
- 102000036639 antigens Human genes 0.000 claims abstract 28
- 108091007433 antigens Proteins 0.000 claims abstract 28
- 230000002265 prevention Effects 0.000 claims abstract 7
- 201000008482 osteoarthritis Diseases 0.000 claims abstract 4
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims abstract 3
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims abstract 3
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims abstract 3
- 238000004519 manufacturing process Methods 0.000 claims abstract 3
- 102000004127 Cytokines Human genes 0.000 claims abstract 2
- 108090000695 Cytokines Proteins 0.000 claims abstract 2
- 102000004190 Enzymes Human genes 0.000 claims abstract 2
- 108090000790 Enzymes Proteins 0.000 claims abstract 2
- 108010002352 Interleukin-1 Proteins 0.000 claims abstract 2
- 102000016611 Proteoglycans Human genes 0.000 claims abstract 2
- 108010067787 Proteoglycans Proteins 0.000 claims abstract 2
- 102000003675 cytokine receptors Human genes 0.000 claims abstract 2
- 108010057085 cytokine receptors Proteins 0.000 claims abstract 2
- 239000003814 drug Substances 0.000 claims abstract 2
- 239000000203 mixture Substances 0.000 claims 7
- 239000002552 dosage form Substances 0.000 claims 3
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 239000007864 aqueous solution Substances 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 238000010367 cloning Methods 0.000 claims 1
- 239000013599 cloning vector Substances 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000006174 pH buffer Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 238000013268 sustained release Methods 0.000 claims 1
- 239000012730 sustained-release form Substances 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2631708P | 2008-02-05 | 2008-02-05 | |
| US61/026,317 | 2008-02-05 | ||
| US8887608P | 2008-08-14 | 2008-08-14 | |
| US61/088,876 | 2008-08-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2010136988A true RU2010136988A (ru) | 2012-03-20 |
Family
ID=40568129
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2010136988/10A RU2010136988A (ru) | 2008-02-05 | 2009-02-05 | Антигенсвязывающие полипептиды против дегенерации хряща |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20110002927A1 (enExample) |
| EP (1) | EP2240515A1 (enExample) |
| JP (1) | JP2011510667A (enExample) |
| CN (1) | CN101939335B (enExample) |
| AU (1) | AU2009212079B2 (enExample) |
| BR (1) | BRPI0907485A2 (enExample) |
| CA (1) | CA2712965A1 (enExample) |
| IL (1) | IL206720A0 (enExample) |
| RU (1) | RU2010136988A (enExample) |
| WO (1) | WO2009097704A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013540757A (ja) | 2010-09-24 | 2013-11-07 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド | カプセル化された作用物質の放出を制御する能力を有するナノ構造ゲル |
| CN104231086B (zh) * | 2013-08-27 | 2019-12-13 | 北京韩美药品有限公司 | 双功能融合蛋白及其制备方法和用途 |
| SG11201604227XA (en) * | 2013-12-13 | 2016-07-28 | Mercury Asset Man Co Ltd | Articular cartilage imaging composition |
| EP3978022A1 (en) * | 2016-05-06 | 2022-04-06 | The Brigham and Women's Hospital, Inc. | Binary self assembled gels for controlled delivery of encapsulated agents to cartilage |
| US11839605B2 (en) | 2018-10-11 | 2023-12-12 | Alivio Therapeutics, Inc. | Non-injectable hydrogel formulations for smart release |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0013810D0 (en) * | 2000-06-06 | 2000-07-26 | Celltech Chiroscience Ltd | Biological products |
| ES2424042T3 (es) * | 2005-06-07 | 2013-09-26 | Esbatech - A Novartis Company Llc | Anticuerpos estables y solubles que inhiben TNF± |
| EP3093026B1 (en) * | 2006-07-10 | 2020-07-01 | ESBATech, an Alcon Biomedical Research Unit LLC | Scfv antibodies which pass epithelial and/or endothelial layers |
-
2009
- 2009-02-05 CA CA2712965A patent/CA2712965A1/en not_active Abandoned
- 2009-02-05 WO PCT/CH2009/000045 patent/WO2009097704A1/en not_active Ceased
- 2009-02-05 RU RU2010136988/10A patent/RU2010136988A/ru unknown
- 2009-02-05 JP JP2010545343A patent/JP2011510667A/ja active Pending
- 2009-02-05 US US12/865,365 patent/US20110002927A1/en not_active Abandoned
- 2009-02-05 BR BRPI0907485-6A patent/BRPI0907485A2/pt not_active Application Discontinuation
- 2009-02-05 CN CN200980104195.1A patent/CN101939335B/zh not_active Expired - Fee Related
- 2009-02-05 EP EP09707332A patent/EP2240515A1/en not_active Withdrawn
- 2009-02-05 AU AU2009212079A patent/AU2009212079B2/en not_active Ceased
-
2010
- 2010-06-30 IL IL206720A patent/IL206720A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2712965A1 (en) | 2009-08-13 |
| JP2011510667A (ja) | 2011-04-07 |
| CN101939335B (zh) | 2015-02-11 |
| EP2240515A1 (en) | 2010-10-20 |
| WO2009097704A1 (en) | 2009-08-13 |
| BRPI0907485A2 (pt) | 2015-08-04 |
| AU2009212079B2 (en) | 2012-08-30 |
| CN101939335A (zh) | 2011-01-05 |
| US20110002927A1 (en) | 2011-01-06 |
| AU2009212079A1 (en) | 2009-08-13 |
| IL206720A0 (en) | 2010-12-30 |
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