RU2010136988A - Антигенсвязывающие полипептиды против дегенерации хряща - Google Patents
Антигенсвязывающие полипептиды против дегенерации хряща Download PDFInfo
- Publication number
- RU2010136988A RU2010136988A RU2010136988/10A RU2010136988A RU2010136988A RU 2010136988 A RU2010136988 A RU 2010136988A RU 2010136988/10 A RU2010136988/10 A RU 2010136988/10A RU 2010136988 A RU2010136988 A RU 2010136988A RU 2010136988 A RU2010136988 A RU 2010136988A
- Authority
- RU
- Russia
- Prior art keywords
- binding polypeptide
- antigen binding
- polypeptide according
- antigen
- polypeptide
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title claims abstract 43
- 102000004196 processed proteins & peptides Human genes 0.000 title claims abstract 43
- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract 43
- 210000000845 cartilage Anatomy 0.000 title claims abstract 13
- 230000007850 degeneration Effects 0.000 title claims abstract 9
- 239000000427 antigen Substances 0.000 claims abstract 28
- 102000036639 antigens Human genes 0.000 claims abstract 28
- 108091007433 antigens Proteins 0.000 claims abstract 28
- 230000002265 prevention Effects 0.000 claims abstract 7
- 201000008482 osteoarthritis Diseases 0.000 claims abstract 4
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims abstract 3
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims abstract 3
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims abstract 3
- 238000004519 manufacturing process Methods 0.000 claims abstract 3
- 102000004127 Cytokines Human genes 0.000 claims abstract 2
- 108090000695 Cytokines Proteins 0.000 claims abstract 2
- 102000004190 Enzymes Human genes 0.000 claims abstract 2
- 108090000790 Enzymes Proteins 0.000 claims abstract 2
- 108010002352 Interleukin-1 Proteins 0.000 claims abstract 2
- 102000016611 Proteoglycans Human genes 0.000 claims abstract 2
- 108010067787 Proteoglycans Proteins 0.000 claims abstract 2
- 102000003675 cytokine receptors Human genes 0.000 claims abstract 2
- 108010057085 cytokine receptors Proteins 0.000 claims abstract 2
- 239000003814 drug Substances 0.000 claims abstract 2
- 239000000203 mixture Substances 0.000 claims 7
- 239000002552 dosage form Substances 0.000 claims 3
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 239000007864 aqueous solution Substances 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 238000010367 cloning Methods 0.000 claims 1
- 239000013599 cloning vector Substances 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000006174 pH buffer Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 238000013268 sustained release Methods 0.000 claims 1
- 239000012730 sustained-release form Substances 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2631708P | 2008-02-05 | 2008-02-05 | |
| US61/026,317 | 2008-02-05 | ||
| US8887608P | 2008-08-14 | 2008-08-14 | |
| US61/088,876 | 2008-08-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2010136988A true RU2010136988A (ru) | 2012-03-20 |
Family
ID=40568129
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2010136988/10A RU2010136988A (ru) | 2008-02-05 | 2009-02-05 | Антигенсвязывающие полипептиды против дегенерации хряща |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20110002927A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2240515A1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2011510667A (cg-RX-API-DMAC7.html) |
| CN (1) | CN101939335B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2009212079B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0907485A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2712965A1 (cg-RX-API-DMAC7.html) |
| IL (1) | IL206720A0 (cg-RX-API-DMAC7.html) |
| RU (1) | RU2010136988A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2009097704A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012040623A2 (en) | 2010-09-24 | 2012-03-29 | The Brigham And Women's Hospital, Inc. | Nanostructured gels capable of controlled release of encapsulated agents |
| CN104231086B (zh) * | 2013-08-27 | 2019-12-13 | 北京韩美药品有限公司 | 双功能融合蛋白及其制备方法和用途 |
| EP3081234B1 (en) | 2013-12-13 | 2020-04-08 | Mercury Asset Management Co., Ltd. | Articular cartilage imaging composition |
| EP3978022A1 (en) * | 2016-05-06 | 2022-04-06 | The Brigham and Women's Hospital, Inc. | Binary self assembled gels for controlled delivery of encapsulated agents to cartilage |
| CA3113948A1 (en) | 2018-10-11 | 2020-04-16 | Alivio Therapeutics, Inc. | Non-injectable hydrogel formulations for smart release |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0013810D0 (en) * | 2000-06-06 | 2000-07-26 | Celltech Chiroscience Ltd | Biological products |
| ES2424042T3 (es) * | 2005-06-07 | 2013-09-26 | Esbatech - A Novartis Company Llc | Anticuerpos estables y solubles que inhiben TNF± |
| LT2046382T (lt) * | 2006-07-10 | 2016-12-12 | Esbatech, An Alcon Biomedical Research Unit Llc | Scfv antikūnai, pereinantys epitelio ir (arba) endotelio sluoksnius |
-
2009
- 2009-02-05 US US12/865,365 patent/US20110002927A1/en not_active Abandoned
- 2009-02-05 EP EP09707332A patent/EP2240515A1/en not_active Withdrawn
- 2009-02-05 CN CN200980104195.1A patent/CN101939335B/zh not_active Expired - Fee Related
- 2009-02-05 CA CA2712965A patent/CA2712965A1/en not_active Abandoned
- 2009-02-05 WO PCT/CH2009/000045 patent/WO2009097704A1/en not_active Ceased
- 2009-02-05 RU RU2010136988/10A patent/RU2010136988A/ru unknown
- 2009-02-05 BR BRPI0907485-6A patent/BRPI0907485A2/pt not_active Application Discontinuation
- 2009-02-05 AU AU2009212079A patent/AU2009212079B2/en not_active Ceased
- 2009-02-05 JP JP2010545343A patent/JP2011510667A/ja active Pending
-
2010
- 2010-06-30 IL IL206720A patent/IL206720A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2240515A1 (en) | 2010-10-20 |
| BRPI0907485A2 (pt) | 2015-08-04 |
| IL206720A0 (en) | 2010-12-30 |
| WO2009097704A1 (en) | 2009-08-13 |
| CN101939335B (zh) | 2015-02-11 |
| AU2009212079B2 (en) | 2012-08-30 |
| AU2009212079A1 (en) | 2009-08-13 |
| US20110002927A1 (en) | 2011-01-06 |
| CN101939335A (zh) | 2011-01-05 |
| CA2712965A1 (en) | 2009-08-13 |
| JP2011510667A (ja) | 2011-04-07 |
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