RU2010123876A - Гетероциклические производные в качестве модуляторов ионных каналов - Google Patents
Гетероциклические производные в качестве модуляторов ионных каналов Download PDFInfo
- Publication number
- RU2010123876A RU2010123876A RU2010123876/04A RU2010123876A RU2010123876A RU 2010123876 A RU2010123876 A RU 2010123876A RU 2010123876/04 A RU2010123876/04 A RU 2010123876/04A RU 2010123876 A RU2010123876 A RU 2010123876A RU 2010123876 A RU2010123876 A RU 2010123876A
- Authority
- RU
- Russia
- Prior art keywords
- pain
- compound according
- acute
- aliphatic group
- halogen
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 claims abstract 26
- 238000000034 method Methods 0.000 claims abstract 4
- 239000000203 mixture Substances 0.000 claims abstract 3
- 208000002193 Pain Diseases 0.000 claims 36
- 230000036407 pain Effects 0.000 claims 29
- 229910052739 hydrogen Inorganic materials 0.000 claims 10
- 239000001257 hydrogen Substances 0.000 claims 9
- 229910052736 halogen Inorganic materials 0.000 claims 8
- 150000002367 halogens Chemical class 0.000 claims 8
- 230000001154 acute effect Effects 0.000 claims 7
- 150000002431 hydrogen Chemical class 0.000 claims 6
- 208000004296 neuralgia Diseases 0.000 claims 6
- 230000001684 chronic effect Effects 0.000 claims 5
- 208000008035 Back Pain Diseases 0.000 claims 4
- 208000005298 acute pain Diseases 0.000 claims 4
- 208000021722 neuropathic pain Diseases 0.000 claims 4
- 208000000094 Chronic Pain Diseases 0.000 claims 3
- 208000023890 Complex Regional Pain Syndromes Diseases 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 208000019695 Migraine disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 206010027599 migraine Diseases 0.000 claims 3
- 201000006417 multiple sclerosis Diseases 0.000 claims 3
- 230000002981 neuropathic effect Effects 0.000 claims 3
- 208000009935 visceral pain Diseases 0.000 claims 3
- 208000004998 Abdominal Pain Diseases 0.000 claims 2
- 206010002383 Angina Pectoris Diseases 0.000 claims 2
- 208000006820 Arthralgia Diseases 0.000 claims 2
- 208000006561 Cluster Headache Diseases 0.000 claims 2
- 208000032131 Diabetic Neuropathies Diseases 0.000 claims 2
- 206010019233 Headaches Diseases 0.000 claims 2
- 208000005615 Interstitial Cystitis Diseases 0.000 claims 2
- 206010028836 Neck pain Diseases 0.000 claims 2
- 206010036376 Postherpetic Neuralgia Diseases 0.000 claims 2
- 208000004550 Postoperative Pain Diseases 0.000 claims 2
- 208000006011 Stroke Diseases 0.000 claims 2
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 230000006378 damage Effects 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 2
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 2
- 201000008482 osteoarthritis Diseases 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- VLLMWSRANPNYQX-UHFFFAOYSA-N thiadiazole Chemical compound C1=CSN=N1.C1=CSN=N1 VLLMWSRANPNYQX-UHFFFAOYSA-N 0.000 claims 2
- 206010044652 trigeminal neuralgia Diseases 0.000 claims 2
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- 206010003011 Appendicitis Diseases 0.000 claims 1
- 206010003591 Ataxia Diseases 0.000 claims 1
- 206010005063 Bladder pain Diseases 0.000 claims 1
- 206010006002 Bone pain Diseases 0.000 claims 1
- 201000006474 Brain Ischemia Diseases 0.000 claims 1
- 206010058019 Cancer Pain Diseases 0.000 claims 1
- 206010064012 Central pain syndrome Diseases 0.000 claims 1
- 206010008120 Cerebral ischaemia Diseases 0.000 claims 1
- 206010008479 Chest Pain Diseases 0.000 claims 1
- 201000009273 Endometriosis Diseases 0.000 claims 1
- 208000024720 Fabry Disease Diseases 0.000 claims 1
- 206010016059 Facial pain Diseases 0.000 claims 1
- 208000001640 Fibromyalgia Diseases 0.000 claims 1
- 208000035895 Guillain-Barré syndrome Diseases 0.000 claims 1
- 206010019909 Hernia Diseases 0.000 claims 1
- 208000007514 Herpes zoster Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 206010021639 Incontinence Diseases 0.000 claims 1
- 206010065390 Inflammatory pain Diseases 0.000 claims 1
- 208000007914 Labor Pain Diseases 0.000 claims 1
- 206010024229 Leprosy Diseases 0.000 claims 1
- 206010049567 Miller Fisher syndrome Diseases 0.000 claims 1
- 208000019430 Motor disease Diseases 0.000 claims 1
- 208000030858 Myofascial Pain Syndromes Diseases 0.000 claims 1
- 206010061533 Myotonia Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000005890 Neuroma Diseases 0.000 claims 1
- 208000001294 Nociceptive Pain Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 206010033557 Palpitations Diseases 0.000 claims 1
- 206010033645 Pancreatitis Diseases 0.000 claims 1
- 206010033647 Pancreatitis acute Diseases 0.000 claims 1
- 208000000450 Pelvic Pain Diseases 0.000 claims 1
- 208000004983 Phantom Limb Diseases 0.000 claims 1
- 206010056238 Phantom pain Diseases 0.000 claims 1
- 206010037596 Pyelonephritis Diseases 0.000 claims 1
- 206010059604 Radicular pain Diseases 0.000 claims 1
- 206010037779 Radiculopathy Diseases 0.000 claims 1
- 206010038419 Renal colic Diseases 0.000 claims 1
- 208000008765 Sciatica Diseases 0.000 claims 1
- 208000034189 Sclerosis Diseases 0.000 claims 1
- 206010040037 Sensory neuropathy hereditary Diseases 0.000 claims 1
- 208000000491 Tendinopathy Diseases 0.000 claims 1
- 206010043255 Tendonitis Diseases 0.000 claims 1
- 206010043269 Tension headache Diseases 0.000 claims 1
- 208000008548 Tension-Type Headache Diseases 0.000 claims 1
- 208000030886 Traumatic Brain injury Diseases 0.000 claims 1
- 206010046543 Urinary incontinence Diseases 0.000 claims 1
- 208000025609 Urogenital disease Diseases 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 201000003229 acute pancreatitis Diseases 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 206010003119 arrhythmia Diseases 0.000 claims 1
- 230000006793 arrhythmia Effects 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 208000034757 axonal type 2FF Charcot-Marie-Tooth disease Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 206010008118 cerebral infarction Diseases 0.000 claims 1
- 238000002512 chemotherapy Methods 0.000 claims 1
- 230000035606 childbirth Effects 0.000 claims 1
- 201000001352 cholecystitis Diseases 0.000 claims 1
- 208000012696 congenital leptin deficiency Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 206010015037 epilepsy Diseases 0.000 claims 1
- 230000001037 epileptic effect Effects 0.000 claims 1
- 201000011384 erythromelalgia Diseases 0.000 claims 1
- 230000005176 gastrointestinal motility Effects 0.000 claims 1
- 231100000869 headache Toxicity 0.000 claims 1
- 208000037584 hereditary sensory and autonomic neuropathy Diseases 0.000 claims 1
- 201000006847 hereditary sensory neuropathy Diseases 0.000 claims 1
- 208000013403 hyperactivity Diseases 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 208000003243 intestinal obstruction Diseases 0.000 claims 1
- 208000001022 morbid obesity Diseases 0.000 claims 1
- 210000002346 musculoskeletal system Anatomy 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 208000015706 neuroendocrine disease Diseases 0.000 claims 1
- 201000001119 neuropathy Diseases 0.000 claims 1
- 230000007823 neuropathy Effects 0.000 claims 1
- 210000000496 pancreas Anatomy 0.000 claims 1
- 210000000578 peripheral nerve Anatomy 0.000 claims 1
- 208000033808 peripheral neuropathy Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 208000001297 phlebitis Diseases 0.000 claims 1
- 201000007094 prostatitis Diseases 0.000 claims 1
- 208000020016 psychiatric disease Diseases 0.000 claims 1
- 238000001959 radiotherapy Methods 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 230000028327 secretion Effects 0.000 claims 1
- 208000007056 sickle cell anemia Diseases 0.000 claims 1
- 201000009890 sinusitis Diseases 0.000 claims 1
- 210000000278 spinal cord Anatomy 0.000 claims 1
- 208000005198 spinal stenosis Diseases 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 210000001738 temporomandibular joint Anatomy 0.000 claims 1
- 201000004415 tendinitis Diseases 0.000 claims 1
- 208000004371 toothache Diseases 0.000 claims 1
- 230000008733 trauma Effects 0.000 claims 1
- 230000009529 traumatic brain injury Effects 0.000 claims 1
- 230000000472 traumatic effect Effects 0.000 claims 1
- 208000026533 urinary bladder disease Diseases 0.000 claims 1
- 102000004310 Ion Channels Human genes 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 0 *c1c(*)c(*)c(CN(CC2)[C@@](CCN3c(cc4)ccc4S(NC4CCCCCCCC4)(=O)=O)C3=O)c2c1* Chemical compound *c1c(*)c(*)c(CN(CC2)[C@@](CCN3c(cc4)ccc4S(NC4CCCCCCCC4)(=O)=O)C3=O)c2c1* 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
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Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Psychology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Steroid Compounds (AREA)
- Cosmetics (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98749007P | 2007-11-13 | 2007-11-13 | |
| US60/987,490 | 2007-11-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2010123876A true RU2010123876A (ru) | 2011-12-20 |
Family
ID=40298764
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2010123876/04A RU2010123876A (ru) | 2007-11-13 | 2008-11-12 | Гетероциклические производные в качестве модуляторов ионных каналов |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8097636B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2220080B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2011503191A (cg-RX-API-DMAC7.html) |
| KR (1) | KR20100101601A (cg-RX-API-DMAC7.html) |
| CN (1) | CN101910166A (cg-RX-API-DMAC7.html) |
| AT (1) | ATE540036T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2008321142A1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2705547A1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2377172T3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL205696A0 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2010005307A (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ585729A (cg-RX-API-DMAC7.html) |
| RU (1) | RU2010123876A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2009064752A2 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA201003352B (cg-RX-API-DMAC7.html) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7615563B2 (en) * | 2003-08-08 | 2009-11-10 | Gonzalez Iii Jesus E | Compositions useful as inhibitors of voltage-gated sodium channels |
| KR20080021030A (ko) * | 2005-05-16 | 2008-03-06 | 버텍스 파마슈티칼스 인코포레이티드 | 이온 채널 조절인자로서의 바이사이클릭 유도체 |
| CA2622076A1 (en) * | 2005-09-09 | 2007-03-15 | Vertex Pharmaceuticals Incorporated | Bicyclic derivatives as modulators of voltage gated ion channels |
| JP2009512717A (ja) * | 2005-10-21 | 2009-03-26 | バーテックス ファーマシューティカルズ インコーポレイテッド | イオンチャネルを調節するための誘導体 |
| CA2687764A1 (en) | 2007-05-25 | 2008-12-04 | Vertex Pharmaceuticals Incorporated | Ion channel modulators and methods of use |
| US7994174B2 (en) * | 2007-09-19 | 2011-08-09 | Vertex Pharmaceuticals Incorporated | Pyridyl sulfonamides as modulators of ion channels |
| JP2011503112A (ja) * | 2007-11-13 | 2011-01-27 | バーテックス ファーマシューティカルズ インコーポレイテッド | 疼痛の処置のためのイオンチャンネルのモジュレーターとしての４（−３−（−２−（フェニル）モルホリノ）−２−オキソピロリジン−１−イル）−ｎ−（チアゾール−２−イル）ベンゼンスルホンアミド誘導体および関連化合物 |
| WO2010002956A2 (en) * | 2008-07-01 | 2010-01-07 | Vertex Pharmaceuticals Incorporated | Heterocyclic derivatives as modulators of ion channels |
| AU2013209958B2 (en) * | 2012-01-16 | 2017-09-07 | Vertex Pharmaceuticals Incorporated | Pyran-spirocyclic piperidine amides as modulators of ion channels |
| CN106045908B (zh) * | 2016-06-14 | 2018-09-28 | 郑州轻工业学院 | 一种新型化合物6,7-二溴-1,2,3,4-四氢异喹啉及其制备方法 |
| CA3070036A1 (en) | 2017-07-21 | 2019-01-24 | Antabio Sas | Chemical compounds |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH666623A5 (de) * | 1985-05-17 | 1988-08-15 | Idc Chemie Ag | Vorrichtung zur behandlung von brandwunden oder verbruehungen. |
| US7615563B2 (en) | 2003-08-08 | 2009-11-10 | Gonzalez Iii Jesus E | Compositions useful as inhibitors of voltage-gated sodium channels |
| CA2539227A1 (en) | 2003-08-08 | 2005-02-17 | Vertex Pharmaceuticals Incorporated | Heteroarylaminosulfonylphenyl derivatives for use as sodium or calcium channel blockers in the treatment of pain |
| EP1891063B1 (en) | 2005-05-10 | 2012-07-25 | Vertex Pharmaceuticals, Inc. | Bicyclic derivatives as modulators of ion channels |
| KR20080021030A (ko) | 2005-05-16 | 2008-03-06 | 버텍스 파마슈티칼스 인코포레이티드 | 이온 채널 조절인자로서의 바이사이클릭 유도체 |
| MX2007015726A (es) | 2005-06-09 | 2008-03-04 | Vertex Pharma | Derivados de indano como moduladores de canales ionicos. |
| CA2622076A1 (en) | 2005-09-09 | 2007-03-15 | Vertex Pharmaceuticals Incorporated | Bicyclic derivatives as modulators of voltage gated ion channels |
| WO2007047474A2 (en) | 2005-10-12 | 2007-04-26 | Vertex Pharmaceuticals Incorporated | Biphenyl derivatives as modulators of voltage gated ion channels |
| JP2009512717A (ja) | 2005-10-21 | 2009-03-26 | バーテックス ファーマシューティカルズ インコーポレイテッド | イオンチャネルを調節するための誘導体 |
| TW200740803A (en) | 2005-12-21 | 2007-11-01 | Vertex Pharma | Heterocyclic derivatives as modulators of ion channels |
| CA2687764A1 (en) | 2007-05-25 | 2008-12-04 | Vertex Pharmaceuticals Incorporated | Ion channel modulators and methods of use |
| US7994174B2 (en) | 2007-09-19 | 2011-08-09 | Vertex Pharmaceuticals Incorporated | Pyridyl sulfonamides as modulators of ion channels |
| JP2011503112A (ja) | 2007-11-13 | 2011-01-27 | バーテックス ファーマシューティカルズ インコーポレイテッド | 疼痛の処置のためのイオンチャンネルのモジュレーターとしての４（−３−（−２−（フェニル）モルホリノ）−２−オキソピロリジン−１−イル）−ｎ−（チアゾール−２−イル）ベンゼンスルホンアミド誘導体および関連化合物 |
| WO2010002956A2 (en) | 2008-07-01 | 2010-01-07 | Vertex Pharmaceuticals Incorporated | Heterocyclic derivatives as modulators of ion channels |
-
2008
- 2008-11-12 MX MX2010005307A patent/MX2010005307A/es active IP Right Grant
- 2008-11-12 KR KR1020107012966A patent/KR20100101601A/ko not_active Withdrawn
- 2008-11-12 AT AT08848685T patent/ATE540036T1/de active
- 2008-11-12 CA CA2705547A patent/CA2705547A1/en not_active Abandoned
- 2008-11-12 RU RU2010123876/04A patent/RU2010123876A/ru not_active Application Discontinuation
- 2008-11-12 EP EP08848685A patent/EP2220080B1/en not_active Not-in-force
- 2008-11-12 WO PCT/US2008/083173 patent/WO2009064752A2/en not_active Ceased
- 2008-11-12 NZ NZ585729A patent/NZ585729A/en not_active IP Right Cessation
- 2008-11-12 US US12/269,109 patent/US8097636B2/en active Active
- 2008-11-12 AU AU2008321142A patent/AU2008321142A1/en not_active Abandoned
- 2008-11-12 JP JP2010534132A patent/JP2011503191A/ja not_active Withdrawn
- 2008-11-12 ES ES08848685T patent/ES2377172T3/es active Active
- 2008-11-12 CN CN2008801223353A patent/CN101910166A/zh active Pending
-
2010
- 2010-05-11 IL IL205696A patent/IL205696A0/en unknown
- 2010-05-12 ZA ZA2010/03352A patent/ZA201003352B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009064752A2 (en) | 2009-05-22 |
| CN101910166A (zh) | 2010-12-08 |
| CA2705547A1 (en) | 2009-05-22 |
| EP2220080A2 (en) | 2010-08-25 |
| US8097636B2 (en) | 2012-01-17 |
| AU2008321142A1 (en) | 2009-05-22 |
| EP2220080B1 (en) | 2012-01-04 |
| AU2008321142A8 (en) | 2010-06-24 |
| MX2010005307A (es) | 2010-07-28 |
| NZ585729A (en) | 2012-04-27 |
| WO2009064752A3 (en) | 2009-08-27 |
| ZA201003352B (en) | 2011-08-31 |
| ATE540036T1 (de) | 2012-01-15 |
| IL205696A0 (en) | 2010-11-30 |
| US20090124655A1 (en) | 2009-05-14 |
| JP2011503191A (ja) | 2011-01-27 |
| KR20100101601A (ko) | 2010-09-17 |
| ES2377172T3 (es) | 2012-03-23 |
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