RU2010101001A - Микроорганизмы с дерегулированной системой витамина в12 - Google Patents
Микроорганизмы с дерегулированной системой витамина в12 Download PDFInfo
- Publication number
- RU2010101001A RU2010101001A RU2010101001/10A RU2010101001A RU2010101001A RU 2010101001 A RU2010101001 A RU 2010101001A RU 2010101001/10 A RU2010101001/10 A RU 2010101001/10A RU 2010101001 A RU2010101001 A RU 2010101001A RU 2010101001 A RU2010101001 A RU 2010101001A
- Authority
- RU
- Russia
- Prior art keywords
- microorganism
- abc
- protein
- genetic change
- seq
- Prior art date
Links
- 244000005700 microbiome Species 0.000 title claims abstract 26
- FDJOLVPMNUYSCM-UVKKECPRSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7, Chemical compound [Co+3].N#[C-].C1([C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)[N-]\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O FDJOLVPMNUYSCM-UVKKECPRSA-L 0.000 title 1
- 230000001419 dependent effect Effects 0.000 title 1
- 230000002068 genetic effect Effects 0.000 claims abstract 23
- 108010078791 Carrier Proteins Proteins 0.000 claims abstract 15
- 108090000623 proteins and genes Proteins 0.000 claims abstract 15
- 102000004169 proteins and genes Human genes 0.000 claims abstract 15
- 230000000694 effects Effects 0.000 claims abstract 10
- 108091028043 Nucleic acid sequence Proteins 0.000 claims abstract 9
- 229930003779 Vitamin B12 Natural products 0.000 claims abstract 9
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 claims abstract 9
- 239000011715 vitamin B12 Substances 0.000 claims abstract 9
- 235000019163 vitamin B12 Nutrition 0.000 claims abstract 9
- 230000001105 regulatory effect Effects 0.000 claims abstract 8
- 150000001875 compounds Chemical class 0.000 claims abstract 6
- 230000002222 downregulating effect Effects 0.000 claims abstract 4
- 230000002074 deregulated effect Effects 0.000 claims abstract 3
- 238000010521 absorption reaction Methods 0.000 claims 6
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 230000003828 downregulation Effects 0.000 claims 3
- 101100130094 Bacillus subtilis (strain 168) metK gene Proteins 0.000 claims 2
- 101100023016 Methanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 / Marburg) mat gene Proteins 0.000 claims 2
- 238000012239 gene modification Methods 0.000 claims 2
- 230000005017 genetic modification Effects 0.000 claims 2
- 235000013617 genetically modified food Nutrition 0.000 claims 2
- 101150063051 hom gene Proteins 0.000 claims 2
- 101150108178 metE gene Proteins 0.000 claims 2
- 101150051471 metF gene Proteins 0.000 claims 2
- 101150042623 metH gene Proteins 0.000 claims 2
- 101150095438 metK gene Proteins 0.000 claims 2
- MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 claims 2
- 101150014006 thrA gene Proteins 0.000 claims 2
- 101150072448 thrB gene Proteins 0.000 claims 2
- 108010006533 ATP-Binding Cassette Transporters Proteins 0.000 claims 1
- 102000005416 ATP-Binding Cassette Transporters Human genes 0.000 claims 1
- 241000186361 Actinobacteria <class> Species 0.000 claims 1
- 241000186226 Corynebacterium glutamicum Species 0.000 claims 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 1
- QEFRNWWLZKMPFJ-ZXPFJRLXSA-N L-methionine (R)-S-oxide Chemical compound C[S@@](=O)CC[C@H]([NH3+])C([O-])=O QEFRNWWLZKMPFJ-ZXPFJRLXSA-N 0.000 claims 1
- QEFRNWWLZKMPFJ-UHFFFAOYSA-N L-methionine sulphoxide Natural products CS(=O)CCC(N)C(O)=O QEFRNWWLZKMPFJ-UHFFFAOYSA-N 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 229930182817 methionine Natural products 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/12—Methionine; Cysteine; Cystine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/34—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/38—Nucleosides
- C12P19/40—Nucleosides having a condensed ring system containing a six-membered ring having two nitrogen atoms in the same ring, e.g. purine nucleosides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07110382 | 2007-06-15 | ||
| EP07110382.4 | 2007-06-15 | ||
| EP08157115 | 2008-05-28 | ||
| EP08157115.0 | 2008-05-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2010101001A true RU2010101001A (ru) | 2011-07-20 |
Family
ID=39769554
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2010101001/10A RU2010101001A (ru) | 2007-06-15 | 2008-06-09 | Микроорганизмы с дерегулированной системой витамина в12 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20100047881A1 (enExample) |
| EP (1) | EP2158324A1 (enExample) |
| JP (1) | JP2010530223A (enExample) |
| KR (1) | KR20100049012A (enExample) |
| CN (1) | CN101849017A (enExample) |
| BR (1) | BRPI0812515A2 (enExample) |
| RU (1) | RU2010101001A (enExample) |
| WO (1) | WO2008152016A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7803589B2 (en) | 2008-01-22 | 2010-09-28 | Genomatica, Inc. | Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol |
| US8906653B2 (en) | 2008-01-23 | 2014-12-09 | Basf Se | Method for fermentatively producing 1,5-diaminopentane |
| SI2262901T1 (sl) | 2008-03-05 | 2019-02-28 | Genomatica, Inc. | Primarni alkohol producirajoči organizmi |
| EP2285973A4 (en) | 2008-05-01 | 2012-04-25 | Genomatica Inc | PROCESS FOR PREPARING METHACRYLIC ACID |
| KR20110097951A (ko) | 2008-12-16 | 2011-08-31 | 게노마티카 인코포레이티드 | 합성가스와 다른 탄소원을 유용 제품으로 전환시키기 위한 미생물 및 방법 |
| AU2010242849A1 (en) | 2009-04-30 | 2011-11-24 | Genomatica, Inc. | Organisms for the production of isopropanol, n-butanol, and isobutanol |
| KR102115497B1 (ko) | 2009-04-30 | 2020-05-26 | 게노마티카 인코포레이티드 | 1,3-부탄다이올 생산 유기체 |
| WO2011017560A1 (en) | 2009-08-05 | 2011-02-10 | Genomatica, Inc. | Semi-synthetic terephthalic acid via microorganisms that produce muconic acid |
| KR20120088753A (ko) | 2009-10-23 | 2012-08-08 | 게노마티카 인코포레이티드 | 아닐린의 제조를 위한 미생물 |
| CA2783096A1 (en) | 2009-12-10 | 2011-06-16 | Genomatica, Inc. | Methods and organisms for converting synthesis gas or other gaseous carbon sources and methanol to 1,3-butanediol |
| BR112012018620A2 (pt) | 2010-01-29 | 2015-09-15 | Genomatica Inc | organismo microbiano de ocorrência não-natural, método para produzir (2-hidroxi-3-metil-4-oxobutoxi) fosfonato, método para produção de p-toluato, método para produzir tereftalato |
| US9023636B2 (en) | 2010-04-30 | 2015-05-05 | Genomatica, Inc. | Microorganisms and methods for the biosynthesis of propylene |
| SG187174A1 (en) | 2010-07-26 | 2013-02-28 | Genomatica Inc | Microorganisms and methods for the biosynthesis of aromatics, 2,4-pentadienoate and 1,3-butadiene |
| CN113025729B (zh) * | 2020-12-24 | 2022-11-04 | 复旦大学 | 结核分枝杆菌对氨基水杨酸耐药相关的基因突变位点及其应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6432686B1 (en) * | 1998-05-12 | 2002-08-13 | E. I. Du Pont De Nemours And Company | Method for the production of 1,3-propanediol by recombinant organisms comprising genes for vitamin B12 transport |
| JP4623825B2 (ja) * | 1999-12-16 | 2011-02-02 | 協和発酵バイオ株式会社 | 新規ポリヌクレオチド |
| DE10239308A1 (de) * | 2002-08-27 | 2004-03-11 | Basf Ag | Verfahren zur fermentativen Herstellung von schwefelhaltigen Feinchemikalien |
| JP2009501512A (ja) * | 2005-06-17 | 2009-01-22 | アイアンウッド ファーマシューティカルズ インコーポレイテッド | 改良されたアミノ酸及び代謝産物生合成 |
-
2008
- 2008-06-09 EP EP08760723A patent/EP2158324A1/en not_active Withdrawn
- 2008-06-09 BR BRPI0812515-5A2A patent/BRPI0812515A2/pt not_active IP Right Cessation
- 2008-06-09 WO PCT/EP2008/057158 patent/WO2008152016A1/en not_active Ceased
- 2008-06-09 RU RU2010101001/10A patent/RU2010101001A/ru not_active Application Discontinuation
- 2008-06-09 JP JP2010511606A patent/JP2010530223A/ja not_active Withdrawn
- 2008-06-09 KR KR1020107000839A patent/KR20100049012A/ko not_active Withdrawn
- 2008-06-09 US US12/518,531 patent/US20100047881A1/en not_active Abandoned
- 2008-06-09 CN CN200880020285A patent/CN101849017A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008152016A9 (en) | 2009-05-07 |
| JP2010530223A (ja) | 2010-09-09 |
| CN101849017A (zh) | 2010-09-29 |
| BRPI0812515A2 (pt) | 2014-12-30 |
| WO2008152016A1 (en) | 2008-12-18 |
| EP2158324A1 (en) | 2010-03-03 |
| KR20100049012A (ko) | 2010-05-11 |
| US20100047881A1 (en) | 2010-02-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20130304 |