RU2007128318A - ПРОДУКТ, СОДЕРЖАЩИЙ ПРОИЗВОДНОЕ ПРОСТАГЛАНДИНА F2α - Google Patents

ПРОДУКТ, СОДЕРЖАЩИЙ ПРОИЗВОДНОЕ ПРОСТАГЛАНДИНА F2α Download PDF

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Publication number
RU2007128318A
RU2007128318A RU2007128318/15A RU2007128318A RU2007128318A RU 2007128318 A RU2007128318 A RU 2007128318A RU 2007128318/15 A RU2007128318/15 A RU 2007128318/15A RU 2007128318 A RU2007128318 A RU 2007128318A RU 2007128318 A RU2007128318 A RU 2007128318A
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Russia
Prior art keywords
derivative
prostaglandin
component
propylene
ethylene
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RU2007128318/15A
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English (en)
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RU2391983C2 (ru
Inventor
Акио КИМУРА (JP)
Акио КИМУРА
Хироси ЯМАДА (JP)
Хироси ЯМАДА
Такехиро КАДО (JP)
Такехиро КАДО
Original Assignee
Сантен Фармасьютикал Ко., Лтд (Jp)
Сантен Фармасьютикал Ко., Лтд
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Publication of RU2007128318A publication Critical patent/RU2007128318A/ru
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Publication of RU2391983C2 publication Critical patent/RU2391983C2/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L23/00—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
    • C08L23/02—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers not modified by chemical after-treatment
    • C08L23/10—Homopolymers or copolymers of propene
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L53/00—Compositions of block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2203/00—Applications
    • C08L2203/02—Applications for biomedical use
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L23/00—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
    • C08L23/02—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers not modified by chemical after-treatment
    • C08L23/10—Homopolymers or copolymers of propene
    • C08L23/14—Copolymers of propene
    • C08L23/142—Copolymers of propene at least partially crystalline copolymers of propene with other olefins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/13—Hollow or container type article [e.g., tube, vase, etc.]
    • Y10T428/1352—Polymer or resin containing [i.e., natural or synthetic]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Claims (7)

1. Продукт, содержащий производное простагландина F2α, в котором жидкий водный препарат, включающий производное простагландина F2α, имеющее в своей молекуле, по меньшей мере, атом фтора, хранится в полимерном контейнере, изготовленном из сополимера пропилена/этилена, в котором соотношение пропиленового компонента к этиленовому компоненту находится в пределах от 94,0/6,0 до 99,5/0,5 (пропиленовый компонент/этиленовый компонент), посредством чего ингибируется уменьшение содержания производного простагландина F2α в жидком водном препарате.
2. Продукт, содержащий производное простагландина F2α, по п. 1, в котором производное простагландина F2α, имеющее в своей молекуле, по меньшей мере, атом фтора, является производным дифтор-простагландина F2α.
3. Продукт, содержащий производное простагландина F2α, по п. 1, характеризующийся тем, что в водном жидком препарате содержится неионный сурфактант.
4. Продукт, содержащий производное простагландина F2α, по п. 3, в котором неионный сурфактант является полисорбатом 80.
5. Продукт, содержащий производное простагландина F2α, по любому из пп. 1-4, в котором жидкий водный препарат является глазными каплями.
6. Способ ингибирования уменьшения содержания производного простагландина F2α, имеющего в своей молекуле, по меньшей мере, атом фтора, в жидком водном препарате, включающий хранение жидкого водного препарата, содержащего производное простагландина F2α, в полимерном контейнере, изготовленном из сополимера пропилена/этилена, в котором соотношение пропиленового компонента к этиленовому компоненту находится в пределах от 94,0/6,0 до 99,5/0,5 (пропиленовый компонент/этиленовый компонент).
7. Полимерный контейнер, изготовленный из сополимера пропилена/этилена, в котором соотношение пропиленового компонента к этиленовому компоненту находится в пределах от 94,0/6,0 до 99,5/0,5 (пропиленовый компонент/этиленовый компонент) для хранения жидкого водного препарата, включающего производное простагландина F2α, имеющего в своей молекуле, по меньшей мере, атом фтора.
RU2007128318/15A 2004-12-24 2005-12-26 Продукт, содержащий производное простагландина f2 альфа RU2391983C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2004-374009 2004-12-24
JP2004374009 2004-12-24

Publications (2)

Publication Number Publication Date
RU2007128318A true RU2007128318A (ru) 2009-01-27
RU2391983C2 RU2391983C2 (ru) 2010-06-20

Family

ID=36601858

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2007128318/15A RU2391983C2 (ru) 2004-12-24 2005-12-26 Продукт, содержащий производное простагландина f2 альфа

Country Status (14)

Country Link
US (1) US20070244196A1 (ru)
EP (1) EP1829545B1 (ru)
KR (1) KR101283874B1 (ru)
CN (1) CN101175496A (ru)
AT (1) ATE555792T1 (ru)
CA (1) CA2592474C (ru)
DK (1) DK1829545T3 (ru)
ES (1) ES2386148T3 (ru)
NO (1) NO338832B1 (ru)
PL (1) PL1829545T3 (ru)
PT (1) PT1829545E (ru)
RU (1) RU2391983C2 (ru)
SI (1) SI1829545T1 (ru)
WO (1) WO2006068266A1 (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2127638A1 (en) 2008-05-30 2009-12-02 Santen Pharmaceutical Co., Ltd Method and composition for treating ocular hypertension and glaucoma
CN106929477B (zh) * 2017-03-20 2020-01-10 江南大学 一株抗前列腺素F2α的特异性单克隆抗体杂交瘤细胞株WXX-2及其应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2886035A (en) * 1955-07-29 1959-05-12 Cutter Lab Venoclysis apparatus
US2985920A (en) * 1958-03-26 1961-05-30 Seiberling Rubber Co Method of making a cored heel
US4310543A (en) * 1980-10-09 1982-01-12 Hoffmann-La Roche Inc. Prostaglandin compositions
ATE82499T1 (de) * 1987-09-18 1992-12-15 R Tech Ueno Ltd Okulare hypotensivagenzien.
US5565492A (en) * 1988-07-18 1996-10-15 Alcon Laboratories, Inc. Prostaglandin combinations in glaucoma therapy
JPH06285135A (ja) * 1993-03-31 1994-10-11 Kyoraku Co Ltd 薬液用プラスチック容器
US5486540A (en) * 1993-10-28 1996-01-23 Allergan, Inc. Cyclopentane heptanoic or heptenoic acid, 2-arylalkyl or arylalkenyl and derivatives as therapeutic agents
ATE285795T1 (de) * 1998-07-14 2005-01-15 Alcon Mfg Ltd Polypropylenbasierte behälter für prostaglandin- enthaltende produkte
US6235781B1 (en) * 1998-07-14 2001-05-22 Alcon Laboratories, Inc. Prostaglandin product
JP3876355B2 (ja) * 2000-09-13 2007-01-31 参天製薬株式会社 点眼液
EP1321144B1 (en) * 2000-09-13 2010-12-08 Santen Pharmaceutical Co., Ltd. Eye drops
WO2002022106A2 (en) * 2000-09-14 2002-03-21 Novartis Ag Stable ophthalmic preparation
TW586946B (en) * 2000-12-22 2004-05-11 Novartis Ag Process to improve stability
JP2003138074A (ja) * 2001-10-30 2003-05-14 Japan Polychem Corp 医療用延伸ブロー容器
ATE450264T1 (de) * 2003-07-31 2009-12-15 Santen Pharmaceutical Co Ltd Prostaglandin enthaltendes produkt
US20050049311A1 (en) * 2003-09-03 2005-03-03 Pharmacia & Upjohn Company Medicinal products comprising prostaglandin compositions and methods of packaging such compositions

Also Published As

Publication number Publication date
RU2391983C2 (ru) 2010-06-20
ES2386148T3 (es) 2012-08-10
NO338832B1 (no) 2016-10-24
CA2592474A1 (en) 2006-06-29
EP1829545B1 (en) 2012-05-02
PT1829545E (pt) 2012-05-21
US20070244196A1 (en) 2007-10-18
CN101175496A (zh) 2008-05-07
WO2006068266A1 (ja) 2006-06-29
KR20070093997A (ko) 2007-09-19
CA2592474C (en) 2013-08-13
PL1829545T3 (pl) 2012-09-28
ATE555792T1 (de) 2012-05-15
SI1829545T1 (sl) 2012-08-31
EP1829545A1 (en) 2007-09-05
DK1829545T3 (da) 2012-07-23
KR101283874B1 (ko) 2013-07-08
NO20073767L (no) 2007-09-14
EP1829545A4 (en) 2009-07-22

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