RU2007123253A - Производные тетералина и индана и их применения - Google Patents
Производные тетералина и индана и их применения Download PDFInfo
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Claims (29)
1. Соединение формулы I
или его фармацевтически приемлемая соль,
где m имеет значение от 0 до 3;
р имеет значение от 1 до 3;
q имеет значение 0, 1 или 2;
Ar представляет собой возможно замещенный арил или возможно замещенный 5-12-членный гетероарил;
каждый R1 независимо представляет собой галогено, С1-12-алкил, C1-12-галогеноалкил, C1-12-гетероалкил, циано, -S(O)t-Ra, -C(=О)-NRbRc, -SO2-NRbRc, -N(Rd)-C(=O)-Re или -C(=O)-Re, где t имеет значение от 0 до 2, каждый из Ra, Rb, Rc и Rd независимо представляет собой водород или C1-12-алкил и Re представляет собой водород, C1-12-алкил, C1-12-алкокси или гидрокси;
каждый из n и r независимо имеет значение 1 или 2; и
Х представляет собой -NR3, когда n имеет значение 2, или Х представляет собой -CHNR4R5, когда n имеет значение 1 или 2, где каждый из R3, R4 и R5 независимо представляет собой водород или метил,
при условии, что исключен 4-(4-хлорфенилтио)-1-(метилпиперазино)индан.
2. Соединение по п.1, где р имеет значение 1 или 2.
3. Соединение по п.2, где q имеет значение 2.
4. Соединение по п.1, где n имеет значение 2.
5. Соединение по п.3, где Х представляет собой -NR3.
6. Соединение по п.5, где r имеет значение 1.
7. Соединение по п.6, где Ar представляет собой возможно замещенный арил.
8. Соединение по п.7, где Ar представляет собой возможно замещенный фенил.
9. Соединение по п.8, где R3 представляет собой водород.
10. Соединение по п.8, где R3 представляет собой метил.
13. Соединение по п.12, где p имеет значение 1 или 2.
14. Соединение по п.13, где q имеет значение 2.
15. Соединение по п.14, где Ar представляет собой возможно замещенный арил.
16. Соединение по п.15, где Ar представляет собой возможно замещенный фенил.
17. Соединение по п.16, где R3 представляет собой водород.
18. Соединение по п.16, где R3 представляет собой метил.
19. Соединение по п.1, где указанное соединение представляет собой соединение формулы IIIа или IIIб
где s имеет значение от 0 до 4;
каждый R6 независимо представляет собой галогено, C1-12-алкил, С1-12-галогеноалкил, C1-12-гетероалкил, циано, -S(O)t-Ra, -C(=O)-NRbRc, -SO2-NRbRc, -N(Rd)-C(=O)-Re или -C(=O)-Re, где t имеет значение от 0 до 2, каждый из Ra, Rb, Rc и Rd независимо представляет собой водород или C1-12-алкил и Re представляет собой водород, C1-12-алкил, C1-12-алкокси или гидрокси; и
R3 является таким, как изложено в п.1.
20. Соединение по п.19, где s имеет значение от 0 до 2 и каждый R6 независимо представляет собой галогено, C1-12-алкил, C1-12-алкокси или C1-12-галогеноалкил.
21. Соединение по п.19, где указанное соединение представляет собой соединение формулы IIIа.
22. Соединение по п.21, где R3 представляет собой водород.
23. Соединение по п.21, где R3 представляет собой метил.
24. Соединение по п.21, где s имеет значение 0 или 1 и R6 представляет собой галогено.
25. Соединение по п.1, где указанное соединение выбрано из
1-(5-бензолсульфонил-индан-1-ил)-пиперазина;
1-(5-бензолсульфонил-индан-1-ил)-пирролидин-3-иламина;
1-[5-(4-фтор-бензолсульфонил)-индан-1-ил]-пиперазина;
1-[5-(2-фтор-бензолсульфонил)-индан-1-ил]-пиперазина;
1-[5-(3-хлор-бензолсульфонил)-индан-1-ил]-пиперазина;
1-[5-(3-хлор-бензолсульфонил)-индан-1-ил]-пиперидин-4-иламина;
1-(7-бензолсульфонил-1,2,3,4-тетрагидро-нафталин-1-ил)-пиперазина;
1-(6-бензолсульфонил-1,2,3,4-тетрагидро-нафталин-1-ил)-пиперазина;
1-[6-(4-фтор-бензолсульфонил)-1,2,3,4-тетрагидро-нафталин-1-ил]-пиперазина;
1-(6-бензолсульфонил-1,2,3,4-тетрагидро-нафталин-1-ил)-пиперидин-4-иламина и
1-(6-бензолсульфонил-1,2,3,4-тетрагидро-нафталин-1-ил)-4-метил-пиперазина.
26. Фармацевтическая композиция, содержащая эффективное количество соединения по п.1 в смеси с фармацевтически приемлемым носителем.
27. Применение соединения формулы I по п.1 в приготовлении лекарства, полезного в лечении болезненного состояния центральной нервной системы.
28. Применение по п.27, где болезненное состояние центральной нервной системы выбрано из психозов, шизофрении, маниакальных депрессий, неврологических расстройств, нарушений памяти, синдрома дефицита внимания, болезни Паркинсона, бокового амиотрофического склероза, болезни Альцгеймера, расстройств приема пищи и болезни Хантингтона.
29. Применение соединения формулы I по п.1 в приготовлении лекарства, полезного в лечении расстройства желудочно-кишечного тракта.
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US63783604P | 2004-12-21 | 2004-12-21 | |
US60/637,836 | 2004-12-21 |
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RU2007123253A true RU2007123253A (ru) | 2009-01-27 |
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US (1) | US7473690B2 (ru) |
EP (1) | EP1831189B1 (ru) |
JP (1) | JP2008524274A (ru) |
KR (1) | KR100899061B1 (ru) |
CN (1) | CN101124210A (ru) |
AT (1) | ATE448216T1 (ru) |
AU (1) | AU2005318595B2 (ru) |
BR (1) | BRPI0515835A (ru) |
CA (1) | CA2591793A1 (ru) |
DE (1) | DE602005017663D1 (ru) |
ES (1) | ES2332526T3 (ru) |
MX (1) | MX2007007481A (ru) |
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BRPI0713742A2 (pt) * | 2006-06-20 | 2013-02-13 | Hoffmann La Roche | derivados de arilsulfonila naftaleno e usos destes |
KR101770979B1 (ko) * | 2010-05-21 | 2017-08-24 | 애브비 인코포레이티드 | 5ht 수용체의 조절제 및 이의 사용방법 |
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DE3901814A1 (de) * | 1988-07-28 | 1990-02-01 | Bayer Ag | Substituierte aminomethylzetraline sowie ihre heterocyclischen analoga |
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2005
- 2005-12-12 RU RU2007123253/04A patent/RU2389723C2/ru not_active IP Right Cessation
- 2005-12-12 AT AT05819702T patent/ATE448216T1/de active
- 2005-12-12 KR KR1020077016596A patent/KR100899061B1/ko not_active IP Right Cessation
- 2005-12-12 DE DE602005017663T patent/DE602005017663D1/de active Active
- 2005-12-12 CA CA002591793A patent/CA2591793A1/en not_active Abandoned
- 2005-12-12 BR BRPI0515835-4A patent/BRPI0515835A/pt not_active IP Right Cessation
- 2005-12-12 MX MX2007007481A patent/MX2007007481A/es not_active Application Discontinuation
- 2005-12-12 JP JP2007547253A patent/JP2008524274A/ja not_active Ceased
- 2005-12-12 CN CNA2005800485088A patent/CN101124210A/zh active Pending
- 2005-12-12 WO PCT/EP2005/013290 patent/WO2006066745A1/en active Application Filing
- 2005-12-12 EP EP05819702A patent/EP1831189B1/en not_active Not-in-force
- 2005-12-12 AU AU2005318595A patent/AU2005318595B2/en not_active Expired - Fee Related
- 2005-12-12 ES ES05819702T patent/ES2332526T3/es active Active
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Also Published As
Publication number | Publication date |
---|---|
JP2008524274A (ja) | 2008-07-10 |
WO2006066745A1 (en) | 2006-06-29 |
DE602005017663D1 (de) | 2009-12-24 |
KR20070088797A (ko) | 2007-08-29 |
ES2332526T3 (es) | 2010-02-08 |
EP1831189B1 (en) | 2009-11-11 |
CN101124210A (zh) | 2008-02-13 |
MX2007007481A (es) | 2007-07-20 |
RU2389723C2 (ru) | 2010-05-20 |
US7473690B2 (en) | 2009-01-06 |
AU2005318595A1 (en) | 2006-06-29 |
ATE448216T1 (de) | 2009-11-15 |
CA2591793A1 (en) | 2006-06-29 |
BRPI0515835A (pt) | 2008-08-12 |
EP1831189A1 (en) | 2007-09-12 |
AU2005318595B2 (en) | 2011-03-03 |
KR100899061B1 (ko) | 2009-05-25 |
US20060160825A1 (en) | 2006-07-20 |
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