RU2006146923A - Метаболиты индолилалкиламина в качестве лигандов 5-гидрокситриптамина-6 - Google Patents
Метаболиты индолилалкиламина в качестве лигандов 5-гидрокситриптамина-6 Download PDFInfo
- Publication number
- RU2006146923A RU2006146923A RU2006146923/04A RU2006146923A RU2006146923A RU 2006146923 A RU2006146923 A RU 2006146923A RU 2006146923/04 A RU2006146923/04 A RU 2006146923/04A RU 2006146923 A RU2006146923 A RU 2006146923A RU 2006146923 A RU2006146923 A RU 2006146923A
- Authority
- RU
- Russia
- Prior art keywords
- indol
- disorder
- substituted
- group
- sulfonyl
- Prior art date
Links
- 239000003446 ligand Substances 0.000 title 1
- 239000002207 metabolite Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 11
- 125000003118 aryl group Chemical group 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 125000001072 heteroaryl group Chemical group 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 3
- 208000019901 Anxiety disease Diseases 0.000 claims 3
- 230000003920 cognitive function Effects 0.000 claims 3
- -1 cycloheteroalkyl Chemical group 0.000 claims 3
- 125000005842 heteroatom Chemical group 0.000 claims 3
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Natural products CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 2
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 2
- QUSNBJAOOMFDIB-UHFFFAOYSA-N Ethylamine Chemical compound CCN QUSNBJAOOMFDIB-UHFFFAOYSA-N 0.000 claims 2
- IMZSLPYVKQTMKF-UHFFFAOYSA-N n-[2-[1-(6-chloroimidazo[2,1-b][1,3]thiazol-5-yl)sulfonylindol-3-yl]ethyl]acetamide Chemical compound C1=CC=C2C(CCNC(=O)C)=CN(S(=O)(=O)C=3N4C=CSC4=NC=3Cl)C2=C1 IMZSLPYVKQTMKF-UHFFFAOYSA-N 0.000 claims 2
- 208000015122 neurodegenerative disease Diseases 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- LRSFBSBUEGEYOX-YTKSKTJISA-N (2s,3s,4s,5r,6s)-6-[2-[1-(6-chloroimidazo[2,1-b][1,3]thiazol-5-yl)sulfonylindol-3-yl]ethylcarbamoyloxy]-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound O1[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1OC(=O)NCCC1=CN(S(=O)(=O)C=2N3C=CSC3=NC=2Cl)C2=CC=CC=C12 LRSFBSBUEGEYOX-YTKSKTJISA-N 0.000 claims 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- 125000006527 (C1-C5) alkyl group Chemical group 0.000 claims 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 1
- UMZCLZPXPCNKML-UHFFFAOYSA-N 2h-imidazo[4,5-d][1,3]thiazole Chemical group C1=NC2=NCSC2=N1 UMZCLZPXPCNKML-UHFFFAOYSA-N 0.000 claims 1
- 108091005435 5-HT6 receptors Proteins 0.000 claims 1
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims 1
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims 1
- 208000011688 Generalised anxiety disease Diseases 0.000 claims 1
- 208000012902 Nervous system disease Diseases 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 claims 1
- 125000002619 bicyclic group Chemical group 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 208000015114 central nervous system disease Diseases 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000029364 generalized anxiety disease Diseases 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000004404 heteroalkyl group Chemical group 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 208000035231 inattentive type attention deficit hyperactivity disease Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000004060 metabolic process Effects 0.000 claims 1
- ZSOAQDINSUCKGF-UHFFFAOYSA-N n-[[1-[(4-chloro-2-methylsulfanyl-1h-imidazol-5-yl)sulfonyl]indol-3-yl]methyl]acetamide Chemical compound N1C(SC)=NC(Cl)=C1S(=O)(=O)N1C2=CC=CC=C2C(CNC(C)=O)=C1 ZSOAQDINSUCKGF-UHFFFAOYSA-N 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/02—Acyclic radicals
- C07H7/033—Uronic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58229004P | 2004-06-23 | 2004-06-23 | |
| US60/582,290 | 2004-06-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2006146923A true RU2006146923A (ru) | 2008-07-27 |
Family
ID=35033547
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2006146923/04A RU2006146923A (ru) | 2004-06-23 | 2005-06-21 | Метаболиты индолилалкиламина в качестве лигандов 5-гидрокситриптамина-6 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7498327B2 (enExample) |
| EP (1) | EP1758898A1 (enExample) |
| JP (1) | JP2008504267A (enExample) |
| KR (1) | KR20070041514A (enExample) |
| CN (1) | CN1976928A (enExample) |
| AR (1) | AR049449A1 (enExample) |
| AU (1) | AU2005258025A1 (enExample) |
| BR (1) | BRPI0512540A (enExample) |
| CA (1) | CA2570818A1 (enExample) |
| CR (1) | CR8825A (enExample) |
| EC (1) | ECSP067096A (enExample) |
| IL (1) | IL180198A0 (enExample) |
| MX (1) | MX2007000182A (enExample) |
| NO (1) | NO20070065L (enExample) |
| PA (1) | PA8637801A1 (enExample) |
| PE (1) | PE20060303A1 (enExample) |
| RU (1) | RU2006146923A (enExample) |
| TW (1) | TW200606148A (enExample) |
| WO (1) | WO2006002125A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7635710B2 (en) * | 2006-02-15 | 2009-12-22 | Neurim Pharmaceuticals (1991) Ltd. | Pyrone-indole derivatives and process for their preparation |
| US9101613B2 (en) | 2006-02-15 | 2015-08-11 | Neurim Pharmaceuticals (1991) Ltd. | Methods for treating neurological disease |
| EP1953153A1 (en) * | 2007-01-31 | 2008-08-06 | Laboratorios del Dr. Esteve S.A. | Heterocyclyl-substituted sulfonamides for the treatment of cognitive or food ingestion related disorders |
| EP2053052A1 (en) | 2007-10-23 | 2009-04-29 | Laboratorios del Dr. Esteve S.A. | Process for the preparation of 6-substituted imidazo[2,1-b]thiazole-5-sulfonyl halide |
| CN104725295B (zh) | 2013-12-20 | 2019-05-24 | 广东东阳光药业有限公司 | 芳杂环类衍生物及其在药物上的应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3489767A (en) * | 1966-01-12 | 1970-01-13 | Sumitomo Chemical Co | 1-(phenylsulfonyl)-3-indolyl aliphatic acid derivatives |
| GB9820113D0 (en) * | 1998-09-15 | 1998-11-11 | Merck Sharp & Dohme | Therapeutic agents |
| US6380166B1 (en) * | 1999-09-13 | 2002-04-30 | American Home Products Corporation | Glucopyranosides conjugates of 2-(4-hydroxy-phenyl)-3-methyl-1-[4-(2-amin-1-yl-ethoxy)-benzyl]-1H-indol-5-ols |
| DK1455779T3 (da) * | 2001-12-20 | 2006-10-30 | Wyeth Corp | Indolylalkylaminderivater som 5-hydroxytryptamin-6-ligander |
| WO2004078719A1 (ja) * | 2003-03-06 | 2004-09-16 | Ono Pharmaceutical Co., Ltd. | インドール誘導体化合物およびその化合物を有効成分とする薬剤 |
| BRPI0412684A (pt) * | 2003-07-17 | 2006-10-03 | Plexxinko Inc | compostos ppar-ativos |
| WO2005040112A1 (en) * | 2003-10-14 | 2005-05-06 | Oxagen Limited | Compounds with pgd2 antagonist activity |
-
2005
- 2005-06-17 PE PE2005000696A patent/PE20060303A1/es not_active Application Discontinuation
- 2005-06-21 MX MX2007000182A patent/MX2007000182A/es active IP Right Grant
- 2005-06-21 CA CA002570818A patent/CA2570818A1/en not_active Abandoned
- 2005-06-21 AR ARP050102544A patent/AR049449A1/es unknown
- 2005-06-21 CN CNA2005800206836A patent/CN1976928A/zh active Pending
- 2005-06-21 EP EP05766100A patent/EP1758898A1/en not_active Withdrawn
- 2005-06-21 RU RU2006146923/04A patent/RU2006146923A/ru not_active Application Discontinuation
- 2005-06-21 WO PCT/US2005/021852 patent/WO2006002125A1/en not_active Ceased
- 2005-06-21 TW TW094120536A patent/TW200606148A/zh unknown
- 2005-06-21 AU AU2005258025A patent/AU2005258025A1/en not_active Abandoned
- 2005-06-21 KR KR1020077000822A patent/KR20070041514A/ko not_active Withdrawn
- 2005-06-21 BR BRPI0512540-5A patent/BRPI0512540A/pt not_active IP Right Cessation
- 2005-06-21 JP JP2007518190A patent/JP2008504267A/ja not_active Withdrawn
- 2005-06-22 US US11/158,702 patent/US7498327B2/en not_active Expired - Fee Related
- 2005-06-23 PA PA20058637801A patent/PA8637801A1/es unknown
-
2006
- 2006-12-19 IL IL180198A patent/IL180198A0/en unknown
- 2006-12-19 EC EC2006007096A patent/ECSP067096A/es unknown
- 2006-12-21 CR CR8825A patent/CR8825A/es not_active Application Discontinuation
-
2007
- 2007-01-04 NO NO20070065A patent/NO20070065L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2005258025A1 (en) | 2006-01-05 |
| ECSP067096A (es) | 2007-02-28 |
| CR8825A (es) | 2007-08-28 |
| US20060003945A1 (en) | 2006-01-05 |
| PA8637801A1 (es) | 2006-06-02 |
| KR20070041514A (ko) | 2007-04-18 |
| TW200606148A (en) | 2006-02-16 |
| BRPI0512540A (pt) | 2008-03-25 |
| WO2006002125A1 (en) | 2006-01-05 |
| IL180198A0 (en) | 2007-06-03 |
| AR049449A1 (es) | 2006-08-02 |
| MX2007000182A (es) | 2007-03-23 |
| JP2008504267A (ja) | 2008-02-14 |
| CA2570818A1 (en) | 2006-01-05 |
| NO20070065L (no) | 2007-01-04 |
| US7498327B2 (en) | 2009-03-03 |
| EP1758898A1 (en) | 2007-03-07 |
| CN1976928A (zh) | 2007-06-06 |
| PE20060303A1 (es) | 2006-05-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20101110 |