RU2006132180A - Кристаллический полиморф базедоксифен ацетата - Google Patents
Кристаллический полиморф базедоксифен ацетата Download PDFInfo
- Publication number
- RU2006132180A RU2006132180A RU2006132180/04A RU2006132180A RU2006132180A RU 2006132180 A RU2006132180 A RU 2006132180A RU 2006132180/04 A RU2006132180/04 A RU 2006132180/04A RU 2006132180 A RU2006132180 A RU 2006132180A RU 2006132180 A RU2006132180 A RU 2006132180A
- Authority
- RU
- Russia
- Prior art keywords
- composition
- weight
- polymorph
- bazedoxifene acetate
- polymorph according
- Prior art date
Links
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 title 1
- OMZAMQFQZMUNTP-UHFFFAOYSA-N acetic acid;1-[[4-[2-(azepan-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methylindol-5-ol Chemical compound CC(O)=O.C=1C=C(OCCN2CCCCCC2)C=CC=1CN1C2=CC=C(O)C=C2C(C)=C1C1=CC=C(O)C=C1 OMZAMQFQZMUNTP-UHFFFAOYSA-N 0.000 claims 20
- 229960003713 bazedoxifene acetate Drugs 0.000 claims 20
- 238000000034 method Methods 0.000 claims 20
- 239000000203 mixture Substances 0.000 claims 19
- 241000124008 Mammalia Species 0.000 claims 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 7
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 238000001228 spectrum Methods 0.000 claims 6
- 230000015572 biosynthetic process Effects 0.000 claims 4
- 208000035475 disorder Diseases 0.000 claims 4
- 238000000634 powder X-ray diffraction Methods 0.000 claims 4
- 239000011541 reaction mixture Substances 0.000 claims 4
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 3
- 239000003054 catalyst Substances 0.000 claims 3
- 229940011871 estrogen Drugs 0.000 claims 3
- 239000000262 estrogen Substances 0.000 claims 3
- 238000005984 hydrogenation reaction Methods 0.000 claims 3
- 239000002904 solvent Substances 0.000 claims 3
- GNVYSOYFHQFUMV-UHFFFAOYSA-N 3-(azepan-1-yl)-2-phenylmethoxy-1h-indole Chemical compound C=1C=CC=CC=1COC=1NC2=CC=CC=C2C=1N1CCCCCC1 GNVYSOYFHQFUMV-UHFFFAOYSA-N 0.000 claims 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 2
- UCJGJABZCDBEDK-UHFFFAOYSA-N bazedoxifene Chemical compound C=1C=C(OCCN2CCCCCC2)C=CC=1CN1C2=CC=C(O)C=C2C(C)=C1C1=CC=C(O)C=C1 UCJGJABZCDBEDK-UHFFFAOYSA-N 0.000 claims 2
- 238000006243 chemical reaction Methods 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 238000002329 infrared spectrum Methods 0.000 claims 2
- 150000003431 steroids Chemical class 0.000 claims 2
- 230000001457 vasomotor Effects 0.000 claims 2
- 206010065687 Bone loss Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 208000033830 Hot Flashes Diseases 0.000 claims 1
- 206010060800 Hot flush Diseases 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 125000003158 alcohol group Chemical group 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- 230000003078 antioxidant effect Effects 0.000 claims 1
- 235000006708 antioxidants Nutrition 0.000 claims 1
- 229960005070 ascorbic acid Drugs 0.000 claims 1
- 235000010323 ascorbic acid Nutrition 0.000 claims 1
- 239000011668 ascorbic acid Substances 0.000 claims 1
- 229960000817 bazedoxifene Drugs 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 235000012000 cholesterol Nutrition 0.000 claims 1
- 229940035811 conjugated estrogen Drugs 0.000 claims 1
- 238000002425 crystallisation Methods 0.000 claims 1
- 230000008025 crystallization Effects 0.000 claims 1
- 230000007812 deficiency Effects 0.000 claims 1
- 238000000113 differential scanning calorimetry Methods 0.000 claims 1
- 238000001938 differential scanning calorimetry curve Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002357 endometrial effect Effects 0.000 claims 1
- -1 for example Substances 0.000 claims 1
- 239000012458 free base Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Reproductive Health (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Gynecology & Obstetrics (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56058204P | 2004-04-07 | 2004-04-07 | |
| US60/560,582 | 2004-04-07 | ||
| US66017805P | 2005-03-10 | 2005-03-10 | |
| US60/660,178 | 2005-03-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2006132180A true RU2006132180A (ru) | 2008-05-20 |
Family
ID=34966308
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2006132180/04A RU2006132180A (ru) | 2004-04-07 | 2005-04-06 | Кристаллический полиморф базедоксифен ацетата |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7683051B2 (https=) |
| EP (1) | EP1732890A1 (https=) |
| JP (2) | JP2007532560A (https=) |
| KR (1) | KR20060135866A (https=) |
| AR (1) | AR048527A1 (https=) |
| AU (1) | AU2005233133A1 (https=) |
| BR (1) | BRPI0509191A (https=) |
| CA (1) | CA2561010A1 (https=) |
| CR (1) | CR8615A (https=) |
| EC (1) | ECSP066911A (https=) |
| IL (1) | IL178236A0 (https=) |
| NO (1) | NO20065052L (https=) |
| PA (1) | PA8629101A1 (https=) |
| PE (1) | PE20060676A1 (https=) |
| RU (1) | RU2006132180A (https=) |
| SG (1) | SG151331A1 (https=) |
| TW (1) | TWI346105B (https=) |
| WO (1) | WO2005100316A1 (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20060676A1 (es) | 2004-04-07 | 2006-07-24 | Wyeth Corp | Polimorfo cristalino de acetato de bazedoxifeno |
| GT200500080A (es) | 2004-04-07 | 2005-10-31 | Polimorfo cristalino de acetato de bazedoxifeno | |
| US8538393B1 (en) | 2004-09-21 | 2013-09-17 | Advanced Ground Information Systems, Inc. | Method to provide ad hoc and password protected digital and voice networks |
| US10645562B2 (en) | 2004-09-21 | 2020-05-05 | Agis Software Development Llc | Method to provide ad hoc and password protected digital and voice networks |
| PE20070188A1 (es) * | 2005-06-29 | 2007-03-16 | Wyeth Corp | Formulaciones de estrogenos conjugados y bazedoxifeno |
| AU2006283121A1 (en) * | 2005-08-24 | 2007-03-01 | Wyeth | Bazedoxifene acetate formulations and manufacturing process thereof |
| PE20090100A1 (es) * | 2007-03-30 | 2009-02-26 | Wyeth Corp | Metodos de separacion y deteccion de acetato de bacedoxifeno en composiciones farmaceuticas |
| CZ302358B6 (cs) * | 2007-07-25 | 2011-03-30 | Zentiva, A. S. | Nové soli bazedoxifenu |
| CN101977897A (zh) * | 2008-02-11 | 2011-02-16 | 惠氏有限责任公司 | 制备乙酸巴多昔芬的多晶型a的方法 |
| US20100016582A1 (en) * | 2008-02-11 | 2010-01-21 | Wyeth | Methods of converting polymorphic form b of bazedoxifene acetate to polymorphic form a of bazedoxifene acetate |
| WO2009102778A1 (en) * | 2008-02-11 | 2009-08-20 | Wyeth | Amorphous polymorph of bazedoxifene acetate |
| ITMI20091109A1 (it) * | 2009-06-23 | 2010-12-24 | Wyeth Corp | Forma polimorfa d di bazedoxifene acetato e metodi per la sua preparazione |
| AR078785A1 (es) | 2009-10-27 | 2011-11-30 | Wyeth Llc | Formulaciones de bazedoxifeno con antioxidantes |
| US8154175B2 (en) * | 2009-12-16 | 2012-04-10 | Hamilton Sundstrand Corporation | Sensing device |
| EP2407467A1 (de) | 2010-07-14 | 2012-01-18 | Sandoz Ag | Kristalline Verbindung von 1-[4-(2-azepan-1-yl-ethoxy)-benzyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol und Milchsäure |
| WO2012007453A1 (en) | 2010-07-14 | 2012-01-19 | Sandoz Ag | Crystalline compound of 1-[4-(2-azepan-1-ylethoxy)benzyl]-2-(4-hydroxyphenyl)-3-methyl-1h-indol-5-ol |
| EP2616463A4 (en) * | 2010-09-14 | 2014-01-08 | Reddys Lab Ltd Dr | PREPARATION OF CRYSTALLINE BAZEDOXIFES AND THEIR SALTS |
| EP2471770A1 (en) | 2010-12-28 | 2012-07-04 | Sandoz Ag | Method of preparing polymorphic pure form A of bazedoxifene acetate |
| WO2013182169A1 (en) | 2012-06-07 | 2013-12-12 | Zentiva, K. S. | Process of preparation of an antioxidant-free polymorphically and chemically stable formulation of bazedoxifene acetate |
| WO2013182170A1 (en) | 2012-06-07 | 2013-12-12 | Zentiva, K. S. | Enhancement of dissolution rate from pharmaceutical composition comprising bazedoxifene acetate |
| US9751835B2 (en) | 2013-05-15 | 2017-09-05 | Indiana University Research And Technology Corporation | Processes and intermediates for preparing indole pharmaceuticals |
| CN111060619B (zh) * | 2019-12-18 | 2022-11-18 | 北京鑫开元医药科技有限公司 | 一种醋酸巴多昔芬杂质的检测方法 |
| US11246874B1 (en) | 2021-04-20 | 2022-02-15 | Oxygen Biotech LLC | Treatment of COVID-19 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5880137A (en) | 1996-04-19 | 1999-03-09 | American Home Products Corporation | 2-phenyl-1- 4-(amino-1-yl-alk-1-ynyl)-benzyl!-1H-indol-5-ols as estrogenic agents |
| DE69707189T2 (de) | 1996-04-19 | 2002-06-20 | American Home Products Corp., Madison | Östrogene Verbindungen |
| TW397821B (en) | 1996-04-19 | 2000-07-11 | American Home Produits Corp | 3-[4-(2-phenyl-indole-1-ylmethyl)-phenyl]-acrylamides and 2-phenyl-1-[4-(amino-1-yl-alk-1-ynyl)-benzyl]-1H-indol-5-ol as well as pharmaceutical compositions of estrogenic agents thereof |
| US5780497A (en) | 1996-04-19 | 1998-07-14 | American Home Products Corporation | 2-phenyl-1- 4-(amino-1-yl-alk-1-ynyl)-benzyl!-1H-indol-5-ols as estrogenic agents |
| US5998402A (en) | 1996-04-19 | 1999-12-07 | American Home Products Corporation | 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indoles as estrogenic agents |
| NZ503793A (en) | 1997-10-15 | 2002-10-25 | Wyeth Corp | Novel aryloxy-alkyl-dialkylamines and processes for preparing these compounds |
| US6005102A (en) | 1997-10-15 | 1999-12-21 | American Home Products Corporation | Aryloxy-alkyl-dialkylamines |
| US6479535B1 (en) * | 1998-05-15 | 2002-11-12 | Wyeth | 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole and estrogen formulations |
| AR029538A1 (es) | 2000-07-06 | 2003-07-02 | Wyeth Corp | Composiciones farmaceuticas de agentes estrogenicos |
| EP1336602A1 (en) | 2002-02-13 | 2003-08-20 | Giovanni Scaramuzzino | Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases |
| IL165395A0 (en) * | 2002-06-25 | 2006-01-15 | Wyeth Corp | Use of thio-oxubdile derivatives in treatment of hormone-related conditions |
| PE20060676A1 (es) | 2004-04-07 | 2006-07-24 | Wyeth Corp | Polimorfo cristalino de acetato de bazedoxifeno |
-
2005
- 2005-04-06 PE PE2005000386A patent/PE20060676A1/es not_active Application Discontinuation
- 2005-04-06 WO PCT/US2005/011724 patent/WO2005100316A1/en not_active Ceased
- 2005-04-06 TW TW094110850A patent/TWI346105B/zh not_active IP Right Cessation
- 2005-04-06 AU AU2005233133A patent/AU2005233133A1/en not_active Withdrawn
- 2005-04-06 BR BRPI0509191-8A patent/BRPI0509191A/pt not_active IP Right Cessation
- 2005-04-06 AR ARP050101367A patent/AR048527A1/es unknown
- 2005-04-06 US US11/100,983 patent/US7683051B2/en active Active
- 2005-04-06 EP EP05738044A patent/EP1732890A1/en not_active Withdrawn
- 2005-04-06 CA CA002561010A patent/CA2561010A1/en not_active Abandoned
- 2005-04-06 KR KR1020067020649A patent/KR20060135866A/ko not_active Withdrawn
- 2005-04-06 SG SG200902227-8A patent/SG151331A1/en unknown
- 2005-04-06 RU RU2006132180/04A patent/RU2006132180A/ru not_active Application Discontinuation
- 2005-04-06 PA PA20058629101A patent/PA8629101A1/es unknown
- 2005-04-06 JP JP2007507487A patent/JP2007532560A/ja not_active Abandoned
-
2006
- 2006-09-12 CR CR8615A patent/CR8615A/es not_active Application Discontinuation
- 2006-09-21 IL IL178236A patent/IL178236A0/en unknown
- 2006-10-06 EC EC2006006911A patent/ECSP066911A/es unknown
- 2006-11-02 NO NO20065052A patent/NO20065052L/no not_active Application Discontinuation
-
2008
- 2008-06-30 JP JP2008171135A patent/JP2009035535A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JP2007532560A (ja) | 2007-11-15 |
| BRPI0509191A (pt) | 2007-09-25 |
| PA8629101A1 (es) | 2005-11-25 |
| KR20060135866A (ko) | 2006-12-29 |
| TWI346105B (en) | 2011-08-01 |
| SG151331A1 (en) | 2009-04-30 |
| EP1732890A1 (en) | 2006-12-20 |
| AR048527A1 (es) | 2006-05-03 |
| TW200606149A (en) | 2006-02-16 |
| CA2561010A1 (en) | 2005-10-27 |
| WO2005100316A1 (en) | 2005-10-27 |
| US7683051B2 (en) | 2010-03-23 |
| NO20065052L (no) | 2006-11-06 |
| PE20060676A1 (es) | 2006-07-24 |
| JP2009035535A (ja) | 2009-02-19 |
| US20050227965A1 (en) | 2005-10-13 |
| AU2005233133A1 (en) | 2005-10-27 |
| CR8615A (es) | 2007-06-06 |
| ECSP066911A (es) | 2006-12-20 |
| IL178236A0 (en) | 2006-12-31 |
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