AR048527A1 - Variedades cristalinas de acetato de bazedoxifeno - Google Patents
Variedades cristalinas de acetato de bazedoxifenoInfo
- Publication number
- AR048527A1 AR048527A1 ARP050101367A ARP050101367A AR048527A1 AR 048527 A1 AR048527 A1 AR 048527A1 AR P050101367 A ARP050101367 A AR P050101367A AR P050101367 A ARP050101367 A AR P050101367A AR 048527 A1 AR048527 A1 AR 048527A1
- Authority
- AR
- Argentina
- Prior art keywords
- bazedoxifen acetate
- varieties
- crystal
- crystal varieties
- degree
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Obesity (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Gynecology & Obstetrics (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Indole Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Composicion farmacéutica que las comprende y usos. Reivindicacion 1: Un polimorfo cristalino (forma A) de acetato de bazedoxifeno, caracterizado porque tiene un patron de difraccion rayos-X en polvo que comprende picos característicos, en términos de 2 Theta, a alrededor de 12,7 degree y alrededor de 18,5 degree .
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US56058204P | 2004-04-07 | 2004-04-07 | |
US66017805P | 2005-03-10 | 2005-03-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR048527A1 true AR048527A1 (es) | 2006-05-03 |
Family
ID=34966308
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP050101367A AR048527A1 (es) | 2004-04-07 | 2005-04-06 | Variedades cristalinas de acetato de bazedoxifeno |
Country Status (18)
Country | Link |
---|---|
US (1) | US7683051B2 (es) |
EP (1) | EP1732890A1 (es) |
JP (2) | JP2007532560A (es) |
KR (1) | KR20060135866A (es) |
AR (1) | AR048527A1 (es) |
AU (1) | AU2005233133A1 (es) |
BR (1) | BRPI0509191A (es) |
CA (1) | CA2561010A1 (es) |
CR (1) | CR8615A (es) |
EC (1) | ECSP066911A (es) |
IL (1) | IL178236A0 (es) |
NO (1) | NO20065052L (es) |
PA (1) | PA8629101A1 (es) |
PE (1) | PE20060676A1 (es) |
RU (1) | RU2006132180A (es) |
SG (1) | SG151331A1 (es) |
TW (1) | TWI346105B (es) |
WO (1) | WO2005100316A1 (es) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007532548A (ja) * | 2004-04-07 | 2007-11-15 | ワイス | バゼドキシフェンアセテートの結晶質多形体 |
SG151331A1 (en) | 2004-04-07 | 2009-04-30 | Wyeth Corp | Crystalline polymorph of a bazedoxifene acetate |
US8538393B1 (en) | 2004-09-21 | 2013-09-17 | Advanced Ground Information Systems, Inc. | Method to provide ad hoc and password protected digital and voice networks |
US10645562B2 (en) | 2004-09-21 | 2020-05-05 | Agis Software Development Llc | Method to provide ad hoc and password protected digital and voice networks |
CN101252921A (zh) * | 2005-06-29 | 2008-08-27 | 惠氏公司 | 轭合雌激素类物质和苯卓昔芬的制剂 |
AU2006283121A1 (en) * | 2005-08-24 | 2007-03-01 | Wyeth | Bazedoxifene acetate formulations and manufacturing process thereof |
PE20090100A1 (es) * | 2007-03-30 | 2009-02-26 | Wyeth Corp | Metodos de separacion y deteccion de acetato de bacedoxifeno en composiciones farmaceuticas |
CZ302358B6 (cs) * | 2007-07-25 | 2011-03-30 | Zentiva, A. S. | Nové soli bazedoxifenu |
US20100016582A1 (en) * | 2008-02-11 | 2010-01-21 | Wyeth | Methods of converting polymorphic form b of bazedoxifene acetate to polymorphic form a of bazedoxifene acetate |
WO2009102778A1 (en) * | 2008-02-11 | 2009-08-20 | Wyeth | Amorphous polymorph of bazedoxifene acetate |
WO2009102773A1 (en) | 2008-02-11 | 2009-08-20 | Wyeth | Methods of preparing polymorphic form a of bazedoxifene acetate |
ITMI20091109A1 (it) | 2009-06-23 | 2010-12-24 | Wyeth Corp | Forma polimorfa d di bazedoxifene acetato e metodi per la sua preparazione |
ES2436841T3 (es) | 2009-10-27 | 2014-01-07 | Wyeth Llc | Formulaciones de bazedoxifeno con antioxidantes |
US8154175B2 (en) * | 2009-12-16 | 2012-04-10 | Hamilton Sundstrand Corporation | Sensing device |
WO2012007453A1 (en) | 2010-07-14 | 2012-01-19 | Sandoz Ag | Crystalline compound of 1-[4-(2-azepan-1-ylethoxy)benzyl]-2-(4-hydroxyphenyl)-3-methyl-1h-indol-5-ol |
EP2407467A1 (de) | 2010-07-14 | 2012-01-18 | Sandoz Ag | Kristalline Verbindung von 1-[4-(2-azepan-1-yl-ethoxy)-benzyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol und Milchsäure |
EP2616463A4 (en) * | 2010-09-14 | 2014-01-08 | Reddys Lab Ltd Dr | PREPARATION OF CRYSTALLINE BAZEDOXIFES AND THEIR SALTS |
EP2471770A1 (en) * | 2010-12-28 | 2012-07-04 | Sandoz Ag | Method of preparing polymorphic pure form A of bazedoxifene acetate |
WO2013182170A1 (en) | 2012-06-07 | 2013-12-12 | Zentiva, K. S. | Enhancement of dissolution rate from pharmaceutical composition comprising bazedoxifene acetate |
WO2013182169A1 (en) | 2012-06-07 | 2013-12-12 | Zentiva, K. S. | Process of preparation of an antioxidant-free polymorphically and chemically stable formulation of bazedoxifene acetate |
JP2016518449A (ja) | 2013-05-15 | 2016-06-23 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションIndiana University Research And Technology Corporation | インドール製剤を調製するためのプロセスおよび中間体 |
CN111060619B (zh) * | 2019-12-18 | 2022-11-18 | 北京鑫开元医药科技有限公司 | 一种醋酸巴多昔芬杂质的检测方法 |
US11246874B1 (en) | 2021-04-20 | 2022-02-15 | Oxygen Biotech LLC | Treatment of COVID-19 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW397821B (en) | 1996-04-19 | 2000-07-11 | American Home Produits Corp | 3-[4-(2-phenyl-indole-1-ylmethyl)-phenyl]-acrylamides and 2-phenyl-1-[4-(amino-1-yl-alk-1-ynyl)-benzyl]-1H-indol-5-ol as well as pharmaceutical compositions of estrogenic agents thereof |
SK281737B6 (sk) | 1996-04-19 | 2001-07-10 | American Home Products Corporation | 2-fenylindolové zlúčeniny, farmaceutický prostriedok s ich obsahom a ich použitie |
US5880137A (en) | 1996-04-19 | 1999-03-09 | American Home Products Corporation | 2-phenyl-1- 4-(amino-1-yl-alk-1-ynyl)-benzyl!-1H-indol-5-ols as estrogenic agents |
US5780497A (en) | 1996-04-19 | 1998-07-14 | American Home Products Corporation | 2-phenyl-1- 4-(amino-1-yl-alk-1-ynyl)-benzyl!-1H-indol-5-ols as estrogenic agents |
US5998402A (en) | 1996-04-19 | 1999-12-07 | American Home Products Corporation | 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indoles as estrogenic agents |
CA2306343C (en) * | 1997-10-15 | 2010-08-03 | American Home Products Corporation | Novel aryloxy-alkyl-dialkylamines |
US6005102A (en) | 1997-10-15 | 1999-12-21 | American Home Products Corporation | Aryloxy-alkyl-dialkylamines |
US6479535B1 (en) * | 1998-05-15 | 2002-11-12 | Wyeth | 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole and estrogen formulations |
AR029538A1 (es) | 2000-07-06 | 2003-07-02 | Wyeth Corp | Composiciones farmaceuticas de agentes estrogenicos |
EP1336602A1 (en) | 2002-02-13 | 2003-08-20 | Giovanni Scaramuzzino | Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases |
MXPA04012419A (es) * | 2002-06-25 | 2005-04-19 | Wyeth Corp | Uso de derivados de tio-oxindol en el tratamiento de condiciones relacionadas con la hormona. |
SG151331A1 (en) | 2004-04-07 | 2009-04-30 | Wyeth Corp | Crystalline polymorph of a bazedoxifene acetate |
-
2005
- 2005-04-06 SG SG200902227-8A patent/SG151331A1/en unknown
- 2005-04-06 US US11/100,983 patent/US7683051B2/en active Active
- 2005-04-06 AR ARP050101367A patent/AR048527A1/es unknown
- 2005-04-06 RU RU2006132180/04A patent/RU2006132180A/ru not_active Application Discontinuation
- 2005-04-06 KR KR1020067020649A patent/KR20060135866A/ko not_active Application Discontinuation
- 2005-04-06 CA CA002561010A patent/CA2561010A1/en not_active Abandoned
- 2005-04-06 TW TW094110850A patent/TWI346105B/zh active
- 2005-04-06 PE PE2005000386A patent/PE20060676A1/es not_active Application Discontinuation
- 2005-04-06 WO PCT/US2005/011724 patent/WO2005100316A1/en active Application Filing
- 2005-04-06 AU AU2005233133A patent/AU2005233133A1/en not_active Withdrawn
- 2005-04-06 EP EP05738044A patent/EP1732890A1/en not_active Withdrawn
- 2005-04-06 JP JP2007507487A patent/JP2007532560A/ja not_active Abandoned
- 2005-04-06 BR BRPI0509191-8A patent/BRPI0509191A/pt not_active IP Right Cessation
- 2005-04-06 PA PA20058629101A patent/PA8629101A1/es unknown
-
2006
- 2006-09-12 CR CR8615A patent/CR8615A/es not_active Application Discontinuation
- 2006-09-21 IL IL178236A patent/IL178236A0/en unknown
- 2006-10-06 EC EC2006006911A patent/ECSP066911A/es unknown
- 2006-11-02 NO NO20065052A patent/NO20065052L/no not_active Application Discontinuation
-
2008
- 2008-06-30 JP JP2008171135A patent/JP2009035535A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
SG151331A1 (en) | 2009-04-30 |
CR8615A (es) | 2007-06-06 |
CA2561010A1 (en) | 2005-10-27 |
EP1732890A1 (en) | 2006-12-20 |
PE20060676A1 (es) | 2006-07-24 |
BRPI0509191A (pt) | 2007-09-25 |
AU2005233133A1 (en) | 2005-10-27 |
TWI346105B (en) | 2011-08-01 |
TW200606149A (en) | 2006-02-16 |
PA8629101A1 (es) | 2005-11-25 |
JP2007532560A (ja) | 2007-11-15 |
ECSP066911A (es) | 2006-12-20 |
WO2005100316A1 (en) | 2005-10-27 |
US7683051B2 (en) | 2010-03-23 |
US20050227965A1 (en) | 2005-10-13 |
JP2009035535A (ja) | 2009-02-19 |
KR20060135866A (ko) | 2006-12-29 |
IL178236A0 (en) | 2006-12-31 |
RU2006132180A (ru) | 2008-05-20 |
NO20065052L (no) | 2006-11-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FB | Suspension of granting procedure |