RU2006123423A - Фармацевтические применения бисфосфонатов - Google Patents
Фармацевтические применения бисфосфонатов Download PDFInfo
- Publication number
- RU2006123423A RU2006123423A RU2006123423/15A RU2006123423A RU2006123423A RU 2006123423 A RU2006123423 A RU 2006123423A RU 2006123423/15 A RU2006123423/15 A RU 2006123423/15A RU 2006123423 A RU2006123423 A RU 2006123423A RU 2006123423 A RU2006123423 A RU 2006123423A
- Authority
- RU
- Russia
- Prior art keywords
- bisphosphonate
- chemotherapeutic agent
- trail
- acceptable salt
- letrozole
- Prior art date
Links
- 229940122361 Bisphosphonate Drugs 0.000 title claims 27
- 150000004663 bisphosphonates Chemical class 0.000 title claims 24
- 239000002246 antineoplastic agent Substances 0.000 claims 17
- 229940127089 cytotoxic agent Drugs 0.000 claims 17
- 229930012538 Paclitaxel Natural products 0.000 claims 10
- 229960001592 paclitaxel Drugs 0.000 claims 10
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 10
- 238000000034 method Methods 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- XRASPMIURGNCCH-UHFFFAOYSA-N zoledronic acid Chemical group OP(=O)(O)C(P(O)(O)=O)(O)CN1C=CN=C1 XRASPMIURGNCCH-UHFFFAOYSA-N 0.000 claims 8
- HPJKCIUCZWXJDR-UHFFFAOYSA-N letrozole Chemical compound C1=CC(C#N)=CC=C1C(N1N=CN=C1)C1=CC=C(C#N)C=C1 HPJKCIUCZWXJDR-UHFFFAOYSA-N 0.000 claims 7
- 229960003881 letrozole Drugs 0.000 claims 7
- 125000003277 amino group Chemical group 0.000 claims 6
- 125000001589 carboacyl group Chemical group 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 239000001257 hydrogen Substances 0.000 claims 6
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 6
- 230000003211 malignant effect Effects 0.000 claims 6
- 239000000825 pharmaceutical preparation Substances 0.000 claims 6
- 229940122815 Aromatase inhibitor Drugs 0.000 claims 4
- 239000003886 aromatase inhibitor Substances 0.000 claims 4
- 229960004276 zoledronic acid Drugs 0.000 claims 4
- 230000006907 apoptotic process Effects 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 150000004677 hydrates Chemical class 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 230000001939 inductive effect Effects 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- 239000002552 dosage form Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000003446 ligand Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 230000005907 cancer growth Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
- A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0328040.1A GB0328040D0 (en) | 2003-12-03 | 2003-12-03 | Pharmaceutical uses of bisphosphonates |
| GB0328040.1 | 2003-12-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2006123423A true RU2006123423A (ru) | 2008-01-20 |
Family
ID=29764511
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2006123423/15A RU2006123423A (ru) | 2003-12-03 | 2004-12-02 | Фармацевтические применения бисфосфонатов |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20070219115A1 (https=) |
| EP (1) | EP1691816A2 (https=) |
| JP (1) | JP2007513118A (https=) |
| KR (1) | KR20060130052A (https=) |
| CN (2) | CN101669958A (https=) |
| AU (1) | AU2004294713B2 (https=) |
| BR (1) | BRPI0417218A (https=) |
| CA (1) | CA2546782A1 (https=) |
| GB (1) | GB0328040D0 (https=) |
| RU (1) | RU2006123423A (https=) |
| WO (1) | WO2005053709A2 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2332636B1 (es) * | 2008-08-06 | 2011-02-10 | Universitat De Les Illes Balears | Composicion de liquido de dialisis. |
| WO2011133687A2 (en) * | 2010-04-20 | 2011-10-27 | President And Fellows Of Harvard College | Methods and compositions for inhibition of beta2-adrenergic receptor degradation |
| CN102961785A (zh) * | 2012-11-09 | 2013-03-13 | 于秀淳 | 一种用于治疗骨巨细胞瘤的瘤腔填充物及其制备方法 |
| AU2018445164B2 (en) | 2018-10-11 | 2025-05-29 | Vifor (International) Ltd. | Inositol phosphates for the treatment of ectopic calcification |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SK288365B6 (sk) * | 1999-02-10 | 2016-07-01 | Astrazeneca Ab | Medziprodukty pre chinazolínové deriváty ako inhibítory angiogenézy |
| BR0213410A (pt) * | 2001-10-19 | 2004-11-03 | Novartis Ag | Usos farmacêuticos de bisfosfonatos |
| AU2003250190A1 (en) * | 2002-07-30 | 2004-02-23 | Novartis Ag | Combination of an aromatase inhibitor with a bisphosphonate |
-
2003
- 2003-12-03 GB GBGB0328040.1A patent/GB0328040D0/en not_active Ceased
-
2004
- 2004-12-02 CA CA002546782A patent/CA2546782A1/en not_active Abandoned
- 2004-12-02 BR BRPI0417218-3A patent/BRPI0417218A/pt not_active IP Right Cessation
- 2004-12-02 RU RU2006123423/15A patent/RU2006123423A/ru not_active Application Discontinuation
- 2004-12-02 US US10/578,290 patent/US20070219115A1/en not_active Abandoned
- 2004-12-02 CN CN200910161293A patent/CN101669958A/zh active Pending
- 2004-12-02 KR KR1020067010798A patent/KR20060130052A/ko not_active Ceased
- 2004-12-02 WO PCT/EP2004/013728 patent/WO2005053709A2/en not_active Ceased
- 2004-12-02 CN CNA2004800360730A patent/CN1889962A/zh active Pending
- 2004-12-02 EP EP04803464A patent/EP1691816A2/en not_active Withdrawn
- 2004-12-02 AU AU2004294713A patent/AU2004294713B2/en not_active Ceased
- 2004-12-02 JP JP2006541901A patent/JP2007513118A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0417218A (pt) | 2007-02-21 |
| EP1691816A2 (en) | 2006-08-23 |
| WO2005053709A2 (en) | 2005-06-16 |
| CN101669958A (zh) | 2010-03-17 |
| WO2005053709A3 (en) | 2006-01-05 |
| US20070219115A1 (en) | 2007-09-20 |
| AU2004294713A1 (en) | 2005-06-16 |
| CA2546782A1 (en) | 2005-06-16 |
| AU2004294713B2 (en) | 2009-04-30 |
| CN1889962A (zh) | 2007-01-03 |
| JP2007513118A (ja) | 2007-05-24 |
| KR20060130052A (ko) | 2006-12-18 |
| GB0328040D0 (en) | 2004-01-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZ9A | Application not withdrawn (correction of the notice of withdrawal) |
Effective date: 20080123 |
|
| FA94 | Acknowledgement of application withdrawn (non-payment of fees) |
Effective date: 20101126 |