RU2006110535A - Промежуточные продукты для получения гибридов оксазолидинона и хинолона - Google Patents
Промежуточные продукты для получения гибридов оксазолидинона и хинолона Download PDFInfo
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- RU2006110535A RU2006110535A RU2006110535/04A RU2006110535A RU2006110535A RU 2006110535 A RU2006110535 A RU 2006110535A RU 2006110535/04 A RU2006110535/04 A RU 2006110535/04A RU 2006110535 A RU2006110535 A RU 2006110535A RU 2006110535 A RU2006110535 A RU 2006110535A
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- WWGLOGYVNNZKRX-UHFFFAOYSA-N CC(C)N(CC(C(C)(C)C)O1)C1=O Chemical compound CC(C)N(CC(C(C)(C)C)O1)C1=O WWGLOGYVNNZKRX-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Claims (11)
1. Соединения формулы (ZP)
в которой U обозначает атом азота или группу СН,
V обозначает атом кислорода, атом серы или группу формулы CR6R7,
W обозначает связь, атом кислорода, атом серы, группу формулы NR8, необязательно замещенную циклоалкиленовую, гетероциклоалкиленовую, алкилциклоалкиленовую, гетероалкилциклоалкиленовую, ариленовую, гетероариленовую, аралкиленовую или гетероаралкиленовую группу,
Х обозначает атом кислорода или атом серы,
Y выбран из группы, включающей
Z обозначает необязательно замещенную алкиленовую, алкениленовую, алкиниленовую, гетероалкиленовую, циклоалкиленовую, гетероциклоалкиленовую, алкилциклоалкиленовую, гетероалкилциклоалкиленовую, ариленовую, гетероариленовую, аралкиленовую или гетероаралкиленовую группу,
остатки R6 и R7 независимо друг от друга представляют собой атом водорода, атом галогена, гидрокси-, амино-, нитро- или тиоловую группу, необязательно замещенный алкильный, алкенильный, алкинильный, гетероалкильныи, арильныи, гетероарильный, циклоалкильный, алкилциклоалкильный, гетероалкилциклоалкильный, гетероциклоалкильный, аралкильный или гетероаралкильный остаток,
R8 представляет собой атом водорода, необязательно замещенный алкильный, алкенильный, алкинильный, гетероалкильныи, арильныи, гетероарильный, циклоалкильный, алкилциклоалкильный, гетероалкилциклоалкильный, гетероциклоалкильный, аралкильный или гетероаралкильный остаток.
2. Соединения по п.1, где U обозначает группу СН.
3. Соединения по п.1, где R6 и R7 представляют собой атомы водорода.
4. Соединения по п.1, где V обозначает атом кислорода.
5. Соединения по п.1, где Y имеет следующую структурную формулу:
6. Соединения по п.1, где W обозначает необязательно замещенную гетероциклоалкиленовую группу, содержащую цикл с 4, 5, 6 или 7 атомами в цикле.
7. Соединения по п.1, где Z обозначает С1-С4алкиленовую группу.
8. Соединения по п.1, где Z обозначает группу СН2 или группу СН2СН2.
9. Соединения по п.1, где Z и W совместно образуют группу формулы
где n обозначает 1 или 2, m обозначает 1 или 2 и о обозначает 1 или 2, при этом данная группа необязательно может быть замещена группой ОН, ОРО3Н2, OSO3Н либо гетероалкильной группой, которая несет по меньшей мере одну ОН-, NH2-, SO3Н-, РО3Н2- или СООН-группу.
10. Соединения по п.1, где W имеет следующую структурную формулу:
11. Применение соединения по п.1 для получения соединения формулы (I)
в которой А обозначает атом азота или группу СН, а остальные остатки имеют указанные в п.1 значения.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2003140485 DE10340485B4 (de) | 2003-09-03 | 2003-09-03 | Verfahren zur Herstellung von Oxazolidinon-Chinolon Hybriden |
| DE10340485.6 | 2003-09-03 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2006110535A true RU2006110535A (ru) | 2007-10-10 |
| RU2373203C2 RU2373203C2 (ru) | 2009-11-20 |
Family
ID=34258351
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2006110535/04A RU2373203C2 (ru) | 2003-09-03 | 2004-09-03 | Промежуточные продукты для получения производных оксазолидинона и хинолона |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US7557214B2 (ru) |
| EP (2) | EP2374806B1 (ru) |
| JP (1) | JP4742039B2 (ru) |
| KR (1) | KR101211025B1 (ru) |
| CN (1) | CN100467466C (ru) |
| AU (1) | AU2004270379B2 (ru) |
| BR (1) | BRPI0414107B8 (ru) |
| CA (1) | CA2537345C (ru) |
| DE (1) | DE10340485B4 (ru) |
| ES (1) | ES2509868T3 (ru) |
| HK (1) | HK1083848A1 (ru) |
| IL (2) | IL173407A0 (ru) |
| MX (1) | MXPA06002366A (ru) |
| NZ (1) | NZ545491A (ru) |
| RU (1) | RU2373203C2 (ru) |
| WO (1) | WO2005023801A1 (ru) |
| ZA (1) | ZA200601178B (ru) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003031443A1 (en) | 2001-10-04 | 2003-04-17 | Morphochem Aktiengesellschaft für kombinatorische Chemie | Dual actions antibiotics comprising a oxazoldinone and a quinolone or naphthyridinone moiety |
| WO2004096221A1 (en) | 2003-04-30 | 2004-11-11 | Morphochem Aktiengesellschaft für kombinatorische Chemie | Use of oxazolidinone-quinoline hybrid antibiotics for the treatment of anthrax and other infections |
| DE10340485B4 (de) * | 2003-09-03 | 2015-05-13 | Morphochem AG Aktiengesellschaft für kombinatorische Chemie | Verfahren zur Herstellung von Oxazolidinon-Chinolon Hybriden |
| EP1709044B2 (en) | 2003-12-18 | 2013-11-20 | Morphochem Aktiengesellschaft Für Kombinatorische Chemie | Oxazolidinone-quinolone hybrid antibiotics |
| US8158797B2 (en) | 2003-12-18 | 2012-04-17 | Morphochem Aktiengesellschaft Fur Kombinatorische Chemie | Oxazolidinone-quinolone hybrid antibiotics |
| US8124623B2 (en) | 2006-11-10 | 2012-02-28 | Actelion Pharmaceuticals Ltd. | 5-hydroxymethyl-oxazolidin-2-one-derivatives and their uses as antibacterials |
| CL2007003332A1 (es) | 2006-11-24 | 2008-06-20 | Actelion Pharmaceuticals Ltd | Compuestos derivados de heterociclos condensados; compuestos intermediarios; composicion farmaceutica; y uso en la prevencion o tratamiento de infecciones bacterianas. |
| US20080176860A1 (en) * | 2007-01-19 | 2008-07-24 | Lutz Weber | Pyridin-2-one compounds |
| US9993469B2 (en) | 2013-05-28 | 2018-06-12 | Morphochem Aktiengesellschaft Für Kombinatorishe Chemie | Combination therapy comprising oxazolidinone-quinolones for use in treating bacterial infections |
| EP3517106A1 (en) | 2013-05-28 | 2019-07-31 | Morphochem Aktiengesellschaft für kombinatorische Chemie | Oxazolidinone-quinolone hybrid antibacterials for the parenteral treatment or prophylaxis of bacterial diseases |
| CN108059624A (zh) * | 2016-11-08 | 2018-05-22 | 上海医药工业研究院 | 用于制备咔哒唑胺关键中间体的制备方法 |
| US10087171B2 (en) | 2016-12-19 | 2018-10-02 | Actelion Pharmaceuticals Ltd | Crystalline forms of cadazolid |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4840956A (en) | 1986-02-18 | 1989-06-20 | Warner-Lambert Company | Novel disubstituted-7-pyrrolidinoquinoline antibacterial agents |
| NZ222047A (en) | 1986-10-08 | 1991-01-29 | Bristol Myers Co | Quinoline - or naphthyridine - carboxylic acid anti-bacterial agents |
| JPH0269478A (ja) | 1988-09-05 | 1990-03-08 | Sagami Chem Res Center | キノロンカルボン酸誘導体 |
| US5491139A (en) | 1988-10-24 | 1996-02-13 | The Procter & Gamble Company | Antimicrobial quinolonyl lactams |
| DE69019859T2 (de) | 1989-03-30 | 1995-10-05 | Wakunaga Seiyaku Kk | Chinolon-Derivate und deren Salze, Verfahren zu deren Herstellung und diese enthaltende antibakterielle Wirkstoffe. |
| CA2119556C (en) | 1991-11-01 | 2004-07-06 | Michael Robert Barbachyn | Substituted aryl- and heteroaryl-phenyloxazolidinones |
| US5221676A (en) | 1992-02-06 | 1993-06-22 | Warner-Lambert Company | 7-substituted quinolones and naphthyridones as antibacterial agents |
| EP0992501B1 (en) | 1995-09-22 | 2002-08-28 | Wakunaga Pharmaceutical Co., Ltd. | Pyridonecarboxylic acid derivatives as antibacterial agents |
| DE19601265A1 (de) | 1996-01-16 | 1997-07-17 | Bayer Ag | 2-Oxo- und 2-Thio-1,2-dihydrochinolinyl-oxazolidinone |
| GB9702213D0 (en) | 1996-02-24 | 1997-03-26 | Zeneca Ltd | Chemical compounds |
| DE19633480A1 (de) | 1996-08-20 | 1998-02-26 | Bayer Ag | Oral applizierbare Formulierungen von Chinolon- und Naphthyridoncarbonsäuren |
| GB9725244D0 (en) | 1997-11-29 | 1998-01-28 | Zeneca Ltd | Chemical compounds |
| EP1049682A1 (en) * | 1998-01-23 | 2000-11-08 | Versicor, Inc. | Oxazolidinone combinatorial libraries, compositions and methods of preparation |
| TW572757B (en) * | 1998-08-24 | 2004-01-21 | Bristol Myers Squibb Co | Novel isoxazolinone antibacterial agents |
| KR100324621B1 (ko) | 1999-04-27 | 2002-02-27 | 박호군 | 퀴놀론이 치환된 옥사졸리디논 유도체 및 그의 제조 방법과 항균제로서의 용도 |
| NZ516853A (en) | 1999-07-28 | 2003-11-28 | Upjohn Co | Oxazolidinones and their use as anti-infectives |
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| WO2002059116A2 (en) | 2000-12-21 | 2002-08-01 | Pharmacia & Upjohn Company | Antimicrobial quinolone derivatives and use of the same to treat bacterial infections |
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| WO2003031441A1 (en) | 2001-10-04 | 2003-04-17 | Morphochen Aktiengesellschaft Für Kombinatorische Chemie | Multiple action compounds |
| WO2003031443A1 (en) | 2001-10-04 | 2003-04-17 | Morphochem Aktiengesellschaft für kombinatorische Chemie | Dual actions antibiotics comprising a oxazoldinone and a quinolone or naphthyridinone moiety |
| RU2365588C2 (ru) | 2002-02-01 | 2009-08-27 | Астразенека Аб | Хиназолиновые соединения |
| US20040132764A1 (en) * | 2002-10-23 | 2004-07-08 | Morphochem Aktiengesellschaft Fuer Kombinatorische Chemie | Antibiotics for the treatment of infections in acidic environments |
| WO2004069816A1 (en) | 2003-02-07 | 2004-08-19 | Ranbaxy Laboratories Limited | Oxazolidinone derivatives as antimicrobials |
| WO2004096221A1 (en) * | 2003-04-30 | 2004-11-11 | Morphochem Aktiengesellschaft für kombinatorische Chemie | Use of oxazolidinone-quinoline hybrid antibiotics for the treatment of anthrax and other infections |
| DE10340485B4 (de) * | 2003-09-03 | 2015-05-13 | Morphochem AG Aktiengesellschaft für kombinatorische Chemie | Verfahren zur Herstellung von Oxazolidinon-Chinolon Hybriden |
| US8158797B2 (en) * | 2003-12-18 | 2012-04-17 | Morphochem Aktiengesellschaft Fur Kombinatorische Chemie | Oxazolidinone-quinolone hybrid antibiotics |
| EP1709044B2 (en) * | 2003-12-18 | 2013-11-20 | Morphochem Aktiengesellschaft Für Kombinatorische Chemie | Oxazolidinone-quinolone hybrid antibiotics |
| AR054608A1 (es) | 2005-08-08 | 2007-06-27 | Actelion Pharmaceuticals Ltd | Derivados de oxazolidinona enlazados a quinolonas como antibacterianos |
| EP2086968B1 (en) | 2006-11-10 | 2012-02-08 | Actelion Pharmaceuticals Ltd. | 5-hydroxymethyl-oxazolidin-2-one derivatives |
| CL2007003332A1 (es) | 2006-11-24 | 2008-06-20 | Actelion Pharmaceuticals Ltd | Compuestos derivados de heterociclos condensados; compuestos intermediarios; composicion farmaceutica; y uso en la prevencion o tratamiento de infecciones bacterianas. |
| MY156304A (en) | 2008-05-09 | 2016-01-29 | Actelion Pharmaceuticals Ltd | 5-hydroxymethyl-oxazolidin-2-one derivatives for treating bacterial intestinal diseases |
-
2003
- 2003-09-03 DE DE2003140485 patent/DE10340485B4/de not_active Expired - Lifetime
-
2004
- 2004-09-03 BR BRPI0414107A patent/BRPI0414107B8/pt active IP Right Grant
- 2004-09-03 NZ NZ545491A patent/NZ545491A/en not_active IP Right Cessation
- 2004-09-03 JP JP2006525723A patent/JP4742039B2/ja not_active Expired - Fee Related
- 2004-09-03 US US10/570,775 patent/US7557214B2/en active Active
- 2004-09-03 ZA ZA200601178A patent/ZA200601178B/en unknown
- 2004-09-03 MX MXPA06002366A patent/MXPA06002366A/es active IP Right Grant
- 2004-09-03 CN CNB2004800252844A patent/CN100467466C/zh not_active Expired - Lifetime
- 2004-09-03 AU AU2004270379A patent/AU2004270379B2/en not_active Expired
- 2004-09-03 RU RU2006110535/04A patent/RU2373203C2/ru active
- 2004-09-03 EP EP10011797.7A patent/EP2374806B1/de not_active Expired - Lifetime
- 2004-09-03 ES ES04764810.0T patent/ES2509868T3/es not_active Expired - Lifetime
- 2004-09-03 WO PCT/EP2004/009858 patent/WO2005023801A1/de active Application Filing
- 2004-09-03 CA CA2537345A patent/CA2537345C/en not_active Expired - Lifetime
- 2004-09-03 EP EP04764810.0A patent/EP1660489B1/de not_active Expired - Lifetime
-
2006
- 2006-01-29 IL IL173407A patent/IL173407A0/en active IP Right Grant
- 2006-02-28 KR KR1020067004155A patent/KR101211025B1/ko active IP Right Grant
- 2006-06-01 HK HK06106306.0A patent/HK1083848A1/xx not_active IP Right Cessation
-
2009
- 2009-06-05 US US12/455,810 patent/US8124772B2/en not_active Expired - Lifetime
-
2010
- 2010-05-12 IL IL205706A patent/IL205706A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| CA2537345A1 (en) | 2005-03-17 |
| BRPI0414107B8 (pt) | 2021-05-25 |
| HK1083848A1 (en) | 2006-07-14 |
| RU2373203C2 (ru) | 2009-11-20 |
| AU2004270379B2 (en) | 2011-03-31 |
| WO2005023801A1 (de) | 2005-03-17 |
| EP2374806B1 (de) | 2016-11-02 |
| BRPI0414107B1 (pt) | 2018-07-03 |
| US20070004769A1 (en) | 2007-01-04 |
| EP1660489B1 (de) | 2014-07-02 |
| IL205706A0 (en) | 2011-08-01 |
| CN100467466C (zh) | 2009-03-11 |
| DE10340485A1 (de) | 2005-05-12 |
| ES2509868T3 (es) | 2014-10-20 |
| JP4742039B2 (ja) | 2011-08-10 |
| JP2007504262A (ja) | 2007-03-01 |
| DE10340485B4 (de) | 2015-05-13 |
| MXPA06002366A (es) | 2006-06-20 |
| EP2374806A1 (de) | 2011-10-12 |
| EP1660489A1 (de) | 2006-05-31 |
| KR101211025B1 (ko) | 2012-12-11 |
| US7557214B2 (en) | 2009-07-07 |
| NZ545491A (en) | 2009-12-24 |
| AU2004270379A1 (en) | 2005-03-17 |
| CA2537345C (en) | 2013-01-29 |
| CN1845923A (zh) | 2006-10-11 |
| ZA200601178B (en) | 2007-04-25 |
| US8124772B2 (en) | 2012-02-28 |
| IL173407A0 (en) | 2006-06-11 |
| BRPI0414107A (pt) | 2007-04-27 |
| US20090306389A1 (en) | 2009-12-10 |
| IL205706A (en) | 2013-06-27 |
| KR20060121849A (ko) | 2006-11-29 |
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