RU2005128830A - Обладающие противоопухолевым действием 2-замещенные d-гомоэстра-1, 3, 5( 10 )-триен-3-илсульфаматы - Google Patents
Обладающие противоопухолевым действием 2-замещенные d-гомоэстра-1, 3, 5( 10 )-триен-3-илсульфаматы Download PDFInfo
- Publication number
- RU2005128830A RU2005128830A RU2005128830/04A RU2005128830A RU2005128830A RU 2005128830 A RU2005128830 A RU 2005128830A RU 2005128830/04 A RU2005128830/04 A RU 2005128830/04A RU 2005128830 A RU2005128830 A RU 2005128830A RU 2005128830 A RU2005128830 A RU 2005128830A
- Authority
- RU
- Russia
- Prior art keywords
- trien
- sulfamate
- homoestra
- methoxy
- dihomoestra
- Prior art date
Links
- IIACRCGMVDHOTQ-UHFFFAOYSA-N sulfamic acid Chemical class NS(O)(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-N 0.000 claims abstract 16
- 238000004519 manufacturing process Methods 0.000 claims abstract 6
- 125000006527 (C1-C5) alkyl group Chemical group 0.000 claims abstract 3
- MQLACMBJVPINKE-UHFFFAOYSA-N 10-[(3-hydroxy-4-methoxyphenyl)methylidene]anthracen-9-one Chemical compound C1=C(O)C(OC)=CC=C1C=C1C2=CC=CC=C2C(=O)C2=CC=CC=C21 MQLACMBJVPINKE-UHFFFAOYSA-N 0.000 claims abstract 3
- 206010028980 Neoplasm Diseases 0.000 claims abstract 2
- 206010060862 Prostate cancer Diseases 0.000 claims abstract 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims abstract 2
- 150000001875 compounds Chemical class 0.000 claims abstract 2
- IIACRCGMVDHOTQ-UHFFFAOYSA-M sulfamate Chemical compound NS([O-])(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-M 0.000 claims 63
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 12
- 125000003047 N-acetyl group Chemical group 0.000 claims 11
- 239000003814 drug Substances 0.000 claims 6
- -1 methylene, difluoromethylene Chemical group 0.000 claims 6
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 2
- 229910052731 fluorine Inorganic materials 0.000 claims 2
- 239000011737 fluorine Substances 0.000 claims 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 2
- 125000003506 n-propoxy group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])O* 0.000 claims 2
- 150000002923 oximes Chemical class 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 210000001752 female genitalia Anatomy 0.000 claims 1
- 210000004392 genitalia Anatomy 0.000 claims 1
- 210000004907 gland Anatomy 0.000 claims 1
- 210000000260 male genitalia Anatomy 0.000 claims 1
- 210000005075 mammary gland Anatomy 0.000 claims 1
- 230000000771 oncological effect Effects 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 230000001629 suppression Effects 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 abstract 2
- 239000008177 pharmaceutical agent Substances 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10307103.2 | 2003-02-19 | ||
| DE10307103A DE10307103A1 (de) | 2003-02-19 | 2003-02-19 | Antitumor wirksame 2-substituierte D-Homostra-1,3,5(10)-trien-3-yl sulfamate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2005128830A true RU2005128830A (ru) | 2007-03-27 |
Family
ID=32841727
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2005128830/04A RU2005128830A (ru) | 2003-02-19 | 2004-02-19 | Обладающие противоопухолевым действием 2-замещенные d-гомоэстра-1, 3, 5( 10 )-триен-3-илсульфаматы |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | USRE42132E1 (https=) |
| EP (1) | EP1594886B1 (https=) |
| JP (1) | JP4718439B2 (https=) |
| CN (1) | CN100343272C (https=) |
| AT (1) | ATE406375T1 (https=) |
| AU (1) | AU2004213148A1 (https=) |
| BR (1) | BRPI0407681A (https=) |
| CA (1) | CA2516184A1 (https=) |
| DE (2) | DE10307103A1 (https=) |
| ES (1) | ES2312965T3 (https=) |
| MX (1) | MXPA05008833A (https=) |
| RU (1) | RU2005128830A (https=) |
| WO (1) | WO2004074309A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2680603C1 (ru) * | 2018-11-08 | 2019-02-25 | Ильясов Шамиль Сионович | Применение 3-о-сульфамата-16,16-диметил-d-гомоэквиленина для лечения онкологических заболеваний |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10307103A1 (de) | 2003-02-19 | 2004-09-09 | Schering Ag | Antitumor wirksame 2-substituierte D-Homostra-1,3,5(10)-trien-3-yl sulfamate |
| US7435757B2 (en) | 2004-07-02 | 2008-10-14 | Schering Ag | 2-substituted D-homo-estra-1,3,5(10)-trienes as inhibitors of 17β-hydroxy steroid dehydrogenase type 1 |
| DE102004032673A1 (de) * | 2004-07-02 | 2006-01-26 | Schering Ag | Neue 2-substituierte D-Homo-estra-1,3,5(10)-triene als Inhibitoren der 17ß-Hydroxysteroiddehydrogenase Typ 1 |
| RU2629186C1 (ru) * | 2016-07-28 | 2017-08-25 | Федеральное государственное автономное образовательное учреждение высшего образования "Дальневосточный федеральный университет" (ДВФУ) | Рацемический 2,17аβ-дисульфамоилокси-3-метокси-D-гомо-8α-эстра-1,3,5(10)-триен в качестве ингибитора пролиферации опухолевых клеток MCF-7 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK465481A (da) * | 1980-11-21 | 1982-05-22 | Hoffmann La Roche | Fremgangsmaade til fremstilling af d-homostemoider |
| GB9118478D0 (en) * | 1991-08-29 | 1991-10-16 | Imperial College | Steroid sulphatase inhibitors |
| US6011024A (en) * | 1991-08-28 | 2000-01-04 | Imperial College Of Science Technology & Medicine | Steroid sulphatase inhibitors |
| US6903084B2 (en) * | 1991-08-28 | 2005-06-07 | Sterix Limited | Steroid sulphatase inhibitors |
| GB9625334D0 (en) * | 1996-12-05 | 1997-01-22 | Imperial College | Compound |
| US6908910B2 (en) | 1993-08-06 | 2005-06-21 | The Children's Medical Center Corporation | Estrogenic compounds as anti-mitotic agents |
| DE4429397C2 (de) * | 1994-08-09 | 2003-11-20 | Jenapharm Gmbh | Estra-1,3,5(10)-trien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen |
| DE4447715C2 (de) * | 1994-08-09 | 1998-02-05 | Jenapharm Gmbh | Verwendung von Estra-1,3,5(10)-trien-Derivaten zur hormonalen Behandlung von Prostatakarzinomen |
| DE19540233B4 (de) * | 1995-10-19 | 2005-08-25 | Schering Ag | Sulfamat-Derivate von 1,3,5(10)-Estratrien-Derivaten, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen |
| US5705495A (en) | 1995-10-19 | 1998-01-06 | Jenapharm Gmbh & Co. Kg. | Sulfamate derivatives of 1,3,5(10)-estratriene derivatives, methods for their production and pharmaceuticals containing these compounds |
| US20040127473A1 (en) * | 1996-12-05 | 2004-07-01 | Reed Michael John | Compound |
| DE19712488A1 (de) * | 1997-03-25 | 1998-10-01 | Knoell Hans Forschung Ev | Steroidsulfamate, Verfahren zu ihrer Herstellung und Anwendung derselben |
| GB2331988B (en) | 1997-12-04 | 2003-04-16 | Imperial College | Polycyclic sulphamate inhibitors or oestrone sulphatase |
| US6054446A (en) * | 1997-12-24 | 2000-04-25 | Sri International | Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use |
| US6046186A (en) * | 1997-12-24 | 2000-04-04 | Sri International | Estrone sulfamate inhibitors of estrone sulfatase, and associated pharmaceutical compositions and methods of use |
| US6548491B2 (en) | 1997-12-24 | 2003-04-15 | Sri International | Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use |
| AU765386B2 (en) * | 1998-06-10 | 2003-09-18 | Sterix Limited | Pharmaceutical composition with tumor necrosis factor a and 2-methoxyestrone-3-(o)-sulphamate for inhibition of estrone sulphatase |
| GB9913536D0 (en) * | 1999-06-10 | 1999-08-11 | Sterix Ltd | Use |
| DE19943708B4 (de) * | 1999-09-08 | 2007-12-20 | Bayer Schering Pharma Ag | Neue C13-substituierte Estra-1,3,5(10)-trien-3-yl-sulfamate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen |
| US6583130B1 (en) * | 1999-09-13 | 2003-06-24 | Schering Ag | C13-substituted estra-1,3,5,(10)-trien-3-yl sulfamates, methods of preparing same, and pharmaceutical compositions containing these compounds |
| WO2001030803A1 (en) * | 1999-10-26 | 2001-05-03 | The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services | B-homoestra-1,3,5(10)-trienes as modulators of tubulin polymerization |
| GB0025788D0 (en) * | 2000-10-20 | 2000-12-06 | Sterix Ltd | Use |
| EP1343803A2 (en) | 2000-11-27 | 2003-09-17 | EntreMed, Inc. | 2-substituted estrogens as antiangiogenic agents |
| GB2371299A (en) * | 2001-01-17 | 2002-07-24 | Sabbir Ahmed | Sulfamate oestrone sulfatase inhibitors |
| DE10114364A1 (de) * | 2001-03-22 | 2002-10-02 | Heraeus Kulzer Gmbh & Co Kg | Verfahren zur Herstellung von antibiotischen Kompositen |
| DE10307103A1 (de) | 2003-02-19 | 2004-09-09 | Schering Ag | Antitumor wirksame 2-substituierte D-Homostra-1,3,5(10)-trien-3-yl sulfamate |
| DE10307104A1 (de) * | 2003-02-19 | 2004-09-23 | Schering Ag | Antitumor wirksame 2-substituierte Estra-1,3,5(10)-trien-3-yl sulfamate |
| DE10307105A1 (de) * | 2003-02-19 | 2004-09-09 | Schering Ag | Antitumor wirksame 2-substituierte 18a-Homoestra-1,3,5(10)-trien-3-yl sulfamate |
-
2003
- 2003-02-19 DE DE10307103A patent/DE10307103A1/de not_active Ceased
-
2004
- 2004-02-19 US US12/351,271 patent/USRE42132E1/en not_active Expired - Fee Related
- 2004-02-19 EP EP04712555A patent/EP1594886B1/de not_active Expired - Lifetime
- 2004-02-19 ES ES04712555T patent/ES2312965T3/es not_active Expired - Lifetime
- 2004-02-19 AT AT04712555T patent/ATE406375T1/de not_active IP Right Cessation
- 2004-02-19 CA CA002516184A patent/CA2516184A1/en not_active Abandoned
- 2004-02-19 DE DE502004007950T patent/DE502004007950D1/de not_active Expired - Lifetime
- 2004-02-19 RU RU2005128830/04A patent/RU2005128830A/ru not_active Application Discontinuation
- 2004-02-19 US US10/546,230 patent/US7244762B2/en not_active Ceased
- 2004-02-19 CN CNB2004800045952A patent/CN100343272C/zh not_active Expired - Fee Related
- 2004-02-19 BR BRPI0407681-8A patent/BRPI0407681A/pt not_active IP Right Cessation
- 2004-02-19 WO PCT/EP2004/001629 patent/WO2004074309A1/de not_active Ceased
- 2004-02-19 AU AU2004213148A patent/AU2004213148A1/en not_active Abandoned
- 2004-02-19 JP JP2006501900A patent/JP4718439B2/ja not_active Expired - Fee Related
- 2004-02-19 MX MXPA05008833A patent/MXPA05008833A/es not_active Application Discontinuation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2680603C1 (ru) * | 2018-11-08 | 2019-02-25 | Ильясов Шамиль Сионович | Применение 3-о-сульфамата-16,16-диметил-d-гомоэквиленина для лечения онкологических заболеваний |
Also Published As
| Publication number | Publication date |
|---|---|
| ATE406375T1 (de) | 2008-09-15 |
| US7244762B2 (en) | 2007-07-17 |
| EP1594886B1 (de) | 2008-08-27 |
| JP4718439B2 (ja) | 2011-07-06 |
| WO2004074309A1 (de) | 2004-09-02 |
| CA2516184A1 (en) | 2004-09-02 |
| USRE42132E1 (en) | 2011-02-08 |
| WO2004074309A8 (de) | 2004-12-16 |
| EP1594886A1 (de) | 2005-11-16 |
| DE10307103A8 (de) | 2004-12-16 |
| JP2006517946A (ja) | 2006-08-03 |
| MXPA05008833A (es) | 2005-10-05 |
| ES2312965T3 (es) | 2009-03-01 |
| CN1751061A (zh) | 2006-03-22 |
| AU2004213148A1 (en) | 2004-09-02 |
| BRPI0407681A (pt) | 2006-03-01 |
| DE502004007950D1 (en) | 2008-10-09 |
| CN100343272C (zh) | 2007-10-17 |
| US20060154985A1 (en) | 2006-07-13 |
| DE10307103A1 (de) | 2004-09-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20080408 |