MXPA05008833A - D-homoestra-1,3,5(10)-trien-3-il-sulfamatos 2-sustituidos con actividad antitumoral. - Google Patents

D-homoestra-1,3,5(10)-trien-3-il-sulfamatos 2-sustituidos con actividad antitumoral.

Info

Publication number
MXPA05008833A
MXPA05008833A MXPA05008833A MXPA05008833A MXPA05008833A MX PA05008833 A MXPA05008833 A MX PA05008833A MX PA05008833 A MXPA05008833 A MX PA05008833A MX PA05008833 A MXPA05008833 A MX PA05008833A MX PA05008833 A MXPA05008833 A MX PA05008833A
Authority
MX
Mexico
Prior art keywords
homoestra
trien
antitumoral
sulfamates
substituted
Prior art date
Application number
MXPA05008833A
Other languages
English (en)
Inventor
Unger Eberhard
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of MXPA05008833A publication Critical patent/MXPA05008833A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

La invencion se refiere a sulfamatos D-homoestra-1,3,5,(10)-trien-3-il 2-sustituidos de la formula general (1), en donde R3 es un grupo C1-C5alquilo o un C1-C5alquiloxi y el uso de los mismos para producir un farmaco para curar enfermedades de tumor que pueden influenciar positivamente al inhibir polimerizacion de tubulina. Los compuestos de la invencion se caracterizan por una D-homosustitucion, en particular al efecto del mismos para inhibir la polimerizacion de tubulina y en que se puede usar, por ejemplo para curar cancer de prostata.
MXPA05008833A 2003-02-19 2004-02-19 D-homoestra-1,3,5(10)-trien-3-il-sulfamatos 2-sustituidos con actividad antitumoral. MXPA05008833A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10307103A DE10307103A1 (de) 2003-02-19 2003-02-19 Antitumor wirksame 2-substituierte D-Homostra-1,3,5(10)-trien-3-yl sulfamate
PCT/EP2004/001629 WO2004074309A1 (de) 2003-02-19 2004-02-19 Antitumor wirksame 2-substituierte d-homoestra-1,3,5(10)-trien-3-yl sulfamate

Publications (1)

Publication Number Publication Date
MXPA05008833A true MXPA05008833A (es) 2005-10-05

Family

ID=32841727

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05008833A MXPA05008833A (es) 2003-02-19 2004-02-19 D-homoestra-1,3,5(10)-trien-3-il-sulfamatos 2-sustituidos con actividad antitumoral.

Country Status (13)

Country Link
US (2) USRE42132E1 (es)
EP (1) EP1594886B1 (es)
JP (1) JP4718439B2 (es)
CN (1) CN100343272C (es)
AT (1) ATE406375T1 (es)
AU (1) AU2004213148A1 (es)
BR (1) BRPI0407681A (es)
CA (1) CA2516184A1 (es)
DE (2) DE10307103A1 (es)
ES (1) ES2312965T3 (es)
MX (1) MXPA05008833A (es)
RU (1) RU2005128830A (es)
WO (1) WO2004074309A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10307103A1 (de) 2003-02-19 2004-09-09 Schering Ag Antitumor wirksame 2-substituierte D-Homostra-1,3,5(10)-trien-3-yl sulfamate
DE102004032673A1 (de) * 2004-07-02 2006-01-26 Schering Ag Neue 2-substituierte D-Homo-estra-1,3,5(10)-triene als Inhibitoren der 17ß-Hydroxysteroiddehydrogenase Typ 1
US7435757B2 (en) 2004-07-02 2008-10-14 Schering Ag 2-substituted D-homo-estra-1,3,5(10)-trienes as inhibitors of 17β-hydroxy steroid dehydrogenase type 1
RU2629186C1 (ru) * 2016-07-28 2017-08-25 Федеральное государственное автономное образовательное учреждение высшего образования "Дальневосточный федеральный университет" (ДВФУ) Рацемический 2,17аβ-дисульфамоилокси-3-метокси-D-гомо-8α-эстра-1,3,5(10)-триен в качестве ингибитора пролиферации опухолевых клеток MCF-7
RU2680603C1 (ru) * 2018-11-08 2019-02-25 Ильясов Шамиль Сионович Применение 3-о-сульфамата-16,16-диметил-d-гомоэквиленина для лечения онкологических заболеваний

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK465481A (da) * 1980-11-21 1982-05-22 Hoffmann La Roche Fremgangsmaade til fremstilling af d-homostemoider
US6011024A (en) * 1991-08-28 2000-01-04 Imperial College Of Science Technology & Medicine Steroid sulphatase inhibitors
GB9625334D0 (en) * 1996-12-05 1997-01-22 Imperial College Compound
GB9118478D0 (en) * 1991-08-29 1991-10-16 Imperial College Steroid sulphatase inhibitors
US6903084B2 (en) * 1991-08-29 2005-06-07 Sterix Limited Steroid sulphatase inhibitors
US6908910B2 (en) 1993-08-06 2005-06-21 The Children's Medical Center Corporation Estrogenic compounds as anti-mitotic agents
DE4429397C2 (de) * 1994-08-09 2003-11-20 Jenapharm Gmbh Estra-1,3,5(10)-trien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
DE4447714C2 (de) * 1994-08-09 1998-02-05 Jenapharm Gmbh Verwendung von Estra-1,3,5(10)-trien-Derivaten zur Hormonsubstitutions-Therapie
US5705495A (en) 1995-10-19 1998-01-06 Jenapharm Gmbh & Co. Kg. Sulfamate derivatives of 1,3,5(10)-estratriene derivatives, methods for their production and pharmaceuticals containing these compounds
DE19540233B4 (de) * 1995-10-19 2005-08-25 Schering Ag Sulfamat-Derivate von 1,3,5(10)-Estratrien-Derivaten, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
US20040127473A1 (en) * 1996-12-05 2004-07-01 Reed Michael John Compound
DE19712488A1 (de) * 1997-03-25 1998-10-01 Knoell Hans Forschung Ev Steroidsulfamate, Verfahren zu ihrer Herstellung und Anwendung derselben
GB2331988B (en) * 1997-12-04 2003-04-16 Imperial College Polycyclic sulphamate inhibitors or oestrone sulphatase
US6046186A (en) 1997-12-24 2000-04-04 Sri International Estrone sulfamate inhibitors of estrone sulfatase, and associated pharmaceutical compositions and methods of use
US6548491B2 (en) 1997-12-24 2003-04-15 Sri International Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use
US6054446A (en) * 1997-12-24 2000-04-25 Sri International Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use
DE69939171D1 (de) * 1998-06-10 2008-09-04 Sterix Ltd Pharmazeutische zusammensetzungen mit tumor nekrose faktor und 2-methoxyestron-3-o-sulphamat als estrone sulphatasehemmern
GB9913536D0 (en) * 1999-06-10 1999-08-11 Sterix Ltd Use
DE19943708B4 (de) * 1999-09-08 2007-12-20 Bayer Schering Pharma Ag Neue C13-substituierte Estra-1,3,5(10)-trien-3-yl-sulfamate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
US6583130B1 (en) * 1999-09-13 2003-06-24 Schering Ag C13-substituted estra-1,3,5,(10)-trien-3-yl sulfamates, methods of preparing same, and pharmaceutical compositions containing these compounds
AU1199701A (en) 1999-10-26 2001-05-08 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The B-homoestra-1,3,5(10)-trienes as modulators of tubulin polymerization
GB0025788D0 (en) * 2000-10-20 2000-12-06 Sterix Ltd Use
WO2002042319A2 (en) 2000-11-27 2002-05-30 Entremed, Inc. 2-substituted estrogens as antiangiogenic agents
GB2371299A (en) * 2001-01-17 2002-07-24 Sabbir Ahmed Sulfamate oestrone sulfatase inhibitors
DE10114364A1 (de) * 2001-03-22 2002-10-02 Heraeus Kulzer Gmbh & Co Kg Verfahren zur Herstellung von antibiotischen Kompositen
DE10307105A1 (de) * 2003-02-19 2004-09-09 Schering Ag Antitumor wirksame 2-substituierte 18a-Homoestra-1,3,5(10)-trien-3-yl sulfamate
DE10307104A1 (de) * 2003-02-19 2004-09-23 Schering Ag Antitumor wirksame 2-substituierte Estra-1,3,5(10)-trien-3-yl sulfamate
DE10307103A1 (de) 2003-02-19 2004-09-09 Schering Ag Antitumor wirksame 2-substituierte D-Homostra-1,3,5(10)-trien-3-yl sulfamate

Also Published As

Publication number Publication date
DE502004007950D1 (en) 2008-10-09
JP4718439B2 (ja) 2011-07-06
ATE406375T1 (de) 2008-09-15
CN1751061A (zh) 2006-03-22
DE10307103A8 (de) 2004-12-16
BRPI0407681A (pt) 2006-03-01
EP1594886A1 (de) 2005-11-16
USRE42132E1 (en) 2011-02-08
CN100343272C (zh) 2007-10-17
US20060154985A1 (en) 2006-07-13
DE10307103A1 (de) 2004-09-09
JP2006517946A (ja) 2006-08-03
RU2005128830A (ru) 2007-03-27
CA2516184A1 (en) 2004-09-02
ES2312965T3 (es) 2009-03-01
EP1594886B1 (de) 2008-08-27
US7244762B2 (en) 2007-07-17
WO2004074309A1 (de) 2004-09-02
WO2004074309A8 (de) 2004-12-16
AU2004213148A1 (en) 2004-09-02

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