USRE42132E1 - Antitumoral D-homoestra-1,3,5(10)-trien-3-yl 2-substituted sulfamates - Google Patents
Antitumoral D-homoestra-1,3,5(10)-trien-3-yl 2-substituted sulfamates Download PDFInfo
- Publication number
- USRE42132E1 USRE42132E1 US12/351,271 US35127104A USRE42132E US RE42132 E1 USRE42132 E1 US RE42132E1 US 35127104 A US35127104 A US 35127104A US RE42132 E USRE42132 E US RE42132E
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- United States
- Prior art keywords
- sulfamate
- trien
- homoestra
- methoxy
- dihomoestra
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 0 [1*]N([2*])S(=O)(=O)OC Chemical compound [1*]N([2*])S(=O)(=O)OC 0.000 description 6
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Definitions
- This invention relates to 2-substituted D-homoestra-1,3,5(10)-trien-3-yl sulfamates and their use for the production of pharmaceutical agents that have an antitumor-active activity.
- Microtubuli are organelles that occur in most eukaryotic cells and take over a number of functions there such as mitosis, intracellular movements, cell migration and the manifestation of the cell shape.
- Microtubuli are polymers that consist of tubulin, which in turn represents a dimer that consists of an ⁇ -unit or a ⁇ -unit. These heterodimers bind two guanosine triphosphate (GTP) molecules, whereby one of the GTPs is securely bonded and the other is replaceable.
- GTP guanosine triphosphate
- the heterodimers polymerize into thread-shaped macromolecules, the so-called protofilaments, which in turn pile up into tubular organelles, the microtubuli.
- Microtubuli are subject to a constant build-up and degradation.
- the equilibrium between growth and degradation depends on the availability of new GTP-tubulin subunits and the rate of hydrolysis of the second bonded GTPs.
- new subunits are cultivated; conversely, on the minus end, subunits diffuse outward.
- cytotoxic substances such as colchicine, vinblastine, vincristine, taxol, epothilone, podophyllotoxin, steganicin, combretastatin and 2-methoxyestradiol influence the build-up or degradation of microtubuli (tubulin polymerization and tubulin depolymerization) and thus are able to influence the cell division in a phase-specific manner.
- This relates primarily to quick-growing, neoplastic cells, whose growth is largely unaffected by intracellular regulating mechanisms. Active ingredients of this type are in principle suitable for treating malignant tumors.
- WO 93/05064 relates to, i.a., compounds of formula whereby R 1 and R 2 , in each case independently of one another, mean hydrogen or a methyl group, provided that at least one of radicals R 1 and R 2 is an H atom, and the radical-O-polycyclic compound is a 3-sterol, whose sulfate ester can be hydrolyzed by an enzyme with steroid-sulfatase activity.
- R 1 and R 2 in each case independently of one another, mean hydrogen or a methyl group, provided that at least one of radicals R 1 and R 2 is an H atom, and the radical-O-polycyclic compound is a 3-sterol, whose sulfate ester can be hydrolyzed by an enzyme with steroid-sulfatase activity.
- Compounds that are substituted specifically in the 2-position of the steroid skeleton are not explicitly disclosed.
- U.S. Pat. No. 6,011,024 is based on WO 93/05064 and covers, e.g., all compounds in which the primary sulfamate function is bonded to a six-membered ring. Compounds that are specifically substituted in the 2-position of the steroid skeleton are in turn not explicitly disclosed.
- WO 96/05216 relates to C2-unsubstituted estra-1,3,5(10)-triene-sulfamate derivatives.
- the pharmaceutical compositions that are disclosed therein can be used for female birth control; menopausal HRT and for treatment of gynecological and andrological images of disease, such as breast cancer or prostate cancer.
- WO 97/14712 relates to steroid sulfamate derivatives of general formula in which R 1 can represent an acyl, alkoxycarbonyl, aminocarbonyl, sulfonyl or sulfonamidyl group; R 2 can represent a hydrogen atom or a metal atom; R 7 and R 8 , independently of one another, can represent H, OH and C 1-5 -alkoxy; F 13 , R 12 and R 11 , independently of one another, can represent H or OH.
- WO 98/42729 relates to 16-halogen-substituted 1,3,5-estratriene-3-monosulfamates as well as 3,17 ⁇ -bissulfamates, which can be alkoxy-substituted at C2.
- the 16-halogen substitution increases both the sulfatase-inhibiting action and the estrogeneity of the corresponding sulfamate derivatives.
- WO 98/24802 relates to sulfamates that inhibit the estrone sulfatase. 2-Methoxyestrone sulfamate is explicitly mentioned. As a potential therapeutic application, breast cancer, but not prostate cancer, is mentioned in the description.
- R 1 and R 2 independently of one another, represent H, alkyl, or together piperidine, morpholine, piperazine
- R 3 H, CN, NO 2 , CO 2 R 4
- R 8 H, NO 2 , NR 6 R 7 .
- breast cancer is mentioned as a possible therapeutic application.
- anti-estrogenic compounds are described that are suitable for treatment of different, primarily estrogen-dependent diseases.
- Preferred compounds have an estra-1,3,5(10)-triene building block and are substituted in 11-position and 17-position.
- Especially preferred are 17-deoxy-estra-1,3,5(10)-trienes.
- 2-Substituted D-homo-estra-1,3,5(10)-trien-3-yl sulfamates also fall under the general formulas, but corresponding compounds are not explicitly mentioned.
- WO 99/64013 relates to a pharmaceutical composition of a sulfamate derivative with a cell signal modifier (such as, e.g., TNF ⁇ ).
- a cell signal modifier such as, e.g., TNF ⁇
- 2-Methoxyestrone sulfamate is explicitly claimed as a preferred sulfamate in this combination; but numerous other steroid-3-sulfamates fall under the scope of the general formula.
- a mechanism of action for the pharmaceutical compositions according to the invention or for the steroid-3-sulfamates contained therein (preferably with at least one 2-alkoxy substituent) 1) inhibition of the glucose absorption in tumor cells, 2) inhibition of tumor angiogenesies, 3) degradation of microtubuli; 4) inducing of apoptosis are described.
- WO 00/76487 relates to substances that inhibit the TNF ⁇ -induced aromatase activity.
- 2-alkoxyestrone-3-sulfamates preferably 2-
- WO 01/18028 describes non-estrogenic estrone sulfatase-inhibiting N-acyl-18a-substituted steroid-3-sulfamates, such as, e.g., 16 ⁇ -fluoro-2-methoxy-18a-homoestradiol-(N-acetylsulfamate) or 16 ⁇ -fluoro-2-methoxy-18a-homoestrone-(N-acetylsulfamate).
- the object of this invention consists in making available additional compounds that effectively inhibit tubulin polymerization.
- this invention comprises the new compounds as pharmaceutical active ingredients, their production, their therapeutic application and the pharmaceutical dispensing forms that contain the new substances.
- the compounds of general formula (I) according to the invention or their pharmaceutically acceptable salts can be used for the production of a pharmaceutical agent, especially for treating tumor diseases that can be influenced positively by the inhibition of tubulin polymerization.
- the compounds according to the invention have better oral bioavailability than 2-methoxyestradiol.
- the C 1 -C 5 -alkyl groups for R 3 or R 20 can readily be a methyl, ethyl, n-propyl, iso-propyl; n-, iso- or tert-butyl; n-, iso- or neo-pentyl group.
- a formyl, acetyl, propionyl, butyryl, or iso-butyryl radical can stand for an acyl radical R 1 and R 2 .
- a methoxy, ethoxy, n-propoxy, iso-propoxy; n-, iso-, or tert-butoxy; n-, iso- or neo-pentoxy group can stand for the C 1 -C 5 -alkoxy radical R 3 or R 20 .
- Preferred according to this invention are compounds of general formula I, in which:
- the compounds of general formula I according to the invention are distinguished in that they more greatly inhibit tubulin polymerization than 2-methoxyestradiol.
- the in-vitro testing of the tubulin polymerization influence was performed as follows:
- microtubular protein was purified from pig brains via cydic assembling/disassembling.
- the buffer system used had the following composition: 20 mmol of PIPES (1,4-piperazine-diethane-sulfonic acid, pKa 6.8), 80 mmol of NaCl, 0.5 mmol of MgCl 2 , 1 mmol of EGTA [ethylene glycol-bis-(2-aminoethylene)-tetraacetic acid].
- protein concentrations of 1 mg/ml (about 10 ⁇ 5 mmol of tubulin) were used.
- the determination of protein was carried out according to the Lowry Method (Lowry et al. J. Biol. Chem. 1951, 193, 265-75) with bovine serum albumin as a standard.
- the assembling of microtubuli was carried out in the presence of 0.25 mmol of GTP and heating the samples to 37° C.
- microtubulus formation was examined by means of turbidimetry at a wavelength of 340 nm.
- the state of equilibrium in which the microtubular protein exhibits no increase in the assemblate concentration (corresponding to the microtubulus concentration) and the turbidity value no longer exhibits an increase, is typically reached after 20 minutes.
- the compounds according to the invention are distinguished by a potent inhibition of cell proliferation.
- the cells of a microtiter plate were stained with crystal violet (reference plate), while the cells in the test plates were incubated for 4 days with the test substances in the concentrations 0.1-10 ⁇ m, as well as with the DMSO solvent by itself (solvent control).
- the cell proliferation was determined by staining cells with crystal violet.
- the extinction of the crystal violet was determined by photometry at 595 nm.
- the percentage of the change in the cell number in the test plates was determined after the extinction values were normalized to the reference plate (0%) and to the solvent control (100%).
- the semi-maximal inhibition of the cell growth (IC50) was determined as the substance concentration, in which 50% of the cell number of the solvent controls were present.
- the daily doses comprise a range of 5 ⁇ g to 50 mg of the compound according to the invention per kg of body weight.
- a recommended daily dose is in the range of 10 ⁇ g to 30 mg per kg of body weight.
- Suitable dosages for the compounds according to the invention are from 0.005 to 50 mg per day per kg of body weight, depending on the age and constitution of the patient, whereby the necessary daily dose can be administered one or more times.
- the compounds according to the invention can, however, also be administered at greater intervals than once per day.
- the formulation of the pharmaceutical preparations based on the new compounds is carried out in a way that is known in the art, by the active ingredient being processed with the vehicles, fillers, substances that influence decomposition, binding agents, moisturizing agents, lubricants, absorbing agents, diluents, flavoring correctives, coloring agents, etc., that are commonly used in galenicals and converted into the desired form of administration.
- the active ingredient being processed with the vehicles, fillers, substances that influence decomposition, binding agents, moisturizing agents, lubricants, absorbing agents, diluents, flavoring correctives, coloring agents, etc., that are commonly used in galenicals and converted into the desired form of administration.
- Remington's Pharmaceutical Science 15 th Edition, Mack Publishing Company, East Pennsylvania (1980).
- tablets coated tablets, capsules, pills, powders, granulates, lozenges, suspensions, emulsions or solutions are suitable.
- aqueous and oily injection solutions or suspensions and corresponding depot preparations can be used.
- the new compounds can be used in the form of suppositories, capsules, solutions (e.g., in the form of enemas) and ointments both for systemic and for local therapy.
- the latter can be used in the form of aerosols and inhalants.
- formulations in gels, ointments, fatty ointments, creams, pastes, powders, milks and tinctures are possible.
- the dosage of the compounds of general formula I should be 0.01%-20% in these preparations to achieve an adequate pharmacological action.
- This invention comprises the compounds of general formula I and their use for the production of a pharmaceutical agent, in particular for treating tumor diseases that can be influenced positively by the inhibition of tubulin polymerization.
- the compounds of general formula I according to the invention are preferably used for the production of a pharmaceutical agent, in particular for treating tumor diseases of the male and female gonads, male and female sex organs including the mammary glands, in particular of prostate cancer or breast cancer.
- compositions that contain at least one especially preferred compound according to the invention, optionally in the form of a pharmaceutically/pharmacologically compatible salt, without or together with pharmaceutically compatible adjuvants and/or vehicles.
- compositions and pharmaceutical agents can be provided for oral, rectal, vaginal, subcutaneous, percutaneous, intravenous or intramuscular administration.
- pharmaceutical compositions and pharmaceutical agents can be provided for oral, rectal, vaginal, subcutaneous, percutaneous, intravenous or intramuscular administration.
- they contain at least one especially preferred compound according to the invention.
- the pharmaceutical agents of the invention are produced with commonly used solid or liquid vehicles or diluents and the commonly used pharmaceutical-technical adjuvants corresponding to the desired type of administration at a suitable dosage in a known way.
- the preferred preparations consist in a dispensing form that is suitable for oral administration.
- Such dispensing forms are, for example, tablets, film tablets, coated tablets, capsules, pills, powders, solutions or suspensions or else depot forms.
- compositions that contain at least one of the compounds according to the invention are preferably administered orally.
- Parenteral preparations such as injection solutions are also considered.
- suppositories and agents for vaginal application can also be mentioned as preparations.
- Corresponding tablets can be obtained by, for example, mixing active ingredient with known adjuvants, for example inert diluents such as dextrose, sugar, sorbitol, mannitol, polyvinyl pyrrolidone, explosives such as corn starch or alginic acid, binding agents such as starch or gelatin, lubricants such as magnesium stearate or talc and/or agents for achieving a depot effect such as carboxyl polymethylene, carboxylmethyl cellulose, cellulose acetate phthalate or polyvinyl acetate.
- the tablets can also consist of several layers.
- Coated tablets accordingly can be produced by coating cores, which are produced analogously to the tablets, with agents that are commonly used in tablet coatings, for example, polyvinyl pyrrolidone or shellac, gum Arabic, talc, titanium oxide, or sugar.
- the shell of the coated tablets can also consist of several layers, whereby the adjuvants that are mentioned above in the tablets can be used.
- Solutions or suspensions with the compounds of general formula I according to the invention can contain additional taste-improving agents such as saccharine, cyclamate or sugar, as well as, e.g., flavoring substances such as vanilla or orange extract.
- additional taste-improving agents such as saccharine, cyclamate or sugar, as well as, e.g., flavoring substances such as vanilla or orange extract.
- suspending adjuvants such as sodium carboxy methyl cellulose or preservatives such as p-hydroxybenzoates.
- Capsules that contain the compounds of general formula I can be produced by, for example, the compound(s) of general formula I being mixed with an inert vehicle such as lactose or sorbitol and encapsulated in gelatin capsules,
- Suitable suppositories can be produced by, for example, mixing with vehicles that are provided for this purpose, such as neutral fats or polyethylene glycol or derivatives thereof.
- the compounds according to the invention can be administered in combination with one or more of the following active ingredients:
- the compounds of general formula I according to the invention can be used for therapy and prophylaxis of other pathologic conditions that are not mentioned above.
- C-atom 2 of an estra-1,3,5(10)-trien-17-one derivative is preferably carried out by Friedel-Crafts acylation as described in the literature (T. Nambara et al. Chem. Pharm. Bull. 1979, 18, 474-480).
- the 2-acyl derivatives that are preferably obtained by Friedel-Crafts acylation can be converted by reduction with sodium borohydride and subsequent hydrogenation into the corresponding 2-alkyl derivatives.
- 17a-oxime, 17a-alkylene (so-called Wittig reaction, see, e.g., S. Schwarz et al. Pkarmazie 2001, 56, 843-849), 17a-difluoromethylene (Wadsworth-Emmons Reaction, S. R. Piettre, L. Cabanas, Tetrahedron Lett. 1996, 37, 5881-4884)
- 17 ⁇ , ⁇ -alkyl derivatives can also be produced from the 2-functionalized derivatives (e.g., R. H. Peters et al., J. Med. Chem. 1989, 32, 1642; G. E. Agoston et al. WO 02/42319) and then are sulfamoylated in 3-position.
- 17-oxiranes (M. Hübner, I. Noack, J. prakt. Chem. 1972, 314, 667) and from them the corresponding 17a-homo derivatives (M. Hübner, K. Ponsold, Z. Chem. 1982, 22, 186) can be produced.
- 17a-Fluorinated derivatives can be produced from the corresponding 17a-oxo or 17a-hydroxy derivatives with diethylamino-sulfur trifluoride (M. Hudlicky, Org. Reactions 1988, 35, 513; J. T. Welch, Fluorine in Bioorganic Chemistry 1991, John Wiley, New York; S, Rozen et al. Tetrahedron Lett. 1979, 20, 1823-1826) and then sulfamoylated.
- diethylamino-sulfur trifluoride M. Hudlicky, Org. Reactions 1988, 35, 513
- J. T. Welch Fluorine in Bioorganic Chemistry 1991, John Wiley, New York
- S Rozen et al. Tetrahedron Lett. 1979, 20, 1823-1826
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10307103 | 2003-02-19 | ||
DE10307103A DE10307103A1 (de) | 2003-02-19 | 2003-02-19 | Antitumor wirksame 2-substituierte D-Homostra-1,3,5(10)-trien-3-yl sulfamate |
PCT/EP2004/001629 WO2004074309A1 (de) | 2003-02-19 | 2004-02-19 | Antitumor wirksame 2-substituierte d-homoestra-1,3,5(10)-trien-3-yl sulfamate |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/546,230 Reissue US7244762B2 (en) | 2003-02-19 | 2004-02-19 | Antitumoral d-homoestra-1,3,5 (10)-trien-3-yl 2-substituted sulfamates |
Publications (1)
Publication Number | Publication Date |
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USRE42132E1 true USRE42132E1 (en) | 2011-02-08 |
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ID=32841727
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
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US10/546,230 Ceased US7244762B2 (en) | 2003-02-19 | 2004-02-19 | Antitumoral d-homoestra-1,3,5 (10)-trien-3-yl 2-substituted sulfamates |
US12/351,271 Expired - Fee Related USRE42132E1 (en) | 2003-02-19 | 2004-02-19 | Antitumoral D-homoestra-1,3,5(10)-trien-3-yl 2-substituted sulfamates |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/546,230 Ceased US7244762B2 (en) | 2003-02-19 | 2004-02-19 | Antitumoral d-homoestra-1,3,5 (10)-trien-3-yl 2-substituted sulfamates |
Country Status (13)
Country | Link |
---|---|
US (2) | US7244762B2 (es) |
EP (1) | EP1594886B1 (es) |
JP (1) | JP4718439B2 (es) |
CN (1) | CN100343272C (es) |
AT (1) | ATE406375T1 (es) |
AU (1) | AU2004213148A1 (es) |
BR (1) | BRPI0407681A (es) |
CA (1) | CA2516184A1 (es) |
DE (2) | DE10307103A1 (es) |
ES (1) | ES2312965T3 (es) |
MX (1) | MXPA05008833A (es) |
RU (1) | RU2005128830A (es) |
WO (1) | WO2004074309A1 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10307103A1 (de) | 2003-02-19 | 2004-09-09 | Schering Ag | Antitumor wirksame 2-substituierte D-Homostra-1,3,5(10)-trien-3-yl sulfamate |
DE102004032673A1 (de) * | 2004-07-02 | 2006-01-26 | Schering Ag | Neue 2-substituierte D-Homo-estra-1,3,5(10)-triene als Inhibitoren der 17ß-Hydroxysteroiddehydrogenase Typ 1 |
US7435757B2 (en) | 2004-07-02 | 2008-10-14 | Schering Ag | 2-substituted D-homo-estra-1,3,5(10)-trienes as inhibitors of 17β-hydroxy steroid dehydrogenase type 1 |
RU2629186C1 (ru) * | 2016-07-28 | 2017-08-25 | Федеральное государственное автономное образовательное учреждение высшего образования "Дальневосточный федеральный университет" (ДВФУ) | Рацемический 2,17аβ-дисульфамоилокси-3-метокси-D-гомо-8α-эстра-1,3,5(10)-триен в качестве ингибитора пролиферации опухолевых клеток MCF-7 |
RU2680603C1 (ru) * | 2018-11-08 | 2019-02-25 | Ильясов Шамиль Сионович | Применение 3-о-сульфамата-16,16-диметил-d-гомоэквиленина для лечения онкологических заболеваний |
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WO1993005064A1 (en) | 1991-08-29 | 1993-03-18 | Imperial College Of Science, Technology And Medicine | Steroid sulphatase inhibitors |
WO1996005217A1 (de) | 1994-08-09 | 1996-02-22 | Jenapharm Gmbh | Pharmazeutische zusammensetzungen mit estra-1,3,5(10)-trien-derivaten |
WO1997014712A2 (de) | 1995-10-19 | 1997-04-24 | Jenapharm Gmbh | Sulfamat-derivate von 1,3,5(10)-estratrien-derivaten, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische zusammensetzungen |
US5705495A (en) | 1995-10-19 | 1998-01-06 | Jenapharm Gmbh & Co. Kg. | Sulfamate derivatives of 1,3,5(10)-estratriene derivatives, methods for their production and pharmaceuticals containing these compounds |
WO1998024802A2 (en) | 1996-12-05 | 1998-06-11 | Imperial College Of Science Technology And Medicine | Compound |
WO1999027935A1 (en) | 1997-12-04 | 1999-06-10 | Sterix Limited | Steroid 3-o-sulphamate derivatives as inhibitors of oestrone sulphatase |
WO1999033858A2 (en) | 1997-12-24 | 1999-07-08 | Sri International | Estrone sulfamate inhibitors of estrone sulfatase, and associated pharmaceutical compositions and methods of use |
WO1999033859A2 (en) | 1997-12-24 | 1999-07-08 | Sri International | Novel anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use |
WO1999064013A1 (en) | 1998-06-10 | 1999-12-16 | Sterix Limited | Pharmaceutical composition with tumor necrosis factor a and 2-methoxyestrone-3-o-sulphamate for inhibition of estrone sulphatase |
US6011024A (en) | 1991-08-28 | 2000-01-04 | Imperial College Of Science Technology & Medicine | Steroid sulphatase inhibitors |
WO2001018028A1 (de) | 1999-09-08 | 2001-03-15 | Jenapharm Gmbh & Co. Kg | Neue c-13-substituierte estra-1,3,5(10)-trien-3-yl-sulfamate, verfahren zu deren herstellung und diese verbindungen enthaltende pharmazeutische zusammensetzungen zur hemmung von östron sulfatase |
WO2001030803A1 (en) | 1999-10-26 | 2001-05-03 | The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services | B-homoestra-1,3,5(10)-trienes as modulators of tubulin polymerization |
US6339079B1 (en) * | 1997-03-25 | 2002-01-15 | Id Pharma Gmbh | Steroid sulfamates, method for the production and use thereof |
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US20060160782A1 (en) | 2003-02-19 | 2006-07-20 | Alexander Hillisch | 2-Substituted estra-1,3,5(10)-triene-3-yl sulfamate with an anti-tumour action |
US20060211670A1 (en) | 2003-02-19 | 2006-09-21 | Alexander Hillisch | Antitumoral18a-homoestra-1,3,5(10)-trien-3yl 2-substituted sulfamates |
US7244762B2 (en) | 2003-02-19 | 2007-07-17 | Sterix Limited | Antitumoral d-homoestra-1,3,5 (10)-trien-3-yl 2-substituted sulfamates |
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DK465481A (da) * | 1980-11-21 | 1982-05-22 | Hoffmann La Roche | Fremgangsmaade til fremstilling af d-homostemoider |
DE4429397C2 (de) * | 1994-08-09 | 2003-11-20 | Jenapharm Gmbh | Estra-1,3,5(10)-trien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen |
GB9913536D0 (en) * | 1999-06-10 | 1999-08-11 | Sterix Ltd | Use |
GB0025788D0 (en) * | 2000-10-20 | 2000-12-06 | Sterix Ltd | Use |
GB2371299A (en) * | 2001-01-17 | 2002-07-24 | Sabbir Ahmed | Sulfamate oestrone sulfatase inhibitors |
DE10114364A1 (de) * | 2001-03-22 | 2002-10-02 | Heraeus Kulzer Gmbh & Co Kg | Verfahren zur Herstellung von antibiotischen Kompositen |
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2003
- 2003-02-19 DE DE10307103A patent/DE10307103A1/de not_active Ceased
-
2004
- 2004-02-19 AU AU2004213148A patent/AU2004213148A1/en not_active Abandoned
- 2004-02-19 US US10/546,230 patent/US7244762B2/en not_active Ceased
- 2004-02-19 ES ES04712555T patent/ES2312965T3/es not_active Expired - Lifetime
- 2004-02-19 JP JP2006501900A patent/JP4718439B2/ja not_active Expired - Fee Related
- 2004-02-19 CA CA002516184A patent/CA2516184A1/en not_active Abandoned
- 2004-02-19 DE DE502004007950T patent/DE502004007950D1/de not_active Expired - Lifetime
- 2004-02-19 WO PCT/EP2004/001629 patent/WO2004074309A1/de active IP Right Grant
- 2004-02-19 RU RU2005128830/04A patent/RU2005128830A/ru not_active Application Discontinuation
- 2004-02-19 US US12/351,271 patent/USRE42132E1/en not_active Expired - Fee Related
- 2004-02-19 AT AT04712555T patent/ATE406375T1/de not_active IP Right Cessation
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Also Published As
Publication number | Publication date |
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ES2312965T3 (es) | 2009-03-01 |
EP1594886B1 (de) | 2008-08-27 |
JP4718439B2 (ja) | 2011-07-06 |
MXPA05008833A (es) | 2005-10-05 |
CA2516184A1 (en) | 2004-09-02 |
WO2004074309A1 (de) | 2004-09-02 |
CN1751061A (zh) | 2006-03-22 |
RU2005128830A (ru) | 2007-03-27 |
DE10307103A8 (de) | 2004-12-16 |
ATE406375T1 (de) | 2008-09-15 |
JP2006517946A (ja) | 2006-08-03 |
US20060154985A1 (en) | 2006-07-13 |
CN100343272C (zh) | 2007-10-17 |
WO2004074309A8 (de) | 2004-12-16 |
DE10307103A1 (de) | 2004-09-09 |
US7244762B2 (en) | 2007-07-17 |
DE502004007950D1 (en) | 2008-10-09 |
BRPI0407681A (pt) | 2006-03-01 |
EP1594886A1 (de) | 2005-11-16 |
AU2004213148A1 (en) | 2004-09-02 |
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