RU2004123794A - Высокочувствительный и непрерывный тест на протеинтирозинфосфатазу при использовании 6,8-дифтор-4-метилумбеллиферилфостата - Google Patents

Высокочувствительный и непрерывный тест на протеинтирозинфосфатазу при использовании 6,8-дифтор-4-метилумбеллиферилфостата Download PDF

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Publication number
RU2004123794A
RU2004123794A RU2004123794/15A RU2004123794A RU2004123794A RU 2004123794 A RU2004123794 A RU 2004123794A RU 2004123794/15 A RU2004123794/15 A RU 2004123794/15A RU 2004123794 A RU2004123794 A RU 2004123794A RU 2004123794 A RU2004123794 A RU 2004123794A
Authority
RU
Russia
Prior art keywords
compound
biological material
difmup
ptp
difluoro
Prior art date
Application number
RU2004123794/15A
Other languages
English (en)
Russian (ru)
Inventor
Штефан ВЕЛЬТЕ (DE)
Штефан ВЕЛЬТЕ
Норберт ТЕННАГЕЛЬС (DE)
Норберт Теннагельс
Штефан ПЕТРИ (DE)
Штефан Петри
Original Assignee
АВЕНТИС ФАРМА ДОЙЧЛАНД ГмбХ (DE)
Авентис Фарма Дойчланд Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2002100173 external-priority patent/DE10200173A1/de
Priority claimed from DE2002136329 external-priority patent/DE10236329A1/de
Application filed by АВЕНТИС ФАРМА ДОЙЧЛАНД ГмбХ (DE), Авентис Фарма Дойчланд Гмбх filed Critical АВЕНТИС ФАРМА ДОЙЧЛАНД ГмбХ (DE)
Publication of RU2004123794A publication Critical patent/RU2004123794A/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/42—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving phosphatase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
RU2004123794/15A 2002-01-04 2002-12-24 Высокочувствительный и непрерывный тест на протеинтирозинфосфатазу при использовании 6,8-дифтор-4-метилумбеллиферилфостата RU2004123794A (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE10200173.1 2002-01-04
DE2002100173 DE10200173A1 (de) 2002-01-04 2002-01-04 Ein hochsensitiver und kontinuerlicher Protein Tyrosin-Phosphatase (PTPase) Test unter Verwendung von 6,8 Difluoro-4-methyl-umbelliferylphosphat (DiFMUP)
DE10236329.3 2002-08-08
DE2002136329 DE10236329A1 (de) 2002-08-08 2002-08-08 Ein hochsensitiver und kontinuierlicher Protein Tyrosin-Phosphatase (PTPase) Test unter Verwendung von 6,8 Difluoro-4-methyl-umbelliferylphosphat (DiFMUP)

Publications (1)

Publication Number Publication Date
RU2004123794A true RU2004123794A (ru) 2005-04-20

Family

ID=26010898

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2004123794/15A RU2004123794A (ru) 2002-01-04 2002-12-24 Высокочувствительный и непрерывный тест на протеинтирозинфосфатазу при использовании 6,8-дифтор-4-метилумбеллиферилфостата

Country Status (12)

Country Link
EP (1) EP1466009A2 (de)
JP (1) JP2005512600A (de)
KR (1) KR20040073539A (de)
CN (1) CN1612939A (de)
AU (1) AU2002361217A1 (de)
BR (1) BR0215452A (de)
CA (1) CA2471601A1 (de)
IL (1) IL162832A0 (de)
MX (1) MXPA04006361A (de)
NO (1) NO20043244L (de)
RU (1) RU2004123794A (de)
WO (1) WO2003056029A2 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100350045C (zh) * 2003-08-21 2007-11-21 北京农业生物技术研究中心 玉米酪氨酸蛋白磷酸酶基因及其编码蛋白与应用
US8008035B2 (en) 2007-01-25 2011-08-30 Roche Diagnostics Operations, Inc. Enhancement of vanadium-containing phosphatase inhibitors
EP1949894B1 (de) * 2007-01-25 2016-06-29 Roche Diagnostics GmbH Verstärkung von vanadiumhaltigen Phosphatasehemmern mit Polyole
CN113155787A (zh) * 2020-12-29 2021-07-23 武汉合研生物医药科技有限公司 一种突变酶shp2 e76k的活性检测方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4072799A (en) * 1998-05-12 1999-12-13 American Home Products Corporation 2,3,5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia

Also Published As

Publication number Publication date
NO20043244L (no) 2004-08-02
KR20040073539A (ko) 2004-08-19
IL162832A0 (en) 2005-11-20
BR0215452A (pt) 2004-11-23
CN1612939A (zh) 2005-05-04
JP2005512600A (ja) 2005-05-12
AU2002361217A1 (en) 2003-07-15
WO2003056029A2 (de) 2003-07-10
CA2471601A1 (en) 2003-07-10
MXPA04006361A (es) 2004-10-04
WO2003056029A3 (de) 2004-04-01
EP1466009A2 (de) 2004-10-13

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Legal Events

Date Code Title Description
FA93 Acknowledgement of application withdrawn (no request for examination)

Effective date: 20060327