RU2004121177A - Применение прамипексола для лечения бокового амитрофического склероза - Google Patents
Применение прамипексола для лечения бокового амитрофического склероза Download PDFInfo
- Publication number
- RU2004121177A RU2004121177A RU2004121177/14A RU2004121177A RU2004121177A RU 2004121177 A RU2004121177 A RU 2004121177A RU 2004121177/14 A RU2004121177/14 A RU 2004121177/14A RU 2004121177 A RU2004121177 A RU 2004121177A RU 2004121177 A RU2004121177 A RU 2004121177A
- Authority
- RU
- Russia
- Prior art keywords
- pramipexole
- tetrahydrobentiazole
- treatment
- alkyl
- sclerosis
- Prior art date
Links
- FASDKYOPVNHBLU-ZETCQYMHSA-N pramipexole Chemical compound C1[C@@H](NCCC)CCC2=C1SC(N)=N2 FASDKYOPVNHBLU-ZETCQYMHSA-N 0.000 title claims abstract 9
- 229960003089 pramipexole Drugs 0.000 title claims abstract 9
- 208000034189 Sclerosis Diseases 0.000 title 1
- 239000000203 mixture Substances 0.000 claims abstract 6
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims abstract 5
- FASDKYOPVNHBLU-UHFFFAOYSA-N N6-Propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine Chemical compound C1C(NCCC)CCC2=C1SC(N)=N2 FASDKYOPVNHBLU-UHFFFAOYSA-N 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 2
- 230000001771 impaired effect Effects 0.000 claims 1
- 210000003470 mitochondria Anatomy 0.000 claims 1
- 210000001700 mitochondrial membrane Anatomy 0.000 claims 1
- 230000036542 oxidative stress Effects 0.000 claims 1
- GLDQAMYCGOIJDV-UHFFFAOYSA-N Pyrocatechuic acid Natural products OC(=O)C1=CC=CC(O)=C1O GLDQAMYCGOIJDV-UHFFFAOYSA-N 0.000 abstract 1
- 230000003247 decreasing effect Effects 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Psychology (AREA)
- Urology & Nephrology (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Toxicology (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biochemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Medicinal Preparation (AREA)
- Artificial Filaments (AREA)
- Noodles (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33938301P | 2001-12-11 | 2001-12-11 | |
| US60/339,383 | 2001-12-11 | ||
| US34737102P | 2002-01-11 | 2002-01-11 | |
| US60/347,371 | 2002-01-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2004121177A true RU2004121177A (ru) | 2005-03-10 |
Family
ID=26991607
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2004121177/14A RU2004121177A (ru) | 2001-12-11 | 2002-12-02 | Применение прамипексола для лечения бокового амитрофического склероза |
Country Status (19)
| Country | Link |
|---|---|
| US (4) | US7157480B2 (https=) |
| EP (4) | EP1453505B1 (https=) |
| JP (2) | JP4500543B2 (https=) |
| KR (1) | KR20040066890A (https=) |
| CN (1) | CN1617720A (https=) |
| AT (1) | ATE480235T1 (https=) |
| AU (1) | AU2002360600B2 (https=) |
| CA (1) | CA2468747C (https=) |
| CY (1) | CY1111237T1 (https=) |
| DE (1) | DE60237635D1 (https=) |
| DK (1) | DK1453505T3 (https=) |
| ES (2) | ES2432527T3 (https=) |
| HU (1) | HUP0500001A3 (https=) |
| IL (1) | IL162408A0 (https=) |
| MX (1) | MXPA04005572A (https=) |
| PL (1) | PL374310A1 (https=) |
| PT (1) | PT1453505E (https=) |
| RU (1) | RU2004121177A (https=) |
| WO (1) | WO2003049705A2 (https=) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2432527T3 (es) * | 2001-12-11 | 2013-12-04 | University Of Virginia Patent Foundation | Uso de pramipexol para tratar la esclerosis lateral amiotrófica |
| US20060281797A1 (en) * | 2001-12-11 | 2006-12-14 | University Of Virginia Patent Foundation | Neurorestoration with R(+) Pramipexole |
| ATE444750T1 (de) * | 2005-08-15 | 2009-10-15 | Univ Virginia | Neurorestauration mit r(+) pramipexol |
| EP1940398A1 (de) * | 2005-10-18 | 2008-07-09 | Boehringer Ingelheim International GmbH | Verwendung von pramipexol zur behandlung des moderaten bis schweren restless legs syndroms (rls) |
| US20070259930A1 (en) * | 2006-04-10 | 2007-11-08 | Knopp Neurosciences, Inc. | Compositions and methods of using r(+) pramipexole |
| US8518926B2 (en) * | 2006-04-10 | 2013-08-27 | Knopp Neurosciences, Inc. | Compositions and methods of using (R)-pramipexole |
| EP2465500A1 (en) * | 2006-05-16 | 2012-06-20 | Knopp Neurosciences, Inc. | Therapeutically effective amounts of R(+) and S(-) pramipexole for use in the treatment of parkinson's disease |
| ATE537826T1 (de) | 2006-05-16 | 2012-01-15 | Knopp Neurosciences Inc | Zusammensetzungen aus r(+)- und s(-)-pramipexol sowie verfahren zu ihrer anwendung |
| CN104107177A (zh) * | 2006-12-14 | 2014-10-22 | 诺普生物科学有限责任公司 | (r)-普拉克索的组合物以及使用该组合物的方法 |
| AU2013209376B2 (en) * | 2006-12-14 | 2016-05-05 | Knopp Biosciences Llc | Compositions and methods of using (r)-pramipexole |
| AU2016210640B2 (en) * | 2006-12-14 | 2018-02-22 | Knopp Biosciences Llc | Compositions and methods of using (r)-pramipexole |
| US8524695B2 (en) * | 2006-12-14 | 2013-09-03 | Knopp Neurosciences, Inc. | Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same |
| JP2010521496A (ja) | 2007-03-14 | 2010-06-24 | ノップ ニューロサイエンシーズ、インク. | キラル精製置換ベンゾチアゾールジアミンの合成 |
| EP2136638A4 (en) * | 2007-03-14 | 2010-05-12 | Knopp Neurosciences Inc | MODIFIED RELEASE FORMULATIONS OF (6R) -4,5,6,7-TETRAHYDRO-N6-PROPYL-2,6-BENZOTHIAZOLE DIAMINE AND METHODS OF USE THEREOF |
| GB0811642D0 (en) * | 2008-06-25 | 2008-07-30 | Univ Edinburgh | Assay |
| US20110190356A1 (en) * | 2008-08-19 | 2011-08-04 | Knopp Neurosciences Inc. | Compositions and Methods of Using (R)- Pramipexole |
| AU2010262970A1 (en) * | 2009-06-19 | 2012-01-12 | Knopp Neurosciences, Inc. | Compositions and methods for treating amyotrophic lateral sclerosis |
| WO2013096816A1 (en) | 2011-12-22 | 2013-06-27 | Biogen Idec Ma Inc. | Improved synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds |
| WO2014031883A1 (en) * | 2012-08-23 | 2014-02-27 | Susan Marie Metcalfe | Neurotherapeutic nanoparticle compositions and devices |
| US10874669B2 (en) | 2012-11-29 | 2020-12-29 | Wayne State University | Neuroprotective agents for treatment of neurodegenerative diseases |
| WO2014085600A1 (en) * | 2012-11-29 | 2014-06-05 | Wayne State University | Neuroprotective agents for treatment of neurodegenerative diseases |
| US9662313B2 (en) | 2013-02-28 | 2017-05-30 | Knopp Biosciences Llc | Compositions and methods for treating amyotrophic lateral sclerosis in responders |
| US9468630B2 (en) | 2013-07-12 | 2016-10-18 | Knopp Biosciences Llc | Compositions and methods for treating conditions related to increased eosinophils |
| PL3019167T3 (pl) | 2013-07-12 | 2021-06-14 | Knopp Biosciences Llc | Leczenie podwyższonych poziomów eozynofili i/lub bazofili |
| DK3033081T3 (da) | 2013-08-13 | 2021-05-31 | Knopp Biosciences Llc | Sammensætninger og fremgangsmåder til behandling af kronisk urticaria |
| EP3038467B1 (en) | 2013-08-13 | 2020-07-29 | Knopp Biosciences LLC | Compositions and methods for treating plasma cell disorders and b-cell prolymphocytic disorders |
| WO2019049145A1 (en) | 2017-09-11 | 2019-03-14 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | COMPOSITIONS AND METHODS FOR NASAL BRAIN MEDICATION ADMINISTRATION FOR SYSTEMIC EFFECT |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US560420A (en) | 1896-05-19 | Steam and oil separator | ||
| DE3447075A1 (de) * | 1984-12-22 | 1986-07-03 | Dr. Karl Thomae Gmbh, 7950 Biberach | Tetrahydro-benzthiazole, deren herstellung und deren verwendung als zwischenprodukte oder als arzneimittel |
| DE3572485D1 (en) | 1984-12-22 | 1989-09-28 | Thomae Gmbh Dr K | Tetrahydro-benzothiazoles, their production and their use as intermediates or drugs |
| DE3937271A1 (de) | 1989-11-09 | 1991-05-16 | Boehringer Ingelheim Kg | Transdermale applikation von 2-amino-6-n-propylamino-4,5,6,7-tetrahydrobenzothiazol |
| FR2688138B1 (fr) * | 1992-03-06 | 1995-05-05 | Rhone Poulenc Rorer Sa | Application de l'amino-2 trifluoromethoxy-6 benzothiazole pour obtenir un medicament destine au traitement de la sclerose laterale amyotrophique. |
| US6156777A (en) | 1994-12-15 | 2000-12-05 | Pharmacia & Upjohn Company | Use of pramipexole as a neuroprotective agent |
| US5650420A (en) * | 1994-12-15 | 1997-07-22 | Pharmacia & Upjohn Company | Pramipexole as a neuroprotective agent |
| ES2159362T3 (es) * | 1995-10-26 | 2001-10-01 | Sanofi Synthelabo | Utilizacion de la 1-(2-naft-2-iletil)-4-(3-trifluorometilfenil)-1,2,3,6-tetrahidropiridina para la preparacion de medicamentos destinados para el tratamiento de la esclerosis lateral amiotrofica. |
| GB9705428D0 (en) | 1997-03-15 | 1997-04-30 | Knoll Ag | Therapeutic agents |
| US6197339B1 (en) * | 1997-09-30 | 2001-03-06 | Pharmacia & Upjohn Company | Sustained release tablet formulation to treat Parkinson's disease |
| PE20000728A1 (es) * | 1998-06-26 | 2000-08-21 | Cocensys Inc | Heterociclos 4-bencil piperidina alquilsulfoxido y su uso como antagonistas receptores subtipo-selectivo nmda |
| DE19830201A1 (de) * | 1998-07-07 | 2000-01-13 | Boehringer Ingelheim Pharma | Mittel mit antidepressiver Wirkung |
| CA2301899C (en) * | 1998-07-27 | 2008-11-18 | Boehringer Ingelheim Pharma Kg | Agent with an antidepressant activity |
| MXPA01004381A (es) * | 1998-11-02 | 2005-09-08 | Elan Corp Plc | Composicion de multiparticulado de liberacion modificada. |
| DE19938825A1 (de) | 1999-08-19 | 2001-04-26 | Boehringer Ingelheim Pharma | Wirkstoffkombination mit Clonidin |
| CA2384840A1 (en) | 1999-09-30 | 2001-04-05 | The General Hospital Corporation | Use of pramipexole as a treatment for cocaine craving |
| PE20011074A1 (es) | 2000-02-23 | 2001-10-04 | Upjohn Co | Uso de pramipexol en el tratamiento de trastornos de adiccion |
| AU7887501A (en) * | 2000-07-06 | 2002-01-21 | Us Gov Health & Human Serv | Tetrahydrobenzothiazole analogues as neuroprotective agents |
| DE10037619A1 (de) * | 2000-08-02 | 2002-02-14 | Daimler Chrysler Ag | Anordnung von Bedienelementen |
| ES2187249B1 (es) * | 2000-09-18 | 2004-09-16 | Synthon Bv | Procedimiento para la preparacion de 2-amino-6-(alquil)amino-4,5,6,7-tetrahidrobenzotiazoles. |
| US20020151526A1 (en) * | 2000-10-06 | 2002-10-17 | Gallop Mark A. | Bile-acid prodrugs of L-dopa and their use in the sustained treatment of parkinsonism |
| DE10137082A1 (de) * | 2001-07-28 | 2003-02-13 | Hexal Ag | Matrixkontrolliertes transdermales therapeutisches System zur Anwendung von Pramiprexol und Ropinirol |
| US20060281797A1 (en) * | 2001-12-11 | 2006-12-14 | University Of Virginia Patent Foundation | Neurorestoration with R(+) Pramipexole |
| ES2432527T3 (es) * | 2001-12-11 | 2013-12-04 | University Of Virginia Patent Foundation | Uso de pramipexol para tratar la esclerosis lateral amiotrófica |
| AU2002316231A1 (en) * | 2002-02-19 | 2003-09-29 | Xenoport, Inc. | Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof |
| US20050226926A1 (en) * | 2002-07-25 | 2005-10-13 | Pfizer Inc | Sustained-release tablet composition of pramipexole |
| PT1610791E (pt) * | 2003-03-31 | 2011-05-23 | Titan Pharmaceuticals Inc | Dispositivo polim?rico implant?vel para liberta??o sustentada de agonista da dopamina |
| US7662987B2 (en) * | 2003-07-15 | 2010-02-16 | Xenoport, Inc. | Methods for synthesis of acyloxyalkyl compounds |
| CN101022788B (zh) * | 2004-08-13 | 2010-11-10 | 贝林格尔·英格海姆国际有限公司 | 包含普拉克索或其可药用盐的延长释放小球制剂、其制备方法及其用途 |
| TW200616604A (en) * | 2004-08-26 | 2006-06-01 | Nicholas Piramal India Ltd | Nitric oxide releasing prodrugs containing bio-cleavable linker |
| ATE444750T1 (de) * | 2005-08-15 | 2009-10-15 | Univ Virginia | Neurorestauration mit r(+) pramipexol |
-
2002
- 2002-12-02 ES ES10008579T patent/ES2432527T3/es not_active Expired - Lifetime
- 2002-12-02 PL PL02374310A patent/PL374310A1/xx unknown
- 2002-12-02 JP JP2003550756A patent/JP4500543B2/ja not_active Expired - Lifetime
- 2002-12-02 HU HU0500001A patent/HUP0500001A3/hu unknown
- 2002-12-02 KR KR10-2004-7008931A patent/KR20040066890A/ko not_active Withdrawn
- 2002-12-02 AU AU2002360600A patent/AU2002360600B2/en not_active Expired
- 2002-12-02 EP EP02795869A patent/EP1453505B1/en not_active Expired - Lifetime
- 2002-12-02 AT AT02795869T patent/ATE480235T1/de active
- 2002-12-02 PT PT02795869T patent/PT1453505E/pt unknown
- 2002-12-02 EP EP10009931A patent/EP2305252A1/en not_active Ceased
- 2002-12-02 EP EP10075571A patent/EP2305253A1/en not_active Withdrawn
- 2002-12-02 DK DK02795869.3T patent/DK1453505T3/da active
- 2002-12-02 CA CA2468747A patent/CA2468747C/en not_active Expired - Lifetime
- 2002-12-02 MX MXPA04005572A patent/MXPA04005572A/es unknown
- 2002-12-02 IL IL16240802A patent/IL162408A0/xx unknown
- 2002-12-02 RU RU2004121177/14A patent/RU2004121177A/ru not_active Application Discontinuation
- 2002-12-02 ES ES02795869T patent/ES2351303T3/es not_active Expired - Lifetime
- 2002-12-02 WO PCT/US2002/039970 patent/WO2003049705A2/en not_active Ceased
- 2002-12-02 CN CNA028278259A patent/CN1617720A/zh active Pending
- 2002-12-02 DE DE60237635T patent/DE60237635D1/de not_active Expired - Lifetime
- 2002-12-02 EP EP10008579.4A patent/EP2246053B1/en not_active Expired - Lifetime
- 2002-12-02 US US10/496,714 patent/US7157480B2/en not_active Expired - Lifetime
-
2006
- 2006-12-21 US US11/614,528 patent/US20070105918A1/en not_active Abandoned
-
2009
- 2009-11-16 JP JP2009260955A patent/JP2010031059A/ja active Pending
-
2010
- 2010-12-08 CY CY20101101132T patent/CY1111237T1/el unknown
-
2011
- 2011-08-01 US US13/195,552 patent/US20110301210A1/en not_active Abandoned
-
2013
- 2013-02-26 US US13/777,603 patent/US20130172394A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2004121177A (ru) | Применение прамипексола для лечения бокового амитрофического склероза | |
| ATE291433T1 (de) | Extrakte von mutterkraut (tanacetum parthenium) gegen entzündliche erkrankungen | |
| BR0116370A (pt) | Composto, composição farmacêutica, uso de um composto, e, método de tratamento de uma doença ou condição mediada por hppar em um paciente. | |
| EA200000723A1 (ru) | Производные 2-(пурин-9-ил)-тетрагидрофуран-3,4-диола | |
| EA200201247A1 (ru) | Соединения для лечения болезни альцгеймера | |
| ATE487493T1 (de) | Azolsäure-derivate, allein oder kombiniert, zur behandlung von diabetes und dyslipidaemien; und zur behandlung von malignen erkrankungen | |
| ATE207355T1 (de) | Behandlung von hyperproliferativen gefässerkrankungen | |
| PT734259E (pt) | Utilizacao de derivados de piperidina para o tratamento da esquizofrenia | |
| DE60236639D1 (de) | Neues verfahren und zusammensetzungen zur örtlichen behandlung von meniere-krankheit, tinnitus und/oder hörverlust | |
| EP1281398A4 (en) | DERIVATIVE COMPOSITIONS CONTAINING AS ACTIVE COENZYME Q. | |
| DE60137635D1 (de) | Verwendung von allopurinol zur behandlung von bluthochdruck | |
| DE69943107D1 (de) | Behandlung von autoimmunerkrankungen | |
| DE60237100D1 (de) | Verwendung von leptin zur behandlung von lipoatropr prädisposition gegenüber der behandlung | |
| DE3686582D1 (de) | Behandlung einer krankheit vom aids-typ. | |
| DE60219614D1 (de) | 3, 7 thiaprostansäurederivate als mittel zur verminderung des augeninnendruckes | |
| DE69916632T2 (de) | Verwendung von zimtsäurederivaten zur herstellung eines medikamentes zur vorbeugung oder behandlung von erkrankungen die durch einen hohen blutfettspiegel bedingt sind | |
| EA199900542A1 (ru) | Соединения сульфоновой кислоты или сульфониламино-n-(гетероаралкил)-азагетероциклиламида | |
| DE60203847D1 (de) | Verbindungen enthaltend S-Tofisopam sowie Verwendung dieser Verbindungen zur Herstellung eines Medikamentes zur Behandlung oder Prophylaxe von Krämpfen und Anfällen | |
| BRPI0211635B8 (pt) | composto ciclo-hexil-sulfona, uso do mesmo, e, composição farmacêutica | |
| DK0994743T3 (da) | Behandling af inflammatoriske lidelser i tarm eller urinblære | |
| BR9809678A (pt) | Derivados de triptolìdeo úteis no tratamento de doenças autoimunes | |
| ATE402257T1 (de) | Antisense gegen c-myc zur behandlung von polyzystischer nierenkrankheit | |
| PT83309A (de) | Neue pyrrolo-benzimidazole pyrrolo-benzoxazole und pyrrolo-benzthiazole verfahren zu ihrer herstellung und diese verbindungen enthaltende arneimittel | |
| BR9809673A (pt) | Derivados de triptolida úteis no tratamento de doenças autoimunes | |
| BR0212249A (pt) | Composto, composição farmacêutica, método de tratamento ou profilaxia de doenças, e, uso de um composto |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA93 | Acknowledgement of application withdrawn (no request for examination) |
Effective date: 20060110 |