RU2000127112A - Применение кислых алкилфумаратов для лечения псориаза, псориатического артрита, нейродермита и регионального энтерита крона - Google Patents
Применение кислых алкилфумаратов для лечения псориаза, псориатического артрита, нейродермита и регионального энтерита кронаInfo
- Publication number
- RU2000127112A RU2000127112A RU2000127112/14A RU2000127112A RU2000127112A RU 2000127112 A RU2000127112 A RU 2000127112A RU 2000127112/14 A RU2000127112/14 A RU 2000127112/14A RU 2000127112 A RU2000127112 A RU 2000127112A RU 2000127112 A RU2000127112 A RU 2000127112A
- Authority
- RU
- Russia
- Prior art keywords
- fumarate
- microtablets
- microgranules
- psoriasis
- regional
- Prior art date
Links
- 239000002253 acid Substances 0.000 title claims 4
- 206010037162 Psoriatic arthropathy Diseases 0.000 title claims 2
- 201000009053 neurodermatitis Diseases 0.000 title claims 2
- 201000004681 psoriasis Diseases 0.000 title claims 2
- 201000001263 psoriatic arthritis Diseases 0.000 title claims 2
- OYNAHELWAOEQBG-JACKDLBFSA-N (Z)-but-2-enedioic acid;3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine;3-[(1R)-1-hydroxy-2-(methylamino)ethyl]phenol;hydrochloride Chemical compound Cl.OC(=O)\C=C/C(O)=O.CNC[C@H](O)C1=CC=CC(O)=C1.C=1C=CC=NC=1C(CCN(C)C)C1=CC=C(Cl)C=C1 OYNAHELWAOEQBG-JACKDLBFSA-N 0.000 title 1
- LDCRTTXIJACKKU-ONEGZZNKSA-N Dimethyl fumarate Chemical compound COC(=O)\C=C\C(=O)OC LDCRTTXIJACKKU-ONEGZZNKSA-N 0.000 claims 5
- 229960004419 dimethyl fumarate Drugs 0.000 claims 5
- -1 alkyl fumarate Chemical compound 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 238000002360 preparation method Methods 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 2
- 206010011401 Crohn's disease Diseases 0.000 claims 1
- 210000004051 Gastric Juice Anatomy 0.000 claims 1
- 230000002378 acidificating Effects 0.000 claims 1
- 239000011248 coating agent Substances 0.000 claims 1
- 238000000576 coating method Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N fumaric acid Chemical compound OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 1
- 239000000546 pharmaceutic aid Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Claims (7)
1. Применение одного или более кислого алкилфумарата общей формулы
где R - C1-5-алкил, в случае необходимости, в смеси с диалкилфумаратом формулы
и, в случае необходимости, обычных фармацевтических вспомогательных веществ и носителей для получения фармацевтической препаративной формы в виде микротаблеток или микрогранул для лечения псориаза, псориатического артрита, нейродермита и регионального энтерита Крона.
где R - C1-5-алкил, в случае необходимости, в смеси с диалкилфумаратом формулы
и, в случае необходимости, обычных фармацевтических вспомогательных веществ и носителей для получения фармацевтической препаративной формы в виде микротаблеток или микрогранул для лечения псориаза, псориатического артрита, нейродермита и регионального энтерита Крона.
2. Применение по п. 1, отличающееся тем, что алкилфумаратом является кислый метилфумарат.
3. Применение по п. 1, отличающееся тем, что алкилфумарат представляет собой смесь кислого метилфумарата с диметилфумаратом.
4. Применение по пп. 1-3 для получения фармацевтической препаративной формы для перорального введения в виде микротаблеток или микрогранул, отличающееся тем, что общий вес активных веществ составляет от 20 до 300 мг.
5. Применение по пп. 1-4, отличающееся тем, что препаративная форма содержит от 10 до 290 весовых частей кислого метилфумарата и от 290 до 10 весовых частей диметилфумарата.
6. Применение по одному из предшествующих пунктов для получения фармацевтической препаративной формы для перорального введения, отличающееся тем, что микротаблетки или микрогранулы снабжены покрытием, устойчивым к желудочному соку.
7. Применение по одному из предшествующих пунктов, отличающееся тем, что микротаблетки или микрогранулы имеют величину от 300 до 2000 мкм.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19814358.3 | 1998-03-31 | ||
| DE19814358A DE19814358C2 (de) | 1998-03-31 | 1998-03-31 | Verwendung von Alkylhydrogenfumaraten zur Behandlung von Psoriasis, psoriatischer Arthritis, Neurodermitis und Enteritis regionalis Crohn |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2000127112A true RU2000127112A (ru) | 2002-08-27 |
| RU2197233C2 RU2197233C2 (ru) | 2003-01-27 |
Family
ID=7863089
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2000127112/14A RU2197233C2 (ru) | 1998-03-31 | 1998-12-08 | Применение кислых алкилфумаратов для лечения псориаза, псориатического артрита, нейродермита и регионального энтерита крона |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US6277882B1 (ru) |
| EP (1) | EP1059920B1 (ru) |
| JP (1) | JP3527890B2 (ru) |
| CN (1) | CN1150898C (ru) |
| AT (1) | ATE219936T1 (ru) |
| AU (1) | AU745281B2 (ru) |
| BG (1) | BG64744B1 (ru) |
| BR (1) | BRPI9815772B8 (ru) |
| CA (1) | CA2283915C (ru) |
| CZ (1) | CZ291788B6 (ru) |
| DE (2) | DE19814358C2 (ru) |
| DK (1) | DK1059920T3 (ru) |
| EE (1) | EE04702B1 (ru) |
| ES (1) | ES2179551T3 (ru) |
| HK (1) | HK1035134A1 (ru) |
| HU (1) | HU228848B1 (ru) |
| IL (1) | IL136835A (ru) |
| NO (1) | NO327750B1 (ru) |
| NZ (1) | NZ505341A (ru) |
| PL (1) | PL191803B1 (ru) |
| PT (1) | PT1059920E (ru) |
| RS (1) | RS49658B (ru) |
| RU (1) | RU2197233C2 (ru) |
| SK (1) | SK285187B6 (ru) |
| TR (1) | TR200001829T2 (ru) |
| WO (1) | WO1999049858A1 (ru) |
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| DE19853487A1 (de) * | 1998-11-19 | 2000-05-25 | Fumapharm Ag Muri | Verwendung von Dialkylfumaraten |
| PL392748A1 (pl) * | 2001-01-12 | 2011-05-09 | Fumapharm Ag | Amidy kwasu fumarowego |
| DE10101307A1 (de) * | 2001-01-12 | 2002-08-01 | Fumapharm Ag Muri | Fumarsäurederivate als NF-kappaB-Inhibitor |
| DE10217314A1 (de) * | 2002-04-18 | 2003-11-13 | Fumapharm Ag Muri | Carbocyclische und Oxacarboncyclische Fumarsäure-Oligomere |
| DE10360869A1 (de) * | 2003-09-09 | 2005-04-07 | Fumapharm Ag | Verwendung von Fumarsäurederivaten zur Therapie der Herzinsuffizienz, der Hyperkeratose und von Asthma |
| SI1663197T1 (sl) * | 2003-09-09 | 2008-06-30 | Biogen Idec Internat Gmbh | Uporaba derivatov fumarne kisline za zdravljenje sräśne insuficience in astme |
| EP2801354B1 (en) | 2004-10-08 | 2017-02-08 | Forward Pharma A/S | Controlled release pharmaceutical compositions comprising a fumaric acid ester |
| US20080004344A1 (en) * | 2004-11-10 | 2008-01-03 | Aditech Pharma Ab | Novel Salts of Fumaric Acid Monoalkylesters and Their Pharmaceutical Use |
| US20100144651A1 (en) * | 2005-07-07 | 2010-06-10 | Aditech Pharma Ab | Novel glucopyranose esters and glucofuranose esters of alkyl- fumarates and their pharmaceutical use |
| EP1915334A2 (en) * | 2005-07-07 | 2008-04-30 | Aditech Pharma AB | Novel salts of fumaric acid monoalkylesters and their pharmaceutical use |
| WO2007042035A2 (en) * | 2005-10-07 | 2007-04-19 | Aditech Pharma Ab | Combination therapy with fumaric acid esters for the treatment of autoimmune and/or inflammatory disorders |
| WO2007042034A1 (en) * | 2005-10-07 | 2007-04-19 | Aditech Pharma Ab | Controlled release pharmaceutical compositions comprising a fumaric acid ester |
| LT2139467T (lt) * | 2007-02-08 | 2016-10-10 | Biogen Ma Inc. | Neuroapsauga, sergant demielinizuojančia liga |
| DE13169139T1 (de) | 2007-02-08 | 2022-07-14 | Biogen MA Inc. | Zusammensetzungen und deren Verwendung zur Behandlung von Multipler Sklerose |
| US8148414B2 (en) | 2008-08-19 | 2012-04-03 | Xenoport, Inc. | Prodrugs of methyl hydrogen fumarate, pharmaceutical compositions thereof, and methods of use |
| EP2379063B2 (en) | 2009-01-09 | 2021-02-24 | Fwp Ip Aps | Pharmaceutical formulation comprising one or more fumaric acid esters in an erosion matrix |
| PT2718257T (pt) | 2011-06-08 | 2018-02-26 | Biogen Ma Inc | Processo para a preparação de fumarato de dimetilo de alta pureza e cristalino |
| WO2013076216A1 (en) | 2011-11-24 | 2013-05-30 | Synthon Bv | Controlled release particles comprising dimethyl fumarate |
| US20130158077A1 (en) | 2011-12-19 | 2013-06-20 | Ares Trading S.A. | Pharmaceutical compositions |
| US9504679B2 (en) | 2011-12-19 | 2016-11-29 | Bjoern Colin Kahrs | Pharmaceutical compositions comprising glitazones and Nrf2 activators |
| BR112014019462B1 (pt) * | 2012-02-07 | 2022-03-22 | Biogen Ma Inc. | Composições farmacêuticas contendo fumarato de dimetila |
| EP2812319A1 (en) | 2012-02-07 | 2014-12-17 | XenoPort, Inc. | Morpholinoalkyl fumarate compounds, pharmaceutical compositions, and methods of use |
| KR101449114B1 (ko) * | 2012-08-21 | 2014-10-13 | 바이오스펙트럼 주식회사 | 푸마르산을 유효성분으로 포함하는 항염 조성물 |
| EP2887934A1 (en) * | 2012-08-22 | 2015-07-01 | XenoPort, Inc. | Methods of administering monomethyl fumarate and prodrugs thereof having reduced side effects |
| CA2882730C (en) | 2012-08-22 | 2019-12-31 | Xenoport, Inc. | Oral dosage forms of methyl hydrogen fumarate and prodrugs thereof |
| US20140171504A1 (en) | 2012-12-14 | 2014-06-19 | Georgia Regents Research Institute, Inc. | Methods of Treating Sickle Cell Disease and Related Disorders Using Fumaric Acid Esters |
| CN105142628A (zh) | 2012-12-21 | 2015-12-09 | 比奥根玛公司 | 氘取代的富马酸盐衍生物 |
| US8669281B1 (en) | 2013-03-14 | 2014-03-11 | Alkermes Pharma Ireland Limited | Prodrugs of fumarates and their use in treating various diseases |
| UA116648C2 (uk) | 2013-03-14 | 2018-04-25 | Алкермес Фарма Айерленд Лімітед | Фумарати як проліки та їх застосування при лікуванні різних захворювань |
| US10179118B2 (en) | 2013-03-24 | 2019-01-15 | Arbor Pharmaceuticals, Llc | Pharmaceutical compositions of dimethyl fumarate |
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| EP3041467A1 (en) | 2013-09-06 | 2016-07-13 | XenoPort, Inc. | Crystalline forms of (n,n-diethylcarbamoyl)methyl methyl (2e)but-2-ene-1,4-dioate, methods of synthesis and use |
| US20150079180A1 (en) | 2013-09-18 | 2015-03-19 | Xenoport, Inc. | Nanoparticle compositions of dimethyl fumarate |
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| US9999672B2 (en) | 2014-03-24 | 2018-06-19 | Xenoport, Inc. | Pharmaceutical compositions of fumaric acid esters |
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-
1998
- 1998-03-31 DE DE19814358A patent/DE19814358C2/de not_active Expired - Lifetime
- 1998-12-08 TR TR2000/01829T patent/TR200001829T2/xx unknown
- 1998-12-08 RS YUP-320/00A patent/RS49658B/sr unknown
- 1998-12-08 DK DK98965783T patent/DK1059920T3/da active
- 1998-12-08 JP JP2000540824A patent/JP3527890B2/ja not_active Expired - Fee Related
- 1998-12-08 CA CA002283915A patent/CA2283915C/en not_active Expired - Fee Related
- 1998-12-08 NZ NZ505341A patent/NZ505341A/en not_active IP Right Cessation
- 1998-12-08 WO PCT/EP1998/007956 patent/WO1999049858A1/de active IP Right Grant
- 1998-12-08 AT AT98965783T patent/ATE219936T1/de active
- 1998-12-08 ES ES98965783T patent/ES2179551T3/es not_active Expired - Lifetime
- 1998-12-08 CZ CZ20003086A patent/CZ291788B6/cs not_active IP Right Cessation
- 1998-12-08 EE EEP200000440A patent/EE04702B1/xx not_active IP Right Cessation
- 1998-12-08 SK SK792-2000A patent/SK285187B6/sk not_active IP Right Cessation
- 1998-12-08 HU HU0103234A patent/HU228848B1/hu not_active IP Right Cessation
- 1998-12-08 IL IL13683598A patent/IL136835A/xx not_active IP Right Cessation
- 1998-12-08 BR BRPI9815772 patent/BRPI9815772B8/pt unknown
- 1998-12-08 RU RU2000127112/14A patent/RU2197233C2/ru not_active IP Right Cessation
- 1998-12-08 PT PT98965783T patent/PT1059920E/pt unknown
- 1998-12-08 EP EP98965783A patent/EP1059920B1/de not_active Expired - Lifetime
- 1998-12-08 CN CNB988138344A patent/CN1150898C/zh not_active Expired - Fee Related
- 1998-12-08 DE DE59804704T patent/DE59804704D1/de not_active Expired - Lifetime
- 1998-12-08 AU AU21593/99A patent/AU745281B2/en not_active Ceased
- 1998-12-08 US US09/402,103 patent/US6277882B1/en not_active Expired - Lifetime
- 1998-12-08 PL PL341240A patent/PL191803B1/pl unknown
-
2000
- 2000-06-06 NO NO20002872A patent/NO327750B1/no not_active IP Right Cessation
- 2000-06-28 BG BG104566A patent/BG64744B1/bg unknown
-
2001
- 2001-08-13 HK HK01105619A patent/HK1035134A1/xx not_active IP Right Cessation
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