RU2000111744A - Очищенная и выделенная днк, химерный полинуклеотид, вектор экспрессии и клетка-хозяин - Google Patents
Очищенная и выделенная днк, химерный полинуклеотид, вектор экспрессии и клетка-хозяин Download PDFInfo
- Publication number
- RU2000111744A RU2000111744A RU2000111744/13A RU2000111744A RU2000111744A RU 2000111744 A RU2000111744 A RU 2000111744A RU 2000111744/13 A RU2000111744/13 A RU 2000111744/13A RU 2000111744 A RU2000111744 A RU 2000111744A RU 2000111744 A RU2000111744 A RU 2000111744A
- Authority
- RU
- Russia
- Prior art keywords
- promoter
- purified
- expression vector
- chimeric polynucleotide
- dna
- Prior art date
Links
- 239000002157 polynucleotide Substances 0.000 title claims 4
- 102000040430 polynucleotide Human genes 0.000 title claims 4
- 108091033319 polynucleotide Proteins 0.000 title claims 4
- 239000013604 expression vector Substances 0.000 title claims 2
- 101710148793 Intercellular adhesion molecule 4 Proteins 0.000 claims abstract 3
- 102100037874 Intercellular adhesion molecule 4 Human genes 0.000 claims abstract 3
- 239000002773 nucleotide Substances 0.000 claims 6
- 125000003729 nucleotide group Chemical group 0.000 claims 6
- 210000004027 cell Anatomy 0.000 claims 2
- 210000003061 neural cell Anatomy 0.000 claims 2
- 101100452024 Homo sapiens ICAM4 gene Proteins 0.000 claims 1
- 101000599868 Homo sapiens Intercellular adhesion molecule 4 Proteins 0.000 claims 1
- 230000000971 hippocampal effect Effects 0.000 claims 1
- 102000048962 human ICAM4 Human genes 0.000 claims 1
- 230000035897 transcription Effects 0.000 claims 1
- 238000013518 transcription Methods 0.000 claims 1
- 239000013598 vector Substances 0.000 claims 1
- 238000000034 method Methods 0.000 abstract 2
- 102000016289 Cell Adhesion Molecules Human genes 0.000 abstract 1
- 108010067225 Cell Adhesion Molecules Proteins 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70525—ICAM molecules, e.g. CD50, CD54, CD102
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2821—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against ICAM molecules, e.g. CD50, CD54, CD102
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Toxicology (AREA)
- General Physics & Mathematics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Food Science & Technology (AREA)
- Plant Pathology (AREA)
- Pathology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Semiconductor Memories (AREA)
- Treatment And Processing Of Natural Fur Or Leather (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Glass Compositions (AREA)
Claims (10)
1. Очищенная и выделенная ДНК, содержащая промотор для ICAM-4 млекопитающего.
2. ДНК по п. 1, отличающаяся тем, что указанный промотор представляет собой промотор для человеческого ICAM-4.
3. ДНК по п. 2, отличающаяся тем, что указанный промотор включен в последовательность SEQ ID N0: 33.
4. ДНК по п. 3, отличающаяся тем, что указанный промотор включен в последовательность из нуклеотидов от приблизительно нуклеотида 1204 до приблизительно нуклеотида 1666 в SEQ ID N0: 33.
5. ДНК по любому из пп. 1-4, отличающаяся тем, что указанный промотор способен специфически стимулировать транскрипцию полинуклеотида, связанного в действии с указанным промотором в нейронной клетке.
6. ДНК по п. 5, отличающаяся тем, что указанная нейронная клетка представляет собой клетку гиппокампа.
7. Химерный полинуклеотид, содержащий промотор для гена человеческого ICAM-4.
8. Химерный полинуклеотид по п. 7, отличающийся тем, что указанный промотор включен в последовательность из нуклеотидов от приблизительно нуклеотида 1204 до приблизительно нуклеотида 1666 в SEQ ID N0: 33.
9. Вектор экспрессии, содержащий ДНК по п. 1 или 7.
10. Клетка-хозяин, трансформированная вектором по п. 9.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/481,130 | 1995-06-07 | ||
| US08/481,130 US5702917A (en) | 1992-01-27 | 1995-06-07 | Polynucleotides encoding human ICAM-4 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2000111744A true RU2000111744A (ru) | 2002-09-10 |
Family
ID=23910735
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU97104028/13A RU2155345C2 (ru) | 1995-06-07 | 1996-06-06 | Способ скрининга невропатологии |
| RU2000111744/13A RU2000111744A (ru) | 1995-06-07 | 2000-05-12 | Очищенная и выделенная днк, химерный полинуклеотид, вектор экспрессии и клетка-хозяин |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU97104028/13A RU2155345C2 (ru) | 1995-06-07 | 1996-06-06 | Способ скрининга невропатологии |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5702917A (ru) |
| EP (2) | EP1308514A3 (ru) |
| JP (2) | JP3349514B2 (ru) |
| CN (2) | CN1597950A (ru) |
| AT (1) | ATE224448T1 (ru) |
| AU (1) | AU721316B2 (ru) |
| BR (1) | BR9606440A (ru) |
| CA (2) | CA2288401A1 (ru) |
| CZ (1) | CZ291974B6 (ru) |
| DE (1) | DE69623746T2 (ru) |
| DK (1) | DK0789763T3 (ru) |
| ES (1) | ES2183961T3 (ru) |
| FI (1) | FI970503A (ru) |
| HU (1) | HUP9901123A3 (ru) |
| IL (2) | IL146447A0 (ru) |
| MX (1) | MX9700941A (ru) |
| NO (1) | NO317150B1 (ru) |
| PL (2) | PL188612B1 (ru) |
| RU (2) | RU2155345C2 (ru) |
| SK (1) | SK284161B6 (ru) |
| WO (1) | WO1996040916A1 (ru) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5702917A (en) * | 1992-01-27 | 1997-12-30 | Icos Corporation | Polynucleotides encoding human ICAM-4 |
| GB9715164D0 (en) * | 1997-07-19 | 1997-09-24 | Medical Res Council | Improvements in or relating to expression of nucleic acid sequences in cerebellar cells |
| CN1132014C (zh) * | 1997-10-02 | 2003-12-24 | 艾科斯有限公司 | Icam－4抗体的应用 |
| AU1117099A (en) * | 1997-10-22 | 1999-05-10 | Icos Corporation | ICAM-6 materials and methods |
| JP2003517276A (ja) * | 1998-11-30 | 2003-05-27 | アイ・ブイ・エフ・サイエンシイズ・コロラド・インコーポレーテツド | 体外受精のための系及び連続的培養液 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0289949B1 (en) * | 1987-05-04 | 1995-10-04 | Dana Farber Cancer Institute | Intercellular adhesion molecules, and their binding ligands |
| PT88641B (pt) * | 1987-10-02 | 1993-04-30 | Genentech Inc | Metodo para a preparacao de uma variante de adesao |
| US5272263A (en) * | 1989-04-28 | 1993-12-21 | Biogen, Inc. | DNA sequences encoding vascular cell adhesion molecules (VCAMS) |
| US5264554A (en) * | 1990-01-19 | 1993-11-23 | The Blood Center Of Southeastern Wisconsin, Inc. | Platelet cell adhesion molecule and variants thereof |
| GB9009548D0 (en) * | 1990-04-27 | 1990-06-20 | Celltech Ltd | Chimeric antibody and method |
| DE69131564T2 (de) * | 1990-07-20 | 2000-01-13 | Bayer Ag | Multimere Formen des menschlichen Rhinovirus-Rezeptorproteins |
| ES2115618T3 (es) * | 1990-08-31 | 1998-07-01 | Boehringer Ingelheim Pharma | Uso de anticuerpos anti-icam en la preparacion de un medicamento para el tratamiento del choque por endotoxinas. |
| JP3288042B2 (ja) * | 1991-06-11 | 2002-06-04 | センター フォア ブラッド リサーチ インコーポレイテッド | 細胞間接着分子−３およびその結合リガンド |
| EP0578819A4 (en) * | 1992-01-27 | 1994-10-12 | Icos Corp | Icam-related protein. |
| US5702917A (en) * | 1992-01-27 | 1997-12-30 | Icos Corporation | Polynucleotides encoding human ICAM-4 |
-
1995
- 1995-06-07 US US08/481,130 patent/US5702917A/en not_active Expired - Fee Related
-
1996
- 1996-06-06 BR BR9606440A patent/BR9606440A/pt not_active Application Discontinuation
- 1996-06-06 AU AU62560/96A patent/AU721316B2/en not_active Ceased
- 1996-06-06 CZ CZ1997292A patent/CZ291974B6/cs not_active IP Right Cessation
- 1996-06-06 ES ES96921310T patent/ES2183961T3/es not_active Expired - Lifetime
- 1996-06-06 IL IL14644796A patent/IL146447A0/xx unknown
- 1996-06-06 RU RU97104028/13A patent/RU2155345C2/ru not_active IP Right Cessation
- 1996-06-06 AT AT96921310T patent/ATE224448T1/de not_active IP Right Cessation
- 1996-06-06 CN CNA2004100342912A patent/CN1597950A/zh active Pending
- 1996-06-06 PL PL96361105A patent/PL188612B1/pl not_active IP Right Cessation
- 1996-06-06 DK DK96921310T patent/DK0789763T3/da active
- 1996-06-06 EP EP02020814A patent/EP1308514A3/en not_active Withdrawn
- 1996-06-06 MX MX9700941A patent/MX9700941A/es not_active IP Right Cessation
- 1996-06-06 CN CNB961908742A patent/CN1152960C/zh not_active Expired - Fee Related
- 1996-06-06 EP EP96921310A patent/EP0789763B1/en not_active Expired - Lifetime
- 1996-06-06 WO PCT/US1996/009146 patent/WO1996040916A1/en not_active Application Discontinuation
- 1996-06-06 SK SK165-97A patent/SK284161B6/sk unknown
- 1996-06-06 HU HU9901123A patent/HUP9901123A3/hu not_active Application Discontinuation
- 1996-06-06 DE DE69623746T patent/DE69623746T2/de not_active Expired - Fee Related
- 1996-06-06 IL IL12009596A patent/IL120095A0/xx unknown
- 1996-06-06 PL PL96318545A patent/PL188878B1/pl not_active IP Right Cessation
- 1996-06-06 CA CA002288401A patent/CA2288401A1/en not_active Abandoned
- 1996-06-06 JP JP50153697A patent/JP3349514B2/ja not_active Expired - Fee Related
- 1996-06-06 CA CA002196431A patent/CA2196431C/en not_active Expired - Fee Related
-
1997
- 1997-02-06 FI FI970503A patent/FI970503A/fi not_active IP Right Cessation
- 1997-02-06 NO NO19970546A patent/NO317150B1/no not_active IP Right Cessation
-
2000
- 2000-05-12 RU RU2000111744/13A patent/RU2000111744A/ru not_active Application Discontinuation
-
2002
- 2002-06-14 JP JP2002174063A patent/JP2003047493A/ja active Pending
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