RU1836368C - Производные 2-имино-3-гетероциклилалкилбензотиазолина или их соли с минеральными или органическими кислотами, обладающие антиконвульсивной активностью - Google Patents

Производные 2-имино-3-гетероциклилалкилбензотиазолина или их соли с минеральными или органическими кислотами, обладающие антиконвульсивной активностью

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Publication number
RU1836368C
RU1836368C SU925010496A SU5010496A RU1836368C RU 1836368 C RU1836368 C RU 1836368C SU 925010496 A SU925010496 A SU 925010496A SU 5010496 A SU5010496 A SU 5010496A RU 1836368 C RU1836368 C RU 1836368C
Authority
RU
Russia
Prior art keywords
salts
heterocyclylalkylbenzothiazoline
imino
possessing
mineral
Prior art date
Application number
SU925010496A
Other languages
English (en)
Inventor
Жимонэ Патрик
Ле Блевек Жозеф
Немесек Консепсьон
Original Assignee
Рон Пуленк-Санте
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8909483A external-priority patent/FR2649704B1/fr
Priority claimed from FR9005889A external-priority patent/FR2661910B1/fr
Application filed by Рон Пуленк-Санте filed Critical Рон Пуленк-Санте
Application granted granted Critical
Publication of RU1836368C publication Critical patent/RU1836368C/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Сущность изобретени : производные 2- амино-3-гетероциклилалкилбензотиазолина ф-лы (I), где RI - 1-пиперазинил, замещенный в положении 4 фенилом, фенилом, замещенным по крайней мере, одним заместителем, выбранным из атома галогена С1-С4-алкила или С1-С4-алкоксигруппы, пиридилом или пиримидинилом; 1,2,3,6-тет- рагидро-1-пиридил, замещенный в положении 4 фенилом, пиперидинил, замещенный в положении 4 фенилом; Q.2 - перфтор-Ci- С4-алкоксигруппа, п 2-3, или их соли с минеральными или органическим кислотами , обладающие антиконвульсионной активностью ф-ла 1: NH N ICHOnKV 1 табл. СП С
SU925010496A 1989-07-13 1992-01-08 Производные 2-имино-3-гетероциклилалкилбензотиазолина или их соли с минеральными или органическими кислотами, обладающие антиконвульсивной активностью RU1836368C (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8909483A FR2649704B1 (fr) 1989-07-13 1989-07-13 Derives d'imino-2 ethyl-3 benzothiazoline, leurs procedes de preparation et les medicaments les contenant
FR9005889A FR2661910B1 (fr) 1990-05-11 1990-05-11 Derives d'imino-2 heterocyclylalkyl-3 benzothiazoline, leur preparation et les medicaments les contenant.

Publications (1)

Publication Number Publication Date
RU1836368C true RU1836368C (ru) 1993-08-23

Family

ID=26227474

Family Applications (1)

Application Number Title Priority Date Filing Date
SU925010496A RU1836368C (ru) 1989-07-13 1992-01-08 Производные 2-имино-3-гетероциклилалкилбензотиазолина или их соли с минеральными или органическими кислотами, обладающие антиконвульсивной активностью

Country Status (20)

Country Link
EP (1) EP0409692B1 (ru)
JP (1) JPH0386871A (ru)
AT (1) ATE102612T1 (ru)
AU (1) AU624972B2 (ru)
CA (1) CA2021031A1 (ru)
CZ (1) CZ281164B6 (ru)
DE (1) DE69007196T2 (ru)
DK (1) DK0409692T3 (ru)
ES (1) ES2062445T3 (ru)
FI (1) FI93109C (ru)
HU (1) HU210827B (ru)
IE (1) IE63318B1 (ru)
IL (1) IL95053A (ru)
NO (1) NO175590C (ru)
NZ (1) NZ234487A (ru)
PL (2) PL164326B1 (ru)
PT (1) PT94701B (ru)
RU (1) RU1836368C (ru)
SK (1) SK278908B6 (ru)
YU (1) YU47723B (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2674853B1 (fr) * 1991-04-03 1995-01-20 Synthelabo Derives de piperidinylguanidine, leur preparation et leur application en therapeutique.
FR2678619B1 (fr) * 1991-07-04 1993-09-17 Rhone Poulenc Rorer Sa Derives de 1,2,4-thiadiazolo[3,4-b]benzothiazole, leur preparation et les medicaments les contenant.
FR2696457B1 (fr) * 1992-10-02 1994-11-25 Rhone Poulenc Rorer Sa Dérivés de 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxyde, leur préparation et les médicaments les contenant.
AU3957093A (en) * 1992-04-15 1993-11-18 Rhone-Poulenc Rorer S.A. 3,4-dihydro-2H-1,2,4-benzothiadiazine-1,1-dioxide-3-carboxyl ic acid derivatives, preparation thereof and drugs containing same
US5889010A (en) * 1995-05-18 1999-03-30 Pfizer Inc. Benzimidazole derivatives having dopaminergic activity

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2631163B2 (de) * 1976-07-10 1978-06-29 Basf Ag, 6700 Ludwigshafen Verfahren zur Herstellung von 2-Iminobenzothiazolen
FR2492258A1 (fr) * 1980-10-17 1982-04-23 Pharmindustrie Nouveau medicament a base d'amino-2 trifluoromethoxy-6 benzothiazole
DE68903484T2 (de) * 1988-12-15 1993-03-18 Rhone Poulenc Sante 2-imino-6-polyfluoralkoxy-benzothiazol-derivate, verfahren zu deren herstellung und arzneimittel, die sie enthalten.
FR2649701B2 (fr) * 1988-12-15 1991-11-22 Rhone Poulenc Sante Derives d'imino-2 benzothiazoline, leurs procedes de preparation et les medicaments les contenant

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Европейский патент № 127133, кл.С 07 В 277/82.1984. *

Also Published As

Publication number Publication date
DE69007196D1 (de) 1994-04-14
CZ342590A3 (en) 1996-01-17
AU624972B2 (en) 1992-06-25
DK0409692T3 (da) 1994-04-05
PL164152B1 (pl) 1994-06-30
IL95053A0 (en) 1991-06-10
NO175590B (no) 1994-07-25
FI903531A0 (fi) 1990-07-12
SK342590A3 (en) 1998-04-08
HU904189D0 (en) 1990-12-28
JPH0386871A (ja) 1991-04-11
CZ281164B6 (cs) 1996-07-17
NO175590C (no) 1994-11-02
IL95053A (en) 1994-05-30
PT94701B (pt) 1997-03-31
AU5884790A (en) 1991-01-17
CA2021031A1 (fr) 1991-01-14
FI93109B (fi) 1994-11-15
DE69007196T2 (de) 1994-06-30
IE63318B1 (en) 1995-04-05
SK278908B6 (sk) 1998-04-08
YU47723B (sh) 1996-01-08
HUT58732A (en) 1992-03-30
FI93109C (fi) 1995-02-27
EP0409692A3 (en) 1991-03-27
PT94701A (pt) 1991-03-20
HU210827B (en) 1995-08-28
NO903113D0 (no) 1990-07-12
IE902551A1 (en) 1991-02-27
NZ234487A (en) 1992-04-28
EP0409692B1 (fr) 1994-03-09
ATE102612T1 (de) 1994-03-15
PL164326B1 (pl) 1994-07-29
YU133990A (sh) 1992-07-20
NO903113L (no) 1991-01-14
ES2062445T3 (es) 1994-12-16
EP0409692A2 (fr) 1991-01-23

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