RS63156B1 - Novi derivati heteroaril amida kao selektivni inhibitori histon deacetilaza 1 i 2 (hdac1-2) - Google Patents
Novi derivati heteroaril amida kao selektivni inhibitori histon deacetilaza 1 i 2 (hdac1-2)Info
- Publication number
- RS63156B1 RS63156B1 RS20220320A RSP20220320A RS63156B1 RS 63156 B1 RS63156 B1 RS 63156B1 RS 20220320 A RS20220320 A RS 20220320A RS P20220320 A RSP20220320 A RS P20220320A RS 63156 B1 RS63156 B1 RS 63156B1
- Authority
- RS
- Serbia
- Prior art keywords
- group
- amino
- pyridin
- fluorophenyl
- optionally substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17382447 | 2017-07-10 | ||
| PCT/ES2018/070491 WO2019012172A1 (es) | 2017-07-10 | 2018-07-09 | Nuevos derivados heteroaryl amida como inhibidores selectivos de histona deacetilasa 1 y 2 (hdac1/2) |
| EP18789777.2A EP3653620B9 (en) | 2017-07-10 | 2018-07-09 | New heteroaryl amide derivatives as selective inhibitors of histone deacetylases 1 and 2 (hdac1-2) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RS63156B1 true RS63156B1 (sr) | 2022-05-31 |
Family
ID=59315557
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RS20220320A RS63156B1 (sr) | 2017-07-10 | 2018-07-09 | Novi derivati heteroaril amida kao selektivni inhibitori histon deacetilaza 1 i 2 (hdac1-2) |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US11241428B2 (https=) |
| EP (1) | EP3653620B9 (https=) |
| JP (1) | JP7026787B2 (https=) |
| KR (1) | KR102574135B1 (https=) |
| CN (1) | CN111051300B (https=) |
| AU (1) | AU2018300123B2 (https=) |
| CY (1) | CY1125343T1 (https=) |
| DK (1) | DK3653620T3 (https=) |
| EA (1) | EA039144B1 (https=) |
| ES (1) | ES2911040T3 (https=) |
| HR (1) | HRP20220472T1 (https=) |
| HU (1) | HUE058353T2 (https=) |
| LT (1) | LT3653620T (https=) |
| MX (1) | MX393982B (https=) |
| PL (1) | PL3653620T3 (https=) |
| PT (1) | PT3653620T (https=) |
| RS (1) | RS63156B1 (https=) |
| SI (1) | SI3653620T1 (https=) |
| SM (1) | SMT202200165T1 (https=) |
| WO (1) | WO2019012172A1 (https=) |
| ZA (1) | ZA202000727B (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7736678B2 (ja) | 2019-10-16 | 2025-09-09 | ケモセントリックス，インコーポレイティド | Ｐｄ－ｌ１疾患の処置のためのヘテロアリール－ビフェニルアミド |
| WO2021117759A1 (ja) * | 2019-12-10 | 2021-06-17 | 塩野義製薬株式会社 | 含窒素芳香族複素環式基を有するヒストン脱アセチル化酵素阻害剤 |
| CN114380751B (zh) * | 2020-03-30 | 2025-03-07 | 上海辉启生物医药科技有限公司 | 二氢化茚胺类衍生物、其制备方法和用途 |
| CA3240229A1 (en) | 2021-12-03 | 2023-06-08 | Tango Therapeutics, Inc. | Novel hdac inhibitors and therapeutic use thereof |
| CN114524799B (zh) * | 2022-03-11 | 2023-05-26 | 沈阳药科大学 | 一种hdac抑制剂及其制备方法和用途 |
| EP4306106A1 (en) * | 2022-07-14 | 2024-01-17 | Universidade de Aveiro | Nitro-containing compounds, compositions and uses thereof |
| CN115463215A (zh) * | 2022-07-26 | 2022-12-13 | 苏州大学 | Hdac9及其抑制剂的新用途 |
| CA3263654A1 (en) | 2022-08-05 | 2024-02-08 | Tango Therapeutics, Inc. | HISTONE DEACETYLASE INHIBITOR FOR THE TREATMENT OF CANCER WITH ALTERED STK11 ACTIVITY OR EXPRESSION |
| CN115304513A (zh) * | 2022-08-25 | 2022-11-08 | 湖北科技学院 | 具有抗炎活性的查尔酮类衍生物及其合成方法和应用 |
| CN115368277B (zh) * | 2022-09-15 | 2024-03-29 | 华侨大学 | 一种含异羟肟酸结构的联苯类化合物及其应用 |
| CN116199636A (zh) * | 2023-02-21 | 2023-06-02 | 杭州医学院 | 靶向肿瘤免疫激酶的2,4-二取代嘧啶衍生物、制备方法及其应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007055942A2 (en) * | 2005-11-03 | 2007-05-18 | Merck & Co., Inc. | Substituted nicotinamide compounds |
| CA2649861A1 (en) * | 2006-04-26 | 2007-11-08 | Merck & Co., Inc. | Disubstituted aniline compounds |
| EP2170339B1 (en) | 2007-06-27 | 2014-10-15 | Merck Sharp & Dohme Corp. | Pyridyl and pyrimidinyl derivatives as histone deacetylase inhibitors |
| KR20120031170A (ko) * | 2009-06-08 | 2012-03-30 | 길리애드 사이언시즈, 인코포레이티드 | 알카노일아미노 벤즈아미드 아닐린 ｈｄａｃ 저해제 화합물 |
| US20160137630A1 (en) * | 2014-10-08 | 2016-05-19 | Acetylon Pharmaceuticals, Inc. | Induction of gata2 by hdac1 and hdac2 inhibitors |
| KR20180022840A (ko) * | 2015-07-02 | 2018-03-06 | 바이오마린 파머수티컬 인크. | 히스톤 데아세틸라제 저해제 |
| US9603950B1 (en) | 2015-10-25 | 2017-03-28 | Institute Of Nuclear Energy Research | Compounds of imaging agent with HDAC inhibitor for treatment of Alzheimer syndrome and method of synthesis thereof |
-
2018
- 2018-07-09 ES ES18789777T patent/ES2911040T3/es active Active
- 2018-07-09 SI SI201830644T patent/SI3653620T1/sl unknown
- 2018-07-09 JP JP2020523052A patent/JP7026787B2/ja active Active
- 2018-07-09 AU AU2018300123A patent/AU2018300123B2/en active Active
- 2018-07-09 LT LTEPPCT/ES2018/070491T patent/LT3653620T/lt unknown
- 2018-07-09 PL PL18789777T patent/PL3653620T3/pl unknown
- 2018-07-09 RS RS20220320A patent/RS63156B1/sr unknown
- 2018-07-09 MX MX2020000349A patent/MX393982B/es unknown
- 2018-07-09 DK DK18789777.2T patent/DK3653620T3/da active
- 2018-07-09 US US16/629,457 patent/US11241428B2/en active Active
- 2018-07-09 PT PT187897772T patent/PT3653620T/pt unknown
- 2018-07-09 CN CN201880056722.5A patent/CN111051300B/zh active Active
- 2018-07-09 WO PCT/ES2018/070491 patent/WO2019012172A1/es not_active Ceased
- 2018-07-09 HR HRP20220472TT patent/HRP20220472T1/hr unknown
- 2018-07-09 EP EP18789777.2A patent/EP3653620B9/en active Active
- 2018-07-09 KR KR1020207003894A patent/KR102574135B1/ko active Active
- 2018-07-09 EA EA202090259A patent/EA039144B1/ru unknown
- 2018-07-09 HU HUE18789777A patent/HUE058353T2/hu unknown
- 2018-07-09 SM SM20220165T patent/SMT202200165T1/it unknown
-
2020
- 2020-02-04 ZA ZA2020/00727A patent/ZA202000727B/en unknown
-
2022
- 2022-04-15 CY CY20221100286T patent/CY1125343T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP3653620B9 (en) | 2022-03-23 |
| JP2020527173A (ja) | 2020-09-03 |
| AU2018300123A1 (en) | 2020-02-13 |
| CY1125343T1 (el) | 2024-12-13 |
| LT3653620T (lt) | 2022-05-10 |
| EP3653620B1 (en) | 2022-02-02 |
| US20200138808A1 (en) | 2020-05-07 |
| ZA202000727B (en) | 2022-07-27 |
| AU2018300123B2 (en) | 2022-03-17 |
| PL3653620T3 (pl) | 2022-06-20 |
| MX2020000349A (es) | 2020-08-17 |
| US11241428B2 (en) | 2022-02-08 |
| KR102574135B1 (ko) | 2023-09-01 |
| CN111051300A (zh) | 2020-04-21 |
| EP3653620A1 (en) | 2020-05-20 |
| WO2019012172A1 (es) | 2019-01-17 |
| ES2911040T3 (es) | 2022-05-17 |
| HRP20220472T1 (hr) | 2022-05-27 |
| HUE058353T2 (hu) | 2022-07-28 |
| SMT202200165T1 (it) | 2022-05-12 |
| DK3653620T3 (da) | 2022-03-28 |
| PT3653620T (pt) | 2022-04-22 |
| KR20200038473A (ko) | 2020-04-13 |
| MX393982B (es) | 2025-03-24 |
| JP7026787B2 (ja) | 2022-02-28 |
| EA202090259A1 (ru) | 2020-05-25 |
| BR112020000564A2 (pt) | 2020-07-21 |
| CN111051300B (zh) | 2022-12-23 |
| CA3069273A1 (en) | 2019-01-17 |
| SI3653620T1 (sl) | 2022-05-31 |
| EA039144B1 (ru) | 2021-12-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RS63156B1 (sr) | Novi derivati heteroaril amida kao selektivni inhibitori histon deacetilaza 1 i 2 (hdac1-2) | |
| CA2684037C (en) | Compounds with anti-cancer activity | |
| ES3060188T3 (en) | Cyclopropyl-amide compounds as dual lsd1/hdac inhibitors | |
| TWI676620B (zh) | 離胺酸特異性去甲基酶-１之抑制劑 | |
| KR20130129244A (ko) | 치환된 6,6-융합된 질소 헤테로환형 화합물 및 이의 용도 | |
| CZ20002349A3 (en) | Inhibition of RAF-kinase by means of aryl- and heteroaryl-substituted heterocyclic ureas | |
| TW201011009A (en) | Novel pyrrolidin-2-ones | |
| JP6918378B2 (ja) | ＣａＭＫＩＩ阻害剤及びその使用 | |
| EP2509974A1 (en) | Pyrazoles derivatives modulators of calcium release -activated calcium channel and methods for treatment of non- small cell lung cancer | |
| JP2015533778A (ja) | がんの治療のための新規フェニル−ピリジン／ピラジンアミド | |
| SG11202110545TA (en) | Inhibitors of notch signalling pathway and use thereof in treatment of cancers | |
| CN112313207A (zh) | 一种氰基取代吡啶及氰基取代嘧啶类化合物、制备方法及其应用 | |
| CN1918148B (zh) | 取代的苯并咪唑和它们诱导细胞凋亡的用途 | |
| CA2929563C (en) | Fluorophenyl pyrazol compounds | |
| WO2016140501A1 (en) | Pyridine n-oxide for enhancer of zeste homolog 2 inhibitors | |
| CA3178647A1 (en) | Substituted tricyclic amides, analogues thereof, and methods using same | |
| CA3069273C (en) | Heteroaryl amide derivatives as selective inhibitors of histone deacetylases 1 and/or 2 (hdac1-2) | |
| CN117820236A (zh) | 组蛋白乙酰转移酶小分子抑制剂及其制备方法和用途 | |
| JP2024516194A (ja) | Ｐｄ１／ｐｄ－ｌ１阻害剤としての化合物及びその方法 | |
| WO2022166990A1 (zh) | 用于抗肿瘤的药物组合 | |
| SG11202110547YA (en) | Compounds for the treatment of oncovirus induced cancer and methods of use thereof | |
| BR112020000564B1 (pt) | Composto de heteroarilamida como inibidor seletivo das histonas desacetilases 1 e/ou 2 (hdac1-2), composição farmacêutica, uso e combinação do mesmo | |
| CN116284043B (zh) | 三环类化合物及其医药用途 | |
| WO2026013620A1 (en) | Irf4 inhibitors and their use for treating cancer and autoimmune disease | |
| CN117551078A (zh) | 芳香单环类衍生物及其制备方法和用途 |