RS63156B1 - Novi derivati heteroaril amida kao selektivni inhibitori histon deacetilaza 1 i 2 (hdac1-2) - Google Patents
Novi derivati heteroaril amida kao selektivni inhibitori histon deacetilaza 1 i 2 (hdac1-2)Info
- Publication number
- RS63156B1 RS63156B1 RS20220320A RSP20220320A RS63156B1 RS 63156 B1 RS63156 B1 RS 63156B1 RS 20220320 A RS20220320 A RS 20220320A RS P20220320 A RSP20220320 A RS P20220320A RS 63156 B1 RS63156 B1 RS 63156B1
- Authority
- RS
- Serbia
- Prior art keywords
- hdac1
- selective inhibitors
- amide derivatives
- histone deacetylases
- heteroaryl amide
- Prior art date
Links
- 102000003964 Histone deacetylase Human genes 0.000 title 1
- 108090000353 Histone deacetylase Proteins 0.000 title 1
- 229940124639 Selective inhibitor Drugs 0.000 title 1
- -1 heteroaryl amide Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP17382447 | 2017-07-10 | ||
PCT/ES2018/070491 WO2019012172A1 (es) | 2017-07-10 | 2018-07-09 | Nuevos derivados heteroaryl amida como inhibidores selectivos de histona deacetilasa 1 y 2 (hdac1/2) |
EP18789777.2A EP3653620B9 (en) | 2017-07-10 | 2018-07-09 | New heteroaryl amide derivatives as selective inhibitors of histone deacetylases 1 and 2 (hdac1-2) |
Publications (1)
Publication Number | Publication Date |
---|---|
RS63156B1 true RS63156B1 (sr) | 2022-05-31 |
Family
ID=59315557
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RS20220320A RS63156B1 (sr) | 2017-07-10 | 2018-07-09 | Novi derivati heteroaril amida kao selektivni inhibitori histon deacetilaza 1 i 2 (hdac1-2) |
Country Status (21)
Country | Link |
---|---|
US (1) | US11241428B2 (sr) |
EP (1) | EP3653620B9 (sr) |
JP (1) | JP7026787B2 (sr) |
KR (1) | KR102574135B1 (sr) |
CN (1) | CN111051300B (sr) |
AU (1) | AU2018300123B2 (sr) |
BR (1) | BR112020000564A2 (sr) |
CA (1) | CA3069273A1 (sr) |
DK (1) | DK3653620T3 (sr) |
EA (1) | EA039144B1 (sr) |
ES (1) | ES2911040T3 (sr) |
HR (1) | HRP20220472T1 (sr) |
HU (1) | HUE058353T2 (sr) |
LT (1) | LT3653620T (sr) |
MX (1) | MX2020000349A (sr) |
PL (1) | PL3653620T3 (sr) |
PT (1) | PT3653620T (sr) |
RS (1) | RS63156B1 (sr) |
SI (1) | SI3653620T1 (sr) |
WO (1) | WO2019012172A1 (sr) |
ZA (1) | ZA202000727B (sr) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114380751A (zh) * | 2020-03-30 | 2022-04-22 | 上海辉启生物医药科技有限公司 | 二氢化茚胺类衍生物、其制备方法和用途 |
CA3240229A1 (en) | 2021-12-03 | 2023-06-08 | Tango Therapeutics, Inc. | Novel hdac inhibitors and therapeutic use thereof |
CN114524799B (zh) * | 2022-03-11 | 2023-05-26 | 沈阳药科大学 | 一种hdac抑制剂及其制备方法和用途 |
EP4306106A1 (en) * | 2022-07-14 | 2024-01-17 | Universidade de Aveiro | Nitro-containing compounds, compositions and uses thereof |
CN115463215A (zh) * | 2022-07-26 | 2022-12-13 | 苏州大学 | Hdac9及其抑制剂的新用途 |
WO2024030659A1 (en) | 2022-08-05 | 2024-02-08 | Tango Therapeutics, Inc. | An hdac inhibitor for treating cancer with a modified stk11 activity or expression |
CN115304513A (zh) * | 2022-08-25 | 2022-11-08 | 湖北科技学院 | 具有抗炎活性的查尔酮类衍生物及其合成方法和应用 |
CN115368277B (zh) * | 2022-09-15 | 2024-03-29 | 华侨大学 | 一种含异羟肟酸结构的联苯类化合物及其应用 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2006312084A1 (en) | 2005-11-03 | 2007-05-18 | Merck Sharp & Dohme Corp. | Substituted nicotinamide compounds |
WO2007127137A2 (en) | 2006-04-26 | 2007-11-08 | Merck & Co., Inc. | Disubstituted aniline compounds |
JP2010531358A (ja) | 2007-06-27 | 2010-09-24 | メルク・シャープ・エンド・ドーム・コーポレイション | ヒストン脱アセチル化酵素阻害剤としてのピリジル及びピリミジニル誘導体 |
BRPI1010884A2 (pt) | 2009-06-08 | 2016-03-15 | Gilead Sciences Inc | composto inibidores hdac de alcanoilamino benzamida anilina |
EP3204006A4 (en) * | 2014-10-08 | 2018-04-04 | Regenacy Pharmaceuticals, LLC | Induction of gata2 by hdac1 and hdac2 inhibitors |
KR20180022840A (ko) * | 2015-07-02 | 2018-03-06 | 바이오마린 파머수티컬 인크. | 히스톤 데아세틸라제 저해제 |
US9603950B1 (en) * | 2015-10-25 | 2017-03-28 | Institute Of Nuclear Energy Research | Compounds of imaging agent with HDAC inhibitor for treatment of Alzheimer syndrome and method of synthesis thereof |
-
2018
- 2018-07-09 SI SI201830644T patent/SI3653620T1/sl unknown
- 2018-07-09 CN CN201880056722.5A patent/CN111051300B/zh active Active
- 2018-07-09 CA CA3069273A patent/CA3069273A1/en active Pending
- 2018-07-09 WO PCT/ES2018/070491 patent/WO2019012172A1/es unknown
- 2018-07-09 MX MX2020000349A patent/MX2020000349A/es unknown
- 2018-07-09 DK DK18789777.2T patent/DK3653620T3/da active
- 2018-07-09 HR HRP20220472TT patent/HRP20220472T1/hr unknown
- 2018-07-09 KR KR1020207003894A patent/KR102574135B1/ko active IP Right Grant
- 2018-07-09 EP EP18789777.2A patent/EP3653620B9/en active Active
- 2018-07-09 JP JP2020523052A patent/JP7026787B2/ja active Active
- 2018-07-09 AU AU2018300123A patent/AU2018300123B2/en active Active
- 2018-07-09 RS RS20220320A patent/RS63156B1/sr unknown
- 2018-07-09 LT LTEPPCT/ES2018/070491T patent/LT3653620T/lt unknown
- 2018-07-09 PT PT187897772T patent/PT3653620T/pt unknown
- 2018-07-09 EA EA202090259A patent/EA039144B1/ru unknown
- 2018-07-09 US US16/629,457 patent/US11241428B2/en active Active
- 2018-07-09 HU HUE18789777A patent/HUE058353T2/hu unknown
- 2018-07-09 BR BR112020000564-9A patent/BR112020000564A2/pt unknown
- 2018-07-09 ES ES18789777T patent/ES2911040T3/es active Active
- 2018-07-09 PL PL18789777T patent/PL3653620T3/pl unknown
-
2020
- 2020-02-04 ZA ZA2020/00727A patent/ZA202000727B/en unknown
Also Published As
Publication number | Publication date |
---|---|
WO2019012172A1 (es) | 2019-01-17 |
JP7026787B2 (ja) | 2022-02-28 |
DK3653620T3 (da) | 2022-03-28 |
EP3653620B1 (en) | 2022-02-02 |
CA3069273A1 (en) | 2019-01-17 |
AU2018300123A1 (en) | 2020-02-13 |
HRP20220472T1 (hr) | 2022-05-27 |
ZA202000727B (en) | 2022-07-27 |
BR112020000564A2 (pt) | 2020-07-21 |
EA039144B1 (ru) | 2021-12-09 |
ES2911040T3 (es) | 2022-05-17 |
CN111051300A (zh) | 2020-04-21 |
US11241428B2 (en) | 2022-02-08 |
MX2020000349A (es) | 2020-08-17 |
KR20200038473A (ko) | 2020-04-13 |
PT3653620T (pt) | 2022-04-22 |
EA202090259A1 (ru) | 2020-05-25 |
AU2018300123B2 (en) | 2022-03-17 |
SI3653620T1 (sl) | 2022-05-31 |
US20200138808A1 (en) | 2020-05-07 |
EP3653620B9 (en) | 2022-03-23 |
LT3653620T (lt) | 2022-05-10 |
KR102574135B1 (ko) | 2023-09-01 |
EP3653620A1 (en) | 2020-05-20 |
CN111051300B (zh) | 2022-12-23 |
JP2020527173A (ja) | 2020-09-03 |
PL3653620T3 (pl) | 2022-06-20 |
HUE058353T2 (hu) | 2022-07-28 |
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