RS62082B1 - Imidazolonilhinolini i njihova primena kao inhibitora atm kinaze - Google Patents
Imidazolonilhinolini i njihova primena kao inhibitora atm kinazeInfo
- Publication number
- RS62082B1 RS62082B1 RS20210817A RSP20210817A RS62082B1 RS 62082 B1 RS62082 B1 RS 62082B1 RS 20210817 A RS20210817 A RS 20210817A RS P20210817 A RSP20210817 A RS P20210817A RS 62082 B1 RS62082 B1 RS 62082B1
- Authority
- RS
- Serbia
- Prior art keywords
- imidazolonyl
- quinolines
- kinase inhibitors
- atm kinase
- atm
- Prior art date
Links
- BAHVJMJZUDCTPT-UHFFFAOYSA-N 4-quinolin-2-ylimidazol-2-one Chemical class O=C1N=CC(C=2N=C3C=CC=CC3=CC=2)=N1 BAHVJMJZUDCTPT-UHFFFAOYSA-N 0.000 title 1
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15000968 | 2015-04-02 | ||
| EP19172903.7A EP3560924B1 (fr) | 2015-04-02 | 2016-03-31 | Imidazolonyl-quinoléines et leur utilisation comme inhibiteurs du atm kinase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RS62082B1 true RS62082B1 (sr) | 2021-08-31 |
Family
ID=52814780
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RS20190993A RS59139B1 (sr) | 2015-04-02 | 2016-03-31 | Imidazolonilhinolini i njihova primena kao inhibitora atm kinaze |
| RS20210817A RS62082B1 (sr) | 2015-04-02 | 2016-03-31 | Imidazolonilhinolini i njihova primena kao inhibitora atm kinaze |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RS20190993A RS59139B1 (sr) | 2015-04-02 | 2016-03-31 | Imidazolonilhinolini i njihova primena kao inhibitora atm kinaze |
Country Status (24)
| Country | Link |
|---|---|
| US (5) | US10457677B2 (fr) |
| EP (3) | EP3560924B1 (fr) |
| JP (2) | JP6791873B2 (fr) |
| KR (2) | KR20240044525A (fr) |
| CN (3) | CN111689963A (fr) |
| AU (3) | AU2016239270B2 (fr) |
| BR (1) | BR122019005502B1 (fr) |
| CA (1) | CA2981365A1 (fr) |
| DK (2) | DK3560924T3 (fr) |
| ES (3) | ES2741853T3 (fr) |
| HR (2) | HRP20191396T1 (fr) |
| HU (2) | HUE045477T2 (fr) |
| IL (3) | IL254714B (fr) |
| LT (2) | LT3560924T (fr) |
| MX (2) | MX2020011558A (fr) |
| PL (2) | PL3560924T3 (fr) |
| PT (2) | PT3560924T (fr) |
| RS (2) | RS59139B1 (fr) |
| RU (1) | RU2743343C2 (fr) |
| SG (2) | SG10202002181UA (fr) |
| SI (2) | SI3277681T1 (fr) |
| TR (1) | TR201911244T4 (fr) |
| WO (1) | WO2016155884A1 (fr) |
| ZA (1) | ZA201707423B (fr) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3560924B1 (fr) * | 2015-04-02 | 2021-03-31 | Merck Patent GmbH | Imidazolonyl-quinoléines et leur utilisation comme inhibiteurs du atm kinase |
| GB201516504D0 (en) | 2015-09-17 | 2015-11-04 | Astrazeneca Ab | Imadazo(4,5-c)quinolin-2-one Compounds and their use in treating cancer |
| GB201519406D0 (en) * | 2015-11-03 | 2015-12-16 | Astrazeneca Ab | Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer |
| WO2018153365A1 (fr) * | 2017-02-27 | 2018-08-30 | 上海瑛派药业有限公司 | Composé tricyclique hétéroaryle fusionné substitué en tant qu'inhibiteur de kinase et son application |
| JOP20190209A1 (ar) * | 2017-03-16 | 2019-09-12 | Astrazeneca Ab | مركبات إيميدازو [ 4، 5-c ] كينولين-2-أون ديوترومية واستخدامها في علاج السرطان |
| JP2021510701A (ja) | 2018-01-12 | 2021-04-30 | プロリンクス エルエルシー | 併用投与の毒性を最小化するためのプロトコルおよび検証用のイメージング剤 |
| AU2019233596A1 (en) * | 2018-03-14 | 2020-10-08 | Merck Patent Gmbh | Compounds and uses thereof to treat tumors in a subject |
| PL3904350T3 (pl) | 2018-04-12 | 2024-02-19 | Bayer Aktiengesellschaft | Pochodne N-(cyklopropylometylo)-5-(metylosulfonylo)-N-{1-[1-(pirymidyn-2-ylo)-1H-1,2,4-triazol-5-ilo]etylo}benzamidu oraz odpowiednie pochodne pirydyno-karboksyamidu jako pestycydy |
| CN110386932A (zh) * | 2018-04-20 | 2019-10-29 | 艾科思莱德制药公司 | 用于抗肿瘤疗法中的双重atm和dna-pk抑制剂 |
| WO2019201283A1 (fr) * | 2018-04-20 | 2019-10-24 | Xrad Therapeutics, Inc. | Inhibiteurs doubles d'atm et d'adn-pk pour une utilisation en thérapie antitumorale |
| GB201814487D0 (en) * | 2018-09-06 | 2018-10-24 | Cycle Pharmaceuticals Ltd | Cancer |
| CN109045042A (zh) * | 2018-09-21 | 2018-12-21 | 上海交通大学医学院附属上海儿童医学中心 | Atm抑制剂在制备抑制急性淋巴细胞性白血病复发的药物中的应用 |
| CA3114646C (fr) * | 2018-09-30 | 2022-03-08 | Medshine Discovery Inc. | Derive de quinolino-pyrrolidin-2-one et application associee |
| EP3947375B1 (fr) * | 2019-03-27 | 2024-04-03 | Merck Patent GmbH | Composés d'imidazolonylquinoline et leurs utilisations thérapeutiques |
| KR20220047290A (ko) * | 2019-07-30 | 2022-04-15 | 엑스래드 테라퓨틱스, 인크. | 항종양 요법에 사용하기 위한 이중 atm 및 dna-pk 억제제 |
| IL292613A (en) | 2019-11-01 | 2022-07-01 | Ares Trading Sa | Combined inhibition of pd-1, tgf-beta and atm along with radiotherapy for cancer treatment |
| WO2021113506A1 (fr) * | 2019-12-04 | 2021-06-10 | Chdi Foundation, Inc. | Inhibiteurs de kinase atm et compositions et procédés d'utilisation de ceux-ci |
| WO2021139814A1 (fr) * | 2020-01-09 | 2021-07-15 | 南京明德新药研发有限公司 | Composé d'imidazole quinoléine et son utilisation |
| WO2021197339A1 (fr) * | 2020-03-30 | 2021-10-07 | 南京明德新药研发有限公司 | Forme cristalline de composé de quinopyrrolidine-2-one servant d'inhibiteur d'atm et son utilisation |
| US20230226041A1 (en) * | 2020-06-18 | 2023-07-20 | Merck Patent Gmbh | Compounds for the treatment of viral infections |
| JP2023539715A (ja) | 2020-06-24 | 2023-09-19 | アストラゼネカ ユーケー リミテッド | 抗体－薬物コンジュゲートとａｔｍ阻害剤との組合わせ |
| MX2023002792A (es) | 2020-09-18 | 2023-03-16 | Merck Patent Gmbh | Preparacion farmaceutica. |
| EP4142710B1 (fr) | 2020-09-21 | 2024-01-31 | Wei Zhong | Composés substitués de 1-(3,3-difluoropipéridin-4-yl)-imidazo[4,5-c]quinoléin-2-one présentant une aptitude à traverser la barrière hémato-encéphalique |
| EP3992191A1 (fr) | 2020-11-03 | 2022-05-04 | Deutsches Krebsforschungszentrum | Dérivés d'imidazo[4,5-c]quinoline et leur utilisation en tant qu'inhibiteurs de kinase atm |
| CN115232122B (zh) * | 2021-04-23 | 2024-05-31 | 石药集团中奇制药技术（石家庄）有限公司 | 炔类化合物及其制备和应用 |
| CN115716829B (zh) * | 2022-11-13 | 2024-05-31 | 药康众拓(江苏)医药科技有限公司 | 一种喹啉并咪唑酮联氘代吡唑类化合物及其应用 |
| US20240247014A1 (en) * | 2022-11-23 | 2024-07-25 | Forward Therapeutics, Inc. | Modulators of tnf-alpha activity |
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| US6221335B1 (en) * | 1994-03-25 | 2001-04-24 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
| ES2193921T3 (es) * | 1999-12-03 | 2003-11-16 | Pfizer Prod Inc | Compuestos de sulfamoilheteroaril-pirazol como agentes antinflamatorios/analgesicos. |
| GB0211649D0 (en) | 2002-05-21 | 2002-07-03 | Novartis Ag | Organic compounds |
| US8106202B2 (en) | 2005-03-21 | 2012-01-31 | Ferrer Internacional, S.A. | Method for making 1-substituted 1H-imidazo [4,5-C] quinolin-4-amine compounds and intermediates therefor |
| GB0510390D0 (en) | 2005-05-20 | 2005-06-29 | Novartis Ag | Organic compounds |
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| US7750168B2 (en) * | 2006-02-10 | 2010-07-06 | Sigma-Aldrich Co. | Stabilized deuteroborane-tetrahydrofuran complex |
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| CN101980708B (zh) | 2008-03-26 | 2013-03-13 | 诺瓦提斯公司 | 作为vegf驱动的血管生成过程的有效调节剂的咪唑并喹啉类及嘧啶衍生物 |
| RS54560B1 (en) | 2008-06-10 | 2016-06-30 | Abbvie Inc. | TRICYCLIC UNITS |
| RU2519200C2 (ru) | 2008-10-01 | 2014-06-10 | Новартис Аг | Применение антагонистов smoothened для лечения связанных с путем hedgehog нарушений |
| MX2011012943A (es) * | 2009-06-04 | 2012-01-27 | Novartis Ag | Derivados de 1h-imidazo-[4,5-c]-quinolinona. |
| WO2010139747A1 (fr) | 2009-06-04 | 2010-12-09 | Novartis Ag | Composés 1h-imidazo [4,5-c] quinolinone utiles pour le traitement des maladies prolifératives |
| GB0919423D0 (en) * | 2009-11-05 | 2009-12-23 | Glaxosmithkline Llc | Novel compounds |
| CN102803227B (zh) * | 2010-03-16 | 2016-01-20 | 默克专利有限公司 | 吗啉基喹唑啉 |
| SG186855A1 (en) * | 2010-06-28 | 2013-02-28 | Merck Patent Gmbh | 2,4- diaryl - substituted [1,8] naphthyridines as kinase inhibitors for use against cancer |
| CN102372711B (zh) | 2010-08-18 | 2014-09-17 | 山东轩竹医药科技有限公司 | 咪唑并喹啉类PI3K和mTOR双重抑制剂 |
| DE102010035744A1 (de) * | 2010-08-28 | 2012-03-01 | Merck Patent Gmbh | Imidazolonylchinoline |
| CN102399218A (zh) | 2010-09-16 | 2012-04-04 | 和记黄埔医药（上海）有限公司 | 一类并合三杂环及其作为pi3k抑制剂的用途 |
| MA34806B1 (fr) | 2010-12-03 | 2014-01-02 | Novartis Ag | Compositions pharmaceutiques |
| CN103012398B (zh) | 2011-09-19 | 2015-10-14 | 上海恒瑞医药有限公司 | 咪唑并喹啉类衍生物及其可药用盐、其制备方法及其在医药上的应用 |
| WO2013154778A1 (fr) | 2012-04-11 | 2013-10-17 | Dana-Farber Cancer Institute, Inc. | Inhibiteurs ciblant l'hôte du virus de la dengue et d'autres virus |
| CA2872541A1 (fr) | 2012-06-06 | 2013-12-12 | Novartis Ag | Combinaison d'un inhibiteur de 17-alpha-hydroxylase (c17,20-lyase) et d'un inhibiteur specifique de pi-3k pour le traitement d'une maladie tumorale |
| NO2714752T3 (fr) * | 2014-05-08 | 2018-04-21 | ||
| EP3560924B1 (fr) * | 2015-04-02 | 2021-03-31 | Merck Patent GmbH | Imidazolonyl-quinoléines et leur utilisation comme inhibiteurs du atm kinase |
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2016
- 2016-03-31 EP EP19172903.7A patent/EP3560924B1/fr active Active
- 2016-03-31 MX MX2020011558A patent/MX2020011558A/es unknown
- 2016-03-31 WO PCT/EP2016/000542 patent/WO2016155884A1/fr active Application Filing
- 2016-03-31 DK DK19172903.7T patent/DK3560924T3/da active
- 2016-03-31 EP EP21165573.3A patent/EP3868761B1/fr active Active
- 2016-03-31 AU AU2016239270A patent/AU2016239270B2/en active Active
- 2016-03-31 CN CN202010644289.6A patent/CN111689963A/zh active Pending
- 2016-03-31 HU HUE16717560A patent/HUE045477T2/hu unknown
- 2016-03-31 MX MX2017012613A patent/MX2017012613A/es active IP Right Grant
- 2016-03-31 US US15/563,680 patent/US10457677B2/en active Active
- 2016-03-31 SI SI201630345T patent/SI3277681T1/sl unknown
- 2016-03-31 PL PL19172903T patent/PL3560924T3/pl unknown
- 2016-03-31 SI SI201631240T patent/SI3560924T1/sl unknown
- 2016-03-31 ES ES16717560T patent/ES2741853T3/es active Active
- 2016-03-31 PT PT191729037T patent/PT3560924T/pt unknown
- 2016-03-31 HU HUE19172903A patent/HUE054745T2/hu unknown
- 2016-03-31 BR BR122019005502-5A patent/BR122019005502B1/pt active IP Right Grant
- 2016-03-31 RS RS20190993A patent/RS59139B1/sr unknown
- 2016-03-31 EP EP16717560.3A patent/EP3277681B1/fr active Active
- 2016-03-31 SG SG10202002181UA patent/SG10202002181UA/en unknown
- 2016-03-31 KR KR1020247009513A patent/KR20240044525A/ko active Search and Examination
- 2016-03-31 SG SG11201708065QA patent/SG11201708065QA/en unknown
- 2016-03-31 KR KR1020177031770A patent/KR102652052B1/ko active IP Right Grant
- 2016-03-31 ES ES19172903T patent/ES2880626T3/es active Active
- 2016-03-31 PL PL16717560T patent/PL3277681T3/pl unknown
- 2016-03-31 PT PT16717560T patent/PT3277681T/pt unknown
- 2016-03-31 CN CN201680031887.8A patent/CN107889488B/zh active Active
- 2016-03-31 CA CA2981365A patent/CA2981365A1/fr active Pending
- 2016-03-31 ES ES21165573T patent/ES2946507T3/es active Active
- 2016-03-31 JP JP2017551589A patent/JP6791873B2/ja active Active
- 2016-03-31 RU RU2017138100A patent/RU2743343C2/ru active
- 2016-03-31 LT LTEP19172903.7T patent/LT3560924T/lt unknown
- 2016-03-31 TR TR2019/11244T patent/TR201911244T4/tr unknown
- 2016-03-31 RS RS20210817A patent/RS62082B1/sr unknown
- 2016-03-31 LT LTEP16717560.3T patent/LT3277681T/lt unknown
- 2016-03-31 CN CN202010644109.4A patent/CN111747952A/zh active Pending
- 2016-03-31 DK DK16717560.3T patent/DK3277681T3/da active
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2017
- 2017-09-26 IL IL254714A patent/IL254714B/en active IP Right Grant
- 2017-11-01 ZA ZA2017/07423A patent/ZA201707423B/en unknown
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2019
- 2019-03-14 US US16/353,559 patent/US10745399B2/en active Active
- 2019-08-01 HR HRP20191396 patent/HRP20191396T1/hr unknown
- 2019-12-17 IL IL271494A patent/IL271494B/en active IP Right Grant
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2020
- 2020-06-24 US US16/910,438 patent/US10975075B2/en active Active
- 2020-06-25 AU AU2020204241A patent/AU2020204241B2/en active Active
- 2020-11-05 JP JP2020185129A patent/JP7111790B2/ja active Active
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2021
- 2021-03-17 US US17/204,619 patent/US11608338B2/en active Active
- 2021-04-22 IL IL282584A patent/IL282584B/en unknown
- 2021-06-23 HR HRP20210981TT patent/HRP20210981T1/hr unknown
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2022
- 2022-10-21 AU AU2022256215A patent/AU2022256215A1/en active Pending
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2023
- 2023-03-01 US US18/116,094 patent/US20230203034A1/en active Pending
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