RS60658B1 - Inhibitori lizin specifične demetilaze-1 - Google Patents
Inhibitori lizin specifične demetilaze-1Info
- Publication number
- RS60658B1 RS60658B1 RS20200980A RSP20200980A RS60658B1 RS 60658 B1 RS60658 B1 RS 60658B1 RS 20200980 A RS20200980 A RS 20200980A RS P20200980 A RSP20200980 A RS P20200980A RS 60658 B1 RS60658 B1 RS 60658B1
- Authority
- RS
- Serbia
- Prior art keywords
- oxo
- methyl
- optionally substituted
- benzonitrile
- amino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Polyamides (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462018365P | 2014-06-27 | 2014-06-27 | |
| EP15811526.1A EP3160956B1 (en) | 2014-06-27 | 2015-06-26 | Inhibitors of lysine specific demethylase-1 |
| PCT/US2015/038089 WO2015200843A1 (en) | 2014-06-27 | 2015-06-26 | Inhibitors of lysine specific demethylase-1 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RS60658B1 true RS60658B1 (sr) | 2020-09-30 |
Family
ID=54938856
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RS20200980A RS60658B1 (sr) | 2014-06-27 | 2015-06-26 | Inhibitori lizin specifične demetilaze-1 |
Country Status (28)
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6521967B2 (ja) | 2013-08-06 | 2019-05-29 | イマーゴ バイオサイエンシーズ インコーポレイテッド | 疾患の治療のためのｋｄｍ１ａ阻害剤 |
| CN106660987B (zh) | 2014-06-27 | 2020-11-06 | 赛尔基因昆蒂赛尔研究公司 | 赖氨酸特异性脱甲基酶-1的抑制剂 |
| EP3164380B1 (en) * | 2014-07-03 | 2022-02-09 | Celgene Quanticel Research, Inc. | Inhibitors of lysine specific demethylase-1 |
| BR112017017074A2 (pt) | 2015-02-12 | 2018-04-10 | Imago Biosciences Inc | Compostos; sal; bis-tosilatos de n-((s)-5-((1r,2s)-2-(4- fluorofenil)ciclopropilamino)-1-(4-metilpiperazin-1- il)-1-oxopentan-2-il)-4-(1h-1,2,3-triazol-1-il)benzamida; sal de tosilato de um composto; sal de bis- tosilato de um composto; compostos, sais, polimorfos ou solvatos; composições farmacêuticas, método para inibição de kdm1a; métodos para tratamento de uma doença mediada por kdm1a ou globina; método para atingir um efeito em um paciente; método para inibir pelo menos uma função de kdm1a |
| CN107849611A (zh) | 2015-06-12 | 2018-03-27 | 奥瑞泽恩基因组学股份有限公司 | 与lsd1抑制剂相关的生物标志物及其用途 |
| WO2017013061A1 (en) | 2015-07-17 | 2017-01-26 | Oryzon Genomics, S.A. | Biomarkers associated with lsd1 inhibitors and uses thereof |
| JP7158023B2 (ja) | 2016-03-15 | 2022-10-21 | オリソン ヘノミクス エセ． アー． | 固形腫瘍の治療における使用のための、ｌｓｄ１阻害剤の組合せ |
| EP3430015B9 (en) | 2016-03-16 | 2025-12-31 | Oryzon Genomics, S.A. | METHODS FOR DETERMINING THE ENGAGEMENT OF A KDM1A TARGET AND CORRESPONDING USEFUL CHEMOPROBE |
| US10150754B2 (en) | 2016-04-19 | 2018-12-11 | Celgene Quanticel Research, Inc. | Histone demethylase inhibitors |
| CN111194306B (zh) | 2016-08-16 | 2023-05-16 | 伊美格生物科学公司 | 用于制备kdm1a抑制剂的方法和过程 |
| EP3535420A1 (en) | 2016-11-03 | 2019-09-11 | Oryzon Genomics, S.A. | Biomarkers for determining responsiveness to lsd1 inhibitors |
| JP2020121925A (ja) * | 2017-04-10 | 2020-08-13 | 三井化学アグロ株式会社 | ピリドン化合物とキノリン系化合物を含有する有害生物防除組成物および有害生物の防除方法、ならびに新規キノリン系化合物 |
| WO2018190324A1 (ja) * | 2017-04-10 | 2018-10-18 | 三井化学アグロ株式会社 | ピリドン化合物を有効成分として含有する抗真菌剤およびその使用方法 |
| WO2018190323A1 (ja) * | 2017-04-10 | 2018-10-18 | 三井化学アグロ株式会社 | ピリドン化合物と有害生物防除剤を含有する有害生物防除組成物および有害生物の防除方法 |
| SG11202000077RA (en) | 2017-08-03 | 2020-02-27 | Oryzon Genomics Sa | Methods of treating behavior alterations |
| AU2019239658A1 (en) * | 2018-03-21 | 2020-11-12 | Suzhou Puhe BioPharma Co., Ltd. | SHP2 inhibitors and uses thereof |
| ES2977656T3 (es) | 2018-05-11 | 2024-08-28 | Imago Biosciences Inc | Inhibidores de KDM1A para el tratamiento de enfermedades |
| CN113631164A (zh) | 2019-03-20 | 2021-11-09 | 奥莱松基因组股份有限公司 | 使用kdm1a抑制剂如化合物伐菲德司他治疗注意缺陷多动症的方法 |
| CN113613653A (zh) | 2019-03-20 | 2021-11-05 | 奥莱松基因组股份有限公司 | 治疗边缘型人格障碍的方法 |
| JP2022546908A (ja) | 2019-07-05 | 2022-11-10 | オリゾン・ゲノミクス・ソシエダッド・アノニマ | Ｋｄｍ１ａ阻害剤を使用した小細胞肺がんの個別化された処置のためのバイオマーカーおよび方法 |
| TW202304416A (zh) | 2021-04-08 | 2023-02-01 | 西班牙商奧萊松基因組股份有限公司 | 用於治療骨髓癌的ｌｓｄ１抑制劑的組合 |
| US20250032454A1 (en) * | 2021-10-18 | 2025-01-30 | Imago Biosciences, Inc. | Kdm1a inhibitors for the treatment of disease |
| US20250295660A1 (en) | 2022-05-09 | 2025-09-25 | Oryzon Genomics, S.A. | Methods of treating nf1-mutant tumors using lsd1 inhibitors |
| JP2025516647A (ja) | 2022-05-09 | 2025-05-30 | オリゾン・ゲノミクス・ソシエダッド・アノニマ | Ｌｓｄ１阻害薬を用いる悪性末梢神経鞘腫（ｍｐｎｓｔ）の治療法 |
| AU2023385514A1 (en) | 2022-11-24 | 2025-07-10 | Oryzon Genomics, S.A. | Combinations of lsd1 inhibitors and menin inhibitors for treating cancer |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE537170T1 (de) * | 2005-03-14 | 2011-12-15 | Merck Sharp & Dohme | Cgrp-rezeptorantagonisten |
| KR20090031913A (ko) * | 2006-06-21 | 2009-03-30 | 이 아이 듀폰 디 네모아 앤드 캄파니 | 세포 증식 억제제로서의 피라지논 |
| CN101842361B (zh) | 2007-06-27 | 2013-06-05 | 阿斯利康(瑞典)有限公司 | 吡嗪酮衍生物及其在治疗肺病中的用途 |
| CL2008002793A1 (es) * | 2007-09-20 | 2009-09-04 | Cgi Pharmaceuticals Inc | Compuestos derivados de amidas sustituidas, inhibidores de la actividad de btk; composicion farmaceutica que los comprende; utiles en el tratamiento del cancer, trastornos oseos, enfermedades autoinmunes, entre otras |
| WO2012013727A1 (en) * | 2010-07-29 | 2012-02-02 | Oryzon Genomics S.A. | Cyclopropylamine derivatives useful as lsd1 inhibitors |
| RU2632915C2 (ru) * | 2012-06-12 | 2017-10-11 | Эббви Инк. | Производные пиридинона и пиридазинона |
| ES2935746T3 (es) * | 2013-12-11 | 2023-03-09 | Celgene Quanticel Res Inc | Inhibidores de desmetilasa-1 específica de lisina |
| CN103804312B (zh) * | 2014-02-17 | 2016-04-20 | 四川百利药业有限责任公司 | 一类氮杂环化合物及其制备方法和用途 |
| SG11201609033TA (en) * | 2014-05-01 | 2016-11-29 | Celgene Quanticel Res Inc | Inhibitors of lysine specific demethylase-1 |
| CN106660987B (zh) | 2014-06-27 | 2020-11-06 | 赛尔基因昆蒂赛尔研究公司 | 赖氨酸特异性脱甲基酶-1的抑制剂 |
-
2015
- 2015-06-26 CN CN201580046216.4A patent/CN106660987B/zh not_active Expired - Fee Related
- 2015-06-26 MX MX2017000179A patent/MX376632B/es active IP Right Grant
- 2015-06-26 SM SM20200443T patent/SMT202000443T1/it unknown
- 2015-06-26 DK DK15811526.1T patent/DK3160956T3/da active
- 2015-06-26 RS RS20200980A patent/RS60658B1/sr unknown
- 2015-06-26 AU AU2015279591A patent/AU2015279591A1/en not_active Abandoned
- 2015-06-26 JP JP2016575362A patent/JP6587241B2/ja not_active Expired - Fee Related
- 2015-06-26 SI SI201531328T patent/SI3160956T1/sl unknown
- 2015-06-26 LT LTEP15811526.1T patent/LT3160956T/lt unknown
- 2015-06-26 ES ES15811526T patent/ES2812626T3/es active Active
- 2015-06-26 CA CA2953810A patent/CA2953810C/en active Active
- 2015-06-26 BR BR112016030697-0A patent/BR112016030697B1/pt not_active IP Right Cessation
- 2015-06-26 HU HUE15811526A patent/HUE050564T2/hu unknown
- 2015-06-26 EA EA201692513A patent/EA030946B1/ru unknown
- 2015-06-26 WO PCT/US2015/038089 patent/WO2015200843A1/en not_active Ceased
- 2015-06-26 SG SG10201911220TA patent/SG10201911220TA/en unknown
- 2015-06-26 HR HRP20201337TT patent/HRP20201337T1/hr unknown
- 2015-06-26 US US15/322,277 patent/US10011583B2/en active Active
- 2015-06-26 KR KR1020177000953A patent/KR102438302B1/ko active Active
- 2015-06-26 PT PT158115261T patent/PT3160956T/pt unknown
- 2015-06-26 SG SG11201610866PA patent/SG11201610866PA/en unknown
- 2015-06-26 PL PL15811526T patent/PL3160956T3/pl unknown
- 2015-06-26 EP EP15811526.1A patent/EP3160956B1/en active Active
-
2016
- 2016-12-22 IL IL249733A patent/IL249733B/en active IP Right Grant
- 2016-12-27 CL CL2016003350A patent/CL2016003350A1/es unknown
-
2017
- 2017-01-04 ZA ZA2017/00069A patent/ZA201700069B/en unknown
- 2017-01-16 CO CONC2017/0000362A patent/CO2017000362A2/es unknown
- 2017-01-26 EC ECIEPI20175635A patent/ECSP17005635A/es unknown
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2018
- 2018-05-29 US US15/991,222 patent/US10597376B2/en not_active Expired - Fee Related
-
2019
- 2019-05-03 JP JP2019087186A patent/JP6851418B2/ja not_active Expired - Fee Related
- 2019-11-07 AU AU2019261771A patent/AU2019261771B2/en not_active Ceased
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2020
- 2020-02-03 US US16/780,704 patent/US11028066B2/en active Active
- 2020-08-14 CY CY20201100759T patent/CY1123475T1/el unknown
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