RO92427A - Anticorpi monoclonali pentru detectarea celulelor maligne si procedeude obtinere a acestora - Google Patents

Anticorpi monoclonali pentru detectarea celulelor maligne si procedeude obtinere a acestora

Info

Publication number
RO92427A
RO92427A RO84114584A RO11458484A RO92427A RO 92427 A RO92427 A RO 92427A RO 84114584 A RO84114584 A RO 84114584A RO 11458484 A RO11458484 A RO 11458484A RO 92427 A RO92427 A RO 92427A
Authority
RO
Romania
Prior art keywords
detection
monoclonal antibodies
malign cells
obtaining procedures
procedures
Prior art date
Application number
RO84114584A
Other languages
English (en)
French (fr)
Inventor
Karl Tryggvason
Lance A Liotta
Original Assignee
Institutul "Victor Babes",Ro
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institutul "Victor Babes",Ro filed Critical Institutul "Victor Babes",Ro
Publication of RO92427A publication Critical patent/RO92427A/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • C12N9/6491—Matrix metalloproteases [MMP's], e.g. interstitial collagenase (3.4.24.7); Stromelysins (3.4.24.17; 3.2.1.22); Matrilysin (3.4.24.23)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96486—Metalloendopeptidases (3.4.24)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2474/00—Immunochemical assays or immunoassays characterised by detection mode or means of detection
    • G01N2474/20—Immunohistochemistry assay
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/811—Test for named disease, body condition or organ function
    • Y10S436/813—Cancer

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Enzymes And Modification Thereof (AREA)
RO84114584A 1983-05-19 1984-05-17 Anticorpi monoclonali pentru detectarea celulelor maligne si procedeude obtinere a acestora RO92427A (ro)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/496,230 US4677058A (en) 1983-05-19 1983-05-19 Detecting malignant cells with monoclonal antibodies specific to type IV collagenase enzyme

Publications (1)

Publication Number Publication Date
RO92427A true RO92427A (ro) 1987-09-30

Family

ID=23971775

Family Applications (1)

Application Number Title Priority Date Filing Date
RO84114584A RO92427A (ro) 1983-05-19 1984-05-17 Anticorpi monoclonali pentru detectarea celulelor maligne si procedeude obtinere a acestora

Country Status (26)

Country Link
US (1) US4677058A (ro)
JP (1) JPS602187A (ro)
AU (1) AU2808784A (ro)
BE (1) BE899663A (ro)
CA (1) CA1230052A (ro)
CH (1) CH668838A5 (ro)
DD (1) DD251208A5 (ro)
DE (1) DE3418625A1 (ro)
DK (1) DK243184A (ro)
ES (1) ES8605904A1 (ro)
FI (1) FI841897A (ro)
FR (1) FR2546302B1 (ro)
GB (1) GB2142030B (ro)
HU (1) HU195004B (ro)
IL (1) IL71802A0 (ro)
IT (1) IT1175842B (ro)
LU (1) LU85366A1 (ro)
NL (1) NL8401616A (ro)
NO (1) NO841993L (ro)
NZ (1) NZ208108A (ro)
PL (1) PL247745A1 (ro)
PT (1) PT78610B (ro)
RO (1) RO92427A (ro)
SE (1) SE8402703L (ro)
YU (1) YU86984A (ro)
ZA (1) ZA843539B (ro)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6294172B1 (en) 1983-08-12 2001-09-25 Dade Behring Marburg Gmbh Monoclonal antibodies with specificity for membrane-associated antigens
US4859581A (en) * 1986-03-10 1989-08-22 Board Of Regents, The University Of Texas System Endoglycosidase assay
CA1339874C (en) * 1987-09-04 1998-05-19 Arthur Zanvel Eisen Dna clone of human type iv collagenase
US4923818A (en) * 1987-09-04 1990-05-08 Washington University DNA clone of human type IV collagenase
US4876332A (en) * 1987-10-08 1989-10-24 Regents Of The Univeristy Of Minnesota Polypeptides with type IV collagen activity
US5280106A (en) * 1988-05-20 1994-01-18 Liotta Lance A Matrix metalloproteinase peptides: role in diagnosis and therapy
US5030555A (en) * 1988-09-12 1991-07-09 University Of Florida Membrane-strip reagent serodiagnostic apparatus and method
DE3909799A1 (de) * 1989-03-24 1990-09-27 Behringwerke Ag Monoklonale antikoerper (mak) gegen tumorassoziierte antigene, ihre herstellung und verwendung
US4992537A (en) * 1989-05-15 1991-02-12 Washington University cDNA encoding 92-kDA type IV collagenase
CA2067797C (en) * 1989-10-18 1997-03-04 Charles R. King Production and use of human nm23 protein and antibodies therefor
JPH0734014B2 (ja) * 1990-01-26 1995-04-12 アメリカ合衆国 コラーゲナーゼを定量的に測定するための方法
WO1992020820A1 (en) * 1991-05-15 1992-11-26 Vanderbilt University Method to determine metastatic potential of tumor cells
US5324634A (en) * 1992-03-31 1994-06-28 The Research Foundation Of State University Of New York Diagnostic tests measuring gelatinase/inhibitor complexes for detection of aggressive and metastatic cancer
JP2673929B2 (ja) * 1993-04-12 1997-11-05 富士薬品工業株式会社 ヒト間質型コラゲナーゼと阻害剤との複合体の免疫学的定量法および臨床診断への応用
US20060102477A1 (en) * 2004-08-26 2006-05-18 Applera Corporation Electrowetting dispensing devices and related methods

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE343949B (ro) * 1966-06-02 1972-03-20 Pharmacia Ab
DE2363854C3 (de) * 1973-12-21 1980-01-03 Behringwerke Ag, 3550 Marburg Substrat zur Proteinasebestimmung sowie dessen Herstellung
US4201763A (en) * 1975-10-09 1980-05-06 Bio-Rad Laboratories, Inc. Solid phase immunofluorescent assay method
NO169947C (no) * 1981-10-27 1992-08-26 Hybritech Inc Fremgangsmaate for fremstilling av et monoklonalt antistoff til et tumorassosiert antigen
US4424278A (en) * 1981-11-16 1984-01-03 Research Corporation Cancer detection procedure using an acyl carrier protein
US4443367A (en) * 1982-04-08 1984-04-17 Monsanto Company Peptide and peptolide substrates for mammalian collagenase

Also Published As

Publication number Publication date
IT1175842B (it) 1987-07-15
ES532597A0 (es) 1986-04-01
DE3418625A1 (de) 1984-11-22
DK243184A (da) 1984-11-20
US4677058A (en) 1987-06-30
HU195004B (en) 1988-03-28
NZ208108A (en) 1988-04-29
PT78610B (en) 1986-07-15
DD251208A5 (de) 1987-11-04
LU85366A1 (fr) 1984-11-19
HUT34261A (en) 1985-02-28
SE8402703L (sv) 1984-11-20
FI841897A0 (fi) 1984-05-11
GB2142030B (en) 1987-02-04
CH668838A5 (de) 1989-01-31
GB8411959D0 (en) 1984-06-13
FR2546302A1 (fr) 1984-11-23
BE899663A (fr) 1984-08-31
JPS602187A (ja) 1985-01-08
DK243184D0 (da) 1984-05-17
YU86984A (en) 1991-01-28
ZA843539B (en) 1985-07-31
NO841993L (no) 1984-11-20
NL8401616A (nl) 1984-12-17
AU2808784A (en) 1984-11-22
GB2142030A (en) 1985-01-09
PL247745A1 (en) 1985-08-27
ES8605904A1 (es) 1986-04-01
PT78610A (en) 1984-06-01
FR2546302B1 (fr) 1988-03-04
CA1230052A (en) 1987-12-08
SE8402703D0 (sv) 1984-05-18
IT8420998A1 (it) 1985-11-18
FI841897A (fi) 1984-11-20
IL71802A0 (en) 1984-09-30
IT8420998A0 (it) 1984-05-18

Similar Documents

Publication Publication Date Title
GB2150288B (en) Immunometric and inhibition assays using monoclonal antibodies
DE3167698D1 (en) Method for the determination of antigens with the aid of two or more monoclonal antibodies
GB2111676B (en) Device and method for determining the presence of antigens or antibodies
DK27884D0 (da) Monoklonale antistofblandinger og anvendelsen deraf til foroeget sensitivitets-immunoassays
IT8123231A0 (it) Saggi immunometrici e di inibizione con l'impiego di anticorpi monoclonici
DK666389D0 (da) Monoklonalt antistof
DK99682A (da) Immunoanalysemetoder under anvendelse af monoklonale antistoffer
RO92427A (ro) Anticorpi monoclonali pentru detectarea celulelor maligne si procedeude obtinere a acestora
NO843293L (no) Monoklonale antistoffer, samt fremgangsmaate for fremstilling av slike
NO302176B1 (no) Fremgangsmåte for fremstilling av et monoklonalt antistoff og et antigen
DK553281A (da) Fremgangsmaade til paavisning af antistof
ES527730A0 (es) Anticuerpos monoclonales
ES531436A0 (es) Procedimiento de obtener y aislar hibridomas secretores de anticuerpos, procedimiento de obtener anticuerpos y metodo de obtener polipeptidos
DE3689948D1 (de) Monoklonale antikörper und testverfahren.
DK188185D0 (da) Monoklonalt antistof
ES546696A0 (es) Procedimiento de preparar anticuerpos monoclonales y metodo de preparar reactivos para detectar canceres
NO170691C (no) Onkofoetale spesifikke monoklonale antistoffer og anvendelse derav
NO177311C (no) Anti-fucosylceramid monoklonalt antistoff
DK717888A (da) Monoklonale antistoffer
DK144485A (da) Monoklonale antistoffer
DK37785D0 (da) Monoclonalt antistof
FR2500754B1 (fr) Anticorps monoclonaux
DK474189A (da) Monoklonalt antistof
DK413389A (da) Monoklonale antistoffer
BE892296A (fr) Anticorps monoclonaux